Protein Alignment faf and USP28

DIOPT Version :9

• Sequence 1: NP_524612.2
• Gene: faf / 43749
• FlyBaseID: FBgn0005632
• Length: 2778
• Species: Drosophila melanogaster
• Sequence 2: NP_001333181.1
• Gene: USP28 / 57646
• HGNCID: 12625
• Length: 1139
• Species: Homo sapiens
• Alignment Length: 1225
• Identity: 230/1225 - (18%)
• Similarity: 396/1225 - (32%)
• Gaps: 474/1225 - (38%)

  Fly  1514 LQISEG-------LLGDEIKWLQRIRENVHATGDTQVHEELLEGHLCLAKELMFFLGADSKAQLN 1571
            |:.|.|       ||.||     |::|....|..|:..|  :||. ...||::        |::.
Human    44 LKASNGDITQAVSLLTDE-----RVKEPSQDTVATEPSE--VEGS-AANKEVL--------AKVI 92

  Fly  1572 ELIHELIDDFLFTASREFLHLRRHGSLRQDTVPPPVCRSPHTIAAACDLLIALCQLCVPNMKLLT 1636
            :|.|:..||.                  |..:...:..||...|...||
Human    93 DLTHDNKDDL------------------QAAIALSLLESPKIQADGRDL---------------- 123

  Fly  1637 NTLIDFVCTDTDPLRE-----WDYLP-PVGARPTKGF-CGLKNAGATCYMNSVLQQLYMVPAVRV 1694
            |.:.:....:|...:.     |...| |...|...|: .||||.|.||:.::|:|.|:.:|..|.
Human   124 NRMHEATSAETKRSKRKRCEVWGENPNPNDWRRVDGWPVGLKNVGNTCWFSAVIQSLFQLPEFRR 188

  Fly  1695 GILRAHGAATTDGEDFSGDSDLTGGGLGSALFSGPASALVSLPSSSSTIEDGLHDVRKNYHVVIL 1759
            .:|.                           :|.|.:.|.:..|         |..::|  ::.:
Human   189 LVLS---------------------------YSLPQNVLENCRS---------HTEKRN--IMFM 215

  Fly  1760 KHVQAIFAHLGHSALQYYVPRG----LWTHFKLLGEPVNLREQQDAVEFFMSLLESLDEGLKA-- 1818
            :.:|.:||.:..|..::..|..    |...|:...|     :|||..||...||:.|::..:.
Human   216 QELQYLFALMMGSNRKFVDPSAALDLLKGAFRSSEE-----QQQDVSEFTHKLLDWLEDAFQLAV 275

  Fly  1819 -LGQPQ-----LMNATLGGSFSDQKICQECPHRYSKEEPFSVFSVDIRNHSSLTESLEQYVKGEL 1877
             :..|:     .|.....|:|..:.:.:..|  :...|.|..:.:.:..:.:|.|.||    |.:
Human   276 NVNSPRNKSENPMVQLFYGTFLTEGVREGKP--FCNNETFGQYPLQVNGYRNLDECLE----GAM 334

  Fly  1878 LEGADAYHCD----KCDKKVVTVKRVCVKKLPPVLAIQLKRFEYDYERVCAIKFNDYFEFPRILD 1938
            :||      |    ..|..|...:.....||||||..:|.|||::.......|.::..|||:|:.
Human   335 VEG------DVELLPSDHSVKYGQERWFTKLPPVLTFELSRFEFNQSLGQPEKIHNKLEFPQIIY 393

  Fly  1939 MEPYTVSG----------LAKLEGEV----------VEVG------------------------- 1958
            |:.|....          :.||:.|:          |:.|
Human   394 MDRYMYRSKELIRNKRECIRKLKEEIKILQQKLERYVKYGSGPARFPLPDMLKYVIEFASTKPAS 458

  Fly  1959 DNC---------------------QTNVETTK--------------------------------- 1969
            ::|                     ||:.|:|.
Human   459 ESCPPESDTHMTLPLSSVHCSVSDQTSKESTSTESSSQDVESTFSSPEDSLPKSKPLTSSRSSME 523

  Fly  1970 ------------------------------------------------------------YELTG 1974
                                                                        |.|..
Human   524 MPSQPAPRTVTDEEINFVKTCLQRWRSEIEQDIQDLKTCIASTTQTIEQMYCDPLLRQVPYRLHA 588

  Fly  1975 IVVHSGQASGGHYFSYILSKNPANGKCQWYKFDDGEVTECKMHEDEEMKAECFGGEYMGETYDNN 2039
            ::||.|||:.|||::||.::    .:..|.|::|..|||...   ||::.:.:||
Human   589 VLVHEGQANAGHYWAYIYNQ----PRQSWLKYNDISVTESSW---EEVERDSYGG---------- 636

  Fly  2040 LKRMQYRRQKRWWNAYMLFYTRCDQTP---VQYEPS-VEQLSLAESRNMVLPLPKPIERSVRHQN 2100
            |:.:         :||.|.|.. |:.|   .:..|: .:|:|..|:      |...::..::..|
Human   637 LRNV---------SAYCLMYIN-DKLPYFNAEAAPTESDQMSEVEA------LSVELKHYIQEDN 685

  Fly  2101 IRFLHSRSIFSVEFFNFIKKLVSCNLLSARSNKITPAAEELSLLGVQLASQFLFHTGFRTKKSLR 2165
            .||......:..|        .||.:....|:..:.:.:..:.....:||..    |.|...|..
Human   686 WRFEQEVEEWEEE--------QSCKIPQMESSTNSSSQDYSTSQEPSVASSH----GVRCLSSEH 738

  Fly  2166 GPVMEWYDALSHHIRSSALVRKWFANHALLS------------PPSRLGEYILMAPSPDVRTVFV 2218
            ..:::  :..:..|.::|...:.....|.||            ..:.|.|.....|.
Human   739 AVIVK--EQTAQAIANTARAYEKSGVEAALSELKEAEPKKPMPQETNLAEQSEQPPK-------- 793

  Fly  2219 KLVVFFCHFAINDEPLTGYDGANLCEQVLISVLRLL-KSEAADYGKHLPHYFSLFSMYVGLGTRE 2282
                      .||...|....:.:.|..:.||.|:| :|:|..|.:.
Human   794 ----------ANDAESTAQPNSEVSEVEIPSVGRILVRSDADGYDEE------------------ 830

  Fly  2283 KQQLLRLNVPLQFIQVAL---------DDGPGPAIKYQYPEFSKLHQV-----VSHLIRCSD--V 2331
                :.|:..:|.:.:|:         |......||..:.|:|:|:|:     .||    ||  :
Human   831 ----VMLSPAMQGVILAIAKARQTFDRDGSEAGLIKAFHEEYSRLYQLAKETPTSH----SDPRL 887

  Fly  2332 SEKCQSSNQNARP-------LSNPFKDPNVAHEELTPLSTECMDLLFNRTGYIKKVIED--TNVG 2387
            ........||..|       |...|.|.|::::|              |:..|.||.:.  ..:|
Human   888 QHVLVYFFQNEAPKRVVERTLLEQFADKNLSYDE--------------RSISIMKVAQAKLKEIG 938

  Fly  2388 DEGLKLLQYCSWENPH-----FSRAVLTEL-LWQCGFAYCHDMRHHTDLLLNILLIDDSWQHHRI 2446
            .:.:.:.:|..|...:     .|..:||.| |:|.|        .:.:.|..::....|
Human   939 PDDMNMEEYKKWHEDYSLFRKVSVYLLTGLELYQKG--------KYQEALSYLVYAYQS------ 989

  Fly  2447 HNALNGVAEEREGLLETIQRAKTHYQKRAYQIIKCLTQLFHKSPIALQMLHTNSN 2501
             ||...:...|.|:.|::...   |::      |||.:|..|   |..:..||.:
Human   990 -NAALLMKGPRRGVKESVIAL---YRR------KCLLELNAK---AASLFETNDD 1031

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
faf	NP_524612.2	peptidase_C19C	1666..2064	CDD:239124	107/573 (19%)
		UCH	1668..2059	CDD:278850	105/565 (19%)
USP28	NP_001333181.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810