DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment faf and usp9

DIOPT Version :9

Sequence 1:	NP_524612.2	Gene:	faf / 43749	FlyBaseID:	FBgn0005632	Length:	2778	Species:	Drosophila melanogaster
Sequence 2:	XP_005167793.1	Gene:	usp9 / 568683	ZFINID:	ZDB-GENE-061019-1	Length:	2594	Species:	Danio rerio

Alignment Length:	2699	Identity:	1271/2699 - (47%)
Similarity:	1709/2699 - (63%)	Gaps:	257/2699 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 TGTVANSSLPGG-GSGSLDGNQDQQPATDSQSSDDVAASLSANSVDSTITIVPP----------- 100
            |.|...|.:.|. |.|.....|.|.|...:|:|       |.||.:....:.||
Zfish     2 TATTRGSPVGGNDGQGQAPDGQSQPPLPQNQTS-------SPNSSNENSPVSPPDDQGQGDSPTP 59

  Fly   101 -EKLISSFPTTKLRSLTQKISNPRWVVPVLPEQELEVLLNAAIELTQAGVDHDCEPCVEFYRNGL 164
             |:...:||.|:|..|...|:.|||||||||:.||||||.|||:|.:.|:|..||.|..|:|:||
Zfish    60 LEEEEPAFPHTELAKLDDMINRPRWVVPVLPKGELEVLLEAAIDLCKKGIDVKCEACQRFFRDGL 124

  Fly   165 STSFAKILTDEAVNSWKNNIHHCILVSCGKLLHLIAIHMQRDNPYLLDLLAIVFDPENKFNTFNA 229
            :.||.||||||||:.||..||.||:.:..:|:.|....:.:|...||:|||:..:|..||:.:|.
Zfish   125 TISFTKILTDEAVSGWKFEIHRCIINNAHRLVELCVTKLSQDWFPLLELLAMATNPHCKFHIYNG 189

  Fly   230 GRQPECFAAPDYIWG-QLDSNKMYARPPPEPKNARGWLVDLINRFGQLGGFDNLLERFNIGLELL 293
            .|..|...|     | ||..::::|| ||:|::.:||||||||:||.|.||..|.:||..|
Zfish   190 TRPSETVPA-----GVQLAEDELFAR-PPDPRSPKGWLVDLINKFGTLNGFQTLHDRFMSG---- 244

  Fly   294 KRNQNKCTGKNISVEGRVENGAQDNRLTLALIHSLLRPFGQCYELLMPATIAKYFMPTWNVVLDL 358
                                    ..|.:.:|.:|::|||||||.|...|:.|||:|...:|...
Zfish   245 ------------------------QALNVQIIAALIKPFGQCYEFLTLHTVKKYFLPIIEMVPQF 285

  Fly   359 LDSFTDEELKREVKPEGRNDYINGIVKSARLLASRLTGQEELIRDLEMFRLKMILRLLQVSSFNG 423
            |::.||||||:|.|.|.:||.::.|:||.:.||||:.||||.:::||:|||||||||||:|||||
Zfish   286 LENLTDEELKKEAKNEAKNDALSMIIKSLKNLASRVPGQEETVKNLEIFRLKMILRLLQISSFNG 350

  Fly   424 KMNALNEINKVLSSVAYFSHRSQPLPHCMPEDEMDWLTADRMAQWIKSSDVLGVVLKDSLHQPQY 488
            |||||||:|||:|||:|::||     |..||:| :||||:|||:||:.:::|.:||:||||||||
Zfish   351 KMNALNEVNKVISSVSYYTHR-----HGNPEEE-EWLTAERMAEWIQQNNILSIVLRDSLHQPQY 409

  Fly   489 VEKLEKIIRFLIKEQALTLDDLDAVWRAQAGKHEAIVKNVHDLLAKLAWDFTPEQLDHLFEAFQA 553
            |||||||:||:|||:||||.|||.:|.||||||||||||||||||||||||:||||||||:.|:.
Zfish   410 VEKLEKILRFVIKEKALTLQDLDNIWAAQAGKHEAIVKNVHDLLAKLAWDFSPEQLDHLFDCFKE 474

  Fly   554 SMTTANKRQRERLLELIRRLAEDDKNGVMAQKVLKLFWTLAHSQEVPPEVLDQALGAHVKILDYS 618
            |.|.|:|:|||:|||||||||||||:||||.|||.|.|.||||.:||.:::||||.||:||||||
Zfish   475 SWTNASKKQREKLLELIRRLAEDDKDGVMAHKVLNLLWNLAHSDDVPVDIMDQALSAHIKILDYS 539

  Fly   619 CSQERDAQKTIWLDKCVDELKSGDGWVLPALRLIRDICCLYDTTTNHAQRTQTSTN---RQQVIE 680
            |||:||.||..|:|:.::||::.|.||:|||:.||:||.|:.....:..:||.|.:   |..:|.
Zfish   540 CSQDRDTQKMQWIDRFIEELRTNDKWVIPALKQIREICSLFGEAPQNLSQTQRSPHVFYRHDLIN 604

  Fly   681 RLQNDYSLVILVTNSLTAYMEKVRQMVTDSPGLDATRILIDGRFPHHVQIAERLEFLKFLLKDGQ 745
            :||::::||.||..:|:||||.:||...:....|...:....|:.|..::.|||.||:|||||||
Zfish   605 QLQHNHALVTLVAENLSAYMENMRQFSKEHADFDPQTVRPGSRYSHVQEVQERLNFLRFLLKDGQ 669

  Fly   746 LWLCADQAKQIWHCLAVNAVFPADREECFRWFGKLMGEEPDLDPGINKDFFENNILQLDPHLLTE 810
            |||||.||||||.|||.||||..|||.||:|:.||||:||||||.|||||||||:|||||.||||
Zfish   670 LWLCAPQAKQIWKCLAENAVFLCDREACFKWYSKLMGDEPDLDPDINKDFFENNVLQLDPSLLTE 734

  Fly   811 SGIKCFERFFKAVNSKEDKLKAIHRGYMLDNEDLIGKDYLWRVITTGGEEIASKAIDLLKEVSTA 875
            :|:|||||||||||.:|.||.|..|.||:|:.:|||.||||||:..|.::|||:|||||||:.|.
Zfish   735 NGMKCFERFFKAVNCREGKLVAKRRAYMMDDLELIGLDYLWRVVIQGSDDIASRAIDLLKEIYTN 799

  Fly   876 LGPRLQENIAEFHEMFIGECCSRLRTHYGNIVILGKTQLQEELDAPDQSDNTNDESKDS-KMRFI 939
            |||:||.|..|.||.||..|..||:..|..:.:|                   |..||| .....
Zfish   800 LGPKLQANQVEIHEDFIQSCFDRLKASYDTLCVL-------------------DGDKDSINCARQ 845

  Fly   940 EAEKMCRILKVLQEYVKECDRSFSGDRVHLPLSRVTRGKNTILYIRFQNPGRSIDDMEIVTHSNE 1004
            ||.:|.|:|.||:||:.|||..:..:|..||:||..|||:..|.:||.|.||.:||::|.:|:|:
Zfish   846 EAIRMVRVLTVLREYITECDSDYHEERTILPMSRAFRGKHITLVVRFPNQGRQVDDLDIWSHTND 910

  Fly  1005 TMAAFKRNLLKRIKGTSTANIKVDLFYANDEMIGVSDEINPLYQYTIRDKMNLTAKLTPVGTGLA 1069
            |:.:.:|.:|.|||..|| :.|::||... |:|..:|:...:.|..::||..:|||||.|...:.
Zfish   911 TIGSVRRCILNRIKANST-HTKIELFIGG-EIIDPADDRKLIGQLNLKDKTLITAKLTQVSANMP 973

  Fly  1070 SSPDSSSDSSTGSP----------PRPCPDMQRVESESTLPGVIISQNYQYTEFFLKLYQLGSDL 1124
            ||||||||||||||          |.|       |.||.|||||:|.:.:|..|..::..||.:|
Zfish   974 SSPDSSSDSSTGSPGNHGNHYSDGPNP-------EVESCLPGVIMSLHVRYISFLWQVADLGCNL 1031

  Fly  1125 EHGRLRDSAKVLLHLLPCDRQTIRQLKIMCKVPKAAVTVAVTGDKIAKDEEEKLYPTEQAGIEDE 1189
            ....|||.|:||:.|:|.|..|:..|:.:|.             ..||..|..|.|
Zfish  1032 NMPLLRDGARVLMKLMPPDNATVENLRAICL-------------DHAKLGENSLSP--------- 1074

  Fly  1190 EEHCTPEQMFLHPTPAQVLYNLSVLHGLLIPALDPLGESALLVQSAWMHSGCAHFVLELLTKNNF 1254
                |.:..|..|:|:||||.:.|::.||:||...|||.|...|..::.||....||.:||:|||
Zfish  1075 ----TLDSRFFGPSPSQVLYLIEVVYALLMPASGTLGEDASDFQYNFLKSGGLPLVLSMLTRNNF 1135

  Fly  1255 LPSADMHTKRASFQCVLRLAKLFLYIVG-----SVLSRV-----GDEPMICDLDNGSRSQVDILK 1309
            ||:|||.|:|.::...|::|||.|..||     ||....     |..| :..::..:..|..:|:
Zfish  1136 LPNADMETRRGAYLNALKIAKLLLTAVGFGHVKSVAEACQPVVEGTIP-VSPINQTTHDQALVLQ 1199

  Fly  1310 QNFSTMPS-SSQGTLRAISAKLAVILAREMLSASPEGDRCRTLFSSTLQWSCPDISTIKAVVQLA 1373
            .....:|: |::..||.::.:||..::.|            ..|.::..  .|||..|:||.::.
Zfish  1200 NALQNIPNPSAECMLRNVAIRLAQQISDE------------NFFQASKY--IPDICVIRAVQKIV 1250

  Fly  1374 WASSCGNLQALGNSSGDFE---------DEVIVPDGQDFSMCKEALEVLTISFILNPSANEALTS 1429
            |||.||::|.:.:|:.:..         :|   ||.:|..:|.|||||:|:.|.|.|:|.:||:.
Zfish  1251 WASGCGSVQHVFSSNEEISKIYEKTNAGNE---PDAEDEQVCCEALEVMTLCFALMPTALDALSK 1312

  Fly  1430 DPNWPKFITSIVLKNPLRHVRQVASEQLFLASTYCAGDRRPFVYMVNLLVGALKTLVPQYESTCA 1494
            :..|..||..::|....:.|||:|.||.||.:|.|....||.::.:.||...|.:...:.....|
Zfish  1313 EKAWQTFIIDLLLHCQSKSVRQMAQEQFFLMATRCCMGHRPLLFFITLLFTVLGSTAKERAKHAA 1377

  Fly  1495 EFFSVLCRTLSYGCIYNWPLQISEGLLGDEIKWLQRIRENVHATGDTQVHEELLEGHLCLAKELM 1559
            ::|::|...|:|....|..|..:|.||.:||.||:|||:.|..||:..|.|.:||||:.:.|||:
Zfish  1378 DYFTLLRHLLNYAFNSNINLPNAEVLLNNEIDWLKRIRDEVKRTGEPGVEETILEGHIGVTKELL 1442

  Fly  1560 FFLGADSKAQLN------ELIHELIDDFLFTASREFLHLRRHGSLRQDTVPPPVCRSPHTIAAAC 1618
            .|...:.|..:.      .||.||:|||||.||..:|...:.|....:.. .|||.:|.||.|..
Zfish  1443 AFQTPEKKFYIGCEKGGASLIKELMDDFLFPASNVYLQYMKSGEFPTEQA-IPVCSTPATINAGF 1506

  Fly  1619 DLLIALCQLCVPNMKLLTNTLIDFVCTDTDPLREWDYLPPVGARPTKGFCGLKNAGATCYMNSVL 1683
            :||:||...||.|:|.:.:||.|......:||.||:||||||.||||||.||||||||||||||:
Zfish  1507 ELLVALAIGCVRNLKQIVDTLTDMYYLGCEPLTEWEYLPPVGPRPTKGFVGLKNAGATCYMNSVI 1571

  Fly  1684 QQLYMVPAVRVGILRAHGAATTDGEDFSGD---SDLTGGGLGSALFSGPASALVSLPSSSSTIED 1745
            |||||:|.:|.|||...|..:...:|.|||   .:.:.......:| |........||.|.: ||
Zfish  1572 QQLYMIPPIRNGILAIEGTGSDVDDDMSGDEKQDNESNVDPRDEVF-GYQHQFDDKPSLSKS-ED 1634

  Fly  1746 GLHDVRKNYHVVILKHVQAIFAHLGHSALQYYVPRGLWTHFKLLGEPVNLREQQDAVEFFMSLLE 1810
                 ||.|::.:|:.:|.||.||..|.||||||||.|..|:|.|||||||||.||:|||.||::
Zfish  1635 -----RKEYNIGVLRQLQVIFGHLASSRLQYYVPRGFWKQFRLWGEPVNLREQHDALEFFNSLVD 1694

  Fly  1811 SLDEGLKALGQPQLMNATLGGSFSDQKICQECPHRYSKEEPFSVFSVDIRNHSSLTESLEQYVKG 1875
            ||||.|||||.|.:::..|||||:||||||.|||||..||.|:..:||||||.:|.:|:||||||
Zfish  1695 SLDEALKALGHPAMLSKVLGGSFADQKICQGCPHRYECEESFTTLNVDIRNHQNLLDSMEQYVKG 1759

  Fly  1876 ELLEGADAYHCDKCDKKVVTVKRVCVKKLPPVLAIQLKRFEYDYERVCAIKFNDYFEFPRILDME 1940
            :|||||:||||:||:|||.||||:.:||||||||||||||:||:||.|||||||||||||.||||
Zfish  1760 DLLEGANAYHCEKCNKKVDTVKRLLIKKLPPVLAIQLKRFDYDWERECAIKFNDYFEFPRELDME 1824

  Fly  1941 PYTVSGLAKLEGEVVEVGDNCQTNVE-----------TTKYELTGIVVHSGQASGGHYFSYILSK 1994
            ||||:|:|||||..|. .:|.|..::           :::|.|.|::|||||||||||:|||:.:
Zfish  1825 PYTVAGVAKLEGSDVH-PENQQQVIQQNEPSEPEPPCSSRYRLVGVLVHSGQASGGHYYSYIIQR 1888

  Fly  1995 NPANG---KCQWYKFDDGEVTECKMHEDEEMKAECFGGEYMGETYDNNLKRMQYRRQKRWWNAYM 2056
            |.:.|   :.:|||||||:||||||.:|||||.:|||||||||.:|:.:|||.|||||||||||:
Zfish  1889 NGSGGEGERNRWYKFDDGDVTECKMDDDEEMKNQCFGGEYMGEVFDHMMKRMSYRRQKRWWNAYI 1953

  Fly  2057 LFYTRCDQTP-----VQYEPSVEQLSLAESRNMVLPLPKPIERSVRHQNIRFLHSRSIFSVEFFN 2116
            |||.|.|...     |:|   :.:|:::...:.| .:|..||||||.||::|:|:|..:|:|:|.
Zfish  1954 LFYERMDTLDKDSELVKY---ITELTVSSKPHQV-KMPSAIERSVRKQNVQFMHNRMQYSLEYFQ 2014

  Fly  2117 FIKKLVSCNLLSARS----NKITPAAEELSLLGVQLASQFLFHTGFRTKKSLRGPVMEWYDALSH 2177
            ||:||::||.:...|    :.:.|.|||::::.:|||::|||.|||.|||.:|||..:|||||..
Zfish  2015 FIRKLLTCNSVYLNSPPGQDHLLPEAEEMAMISIQLAARFLFSTGFHTKKIVRGPASDWYDALCI 2079

  Fly  2178 HIRSSALVRKWFANHALLSPPSRLGEYILMAPSPDVRTVFVKLVVFFCHFAINDEPL-------- 2234
            .:|.|..||.|||::.|.:.|:|..||:|..||.:||..|.||:||..||::.|.|.
Zfish  2080 LLRHSKNVRYWFAHNVLFAYPNRFSEYLLECPSAEVRGAFSKLIVFIAHFSLQDGPCPTPIASPG 2144

  Fly  2235 ---TGYDGANLCEQVLISVLRLLKSEAADYGKHLPHYFSLFSMYVGLGTREKQQLLRLNVPLQFI 2296
               .|.|..:|.|.:..:||.||:.|.:::|:||..||:||.||..||..||.|||:|.||..|:
Zfish  2145 PSSQGCDNLSLSEHLFRAVLNLLRREVSEHGRHLQQYFNLFVMYANLGLAEKTQLLKLGVPATFM 2209

  Fly  2297 QVALDDGPGPAIKYQYPEFSKLHQVVSHLIRCSDVSEKCQSSNQNARPLSNPFKDPNVAHEELTP 2361
            .||||:||||.|||||.|..||:.|||.|:||.||:.:.|||.....||:||:.|||.. ..:.|
Zfish  2210 LVALDEGPGPPIKYQYAELGKLYTVVSQLVRCCDVTSRMQSSINGNPPLANPYGDPNTT-TPIMP 2273

  Fly  2362 LSTECMDLLFNRTGYIKKVIEDTNVGDEGLKLLQYCSWENPHFSRAVLTELLWQCGFAYCHDMRH 2426
            |....:|:||.||.|:||:|||.:..::.:|||::|.||||.||..||:|||||..::|.:::|.
Zfish  2274 LQQLVVDILFVRTSYVKKIIEDCSNSEDTIKLLRFCCWENPQFSSTVLSELLWQVAYSYTYELRP 2338

  Fly  2427 HTDLLLNILLIDDSWQHHRIHNALNGVAEEREGLLETIQRAKTHYQKRAYQIIKCLTQLFHKSPI 2491
            :.||||.||.|:||||.|||||.|.|:.::|:||.:||||:|.||||||||.|||:..||....:
Zfish  2339 YLDLLLQILFIEDSWQTHRIHNVLKGIPDDRDGLFDTIQRSKNHYQKRAYQCIKCMVALFSNCSV 2403

  Fly  2492 ALQMLHTNSNITRHWSIAVEWLQGELDRQRGIG-CQYNSYSWSPPAQSNDNTNGYMLERSQSAKN 2555
            |.|:|.:|.::.|.|:.|||||..||:|:...| .||...:||||.|||:.:|||.||||.||:.
Zfish  2404 AYQILQSNGDLKRKWTWAVEWLGDELERRPYTGNTQYTYNNWSPPVQSNETSNGYFLERSHSARM 2468

  Fly  2556 TWSMAFELCPDE--------VSEK-------------------TDENNEPNLETNMDENKSEPVA 2593
            |.:.|.||||:|        |||:                   ..::.||:.:..:||  .:|..
Zfish  2469 TLAKACELCPEECHLTKHEVVSEEDAGRNPSSTQQLLPGEVTGPQQHTEPDEQEALDE--QDPSP 2531

  Fly  2594 QPGGVLEGSTGGTEQLPENKTPTTSSPSTAAWPA 2627
            .....|...:.|::...:|..|.| .|.|.  ||
Zfish  2532 PEDTALYPHSPGSKFQQQNNLPHT-QPYTG--PA 2562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
faf	NP_524612.2	peptidase_C19C	1666..2064	CDD:239124	249/414 (60%)
faf	NP_524612.2	UCH	1668..2059	CDD:278850	244/407 (60%)
usp9	XP_005167793.1	peptidase_C19C	1554..1961	CDD:239124	249/414 (60%)
usp9	XP_005167793.1	UCH	1556..1956	CDD:278850	244/407 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1251	1.000	Domainoid score	I10
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3418
Inparanoid	1	1.050	2290	1.000	Inparanoid score	I33
OMA	1	1.010	-	-		QHG58606
OrthoDB	1	1.010	-	-		D22076at33208
OrthoFinder	1	1.000	-	-		FOG0002455
OrthoInspector	1	1.000	-	-		oto39276
orthoMCL	1	0.900	-	-		OOG6_102574
Panther	1	1.100	-	-	LDO	PTHR24006
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4564
SonicParanoid	1	1.000	-	-		X1635
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	13.010