DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment faf and usp34

DIOPT Version :10

Sequence 1:NP_524612.2 Gene:faf / 43749 FlyBaseID:FBgn0005632 Length:2778 Species:Drosophila melanogaster
Sequence 2:XP_009292973.3 Gene:usp34 / 562779 ZFINID:ZDB-GENE-100210-6 Length:3624 Species:Danio rerio


Alignment Length:2441 Identity:481/2441 - (19%)
Similarity:831/2441 - (34%) Gaps:839/2441 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   615 LDYSCSQERDAQKTIWLDKCVDE--LKSGDGWVLPALRLIRDICCLYDTTTNHAQRTQTSTNRQ- 676
            ||..|   :.....:| |...|:  :...:|.:..|.:|:..:.|.:             |:|| 
Zfish   909 LDNVC---KKGNTLLW-DLVQDDNAIHLSEGLINEAEKLLCSLVCWF-------------TDRQI 956

  Fly   677 ------QVIERLQNDYSLVILV------------------TNSLTAYMEKVRQMVTDSPGLDATR 717
                  ..:|.|.|..|:|:.:                  |:.:|.:.||...|:         :
Zfish   957 RMRFIEGCLENLANHRSVVVSLRLLPKLFGTFQQFGSSYDTHWITMWAEKELHMM---------K 1012

  Fly   718 ILID----------------GRFPHHVQIAERLEFL----KFLLKDGQLWLCADQAKQIWHCLAV 762
            :..|                ..:.|..::..||:||    ..|.......|..:|...:||||  
Zfish  1013 LFFDDLLHYIQEVREQRHKFALYSHSAEVQVRLQFLTCVFSTLGSPDHFRLSLEQVDILWHCL-- 1075

  Fly   763 NAVFPADREECF----RWFGKLMGEEPDLDPGIN--KDFFENNILQLDPHLLTESGIKCFE---R 818
                 .:..||:    .||...:..:.....|:.  |..|...:.||.|..::.:|:..|:   .
Zfish  1076 -----VEDSECYDDALHWFLNQVRSKDQHAMGMETYKHLFLEKMPQLKPETISMTGLNLFQHLCN 1135

  Fly   819 FFKAVNSKEDKLKAIHRGYMLDNEDLIGKDYLWRVITTGGEEIASKAIDLLKEVSTALGPRLQEN 883
            ..:...|..|.         ..|.:|.|.|.||      |..:.:::.|:               
Zfish  1136 LARLATSAYDS---------SSNCELCGMDQLW------GIALRAQSADI--------------- 1170

  Fly   884 IAEFHEMFIGECCSRLRTHYGN-IVILGKTQLQEELDAPDQSDNTNDESKDSKMRFIEAEKMCRI 947
                         ||....|.| ..|.|||.|::|                              
Zfish  1171 -------------SRAAIQYINSYYISGKTGLEKE------------------------------ 1192

  Fly   948 LKVLQEYVKECDRSFS------GDRVHLPLSRVTRGKNTILYIRFQNPGRSIDDMEIVTHSNETM 1006
                ||::.:|..|..      ....|..|:.:.||   :|.::              ||    :
Zfish  1193 ----QEFISKCMESLMMASANLEKDAHSSLTIIERG---LLLLK--------------TH----L 1232

  Fly  1007 AAFKRNLLK-----RIKGTSTAN-------------------------IKVDLFYANDEMIGVSD 1041
            .||:|....     :|:||..::                         :.::: |.:|::..:..
Zfish  1233 EAFRRRFAYHLRQWQIEGTGISSHLKALSDKQSLPLRIVCQPAGLPDKMTIEM-YPSDQVADLRA 1296

  Fly  1042 EINPLYQYTIRDKMNLTAKLTPVGT---------GL-------ASSPDSSSD------------- 1077
            |:...|:...:|:::..|:|...|.         ||       :|..:.::|             
Zfish  1297 EVTHWYENLQKDQLSQQAQLQEFGQTSRQQDFPGGLMGPVRMISSGHELTTDYDEKTLHELGFKD 1361

  Fly  1078 -----SSTGSPPR--------------PCPDMQRVESESTLPGVIISQNYQYTEFFLKLYQLGSD 1123
                 .|.|:|.|              |.|..:.:      |.:::.|....|..|         
Zfish  1362 MQMVFVSLGAPRRERKGEGVQLPASCLPPPQKEHI------PMLLLLQEPHLTTLF--------- 1411

  Fly  1124 LEHGRLRDSAKVLLHLLPC------DRQTIRQLKIMCKVPKAAVTVAVTGDKIAKDEEE--KLYP 1180
                       .||.:|.|      ||.......:.|:      .:.:..:.:::...|  .|.|
Zfish  1412 -----------DLLEMLACFKPPGPDRPQHSTESVRCE------ELHLHAENLSRRVWELLMLLP 1459

  Fly  1181 T----EQA--GIEDE---EEHCTPEQMFLHPTPAQVLYNLSVLHGL-----------------LI 1219
            |    .||  .|.||   :..|..:.:.: .:|.::||.|.::..|                 |.
Zfish  1460 TCPSMLQAFQNISDETGSDGLCWKDLLRI-KSPHKLLYALEIIEALGKPNRRIHRESTGSYSDLY 1523

  Fly  1220 PALDPLGESAL-LVQSAW----MHSGCAHFVLELLTKNNFLPSADMHTKRAS------FQCVLRL 1273
            |..|...|..: ..::.|    :.||....:|::..      ||.:..|...      ..|:..|
Zfish  1524 PDSDDSSEEQIENSKNTWSCKFVSSGGLQLLLDIFN------SAILEPKEQESWTVWLLDCLACL 1582

  Fly  1274 AKLFLYIVGSVLSRVGDEPMICDL-----------------------------DNGSRSQVDILK 1309
            .||        :.:...:|...||                             |:|....:..|.
Zfish  1583 LKL--------ICQFAVDPADLDLAYHDVFAWSGLTDTQRKRAWPGKSRKTTGDHGKGLHIPRLT 1639

  Fly  1310 QNFSTMPSSSQGTLRAISAKLAV-ILAREMLSASPEGDRCRTLFSSTLQWSCPDISTIKAVVQLA 1373
            :.|.::...:....|.|:..... .||..:|.|..: .|.|...:....|           :.::
Zfish  1640 EVFLSLVQGTNLIQRLINVAYTYDNLAHRVLKAQSD-HRSRHEVTHYSMW-----------LLVS 1692

  Fly  1374 WASSCGNLQALGNSSGDFEDEVIVPDGQDFSMCKEALEVLTISFILNPSANEALTSDPNWPKFIT 1438
            ||..|                         |:.|.:|           :.:|.|   .:|.|.:|
Zfish  1693 WAHCC-------------------------SLVKSSL-----------ADSEHL---HDWLKKLT 1718

  Fly  1439 SIVLKNPLRHVRQVASEQLF-LASTYCAGD---RRPFVYMV--NLL-----VGALKTL-VPQYE- 1490
            .::   |...|||.|...|: |:.:...|.   .|.|:.:.  .||     ..|||.| |..:| 
Zfish  1719 LLI---PETAVRQEACSGLYKLSLSGLEGGESINRSFLLLAASTLLKFLPDAQALKPLRVEDFEE 1780

  Fly  1491 -----STCAEFFSVLCRTLSYGCIYNWPLQISEGLLGDEIKWLQRIRENVH---ATGDTQVHEEL 1547
                 |.|.|:|.:||:.:                            :|:|   |:..|.:..:.
Zfish  1781 EAMFRSGCKEYFWLLCKLI----------------------------DNIHVKDASQTTLLDLDA 1817

  Fly  1548 LEGHL--CLAKELMFFLGADSKAQLNELIHELIDDFL----------------FTASR---EFLH 1591
            |..||  |:.          |:..|::....:.||.|                |..||   ||| 
Zfish  1818 LARHLADCIR----------SREILDQQDGAIEDDGLTGLLRLATSVLKHKPPFKFSREGQEFL- 1871

  Fly  1592 LRRHGSLRQDT------VP------PPVCRSPHTIAAACDLLIALCQLCVPNMKLLTNTLIDFVC 1644
                    :||      :|      .|.|:||...|||.|||:.:.:..|.|.:||.|.::....
Zfish  1872 --------RDTYDLLFLLPSLKDRQQPKCKSPAARAAAYDLLVEVVKGSVENYRLLHNWVMSQHM 1928

  Fly  1645 TDTDPLREWDYLPPVGARPTKGFCGLKNAGATCYMNSVLQQLYMVPAVRVGILRAHGAATTDGED 1709
            ..:....:|||.|....|....|.||.|.|||||:.|.:|||||:|..|                
Zfish  1929 QASHAPYKWDYWPHDDVRAECRFVGLTNLGATCYLASTIQQLYMIPEAR---------------- 1977

  Fly  1710 FSGDSDLTGGGLGSALFSGPASALVSLPSSSSTIEDGLHDVRKNYHVVILKHVQAIFAHLGHSAL 1774
                         .|:|:...|                .|::   |...|..:|.:|.:|..|..
Zfish  1978 -------------QAVFTAKYS----------------EDIK---HKTTLLELQKMFTYLMESER 2010

  Fly  1775 QYYVPRGLWTHFKLLGEPVNLREQQDAVEFFMSLLESLDEGLKALGQPQLMNATLGGSFSDQKIC 1839
            :.|.||.....:.:..:|:|..||:|..|||..|:..::|..:.|  ...:....||..::..:.
Zfish  2011 KAYNPRPFCKTYTMDKQPLNTGEQKDMTEFFTDLITKIEEMSQDL--KNTVKTLFGGVITNNVVS 2073

  Fly  1840 QECPHRYSKEEPFSVFSVDIRNHSSLTESLEQYVKGELLEGADAYHCDKCDKKVVTVKRVCVKKL 1904
            .:|.|.....|.|......:.:..::.|||::....:.|||.:.|.|.:|.|||...||.|.|||
Zfish  2074 LDCDHVSQTAEEFYTVRCQVADMKNIYESLDEVTIKDTLEGDNMYTCSQCGKKVRAEKRACFKKL 2138

  Fly  1905 PPVLAIQLKRFEYDYERVCAIKFNDYFEFPRILDMEPYTVSGLAKLEGEVVEVGDNCQTNV-ETT 1968
            |.:|:....|:.::...:...|.|.:|.||..|||.|||...|...........|:....| |:.
Zfish  2139 PRILSFNTMRYTFNMVTMMKEKVNTHFSFPLRLDMTPYTEDFLMAKGDRKEGFRDDSDAKVAESY 2203

  Fly  1969 KYELTGIVVHSGQASGGHYFSYILS-KNP---ANGKCQWYKFDDGEVTECKMHEDEEMKAECFGG 2029
            :|:|.|:.||:|.|.||||:|:|.. .||   .|.|  ||.|:|.||   |..:..::.:|||||
Zfish  2204 EYDLIGVTVHTGTADGGHYYSFIRDIINPHAYRNNK--WYLFNDAEV---KPFDSAQLASECFGG 2263

  Fly  2030 EYMGETYDNNLKRMQYRRQKRWWNAYMLFYTRCDQTPVQYEPSVEQLSLAESRNMVLPLPKPIER 2094
            |...:|||:...:......::..:||||||.|.:         ||:   ...::....:...:..
Zfish  2264 EMTTKTYDSVTDKFMDFSFEKTHSAYMLFYKRVE---------VEE---ENGKDFNFDISPDLLE 2316

  Fly  2095 SVRHQNIRFLHSRSIFSVEFFNFIKKLVSCNLLSARSNKITPAAEELSLLGVQLASQFLFHTGFR 2159
            .:.|.|::||..::||...:|.|:.:|  |:.:.:    ..|..:.:||:..:|::.|:..|...
Zfish  2317 WIWHDNMQFLQDKNIFEHTYFGFMWQL--CSSIPS----TLPDPKSVSLMTAKLSTSFVLETFIH 2375

  Fly  2160 TKKSLRGPVMEWYDALSHHIRSSALVRKWFANHALLSP--PSRLGEYILMAPSPDVRTVFVKLVV 2222
            :|:  :..:::|.:.|:....:|....:||.:......  |.::   ::..|:..||.:|.:|.:
Zfish  2376 SKE--KPTMLQWIELLTKQFNNSQAACEWFLDQMADDNWWPMQI---LIKCPNQIVRQMFQRLCI 2435

  Fly  2223 --------FFCHFAIN----------DEPLTGYDGANLCEQVLISVLRLLKSEAADYGKHLPHYF 2269
                    ...|..:.          |.|:......:...:.:.::|.:::.....:.|||..||
Zfish  2436 HVIQRLRPVHAHLYLQPGMEDGSDDMDGPVEDIGSRSCVTRFVKTLLSIMEHGVKPHSKHLTEYF 2500

  Fly  2270 SLFSMYVGLGTREKQQLLRL---NVPLQF-----------IQVALDDGPG-----------PAIK 2309
            :....:..:|..|.|.||.|   ::.:.|           ::|..::..|           ...|
Zfish  2501 AFLYEFAKMGEEESQFLLSLQAISIMVHFYMGTKGPENPQVEVLSEEEEGEEDEEEDILSLAEEK 2565

  Fly  2310 YQYPEFSKLHQVVSHLIRCSDVSEKCQSSNQNARPLSN----PFKDPNVAHEELTPLSTECMDLL 2370
            |:.....|:..::|.|:..|........|..:...|:.    ||...::  .:...:...| :|:
Zfish  2566 YRPAALEKMIALISLLVEQSRSERHLTLSQSDMAALTGGKGFPFLFQHI--RDSINIRQTC-NLI 2627

  Fly  2371 FNRTGYIKKVIED------TNVGDEGLKLLQYCSWENPHFSRAVLTEL----------------- 2412
            |:...|..::.|.      |::.    ||....:  ||.|.  :||.|                 
Zfish  2628 FSLCRYNNRLAEHIVSMLFTSIA----KLTPEAA--NPFFK--LLTMLMEFAAGPPGMPSFASYI 2684

  Fly  2413 ---LWQCGFAYCHDMRHHTDLLLNILLID-------DSWQHHRIHNALNGVAEEREGLLETIQRA 2467
               :|:.       :.::....|:.|.:.       .||.   :.|..|.|  ||..|.....|.
Zfish  2685 LQRIWEV-------IEYNPSQCLDWLAVQTPRNKLAHSWV---LQNMENWV--ERFLLAHNYPRV 2737

  Fly  2468 KT-------------------------HYQKR-----------AYQIIKCLTQLFHKSPIALQM- 2495
            :|                         |...|           .:|:...|..|..::.:.:.: 
Zfish  2738 RTSAAYLLVSLIPSNSFRQMFRSTRSLHIPTRDLPLSPDTTVVLHQVYNLLLGLLGRAKLYVDVP 2802

  Fly  2496 LHTNSNITRHWSIAVEWLQGELDRQRGIGCQYNSY---SWS--------PPAQSNDNTNGYMLER 2549
            :|..:.:.:::|.....|..:.::     ..::||   .|:        |...:|.|        
Zfish  2803 VHGTTKLVQYFSFMTYCLISKTEK-----LMFSSYFMDLWNLFQPKLSEPAIATNHN-------- 2854

  Fly  2550 SQSAKNTWSMAFELCPDEVSEKTDEN-----NEPNLETNM-------DENKSEPVAQPGGVL--- 2599
            .|:..:.|   :.:|.|     ..||     ..|.:..|:       |.:..|.|....|:|   
Zfish  2855 KQALLSFW---YNVCVD-----CSENVRLIIQNPVVTKNIAFNYILADHDDQEVVLFNRGMLPAY 2911

  Fly  2600 --------EGSTGGTEQLP---------ENKTPTTS 2618
                    |.|...|.||.         :|.||..|
Zfish  2912 YAILRMCCEQSPAFTRQLASHQNIQWAFKNLTPHAS 2947

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fafNP_524612.2 Ubl1_cv_Nsp3_N-like <994..1060 CDD:475130 13/95 (14%)
peptidase_C19C 1666..2064 CDD:239124 123/402 (31%)
DUF3517 2198..2566 CDD:463438 78/495 (16%)
usp34XP_009292973.3 peptidase_C19C 1950..2297 CDD:239124 123/401 (31%)
DUF3517 2416..2749 CDD:463438 60/358 (17%)

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