Protein Alignment faf and Usp47

DIOPT Version :10

• Sequence 1: NP_524612.2
• Gene: faf / 43749
• FlyBaseID: FBgn0005632
• Length: 2778
• Species: Drosophila melanogaster
• Sequence 2: XP_001237119.3
• Gene: Usp47 / 4576308
• VectorBaseID: AGAMI1_010333
• Length: 1386
• Species: Anopheles gambiae
• Alignment Length: 1202
• Identity: 238/1202 - (19%)
• Similarity: 409/1202 - (34%)
• Gaps: 441/1202 - (36%)

  Fly  1667 FCGLKNAGATCYMNSVLQQLYMVPAVRVGILRAHGAATTDGEDFSGDSDLTGGGLGSALFSGPAS 1731
            |.||.|...|||:||:||.|||.|..|..:....    .||||.:.........|...|.:.|.|
Mosquito   212 FRGLVNQAMTCYLNSLLQGLYMTPEFRNALYNWE----FDGEDEAKSIPYQLQKLFVNLQTSPKS 272

  Fly  1732 ALVSLPSSSSTIEDGLHDVRKNYHVVILKHVQAIFAHLGHSALQYYVPRGLWTHFKLLGEPVNLR 1796
            |:.:.            |:.:::               |..:.:.:
Mosquito   273 AVETT------------DLTRSF---------------GWDSAEGW------------------- 291

  Fly  1797 EQQDAVEFFMSLLESLDEGLKALGQPQLMNATLGGSFSDQKICQECPHRYSKEEPFSVFSVDIRN 1861
            :|.|..|....:.::|:...|...:..|:|....|...|...|.||.....:|:.|....:.:|.
Mosquito   292 QQHDIQELCRVMFDALEHKFKRTEEADLINRLYQGHMIDYVRCLECNTEKQREDKFLDIPLPVRP 356

  Fly  1862 HSS------LTESLEQYVKGELLEGADAYHCDKCDKKVVTVKRVCVKKLPPVLAIQLKRFEYDYE 1920
            ..|      :.::|:.:||.|:|..::.|.||.|:||....|.:...|.|.:|.:.||||::||:
Mosquito   357 FGSTVANECVEDALQGFVKPEILNESNQYFCDTCNKKCDAHKGLKFTKFPYILTLHLKRFDFDYQ 421

  Fly  1921 RVCAIKFNDYFEFPRILDMEPY------------------------TVSGLAKLEG----EVVE- 1956
            ....||.||...||.:|::..:                        |.:|.|...|    |..|
Mosquito   422 SFHRIKLNDKVTFPELLNLNHFVSSTPTLTTSTIAAAAAAAAAAASTTNGTANGNGPMMMETAEN 486

  Fly  1957 --VGDNCQ-----------------TNVETT---------------------------------- 1968
              ..|.|.                 |:|.:|
Mosquito   487 FMKSDECSTTDSGSALEEDSFQNGGTSVSSTTTTPNDQFMAQDDDEGIDMDLTTNGDSKSSPVNN 551

  Fly  1969 --------KYELTGIVVHSGQASGGHYFSYILSKNPANGKCQWYKFDDGEV---TECKMHEDEEM 2022
                    ||||..|::|:|.||||||::||  |:..:|:  |:.|:|..|   |:..:|:.
Mosquito   552 SFNAPGPYKYELFAIMIHAGSASGGHYYAYI--KDFKSGR--WFSFNDQTVLPITQEDIHKS--- 609

  Fly  2023 KAECFGG-----EYMGETYDNNLKRMQYRRQKRWWNAYMLFYTRCDQTPVQYEPSVEQLSLAESR 2082
                :||     .|.| .|.::.            |||||.|.:.|                 |.
Mosquito   610 ----YGGGSYKTSYTG-AYTSST------------NAYMLMYRQID-----------------SE 640

  Fly  2083 NMVLPLPKPIERSVRHQNIRFLHSRSIFSVEFFNFIKKLVSCNLLSARSNKITPAAEELSLLGVQ 2147
            ...||:.:.                     :|.:.||:||    :..|:|:...:.:.|.:..:.
Mosquito   641 KNALPISEE---------------------QFPDHIKRLV----MKIRANEGNHSRDHLDMTRLT 680

  Fly  2148 LASQFLFHTGFRTKKSLRGPVMEWYDALSHHIRSSALVRKWFANHALLSPPSRLGEYILMAPSPD 2212
            :|     :...|| ::::|..|..:.:                        |.|.|.:..|
Mosquito   681 VA-----YENPRT-RTIKGHKMAVFTS------------------------STLAETVQEA---- 711

  Fly  2213 VRTVFVK---------LVVFFCHFAINDEPLTGYDGANLCEQVLISVLRLLKS------EAADYG 2262
            ||.:.:|         ||.:.|:....:....|::     |:.:..|:|:||.      |..:.|
Mosquito   712 VRVLHLKGTVPVERCRLVGYDCNARTIERSFEGHE-----EKTIDEVMRMLKRCDSLLLEVREEG 771

  Fly  2263 KHLPHYFSLFSMYVGLGTREKQQLLRLNVPLQFIQVALDDGPGP-AIKYQYPEFSKLHQVVSHLI 2326
            :                |.|:.|:..:...:..:.|...|..|| :|:      :.|.|.|:
Mosquito   772 E----------------TFEEYQVQGVMTKVYKVDVNGRDVEGPVSIR------ANLSQTVA--- 811

  Fly  2327 RCSDVSEKCQSSNQNARPLSNPFKDPNVAHEELTPLSTECMDLLFNRTGYIKKVIEDTNVGDEGL 2391
                     |.....||.|            :|.|                |.::....|..|..
Mosquito   812 ---------QYRAIIARKL------------KLNP----------------KAILVGMTVHKESA 839

  Fly  2392 KLLQY--CSWENPHFSRAVLTELLWQCGFAYCHDMRHHTDLLLNILLIDDSWQHHRIHNALNGVA 2454
            ||||.  .:.|:.||             ..||                       ::...:...|
Mosquito   840 KLLQTDDATLEDEHF-------------IEYC-----------------------KVFVTVAPTA 868

  Fly  2455 -EEREGLLETIQRAKTHYQKRAYQIIKCLTQLFHKSPIALQMLHTNSNITRHWSIAVEWLQGELD 2518
             ::||......:    |:.:|...::.....|.:..|..|:.| :...:::....|:
Mosquito   869 GDDREQYGARFR----HFIQRLDHLVSFYIVLPNMDPDTLESL-SIPRLSKETLAAI-------- 920

  Fly  2519 RQRGIGCQYNSYSWSPPAQSNDNTNGYMLERSQSAKNTWSMAFELCPDEVSEKTDENNEPNLETN 2583
                      :.:.||.|....::|.   |.|..:.|..::..:   |.|..|.  |.:.:| ||
Mosquito   921 ----------AAADSPMAGGTGDSNS---EDSSLSDNDRTLVED---DFVHIKL--NGDLHL-TN 966

  Fly  2584 MDENKSEPVAQPGGVLEGSTGGTEQLPENKTPTTSSPSTAAWPARGDSNAIPRLSRQL------- 2641
            ...:.:..::. |...:||:..|.     .|||:||....:.....|.:|  :|:..|
Mosquito   967 GGSSGAGAMSN-GAAAKGSSKATA-----TTPTSSSNGFKSDDEEEDEDA--KLAEMLQECRAQE 1023

  Fly  2642 -FGAYT--STGSGSTSGGSAPTSALTTTAGSGANSETESSAQETTGETTING---------LTNS 2694
             :...|  :|.|.|::|.|..:||..:|.....:|.::...|....:.:.|.         |..|
Mosquito  1024 YYFKVTPLNTASSSSNGASNGSSADDSTRSHSTDSGSQKLVQVLIDKRSCNAYLKYRLQSYLQIS 1088

  Fly  2695 LDQMEI-TAKKKC----RRVIIKKLVESKDEE 2721
            :|..:: ::...|    ...::|:| |.||::
Mosquito  1089 MDYFKVFSSDALCPTNDSANLLKEL-EYKDDD 1119

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
faf	NP_524612.2	Ubl1_cv_Nsp3_N-like	<994..1060	CDD:475130
		peptidase_C19C	1666..2064	CDD:239124	116/500 (23%)
		DUF3517	2198..2566	CDD:463438	64/386 (17%)
Usp47	XP_001237119.3	None