DRSC/TRiP Functional Genomics Resources

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Protein Alignment faf and puf

DIOPT Version :9

Sequence 1:NP_524612.2 Gene:faf / 43749 FlyBaseID:FBgn0005632 Length:2778 Species:Drosophila melanogaster
Sequence 2:NP_001262923.1 Gene:puf / 42935 FlyBaseID:FBgn0039214 Length:3930 Species:Drosophila melanogaster


Alignment Length:3637 Identity:652/3637 - (17%)
Similarity:1104/3637 - (30%) Gaps:1421/3637 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 RRHTTGQPGSTAPSSSSSTTSTTTTTTSPAQSAGSGSGIGTGTGTVANSSLPGGGSGSLDGNQDQ 70
            |.....:..:.|.:..||..:.......|:.|||..:                  .||.||...:
  Fly   105 REQQRDEASAQAEAKESSAPAEEPKKEEPSGSAGEEA------------------QGSGDGPAKK 151

  Fly    71 QPATDSQSSDDVAASLSANSVDSTITIVPPEKLISSFPTTKLRSLTQKISNPRWVVPVLPEQELE 135
            .|.                   ...|..||:   ::.|..|  |..|....| |::|.:  ::|.
  Fly   152 PPV-------------------GPCTPPPPQ---TANPQHK--SHLQYTEEP-WILPEV--EKLL 189

  Fly   136 VLLNAAIELTQAGVDHDCEPCVEFYRNGLSTSFAKILTDEAVNSWKNNIHHCILVSCGKLLHLIA 200
            ||::....|.        .|....:::|:.:....:..:||        ||..|: |.  ||   
  Fly   190 VLVSKVFLLN--------FPLYIAHKHGMHSRLDDLQAEEA--------HHLALI-CD--LH--- 232

  Fly   201 IHMQRDNP-YLLDLLAIVFDPENKFNTFNAGRQPECFAAPDYIWGQLDSNKMYARPPPEPKNARG 264
               ..|.| |||..:::.      .|:...|....||..||                        
  Fly   233 ---DNDLPIYLLRNVSLF------CNSGGFGAMSLCFEHPD------------------------ 264

  Fly   265 WLVDLINRFGQLGGFDNLLERFNIGLELLKRNQNKCTGKNISVEGRVENGAQDNRLTLALIHSLL 329
                                                                   |.::..||:.
  Fly   265 -------------------------------------------------------LPVSTAHSMT 274

  Fly   330 RPFGQCYELLMPATIAKYFMPTWNVVLDLLDSFTDEELKREVKPEGRNDYINGIVKSARLLASRL 394
            .........|......:.|:|..:.:|..:...:|:.| |........|::...::....:|...
  Fly   275 AAVSNVKLWLNYHCNTQLFVPLRSRILQYMCKLSDQSL-RSAATRAMADFVWSSMRDPLDVAVNF 338

  Fly   395 TGQEELIRDLEMF-RLKMILRLLQVSSFNGKMNALNEINKVLSSVAYFSHRSQPLPHCMPE--DE 456
             ..|.|....:.| ...:.:||..::..|..:|..|||                   |..|  :|
  Fly   339 -DTEGLALAFKYFTSTTLTMRLAGMAQINAHINLFNEI-------------------CTTETVNE 383

  Fly   457 MDWLTADRMAQWIKSSDVLGVVLKDSLHQPQYVEKLEKIIRFLIKEQALTLDDLDAVWRAQAGKH 521
            :: |...|:|.|:..:.::..:...:|| .:.|::...::.||..|..::.:|:..:|:|...||
  Fly   384 VE-LFGQRIANWLTENHIVQHLFGPNLH-VEIVKQAHVLLNFLAVENQISEEDIKLIWQATQLKH 446

  Fly   522 EAIVKNVHDLLAKLAWDFTPEQLDHLFEAF----------------------------------- 551
              ..|.:.|:|..|..:.||....||:...                                   
  Fly   447 --CSKTIFDILPSLVKNLTPRPAMHLYSLLCRMDPKEHTEQSIYIASALTKQLWTRDTSRSQMNL 509

  Fly   552 ----------------------------------------------------------------- 551
                                                                             
  Fly   510 MQDHLLGSNVTASSSDSGSIEGSNTEDDHVGADDSSIASGGGGGGVGNKSPIDGVTPCKQARHRR 574

  Fly   552 -----------------QASMTTANKR--------------QRERLLEL-----------IRRLA 574
                             .|.:...|||              |....|||           .||..
  Fly   575 HICDPTTEKGKQISPEDMAKVDLVNKRIVNIIDNTSSEEELQSRAALELQLHRSRKKTSNKRRRQ 639

  Fly   575 EDDKNGVMAQKVLKLFW-----------------------TLAHSQE---------VPPEVLD-- 605
            :.:|..::..::::: |                       .||.|.|         ||..||.  
  Fly   640 KTNKQIILPHELVEI-WDGVEDVPSSDEADGEADGDGEGELLADSDECSDGATSQLVPDAVLKHL 703

  Fly   606 QALGAHVKILD---------------YSCSQERDAQKTIW------LDKCVDEL----------- 638
            |..|..::.::               ||......::|.:.      :..|.:||           
  Fly   704 QGEGPFIRAIETNINELLSGAENDGSYSSPMSNKSEKNLADFDDEDVSPCEEELAQLVSSRANCS 768

  Fly   639 -----------------------KSGDGWVLPALRLIRDICCLYDTTTNHAQRTQTSTNRQQVI- 679
                                   |||:..|..|...:....    ..|..||:|..:.|||..: 
  Fly   769 DVPPAFAAAAAAMMVAQSAMALQKSGESNVAAAAAAVAAAA----AATGTAQQTLVAMNRQASVA 829

  Fly   680 ----------ERLQNDYSLVILVTNSLTAYMEKVRQMVTDSPGLDATRILIDGRFPHHVQIAERL 734
                      .:..:|..|:.:|:.....:..|..|..:.|           |..|  ||.:.:|
  Fly   830 AAAAVVAAAKAKSDSDVDLMDVVSGGKQHHSPKASQGSSTS-----------GSTP--VQPSFKL 881

  Fly   735 E--------FLKFLLKDGQLWLCADQAKQIWHCLAVNA--------VFPADR-------EEC--- 773
            .        .|..||:|       |:..|:...||:.|        .|..||       |.|   
  Fly   882 NDVCQPGNTLLWDLLQD-------DKIGQLGESLALEAEKALATLLCFSMDRQLRTKFIEGCLYN 939

  Fly   774 ----------FRWFGKLMGEEPDLDPG--------------INKDFFENNILQLDPH---LLTES 811
                      .|...||........|.              :.:.||.|.......|   |:|::
  Fly   940 VANNRSVIVSLRLLPKLFASFQQFRPSDTHSMTMWAERNHRMMQCFFNNIRHYARRHAEVLITQN 1004

  Fly   812 G---------------------IKCFERFFKAVNSKEDKLKAIHRGYMLDNEDLIGKDYLWRVI- 854
            |                     ::.....|..|.|.        :.:.|..|.|   |.||..: 
  Fly  1005 GEQQQQQLGGQLYSHKTQVSVRLQFLSSIFSTVGSP--------KSFRLTLEQL---DALWEWLA 1058

  Fly   855 ----------------TTGGEEIASKAIDLLKEVSTALGPRLQENIAEFHEMFIG---ECCSRLR 900
                            ..||::.| ..|:.|:.:.....|.|:..  ||..:.:|   :.||..|
  Fly  1059 HDPECADCYFSWLQAQAKGGDQHA-LGIEALQHLYLKKLPELRPE--EFSMVALGLFQQLCSFAR 1120

  Fly   901 ---THYGN-------------IVILGKTQLQEELDAPDQSDNTNDESKDSKMRFIEAEKMCRILK 949
               ..|.|             :..|.|..|:.:         :||.|. :.:::|....|.:.|:
  Fly  1121 IAMAEYDNHSDQISASASAVGMYHLWKIALRAQ---------SNDVSL-AAIQYINMYYMGQQLR 1175

  Fly   950 VLQEYVKECDRSFSGDRVHL-------PLSRVTRG---KNTIL-----YIRFQNPGRSIDDMEIV 999
            :.:|:|.:|..:.......|       .|.||.||   .||.|     ...|.....:|:...|.
  Fly  1176 LEKEFVSQCMENLVQAATALESIDDENALMRVQRGLLLLNTHLDTFRRRYAFHLRRWAIEGKGIG 1240

  Fly  1000 THSN--------------ETMAAFKRNLLKRIKGTSTANIKVDL-----------------FYAN 1033
            :|||              :.....:::||:.......|::|.::                 ...:
  Fly  1241 SHSNLKNEGAGPPLRIVLQQAGLSEKSLLQMHACDLIADLKAEVSKWWESLQTGLAAPVLGLLLS 1305

  Fly  1034 D---EMIGVSDEINPLY-QYTIRD---KMNLTAKLTPVGTGLASSPDSSSDSSTGSPPRPCPDMQ 1091
            |   .:|....|:...| :.::.|   |.|....::..|.| |...:|:.:..:..||.|     
  Fly  1306 DGPLRIITQGQELTSDYDERSLGDAGFKDNQIVYVSLGGRG-ARRKESNLEHPSMLPPPP----- 1364

  Fly  1092 RVESESTLPGVIISQNYQYTEFFLKLYQLG----------------SDLEHGRLRDSAKVLLHLL 1140
                :..||.|::.|...:.:.|..:..||                :.|...|:.|    :|.:|
  Fly  1365 ----KECLPTVLLLQPKYFEKLFCLMQTLGDMQPQASTVNPQHHTKAQLLSRRVWD----ILAML 1421

  Fly  1141 PCD------------------------------------RQTIRQL-------KIMCK---VPKA 1159
            |.:                                    :|..|.|       |.|..   |...
  Fly  1422 PTNPHILDAFKSLVTDLSELEQLDAGGEEEQLATKRKQIKQKFRDLLDPNNLQKFMYSLHIVESL 1486

  Fly  1160 AVTVAVTGD--------------------------------------KIAKDE----EEKLYPTE 1182
            |:|.:..|:                                      |::|::    |..|.||.
  Fly  1487 ALTSSRRGESNGNVAMGNTPEQVRVKKSSMGRRRNSNEQPPPPPPEVKMSKEQLCELEAPLTPTP 1551

  Fly  1183 QAGIED------------------------------EEEHCTPEQMFLHPTPAQVLYNLSVLH-- 1215
            ..|::|                              |:|...|......|:|......|||:.  
  Fly  1552 STGLQDVETEASSSSGGDKENQPKQHSKRQKKGETFEQEKERPVGCSTPPSPTPPPPALSVVERG 1616

  Fly  1216 -----------GLLIPALDPLGESAL--------LVQSAWMHSGCAHFVLELLTKNNF--LPSAD 1259
                       |.|....:...|..|        |..:.|.|. |...:|.:|....|  |.|||
  Fly  1617 DNKWSEAFVKCGGLRHLYEIFSEGQLQQSAHPKELALNEWRHD-CLASLLRILWLLGFEELQSAD 1680

  Fly  1260 MH---TKRASF--------QCVLRLAKLFLYIVGSVLSRVGDEPMICDLDNGSRSQVDILKQNFS 1313
            .|   ::...|        ||:.||:.:           :.||  :......|.:...:....|.
  Fly  1681 AHVLMSRPHPFMLQLMEVPQCLTRLSSI-----------LNDE--VHQQHQASSANPLVFPYQFQ 1732

  Fly  1314 TMPSSSQGTLRAISAKLAVILAREMLSASPEGDRCRTLFSSTLQWSCPDISTIKAVVQLAWASSC 1378
            .:.:...|..:.|...:.::::  .:.||.|..|                        |.||   
  Fly  1733 HLRTGFWGRAQLIQFAMNILVS--FVHASAEARR------------------------LLWA--- 1768

  Fly  1379 GNLQALGNSSGDFEDEVIVPDGQDFSMCKEALEVLTISFILNPSANEALTSDPNWPKFITSIVLK 1443
                               |.|.|.  |:                         |   :...:|:
  Fly  1769 -------------------PTGTDH--CR-------------------------W---LQKFILE 1784

  Fly  1444 NPLRHVRQVASEQLFLASTYCAGDRRPFVYMVNLLVGALKTLVP--------------------- 1487
            :|...||:.....|:   ..|.|:...:..::..|:..|..|:|                     
  Fly  1785 DPEPAVRREICAGLY---RICLGNAHSYRLLLAPLLHKLIALLPLAEQMSSGNQHTQFLLSEEGK 1846

  Fly  1488 -QYESTCAEFFSVLCRTLSYGCIYNWPLQISEGLLGDEIKWLQRIRENVHATGDTQVHEELLEGH 1551
             .|...|.::|.:|.|.:.         .:|..::.:|...::.:.|::..:..|:.:.||..|:
  Fly  1847 DPYGPACRDYFWLLARLVD---------TLSPEMVAEEHIDIEMLCESISQSILTREYYELRHGY 1902

  Fly  1552 --------LCLAKELMFFLGADSKAQLN----ELIHELIDDFLF----TASREFLHLRRHGSLRQ 1600
                    |.|...|:.:   |:..:..    ..|.:|| .|||    .|.|:            
  Fly  1903 QDDGLVGLLNLMSNLIKY---DTTFKYTPKALSFIEQLI-GFLFDMPSPADRQ------------ 1951

  Fly  1601 DTVPPPVCRSPHTIAAACDLLIALCQLCVPNMKLLTNTLIDFVCTDTDPLREWDYLPPVGARPTK 1665
                .|.|:|..:.|:|.|||:.||:.|..|...|...|:....:.......|||.|....|...
  Fly  1952 ----KPKCKSASSRASAYDLLVELCRGCATNYAYLHGRLLAQHKSGPKQPYPWDYWPRDEGRAEC 2012

  Fly  1666 GFCGLKNAGATCYMNSVLQQLYMVPAVRVGILRAHGAATTDGEDFSGDSDLTGGGLGSALFSGPA 1730
            |:.||.|.||||||.|.:|.|||:|..|..:||.                             |.
  Fly  2013 GYVGLTNLGATCYMASCVQHLYMMPQARAAVLRV-----------------------------PP 2048

  Fly  1731 SALVSLPSSSSTIEDGLHDVRKNYHVVILKHVQAIFAHLGHSALQYYVPRGLWTHFKLLGEPVNL 1795
            :|                 .||  |...|..:|.:||:|..|..:.|.||.....:::..:|:|.
  Fly  2049 NA-----------------ARK--HGPTLLELQRMFAYLLESERKSYNPRSFCRVYQMDHQPLNT 2094

  Fly  1796 REQQDAVEFFMSLLESLDEGLKALGQPQLMNATLGGSFSDQKICQECPHRYSKEEPFSVFSVDIR 1860
            .||:|..|||:.|:..|::....|  ..|:.....||.|:..:..:|.|.....|.|......:.
  Fly  2095 GEQKDMAEFFIDLVSKLEDMTPDL--KHLVKRLFCGSLSNNVVSLDCGHVSRTAEDFYTVRCQVA 2157

  Fly  1861 NHSSLTESLEQYVKGELLEGADAYHCDKCDKKVVTVKRVCVKKLPPVLAIQLKRFEYDYERVCAI 1925
            :..:|.|||::....:.|||.:.|.|.:|.|||...||.|.||||.:|.....|:.::...:...
  Fly  2158 DMRNLQESLDEVTVKDTLEGDNMYTCSQCGKKVRAEKRACFKKLPQILCFNTMRYTFNMVTMLKE 2222

  Fly  1926 KFNDYFEFPRILDMEPYTVSGL-------------AKLEGEVVEVGDNCQTNVETT--------- 1968
            |.|.:|.||..|:|..|....|             .:.||.......|.....|.|         
  Fly  2223 KVNTHFSFPLRLNMCHYVEKTLMPQQYKEERERRQKEKEGADGSGDGNDNEKAEATLDDDIEECY 2287

  Fly  1969 KYELTGIVVHSGQASGGHYFSYI--LSKNPANGKCQWYKFDDGEVTECKMHEDEEMKAECFGGEY 2031
            :|||.|:.||:|.|.||||:|:|  .:|...:...:|:.|:|.||   |..:..::.|||||||.
  Fly  2288 EYELVGVTVHTGTADGGHYYSFIKERTKTSYHTHERWFLFNDAEV---KPFDPSQIAAECFGGEM 2349

  Fly  2032 MGETYDNNLKRMQYRRQKRWWNAYMLFYTR--------------CDQTPVQYEPSVEQLSLAESR 2082
            ..:|||:..::......::..:||||||.|              ...||   .|:||:.|.||..
  Fly  2350 TSKTYDSVTEKYLDFSFEKTNSAYMLFYERRLPEHLQRRHSELLVTPTP---SPTVEEKSEAEEP 2411

  Fly  2083 NMV-------------------------------------------------LPLPKPIERSVR- 2097
            ..:                                                 .|..|.||:..| 
  Fly  2412 TKMETSSSEIKADVDVEVEVEEKDKEKPAQTDTESKETPAKEEIADDKSKQDEPEEKKIEKQSRE 2476

  Fly  2098 -------------------------------HQ-------------------------------- 2099
                                           ||                                
  Fly  2477 GEEKSETDEKPTEMTTVSTEEEKQPTANCDNHQQNNNSNSKASNDQQPSTSKAAQKLQLFRPLLN 2541

  Fly  2100 ----------NIRFLHSRSIFSVEFFNFIKKL---VSCNLLSARSNKITPAAEELSLLGVQLASQ 2151
                      |.:||..|:||...:|||:.::   :..:|:|         ..:::.:..:|:..
  Fly  2542 KELEDWIWQDNRQFLQDRNIFEHTYFNFMWQICGHIPQSLIS---------ETDVTCMAAKLSVS 2597

  Fly  2152 FLFHTGFRTKKSLRGPVM-EWYDALSHHIRSSALVRKWFANHALLSP--PSRLGEYILMAPSPDV 2213
            |...|....|:.   |.| .|.:.|:....:|....:||.:|....|  |.::   ::..|:..|
  Fly  2598 FFIETFIHAKEK---PTMVPWVELLTKQFNASQEACEWFLSHMSQEPYWPVQV---LIQCPNQMV 2656

  Fly  2214 RTVFVKLVVF--------FCHFAI------NDEPLTGYDGANLCEQVLISVLRLLKSEAADYGKH 2264
            |.:|.:||:.        ..|..:      :|:.|.|.  |:...:.:.|::.||:..|....:|
  Fly  2657 RQMFQRLVIHVIQQLRASHAHLYLEVETDEDDKELIGQ--ASCVTRFIGSLISLLEHGARANLRH 2719

  Fly  2265 LPHYFSLFSMYVGLGTREKQQLLRLNVPLQFIQVAL---------------DDGPGPAIKYQYPE 2314
            |..||.|...:..:|..|...|||:.|....:...|               |:....|:..:...
  Fly  2720 LSEYFGLLCEFSRMGDEEAMYLLRIGVLKSLVDFYLGHKQTDSIDISSDNEDNSSEEALSVEKMR 2784

  Fly  2315 FSKLHQVVSHLIRCSDVSEKCQSSN-----------------------QNARPLSNPFKDPNVAH 2356
            .:.|.::::   .|:.:.|:.:.::                       |..:...||.:..::.|
  Fly  2785 PASLDKMIA---LCASLVERSRGADFRLRLSPKDFSAIAGGKGFPFLYQQIKDGINPHQTKHLIH 2846

  Fly  2357 -----EELTPLSTECMDLLF-NRTGY---------IKKVIEDTNVGDEGL----KLLQYCSWENP 2402
                 :|  .|:|:.:.:|| :.|.:         :..::.:|..|..||    :|:....|:..
  Fly  2847 ALCRWDE--RLATQIIGMLFASVTKHTELCAPFFKLLTLLTETQGGPVGLPCFTQLILPRMWDAA 2909

  Fly  2403 HFSRAVLTELL--------------------WQCGFAYCHD---MRHHTDLLLNILLIDDSWQ-H 2443
            .:....:.:.|                    |...|...||   :|:....||..|:....:: :
  Fly  2910 EYCPQSVLDWLSLQATKNKIAHAWILQSAEKWLEQFLLAHDNTRVRNAAAFLLVALVPSQPFRAN 2974

  Fly  2444 HRIHN-----ALNGVAEEREGLLETIQRAKTHYQKRAYQIIKCLTQLFHKSPIALQM-LHTNSNI 2502
            .|.|:     |||.         .:.:...:..|...:|:|..|.:|...:.:...: .|..:.:
  Fly  2975 FRAHSQHKLLALNP---------HSYRDINSDAQAVLHQVITLLLRLLRPARVYADIGAHGTTKL 3030

  Fly  2503 TRHWSIAVEWLQGELDRQRGIGCQYNSYSW----------SPPAQSNDNTNGYMLERSQSAKNTW 2557
            |.::::....:..:.::.  :...|....|          |.||..|          ..:....|
  Fly  3031 TAYFNLLSYCMVSKTEKL--MASSYMRSLWELFHPRLSEPSVPAHHN----------KHALLTFW 3083

  Fly  2558 SMAFELCPDEVSEKTDENNEPNLETNM-------DENKSEPVAQPGGVL-----------EGSTG 2604
            ..:...||:..::..   |.|.:..|:       |.:.:|.|.....:|           |.|..
  Fly  3084 HHSLVDCPENAAQVA---NCPEITRNIAFNYILADHDDAEIVTYNRSMLPAYYGLLRLCCEQSRA 3145

  Fly  2605 GTEQLPENKTPTTSSPSTAAWPARGDSNAIPRLSRQLFGAYTSTGSGSTSGGSAPTSALTTTAGS 2669
            .|.||.:::        ...|..:   |..|..::.                :|....|......
  Fly  3146 LTRQLSQHQ--------NLQWAFK---NITPHPTQY----------------AAAVDELFKLMAL 3183

  Fly  2670 GANSETESSAQETTGET-----TINGLTNSLDQMEITAKKKCRRVI--IKKLVESKDEEDAT 2724
            .|....::|.||....|     .|...|:|||     |:.....:|  :|.||:  :|||.|
  Fly  3184 FATRHPDASEQEKLDVTQFRRAVIVSYTSSLD-----ARVSWSTLISALKILVD--NEEDRT 3238

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fafNP_524612.2 peptidase_C19C 1666..2064 CDD:239124 126/435 (29%)
UCH 1668..2059 CDD:278850 122/414 (29%)
pufNP_001262923.1 peptidase_C19C 2013..2382 CDD:239124 126/421 (30%)
UCH 2014..2377 CDD:278850 122/415 (29%)
DUF3517 2723..>2877 CDD:288853 25/158 (16%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5077
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D625455at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm14202
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR24006
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
44.010

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