Protein Alignment faf and Usp8

DIOPT Version :10

• Sequence 1: NP_524612.2
• Gene: faf / 43749
• FlyBaseID: FBgn0005632
• Length: 2778
• Species: Drosophila melanogaster
• Sequence 2: NP_650948.2
• Gene: Usp8 / 42509
• FlyBaseID: FBgn0038862
• Length: 896
• Species: Drosophila melanogaster
• Alignment Length: 1026
• Identity: 209/1026 - (20%)
• Similarity: 342/1026 - (33%)
• Gaps: 365/1026 - (35%)

  Fly  1167 GDKIAKDEEEKLYPT-EQAGIEDEEE------------------------HCTPEQMFLHPTPA- 1205
            |.||..:...|||.| |:..::.:||                        |.|..:..|..|.:
  Fly    29 GMKILLNTARKLYMTAEEYRLDGDEELAYITYMKYFNMLTAIHKKSDYPSHKTTVRQMLGDTESN 93

  Fly  1206 --------QVLYNLSVLHGLLIPALDPLG-----------ESALLVQSAWMHSG---CAHFVLEL 1248
                    :::.:|...:.....|.:|:.           :|.:...:.:...|   |......:
  Fly    94 RRIMDTLEEIINSLRHRYAQQHQAPEPIAPDLVSNGRAGVDSPITQPTQYARLGLITCQDLYRRM 158

  Fly  1249 LTKNNFL----PSADMHTKRASFQCVLRLAKLFLYIVGSVLSRVGDEPMICDLDNGSRSQVDILK 1309
            ..|:..:    ||||......::.|...:                .|.:|....:..|.|
  Fly   159 QEKSVLVMDCRPSADYEASHLTYYCAFNV----------------PEELITPGMSAGRLQ----- 202

  Fly  1310 QNFSTMPSSSQGTLRAISAKLAVILAR-EMLSASPEGDRC-RTLFSSTLQWSCPDISTIKAVVQL 1372
               :.:.||::.:..:.|.|.:|:|.. ....|.|..:.. .||......|. ||: |.:|.:|:
  Fly   203 ---ARLSSSAKASWASRSVKDSVVLMDWNTKDAQPATNTAISTLLDILKNWD-PDV-TYRAPIQI 262

  Fly  1373 A----------WASSCGN--LQALGNSSGDFE--DEVIVPDGQDFSMCKEALEVLTISFILNPS- 1422
            .          :.:.|.|  :||...::.|.|  |::..|...|.:| ||  ::....|...|.
  Fly   263 VEGGYEYFIMMYPTHCTNPSVQAPQQNNNDIETIDDIEYPSIHDITM-KE--DISAKDFRPRPDF 324

  Fly  1423 ----------ANEALTSDPNWPKFITSIVLKNPLRHVRQVA--SEQLFLASTYCAGDRRPFVYMV 1475
                      .||...|.|:.|....:.::::....:::..  .|||..||..
  Fly   325 NRANKPAATRVNEQGISRPSPPAKPIAEIMRDQAEFLQRAEQNDEQLEKASKM------------ 377

  Fly  1476 NLLVGALKTLVPQYESTCAEFFSVLCRTLSYGCIYNWPLQISEGLLGDEIKWLQRIRENVHATGD 1540
                                                |..|.:||             :.::||.|
  Fly   378 ------------------------------------WKRQAAEG-------------DGLNATED 393

  Fly  1541 TQVHEELLEGHLCLAKELMFFLGADSKAQ-----LNELIHEL----------------------- 1577
            .::|..:|:              .:||||     .|.|..||
  Fly   394 QELHFRILQ--------------LESKAQDYIVENNRLREELSRIQELHNVTQQLSQKEVEATRN 444

  Fly  1578 ----------ID----------DFLFTASREFLHLRRHGSLRQDTVPPPVCRSPHTIAAACDLLI 1622
                      :|          :.|...:||   .::|......:.||...|:...:....|.|.
  Fly   445 IESKIRERQRLDEQHELERQERERLLAIARE---TKKHYKSPTPSGPPSPGRNLEDVHVVSDSLE 506

  Fly  1623 ALCQL-------CVPN----------MKLLTNTLIDFVCTDTDPLREWDYLPPVGARPTKGFCGL 1670
            :|.||       ..||          ||.....:      :....|..|:.|.:|....:|..||
  Fly   507 SLLQLTGDPDPTIAPNKAEIPTFDRAMKPQPRNV------ERTSQRVRDFSPVIGQNVGRGLTGL 565

  Fly  1671 KNAGATCYMNSVLQQLYMVPAVRVGILRAHGAATTDGEDFSGDSDLTGG-------GLGSALFSG 1728
            ||.|.||||||:||.|...|.:      .....:...:::...|:.|.|       .|...|::|
  Fly   566 KNLGNTCYMNSILQCLSNTPQL------TEYCISDKYKNYISRSNKTNGQVIEEVAALIKELWNG 624

  Fly  1729 PASALVSLPSSSSTIEDGLHDVRKNYHVVILKHVQAIFAHLGHSALQYYVPRGLWTHFKLLGEPV 1793
            ....:.|            .|:|     .::...|.||             ||:
  Fly   625 QYKCVAS------------RDLR-----YVVGQYQKIF-------------RGV----------- 648

  Fly  1794 NLREQQDAVEFFMSLLESLDEGLKALGQP---QLMNAT------------------LGGSFSDQK 1837
               :|||:.||...|::.|...|:.|..|   ::::|:                  ..|......
  Fly   649 ---DQQDSHEFLTILMDWLHSDLQTLHVPRQREMISASEKAWLEFTKAKESMILHLFYGQMKSTV 710

  Fly  1838 ICQECPHRYSKEEPFSVFSVDIRNHSS---LTESLEQYVKGELLEGADAYHCDKCDKKVVTVKRV 1899
            .|..|....:..|.||..|:::..:|:   |.:.::.|..||.:.|   ::|..|..|...:|::
  Fly   711 KCVACHKESATYESFSNLSLELPPNSNVCQLNQCMDMYFSGERIHG---WNCPSCKTKRDAIKKL 772

  Fly  1900 CVKKLPPVLAIQLKRFEYDYERVCA-IKFNDYFEFP-RILDMEPYTVSGLAKLEGEVVEVGDNCQ 1962
            .:.||||||.:.||||..|.....: :|..:|..|| ..|||.||    :|:.|...|
  Fly   773 DISKLPPVLVVHLKRFYADPSNSGSYMKKQNYLRFPLENLDMNPY----IARAESRAV------- 826

  Fly  1963 TNVETTK-YELTGIVVHSGQASGGHYFSYILSKNPANGKCQWYKFDDGEVT 2012
                |.| |:|..:..|.|...||||.::..|.|  .||  |:||||..|:
  Fly   827 ----TPKTYQLYAVSNHYGTMEGGHYTAFCKSAN--YGK--WFKFDDQVVS 869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
faf	NP_524612.2	Ubl1_cv_Nsp3_N-like	<994..1060	CDD:475130
		peptidase_C19C	1666..2064	CDD:239124	101/381 (27%)
		DUF3517	2198..2566	CDD:463438
Usp8	NP_650948.2	USP8_dimer	2..114	CDD:462647	15/84 (18%)
		RHOD	148..278	CDD:444705	27/155 (17%)
		Smc	<361..>511	CDD:440809	33/227 (15%)
		Peptidase_C19R	564..887	CDD:239139	100/378 (26%)