DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment faf and Usp47

DIOPT Version :9

Sequence 1:	NP_524612.2	Gene:	faf / 43749	FlyBaseID:	FBgn0005632	Length:	2778	Species:	Drosophila melanogaster
Sequence 2:	NP_523937.2	Gene:	Usp47 / 38644	FlyBaseID:	FBgn0016756	Length:	1556	Species:	Drosophila melanogaster

Alignment Length:	1138	Identity:	238/1138 - (20%)
Similarity:	382/1138 - (33%)	Gaps:	357/1138 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1648 DPLREWDYLPPVGA------------------RPTKGFCGLKNAGATCYMNSVLQQLYMVPAVRV 1694
            |.||.|..:...||                  ...:|:.||.|...|||:||:||.|:|.|..|.
  Fly   358 DELRAWQRVNTTGADFVSSATTETEAEARQASLGPRGYVGLVNQAMTCYLNSLLQALFMTPEFRN 422

  Fly  1695 GILRAHGAATTDGEDFSGDSDLTGGGLGSALFSGPASALVSLPSSSSTIEDGLHDVRKNYHVVIL 1759
            .:.|         .:|..|::                                   .||    |.
  Fly   423 ALYR---------WEFDNDNE-----------------------------------AKN----IP 439

  Fly  1760 KHVQAIFAHLGHSALQYYVPRGLWTHFKLLGEPVNLREQQDAVEFFMSLLESLDEGLKALGQPQL 1824
            ..:|.:|.:|..|.........|...|.  .:.....:|.|..|....:.::|:...|...|..|
  Fly   440 YQLQKLFLNLQTSPKAAVETTDLTRSFG--WDSTEAWQQHDIQELCRVMFDALEHKFKNTKQANL 502

  Fly  1825 MNATLGGSFSDQKICQECPHRYSKEEPFSVFSVDIR------NHSSLTESLEQYVKGELLEGADA 1883
            ::....|..:|...|.||....::|:.|....:.:|      .:.|:.|:|..:|:.|.|:|.:.
  Fly   503 ISNLYEGKMNDYVKCLECNTEKTREDTFLDIPLPVRPFGSSSAYGSIEEALRAFVQPETLDGNNQ 567

  Fly  1884 YHCDKCDKKVVTVKRVCVKKLPPVLAIQLKRFEYDYERVCAIKFNDYFEFPRILDMEPY------ 1942
            |.|:||.||....|.:..|..|.:|.:.||||::||:.:..||.||...||:.|::..:
  Fly   568 YLCEKCKKKCDAHKGLHFKSFPYILTLHLKRFDFDYQTMHRIKLNDRVTFPQTLNLNTFINRSGN 632

  Fly  1943 ----------TVSGLAKLEGEVVEVGDNCQTNVETTK---------------------------- 1969
                      ||...:..:.......||..:.|.||.
  Fly   633 SGEQNSQLNGTVDDCSTADSGSAMEDDNLSSGVVTTASSSQHENDLNDEDEGIDMSSSTSKSAKQ 697

  Fly  1970 ------YELTGIVVHSGQASGGHYFSYILSKNPANGKCQWYKFDDGEVTECKMHEDEEMKAECFG 2028
                  |||..|::|||.||||||::||  |:..|.  :|:.|:|..||.....:.:    ..||
  Fly   698 GSGPYLYELFAIMIHSGSASGGHYYAYI--KDFDNN--EWFCFNDQNVTSITQEDIQ----RSFG 754

  Fly  2029 ---GEYMGETYDNNLKRMQYRRQKRWWNAYMLFYTRCDQTPVQYEPSVEQLSLAESRNMVLPLPK 2090
               |.|....|.::.            |||||.|.:.|....:....|...    ..::...|||
  Fly   755 GPNGSYYSSAYTSST------------NAYMLMYRQVDAKRNELVAKVADF----PEHIKTLLPK 803

  Fly  2091 -------PIERSVRHQNIRFLHSRSIFS--VEFFN-FIKKLVSCNLLSARS---NKITPAAEELS 2142
                   .:.|..||..:..|....::.  |.|:| .:||:....:..::|   |.:..:|.|
  Fly   804 LHSEEETRVSRLGRHITVTDLALPDLYKPRVYFYNPSLKKMKITRVYVSQSFNINLVLMSAYE-- 866

  Fly  2143 LLGVQ----------LASQFLFHTGFRTKKSLRGPVMEWYDALSHHIRSSALVRKWFANHALLSP 2197
            :|.|:          :|......|..::.:|...|.:....|..::.....|..:.......:.|
  Fly   867 MLNVEQFAPLSRCRLVAYNSSMDTIIQSLESCTDPALTELRAAQNYSLDFLLEYRAEDQEFEVYP 931

  Fly  2198 PSRLGEYILMAPSPDVRTVFVKLVVFFCHFAINDEPLTGYDGANLCEQVLISVLRLLKSEAADYG 2262
            |:.:..|:...   |:.|:.:            |.|...|..|.             :.||:|..
  Fly   932 PNGITWYVFKV---DLSTMAM------------DGPFLVYSAAR-------------EREASDVL 968

  Fly  2263 KHLPHYFSLFSMYVGLGTREKQQLL---RLNVPLQFIQVALDDGPGP---------------AIK 2309
            :.        |:.:.|...|:|.||   |..||..|  |:.|..|.|               :|.
  Fly   969 RR--------SIALRLHISEQQFLLATVRATVPKAF--VSYDPHPTPEALQHLQNMANTQFKSIT 1023

  Fly  2310 YQYPEFSKLHQVVSHLIRCSDV-SEKCQS------------------SNQN-------ARPLSNP 2348
            |.|............::....| |.:|.|                  |:.|       .|.|..|
  Fly  1024 YFYLNVPNTDAATLEMLGVPTVESVECASGGDVVDAAMMNGVAPGHMSSSNDYDWRRYKRDLVEP 1088

  Fly  2349 FKDPNVAH-----EELTPLSTECMDLLFNRTGYIKKVIEDTNVGDEGLKLLQYCSW-ENPHFS-- 2405
            ...|:.:|     .|.:.||..      :||     ::|..|:...|....|..|. .:|..|
  Fly  1089 MSQPSPSHGHESNSEDSSLSDG------DRT-----LVETDNMAHRGGGDSQVSSTSHSPQLSSP 1142

  Fly  2406 --RAVLTELLWQCGFAYCHDMRHHTDL-LLNILLIDDSWQHH----RIH-------NALNGVAEE 2456
              .|...:.:.:. .|||:....:... :::.||:..|..|.    ::.       .:.:|...:
  Fly  1143 EDEAASHDAMMRV-HAYCNGNGSYAAADVVDPLLLPTSTNHFFYATKVECVDVVGTGSSSGHQSD 1206

  Fly  2457 REGLLETIQRA-----KTHYQKRAYQIIKCLTQLFHKSPIA---LQMLHTNSNITRHWSIAVEWL 2513
            .|..|....||     .||.:..|::  |.:.||. :.|.|   ||..|.|:
  Fly  1207 EEAQLRKPTRAYKLLVGTHMRMGAFK--KHIEQLI-QVPAAHFKLQRKHDNN------------- 1255

  Fly  2514 QGELDRQRGIGCQYNSYSWSPPAQSNDNTNGYMLERSQSAKNTWSMAFELCPDEVSEK------T 2572
                                    .::|.|..::...:....|..:...|.|||...|      .
  Fly  1256 ------------------------LSNNQNNSLVHLIEGETLTVELGKTLEPDEFKAKIHFLRLA 1296

  Fly  2573 DENNEP-----------NLETNMDENKSEPVAQ 2594
            |.:||.           |..|..::.|.|.||:
  Fly  1297 DIDNETSKLPCVCEWVYNANTTAEQAKKELVAK 1329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
faf	NP_524612.2	peptidase_C19C	1666..2064	CDD:239124	112/456 (25%)
faf	NP_524612.2	UCH	1668..2059	CDD:278850	110/449 (24%)
Usp47	NP_523937.2	TEBP_beta	<119..234	CDD:254188
		Rib_recp_KP_reg	122..265	CDD:282899
		peptidase_C19C	394..780	CDD:239124	112/455 (25%)
		UCH	395..776	CDD:278850	110/450 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456901
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24006
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840