DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment faf and Usp34

DIOPT Version :9

Sequence 1:NP_524612.2 Gene:faf / 43749 FlyBaseID:FBgn0005632 Length:2778 Species:Drosophila melanogaster
Sequence 2:XP_038948159.1 Gene:Usp34 / 360990 RGDID:1565181 Length:3584 Species:Rattus norvegicus


Alignment Length:2889 Identity:551/2889 - (19%)
Similarity:916/2889 - (31%) Gaps:1098/2889 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 RHTTGQPGSTAPSSSSSTTSTTTTTTSPAQSAGSGSGIGTGTGTVANSSLPGGGSGS-------- 63
            :|...:...|..|...|:..|..:....:...||.||...|:....|||.....:||        
  Rat   548 KHVQQRLSDTEESMQGSSDETANSGEDGSSGPGSSSGQSDGSSHEVNSSHASQSAGSPGSELQSE 612

  Fly    64 ----------------------LDGNQDQQPATDSQSSDDVAASLSANSVDSTITIVPPEKLISS 106
                                  .:..:|::...|.:..||       :..|......||:.... 
  Rat   613 DIADIEALKEEEEEEEEEEEEEEEEEEDEEEEEDDEEEDD-------DDDDDDHAHNPPKNTCG- 669

  Fly   107 FPTTKLRSLTQKISNPRWVVPVLPEQELEVLLNAAIELTQAGVDHDCEPCVEFYRNGLSTSFAK- 170
               |::|:  :|:.|                 .|||.|.::....:        |||......| 
  Rat   670 ---TEMRN--RKLEN-----------------QAAICLGESQATSE--------RNGTHGGAGKD 704

  Fly   171 -ILTDEAVNSWKNNIHHCILVSCGKLLHLIAIHMQRDNPYLLDLLAIVFDPENKFN------TFN 228
             :...|.:.|..|.|.                        :||..|...|||:..:      ...
  Rat   705 LVFNTEPLPSVDNRIR------------------------MLDACAHSEDPEHDISGEMSSAHIA 745

  Fly   229 AGRQPECFAAPDYIWGQLDSNKMYARPPPEPKNAR------------------------------ 263
            .|.|..|........|:...|:::        |.|                              
  Rat   746 QGSQESCITRSGDFLGETIGNELF--------NCRQFIGPQHHHHHHHHHHHHHHHHHHHHHHHD 802

  Fly   264 GWLVDLINRFGQLGGFDNLLERFNIGLELLKRNQNKCTGKNISVEGRVENGAQDNRLTLALIHSL 328
            |.:||                      ::|..:...|:...:|.:.  |....|           
  Rat   803 GHMVD----------------------DMLSADDVSCSSSQVSAKS--EKNMAD----------- 832

  Fly   329 LRPFGQCYELLMPATIAKYFMPTWNVVLDLLDSFTDEELKREVKPEGRNDYINGIVKSARLLASR 393
                                             |..||                           
  Rat   833 ---------------------------------FDGEE--------------------------- 837

  Fly   394 LTGQEELIRDLEMFRLKMILRLLQVSSFNGKMNALNEINKVLSSVAYFSHRSQ-PL--PHCMPED 455
             :|.||              .|:|::|.....:.|.:....|:|: |..|.|| |.  .|....:
  Rat   838 -SGCEE--------------ELVQINSHAELTSHLQQHLPNLASI-YHEHLSQGPAVHKHQFSSN 886

  Fly   456 EMDWLTADRMAQWIKSSDVLGVVLKDSLHQPQYVEKLEKIIRFLIKEQALTLDDLDAVWRAQAGK 520
            .:..:..|.:.:  |.:.:|..:::|                    :.|:.|.            
  Rat   887 AVTDINLDNVCK--KGNTLLWDIVQD--------------------DDAINLS------------ 917

  Fly   521 HEAIVKNVHDLLAKLAWDFTPEQLDHLFEAFQASMTTANKRQRERLLELIRRLAEDDKNGVMAQK 585
             |.::.....||..|...||..|:                  |.|.:|.......::::.|::.:
  Rat   918 -EGLINEAEKLLCSLVCWFTDRQI------------------RMRFIEGCLENLGNNRSVVISLR 963

  Fly   586 VL-KLFWTLAHSQEVPPEVLDQALGAHVKILDYSCSQERDAQKTIWLDKCVDELKSGDGWVLPAL 649
            :| |||.|.            |..|:              :..|.|:..          |.    
  Rat   964 LLPKLFGTF------------QQFGS--------------SYDTHWITM----------WA---- 988

  Fly   650 RLIRDICCLYDTTTNHAQRTQTSTNRQQVIERLQNDYSLVILVTNSLTAYMEKVRQMVTDSPGLD 714
                                             :.:.:::.|..::|..|::.:|          
  Rat   989 ---------------------------------EKELNMMKLFFDNLVYYIQGIR---------- 1010

  Fly   715 ATRILIDGR-----FPHHVQIAERLEFL----KFLLKDGQLWLCADQAKQIWHCLAVNAVFPADR 770
                  :||     :.|..::..||:||    ..|.......|..:|...:||||       .:.
  Rat  1011 ------EGRQKHTLYSHSAEVQVRLQFLTCVFSTLGSPDHFRLSLEQVDILWHCL-------VED 1062

  Fly   771 EECF----RWFGKLMGEEPDLDPGIN--KDFFENNILQLDPHLLTESGIKCFERFFKAVNSKEDK 829
            .||:    .||...:..:.....|:.  |..|...:.||.|..::.:|:..|:..   .|.....
  Rat  1063 SECYDDALHWFLNQVRSKDQHAMGMETYKHLFLEKMPQLKPETISMTGLNLFQHL---CNLARLA 1124

  Fly   830 LKAIHRGYMLDNEDLIGKDYLWRVITTGGEEIASKAIDLLKEVSTALGPRLQENIAEFHEMFIGE 894
            ..|...|   .|.:|.|.|..|      |..:.:::.|:                          
  Rat  1125 TSAYDGG---SNSELCGMDQFW------GIALRAQSGDV-------------------------- 1154

  Fly   895 CCSRLRTHYGN-IVILGKTQLQEELDAPDQSDNTNDESKDSKMRFIEAEKMCRILKVLQEYVKEC 958
              ||....|.| ..|.|||.|::|                                  ||::.:|
  Rat  1155 --SRAAIQYINSYYINGKTGLEKE----------------------------------QEFISKC 1183

  Fly   959 DRSFS------GDRVHLPLSRVTRGKNTILYIRFQNPGRSIDDMEIVTHSNETMAAFKRNLLK-- 1015
            ..|..      ....|..|:.:.||   :|.::              ||    :.||:|....  
  Rat  1184 MESLMIASSSLEQESHSSLTVIERG---LLMLK--------------TH----LEAFRRRFAYHL 1227

  Fly  1016 ---RIKGTSTAN-------------------------IKVDLFYANDEMIGVSDEINPLYQYTIR 1052
               :|:||..::                         :.::: |.:|::..:..|:...|:...:
  Rat  1228 RQWQIEGTGISSHLKALSDKQSLPLRVVCQPAGLPDKMTIEM-YPSDQVADLRAEVTHWYENLQK 1291

  Fly  1053 DKMNLTAKLTPVGTG----------------LASSPDSSSD------------------SSTGSP 1083
            :::|..|:|...|..                ::|..:.::|                  .|.|:|
  Rat  1292 EQINQQAQLQEFGQSSRKGEFPGGLMGPVRMISSGHELTTDYDEKALHELGFKDMQMVFVSLGAP 1356

  Fly  1084 -----------PRPC-PDMQRVESESTLPGVIISQNYQYTEFFLKLYQLGS-----------DLE 1125
                       |..| |..|:    ..:|.:::.|....|..|..|..|.|           |.|
  Rat  1357 RRERKGEGVQLPASCLPPPQK----DNIPMLLLLQEPHLTTLFDLLEMLASFKPPSGKVAVDDSE 1417

  Fly  1126 HGRLRD--------SAKV--LLHLLP-C-----------DRQT--------IRQLKIMCKVPKAA 1160
            ..:..:        |.:|  ||.||| |           |.|:        :.::|...|:..|.
  Rat  1418 SLKCEELHLHAENLSRRVWELLMLLPTCPNMLTAFQSISDEQSNDGVNWKELLKIKSAHKLLYAL 1482

  Fly  1161 VTVAVTGDKIAKDEEEK------LYPTEQAGIEDEEEH------CTPEQMFLHPTPAQVLYNLSV 1213
            ..:...|....:...|.      |||......||:.|:      |    .|:.....|.|  |.:
  Rat  1483 EIIEALGKPNRRIRRESTGSYSDLYPDSDDSSEDQVENSKNSWTC----KFVAAGGLQQL--LEI 1541

  Fly  1214 LHGLLIPALDPLGESALLVQSAWMHSGCAHFVLELLTKNNFLPS---------------ADMHTK 1263
            .:..:   |:|....:..|   | ...|...:|:|:.:....||               |:.|.|
  Rat  1542 FNSAM---LEPKEHESWTV---W-QLDCLACLLKLICQFAVDPSDLDLAYHDVFAWSGIAESHRK 1599

  Fly  1264 RA--------------SFQCVLRLAKLFLYIVGSVLSRVGDEPMICDLDNGSRSQVDILKQNFST 1314
            ||              |.. |.||.::||.:|                                 
  Rat  1600 RAWPGKSRKAAGDHAKSLH-VPRLTEVFLVLV--------------------------------- 1630

  Fly  1315 MPSSSQGTLRAISAKLAVILAREMLSASPEGDRC--RTLFSSTLQWSCPDISTIKAVVQLAWASS 1377
                 |||          .|.:.::|.:...|..  |.|.:.:...|..::|.....:.::||..
  Rat  1631 -----QGT----------SLIQRLMSVAYTYDHLAPRVLKAQSDHRSRHEVSHYSMWLLVSWAHC 1680

  Fly  1378 CGNLQALGNSSGDFEDEVIVPDGQDFSMCKEALEVLTISFILNPSANEALTSD--PNWPKFITSI 1440
            |                         |:.|.:|                ..||  .:|.:.:|.:
  Rat  1681 C-------------------------SLVKSSL----------------ADSDHLQDWLRKLTLL 1704

  Fly  1441 VLKNPLRHVRQVASEQLFLASTYCAGD--RRPFVYMV--NLL-----VGALKTL-VPQYEST--- 1492
            :.:..:||.......:|.| |....||  .|.|:.:.  .||     ..|||.| :..||..   
  Rat  1705 IPETAVRHESCNGLYKLSL-SGLDGGDSIHRSFLLLAASTLLKFLPDAQALKPLRIDDYEEEPML 1768

  Fly  1493 ---CAEFFSVLCRTLSYGCIYNWPLQISEGLLGDEIKWLQRIRENVH---ATGDTQVHEELLEGH 1551
               |.|:|.:||:.:                            :|:|   |:..|.:..:.|..|
  Rat  1769 KPGCKEYFWLLCKLV----------------------------DNIHIKDASQTTLLDLDALARH 1805

  Fly  1552 L--CLAKELMFFLGADSKAQLNELIHELIDDFL----------------FTASR---EFLH---- 1591
            |  |:.          |:..|:.|...|.||.|                |..||   |||.    
  Rat  1806 LADCIR----------SREILDHLDGNLEDDGLSGLLRLATSVIKHKPPFKFSREGQEFLRDVFN 1860

  Fly  1592 ----LRRHGSLRQDTVPPPVCRSPHTIAAACDLLIALCQLCVPNMKLLTNTLIDFVCTDTDPLRE 1652
                |......||     |.|:|..:.|||.|||:.:.:..|.|.:|:.|.::...........:
  Rat  1861 LLFLLPSLKDRRQ-----PKCKSHSSRAAAYDLLVEMVKGSVENYRLVHNWVMAQHMQSAHAPYK 1920

  Fly  1653 WDYLPPVGARPTKGFCGLKNAGATCYMNSVLQQLYMVPAVRVGILRAHGAATTDGEDFSGDSDLT 1717
            |||.|....|....|.||.|.|||||:.|.:|||||:|..|                        
  Rat  1921 WDYWPHEDVRAECRFVGLTNLGATCYLASTIQQLYMIPEAR------------------------ 1961

  Fly  1718 GGGLGSALFSGPASALVSLPSSSSTIEDGLHDVRKNYHVVILKHVQAIFAHLGHSALQYYVPRGL 1782
                 .|:|:...|                .|::   |...|..:|.:|.:|..|..:.|.||..
  Rat  1962 -----QAVFTAKYS----------------EDMK---HKTTLLELQKMFTYLMESECKAYNPRPF 2002

  Fly  1783 WTHFKLLGEPVNLREQQDAVEFFMSLLESLDEGLKALGQPQLMN---ATLGGSFSDQKICQECPH 1844
            ...:.:..:|:|..||:|..|||..|:..::|     ..|:|.|   :..||..::..:..:|.|
  Rat  2003 CKTYTMDKQPLNTGEQKDMTEFFTDLITKVEE-----MSPELKNTVKSLFGGVITNNVVSLDCEH 2062

  Fly  1845 RYSKEEPFSVFSVDIRNHSSLTESLEQYVKGELLEGADAYHCDKCDKKVVTVKRVCVKKLPPVLA 1909
            .....|.|......:.:..::.|||::....:.|||.:.|.|..|.|||...||.|.||||.:|:
  Rat  2063 VSQTAEEFYTVRCQVADMKNIYESLDEVTIKDTLEGDNMYTCSHCGKKVRAEKRACFKKLPRILS 2127

  Fly  1910 IQLKRFEYDYERVCAIKFNDYFEFPRILDMEPYT---VSGLAKLEGEVVEVGDNCQTNVETTKYE 1971
            ....|:.::...:...|.|.:|.||..|||.|||   :.|.:..:....:|||:.: :.|:.:|:
  Rat  2128 FNTMRYTFNMVTMMKEKVNTHFSFPLRLDMTPYTEDFLMGKSDRKEGFKDVGDHSK-DTESYEYD 2191

  Fly  1972 LTGIVVHSGQASGGHYFSYILS-KNP---ANGKCQWYKFDDGEVTECKMHEDEEMKAECFGGEYM 2032
            |.|:.||:|.|.||||:|:|.. .||   .|.|  ||.|:|.||   |..:..::.:||||||..
  Rat  2192 LIGVTVHTGTADGGHYYSFIRDIVNPHAYKNNK--WYLFNDAEV---KPFDSAQLASECFGGEMT 2251

  Fly  2033 GETYDNNLKRMQYRRQKRWWNAYMLFYTRCDQTPVQYEPSVEQLSLAESRNMVLPLPKPIERSVR 2097
            .:|||:...:......::..:||||||.|       .||..|     ..|.....:...:...:.
  Rat  2252 TKTYDSVTDKFMDFSFEKTHSAYMLFYKR-------MEPEEE-----NGREYKFDVSSELLEWIW 2304

  Fly  2098 HQNIRFLHSRSIFSVEFFNFIKKLVSCNLLSARSNKITPAAEELSLLGVQLASQFLFHTGFRTKK 2162
            |.|::||..::||...:|.|:.:|.||      .....|..:.:||:..:|::.|:..|...:|:
  Rat  2305 HDNMQFLQDKNIFEHTYFGFMWQLCSC------IPSTLPDPKAVSLMTAKLSTSFVLETFIHSKE 2363

  Fly  2163 SLRGPVMEWYDALSHHIRSSALVRKWFANHALLSPPSRLG-------EYILMAPSPDVRTVFVKL 2220
              :..:::|.:.|:....:|....:||.:        |:.       :.::..|:..||.:|.:|
  Rat  2364 --KPTMLQWIELLTKQFNNSQAACEWFLD--------RMADDDWWPMQILIKCPNQIVRQMFQRL 2418

  Fly  2221 VV--------FFCHFAINDEPLTGYD---------GANLCEQVLISVLRLLKSEAA-DYGKHLPH 2267
            .:        ...|..:......|.|         |...|....:..|.|:..... .:.|||..
  Rat  2419 CIHVIQRLRPVHAHLYLQPGMEDGSDDMDASVEDIGGRSCVTRFVRTLLLIMEHGVKPHSKHLTE 2483

  Fly  2268 YFSLFSMYVGLGTREKQQLLRLNVPLQFIQVALDDGPGPAIKYQYPEFSKLHQVVSHLIRCSDVS 2332
            ||:....:..:|..|.|.||.|......:...:.. .||    :.|:...|.:            
  Rat  2484 YFAFLYEFAKMGEEESQFLLSLQAISTMVHFYMGT-KGP----ENPQVEVLSE------------ 2531

  Fly  2333 EKCQSSNQNARPLSNPFKDPNVAHEELTPLSTECMDLLFNRTGYIKKVIEDTNVGDEGLKLLQYC 2397
            |:.:...:....||       :|.|:..|.:.|.|..|      :..::|.:. .:..|.|.|  
  Rat  2532 EEGEEEEEEEDILS-------LAEEKYRPAALEKMIAL------VALLVEQSR-SERHLTLSQ-- 2580

  Fly  2398 SWENPHFSRAVLTELLWQCG-----FAYCH-----DMRHHTDLLLNILLIDDSWQHHRIHNALNG 2452
                        |::....|     |.:.|     ::|...:|:.::.         |.:|.|  
  Rat  2581 ------------TDMAALTGGKGFPFLFQHIRDGINIRQTCNLIFSLC---------RYNNRL-- 2622

  Fly  2453 VAEEREGLLETIQRAKTHYQKRAYQIIKCLTQLFH-------KSPIALQMLHTNSNITRHWSI-- 2508
             ||....:|.|.....|  .:.|....|.||.|..       ..|.|..:|.      |.|.:  
  Rat  2623 -AEHIVSMLFTSIAKLT--PEAANPFFKLLTMLMEFAGGPPGTPPFASYILQ------RIWEVIE 2678

  Fly  2509 -----AVEWLQGELDRQRGIGCQYNSYSW 2532
                 .::||..:..|.:      .::||
  Rat  2679 YNPSQCLDWLAVQTPRNK------LAHSW 2701

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fafNP_524612.2 peptidase_C19C 1666..2064 CDD:239124 126/407 (31%)
UCH 1668..2059 CDD:278850 122/400 (31%)
Usp34XP_038948159.1 peptidase_C19C 1934..2283 CDD:239124 126/414 (30%)
DUF3517 2401..2734 CDD:403300 69/372 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D625455at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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