DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment faf and Usp7

DIOPT Version :9

Sequence 1:	NP_524612.2	Gene:	faf / 43749	FlyBaseID:	FBgn0005632	Length:	2778	Species:	Drosophila melanogaster
Sequence 2:	NP_001019961.1	Gene:	Usp7 / 360471	RGDID:	1306915	Length:	1103	Species:	Rattus norvegicus

Alignment Length:	889	Identity:	212/889 - (23%)
Similarity:	320/889 - (35%)	Gaps:	264/889 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1642 FVCTDTDPLREWDYLPPVGARPTKGFCGLKNAGATCYMNSVLQQLYMVPAVRVGILRAHGAATTD 1706
            ||..|......||      ::...|:.||||.||||||||:||.|:....:|    :|.....|:
  Rat   195 FVQADAPHGVAWD------SKKHTGYVGLKNQGATCYMNSLLQTLFFTNQLR----KAVYMMPTE 249

  Fly  1707 GEDFSGDSDLTGGGLGSALFSGPASALVSLPSSSSTIEDGLHDVRKNYHVVILKHVQAIFAHLGH 1771
            |:|.|                      .|:|.:                      :|.:|..|.|
  Rat   250 GDDSS----------------------KSVPLA----------------------LQRVFYELQH 270

  Fly  1772 SALQYYVPRGLWTHFKLLG-EPVNLREQQDAVEFFMSLLESLDEGLKALGQPQLMNATLGGSFSD 1835
            |.    .|.|.....|..| |.::...|.|..|....||::::..:|.    ..:..|:...|..
  Rat   271 SD----KPVGTKKLTKSFGWETLDSFMQHDVQELCRVLLDNVENKMKG----TCVEGTIPKLFRG 327

  Fly  1836 QKI----CQECPHRYSKEEPFSVFSVDIRNHSSLTESLEQYVKGELLEGADAYHCDKCDKKVVTV 1896
            :.:    |:|..:|..:.|.:....:.|:...::.||...||..|.|:|.:.|...:...:...
  Rat   328 KMVSYIQCKEVDYRSDRREDYYDIQLSIKGKKNIFESFVDYVAVEQLDGDNKYDAGEHGLQEAE- 391

  Fly  1897 KRVCVKKLPPVLAIQLKRFEYDYERVCAIKFNDYFEFPRILDMEPYTVSGLAKLEGEVVEVGDNC 1961
            |.|....|||||.:||.||.||.:....||.||.||||..|.::.:    |.|.:.:
  Rat   392 KGVKFLTLPPVLHLQLMRFMYDPQTDQNIKINDRFEFPEQLPLDEF----LQKTDPK-------- 444

  Fly  1962 QTNVETTKYELTGIVVHSGQASGGHYFSYILSKNPANGKCQWYKFDDGEVTECKMHEDEEMKAEC 2026
                :...|.|..::||||...||||..|:   || .|..:|.||||..|:.|...|..|..
  Rat   445 ----DPANYILHAVLVHSGDNHGGHYVVYL---NP-KGDGKWCKFDDDVVSRCTKEEAIEHN--- 498

  Fly  2027 FGGEYMGETYDNNLKRMQYRRQKRWWNAYMLFYTRCDQTP------------------VQYEPSV 2073
            :||      :|::|.      .:...|||||.|.|..:..                  :|.|..:
  Rat   499 YGG------HDDDLS------VRHCTNAYMLVYIRESKLSEVLQAVTDHDIPQQLVERLQEEKRI 551

  Fly  2074 EQLSLAESRNMVLPLPKPI----------------ERSVRHQNIRFLHSRSIFSVEF-------F 2115
            |.....|.:...|.:...|                |..||:...:.|.:.|:  .||       .
  Rat   552 EAQKRKERQEAHLYMQVQIVAEDQFCGHQGNDMYDEEKVRYTVFKVLKNSSL--AEFVQSLSQTM 614

  Fly  2116 NFIKKLVSCNLLSARSNKITPAAEELSLLGVQLASQFLFHTGFRTKKSLRGPVMEW---YDALSH 2177
            .|.:..:....:.||||    ..:..::|..:.       .|.:|...|......|   .:.:..
  Rat   615 GFPQDQIRLWPMQARSN----GTKRPAMLDNEA-------DGSKTMIELSDNENPWTIFLETVDP 668

  Fly  2178 HIRSS-ALVRKWFANHALL------SPPSRLGEY---ILMAPSPDVRTVFVKLVVFFCHFA--IN 2230
            .:.:| |.:.|:..:|.::      .|.:|...|   |....|..:|    .|:...|..|  |.
  Rat   669 ELAASGATLPKFDKDHDVMLFLKMYDPKTRSLNYCGHIYTPISCKIR----DLLPVMCDRAGFIQ 729

  Fly  2231 DEPLTGYDGA--NLCEQVL---ISVLRLL-------------------KSE---AADYGKHLPHY 2268
            |..|..|:..  ||.|::.   :|:.:.|                   .||   |.:|.:.|.|.
  Rat   730 DTSLILYEEVKPNLTERIQDYDVSLDKALDELMDGDIIVFQKDDPENDNSELPTAKEYFRDLYHR 794

  Fly  2269 FSLF----------SMYVGLGTR------EKQQLLRLNVP---LQFIQ-VALDDGPGPAIKYQYP 2313
            ..:.          ...|.|..|      .|....|||..   |||.: ....||||..:::.|.
  Rat   795 VDVIFCDKTIPNDPGFVVTLSNRMNYFQVAKTVAQRLNTDPMLLQFFKSQGYRDGPGNPLRHNYE 859

  Fly  2314 -------EFSKLHQ----VVSHL-IRCSDV----SEKCQSSNQNARPLSNPFKDPNVAHEELT-- 2360
                   :|.|..|    ....| ::.:|.    |.||...|...|            .||:|
  Rat   860 GTLRDLLQFFKPRQPKKLYYQQLKMKITDFENRRSFKCIWLNSQFR------------EEEITLY 912

  Fly  2361 PLSTECM-DLLFNRTGYIKKVIEDTNVGDEG---LKLLQYCSWE 2400
            |....|: |||..    .||.:|   :|||.   |:||:..|::
  Rat   913 PDKHGCVRDLLEE----CKKAVE---LGDEASGRLRLLEIVSYK 949

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
faf	NP_524612.2	peptidase_C19C	1666..2064	CDD:239124	113/402 (28%)
faf	NP_524612.2	UCH	1668..2059	CDD:278850	110/395 (28%)
Usp7	NP_001019961.1	Interaction with TSPYL5. /evidence=ECO:0000250\|UniProtKB:Q93009	1..209		5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40
		Interaction with p53/TP53 and MDM2. /evidence=ECO:0000250\|UniProtKB:Q93009	54..209		5/19 (26%)
		COG5077	56..1101	CDD:227409	212/889 (24%)
		MATH_HAUSP	68..203	CDD:239741	3/7 (43%)
		Necessary for nuclear localization. /evidence=ECO:0000250\|UniProtKB:Q93009	71..206		3/10 (30%)
		peptidase_C19C	213..524	CDD:239124	113/402 (28%)
		USP7_ICP0_bdg	621..866	CDD:289221	52/259 (20%)
		USP7_C2	876..1087	CDD:291217	25/93 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810