Protein Alignment faf and Usp24

DIOPT Version :9

• Sequence 1: NP_524612.2
• Gene: faf / 43749
• FlyBaseID: FBgn0005632
• Length: 2778
• Species: Drosophila melanogaster
• Sequence 2: XP_006503239.1
• Gene: Usp24 / 329908
• MGIID: 1919936
• Length: 2637
• Species: Mus musculus
• Alignment Length: 2839
• Identity: 799/2839 - (28%)
• Similarity: 1285/2839 - (45%)
• Gaps: 543/2839 - (19%)

  Fly    34 PAQSAGSGSGIGTG----TGTVANSSLPGGGSGSLDGNQDQQPA----TDSQSSDDVAASLSANS 90
            |..|.|...|.|.|    :|:..:....||.:|. .|..|..||    .|::.:|: ..:.|...
Mouse    55 PMDSGGPSPGPGGGPRGDSGSDGSGPSRGGSTGG-GGGFDPPPAYHEVVDAEKNDE-NGNCSGEG 117

  Fly    91 VDSTITIVPPEKLISSFPTTKLRSLTQKISNPRWVVPVLPEQELEVLLNAAIELTQAGVDHDCEP 155
            ::              ||||.|..|..::....|.:|...|:.|...|.|:..|.:.|:....|.
Mouse   118 IE--------------FPTTNLYELESRVLTDHWSIPYKREESLGKCLLASTYLARLGLSESDEN 168

  Fly   156 CVEFYRNGLSTSFAKILTDEAVNSWKNNIHHCILVSCGKLLHLIAIHMQRDNPY---LLDLLAIV 217
            |..|....:..:|.|:||..||:.|...||..|......|:.|:|..|::| |.   ||.:|.:.
Mouse   169 CKRFMERCMPEAFKKLLTSSAVHKWGTEIHEGIYNMLMLLIELVAERMKQD-PIPIGLLGVLTMA 232

  Fly   218 FDPENKFNTFNAGRQPECFAAPDYIWGQL-DSNKMYARPPPE--PKNARGWLVDLINRFGQLGGF 279
            |:|:|:::..|.      .......|.:: ....|:|..|..  .|...||:|||:|:||:||||
Mouse   233 FNPDNEYHFKNR------MKVSQRNWAEVFGEGNMFAISPVSTFQKEPHGWVVDLVNKFGELGGF 291

  Fly   280 DNLLERFNIGLELLKRNQNKCTGKNISVEGRVENGAQDNRLTLALIHSLLRPFGQCYELLMPATI 344
            ..:              |.|...::|.               |..:.:|::|.|.|.|.|..:.:
Mouse   292 AAI--------------QAKLHSEDIE---------------LGAVSALVQPLGVCAEYLNSSVV 327

  Fly   345 AKYFMPTWNVVLDLLDSFTDEELKREVKPEGRNDYINGIVKSARLLASRLTGQEELIRDLEMFRL 409
            .....|.....:..:.|..:::||     :.|...|..::.:.:||..|.  |..|:..::..||
Mouse   328 QPMLDPVILTTIQDVRSVEEKDLK-----DKRLVSIPELLSAIKLLCMRF--QPALVTTVDALRL 385

  Fly   410 KMILRLLQVSSFNGKMNALNEINKVLSSVAYFSHRSQPLPHCMPEDEMDWLTADRMAQWIKSSDV 474
            .::||:|:...|:.|||:|.|:.|::..    |..|:.:.:.        :..||:..|:..:.|
Mouse   386 DILLRMLKSPHFSAKMNSLKEVTKLIED----STLSKSVKNA--------IDTDRLLDWLVENSV 438

  Fly   475 LGVVLKDSLHQPQYVEKLEKIIRFLIKEQALTLDDLDAVWRAQAGKHEAIVKNVHDLLAKLAWDF 539
            |.:.|:.::.|.||.::::.||..|  ...|:||:|..:|:.|:|:...:::|:|.::|..|..|
Mouse   439 LSIALEGNIDQAQYCDRIKGIIELL--GSKLSLDELTKIWKIQSGQSSTVIENIHTIIAAAAVKF 501

  Fly   540 TPEQLDHLFEAFQASMTTANKRQRERLLELIRRLAEDDKNGVMAQKVLKLFWTLAHSQEVPPEVL 604
            ..:||:|||...|.|..|.:.|.|::||.||.|:..:.:....:.|||.:.|.|||...:|..::
Mouse   502 NADQLNHLFVLIQKSWETESDRVRQKLLSLIGRIGREARFEATSGKVLDVLWELAHLPTLPSSLI 566

  Fly   605 DQALGAHVKILD--YSCSQERDAQKTIWLDKCVDELK---------------------SGD---- 642
            .|||..|:.||.  |:.   ::|.|..::.||::::|                     :||
Mouse   567 QQALEEHLTILSDAYAV---KEAVKRSYIIKCIEDIKRPGEWSSLEKNKKDGFKQGGLTGDYVSL 628

  Fly   643 ------------------GWVLPALRLIRDICCLYDTTTNHAQRTQTSTNRQQVIERLQNDYSLV 689
                              .||:||||.:.:|      |.:..::|....:: .:|:.|:.::.:|
Mouse   629 PGYTETKRRSSQLNNPQFVWVVPALRQLHEI------TRSFIKQTYQKQDK-SIIQDLKKNFEIV 686

  Fly   690 ILVTNSLTAYMEKVRQMVTDSPGLDATRILIDGRFPHHVQIAERLEFLKFLLKDGQLWLCADQAK 754
            .|||.||.| ..::...|....||... .|:|||:.:...:...|:||.|.|::..|:|..::||
Mouse   687 KLVTGSLLA-CHRLAAAVAGPGGLTGL-TLVDGRYTYREYLEAHLKFLAFFLQEATLYLGWNRAK 749

  Fly   755 QIWHCLAVNA-VFPADREECFRWFGKLMGEEPDLDPGINKDFFENNILQLDPHLLTESGIKCFER 818
            :||.||.... |...|||.||.||.|  |:. ||:..:.:..|:..||:|:.:.:|.:|...|:.
Mouse   750 EIWECLVTGQDVCELDREMCFEWFTK--GQH-DLESDVQQQLFKEKILKLESYEITMNGFNLFKT 811

  Fly   819 FFKAVNSKEDKLKAIHRGYMLDNEDLIGKDYLWRV-ITTGGEEIASKAIDLLKEVS-TALGPRLQ 881
            ||:.||..:.:||.......::..:|:|.|::|:: :.:..||||::||.|:...| ..|.|||:
Mouse   812 FFENVNLCDHRLKRQGAQLYVEKLELVGMDFIWKIAMESPDEEIANEAIQLIINYSYINLNPRLK 876

  Fly   882 ENIAEFHEMFIGECCSRLR-----------THYGNIVILGKTQLQEELDAPDQSDNTNDESKDSK 935
            ::....|:.||.:|.:||.           ||    .:...|::......|..:.:.....:.:|
Mouse   877 KDSVSLHKKFIADCYTRLEAASSALGGPTLTH----AVTRATKMLTATAMPTVATSVQSPYRSTK 937

  Fly   936 MRFIEAEKMCRILKVLQEYVKECDRSFSGDRVHLPLSRVTRGKNTILYIRFQNPGRSIDDMEIVT 1000
            :..||     |:|.:.:.||...:..:|..|..||......|....|.:.:::   :.|...:..
Mouse   938 LVIIE-----RLLLLAERYVITIEDFYSVPRTILPHGASFHGHLLTLNVTYES---TKDTFTVEA 994

  Fly  1001 HSNETMAAFKRNLLKRIKGTSTANIKVDLFYANDEMIGVSDEINPLYQYTIRDKMNLTAKLTPVG 1065
            |||||:.:.:..:.|:: .:...||::   :.||.::.|:.:...|:|....|:..||.|.:..|
Mouse   995 HSNETIGSVRWKIAKQL-CSPVDNIQI---FTNDSLLTVNKDQKLLHQLGFSDEQVLTVKTSGSG 1055

  Fly  1066 TGLASSPDSSSDSSTGSPPRPCPDMQRVESESTLPGVIISQNYQYTEFFLKLYQLGSDLEHGRLR 1130
            |...||.|||:.||:.| .........:|.|.:||||:::   .....|..|||| ::||..|:.
Mouse  1056 TPSGSSADSSTSSSSSS-SGAFSSSYAMEQEKSLPGVVMA---LVCNVFDMLYQL-ANLEEPRIT 1115

  Fly  1131 DSAKVLLHLLPCD---RQTIRQLKIMCKVPKAAVTVAVTGDKIAKDEEEKLYPTEQAGIEDEEEH 1192
            ...:.||.|:|.|   ::.:.||..:             |.|.....|.....::...:..:::|
Mouse  1116 LRVRKLLLLIPTDPAIQEALDQLDSL-------------GRKKTLLSETSSQSSKSPSLSSKQQH 1167

  Fly  1193 CTP------EQMFLHPTPA----QVLYNLSVLHGLLIP-ALDPLGES-ALLVQSAWMHSGCAHFV 1245
             .|      |.:|....|.    :|||||.||...|:| |.|.:..| |......::.:|....|
Mouse  1168 -QPSASSILESLFRSFAPGMSTFRVLYNLEVLSSKLMPTADDDMARSCAKSFCENFLKAGGLSLV 1231

  Fly  1246 LELLTKNNFLPSADMHTKRASFQCVLRLAKLFLYIVGSVLSRVGDEPMICD---------LDNGS 1301
            :.::.:::.....|..|::..:...|:||:..|  ||..:....||.:..|         ..|.|
Mouse  1232 VNVMQRDSIPSEVDYETRQGVYSICLQLARFLL--VGQTMPTSLDEDLTKDGIEALSSRPFRNVS 1294

  Fly  1302 RS---QVDIL----KQNFSTMPSSSQGTLRAISAKLAVILAREMLSASPEGDRCRTLFSSTLQWS 1359
            |.   |:.:.    |.::..:..|.:.::|......|..:|.:.:.||.        |:
Mouse  1295 RQTSRQMSLCGTPEKSSYRQLSVSDRSSIRVEEIIPAARVAIQTMEASD--------FT------ 1345

  Fly  1360 CPDISTIKAVVQLAWASSCGNLQALGNSSGDFEDEVIVPDG------------------------ 1400
                :|:...::|:||::.|.|..:|:|....|...:.|.|
Mouse  1346 ----ATVACFMRLSWAAAAGRLDLVGSSQPIKESNSLFPAGIRSRLSSSGSNCSSSSEGEPAALH 1406

  Fly  1401 ------------QDFSMCKEALEVLTISFILNPSANEALTSDPNWPKFITSIVLKNPLRHVRQVA 1453
                        :|..:..|||.:|.....|......:..|.|....||..|:|.:|...:|:||
Mouse  1407 AGICVRQQSVSTKDALIAGEALSLLVTCLQLRSQQLASFYSLPCVADFIIDILLGSPSAEIRRVA 1471

  Fly  1454 SEQLF-LASTYCAGDRRPFVYMVN-LLVGALKTL-VPQYEST-------------CAEFFSVLCR 1502
            .:||: |:.|..:.  .|.|...| .|:|.:.|. :|.:..|             |.|:|.:.|:
Mouse  1472 CDQLYTLSQTDTSA--HPEVQKPNQFLLGVILTAQLPLWSPTSIMRGVNQRLLSQCMEYFDLRCQ 1534

  Fly  1503 TLSYGCIYNWPLQISE---------GLLGDEIKWLQRIRENVHATGDTQVHEE---LLEGHLCLA 1555
            .|.       .|..||         .:|.|||.||.....|  .|.|.:..|.   ||.|||.|.
Mouse  1535 LLD-------DLTTSEMDQLRISPATMLEDEITWLDNFEPN--RTADCETSEADNILLAGHLRLI 1590

  Fly  1556 KELMFFLGADSKAQLNELIHELIDDFLFTASREFLHLRRHGS----LRQDTVPPPVCRSPHTIAA 1616
            |.|:...||:.:...:.||..|:|||||.|||..::.....|    .:||.  .|.|.:.::..|
Mouse  1591 KTLLSLCGAEKEMLGSSLIKPLLDDFLFRASRIIVNSHSPASSAAISQQDF--HPKCSTVNSRLA 1653

  Fly  1617 ACDLLIALCQLCVPNMKLLTNTLIDFVCTDTDP--LREWDYLPPVGARPTKGFCGLKNAGATCYM 1679
            |.::|:.|......|::::|..|:. :....||  .:|:||||||.:|.:.||.||:|.||||||
Mouse  1654 AYEVLVMLADSSPSNLQIITKELLS-MHHQPDPALTKEFDYLPPVDSRSSSGFVGLRNGGATCYM 1717

  Fly  1680 NSVLQQLYMVPAVRVGILRAHGAATTDGEDFSGDSDLTGGGLGSALFSGPASALVSLPSSSSTIE 1744
            |:|.|||||.|                                     |...:|:|:...:...:
Mouse  1718 NAVFQQLYMQP-------------------------------------GLPESLLSVDDDTDNPD 1745

  Fly  1745 DGLHDVRKNYHVVILKHVQAIFAHLGHSALQYYVPRGLWTHFKLLGEPVNLREQQDAVEFFMSLL 1809
            |.           :...||::|.||..|.||||||...|..||:..:.:.:||||||.|||.||:
Mouse  1746 DS-----------VFYQVQSLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLI 1799

  Fly  1810 ESLDEGLKALGQPQLMNATLGGSFSDQKICQECPHRYSKEEPFSVFSVDIRNHSSLTESLEQYVK 1874
            :.:||.||.:|:.|:...|..|.:||||||::|||||.:||.|...::.:.:..||..||:|:|:
Mouse  1800 DQMDEYLKKMGREQIFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEISLDQFVR 1864

  Fly  1875 GELLEGADAYHCDKCDKKVVTVKRVCVKKLPPVLAIQLKRFEYDYERVCAIKFNDYFEFPRILDM 1939
            ||:|||::||:|:||.:|.:||||.|:|.||.||.|.|.||.:|:|...:||:::...||.:|:|
Mouse  1865 GEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWMLNM 1929

  Fly  1940 EPYTVSGLAKLEGEVVEVGDNCQTNVE-------------TTKYELTGIVVHSGQASGGHYFSYI 1991
            |||||:|:|:.:.. .|||:|.: |::             |..|||.|::||||||..|||:|:|
Mouse  1930 EPYTVAGMARQDSS-SEVGENGR-NMDQGGGGSPRKKVALTENYELVGVIVHSGQAHAGHYYSFI 1992

  Fly  1992 LSKNPANGKCQWYKFDDGEVTECKMHEDEEMKAECFGGEYMGETYDNNLKRMQYRRQKRWWNAYM 2056
            ..:... ||.:||||:|..:.|..:: ||.::.|||||||..:.||........||  |:|||||
Mouse  1993 KDRRGC-GKGKWYKFNDTVIEEFDLN-DETLEYECFGGEYRPKVYDQTNPYTDVRR--RYWNAYM 2053

  Fly  2057 LFYTR-CDQ-----------------------------------TPVQYEPSVEQLSL------- 2078
            |||.| .||                                   :|..:.|:.::||:
Mouse  2054 LFYQRVSDQNSPVLPKKSRVSVVRQEAEDLSLSAPSSPEISPQSSPRPHRPNNDRLSILTKLVKK 2118

  Fly  2079 AESRNM-VLPLPKPIERSVRHQNIRFLHSRSIFSVEFFNFIKKLVSCNLLSARSNKITPAAEELS 2142
            .|.:.: |..:|..|.:.||.:|::|:.:|.::|.::|:|:..|.|.|....: :...|...::|
Mouse  2119 GEKKGLFVEKMPARIYQMVRDENLKFMKNRDVYSSDYFSFVLSLASLNATKLK-HPYYPCMAKVS 2182

  Fly  2143 LLGVQLASQFLFHTGFRTKKSLRGPVMEWYDALSHHIRSSALVRKWFANHALLSPPSRLGEYILM 2207
            |   |||.||||.|..||||.||....||...:...:..|....:|...:.:.|....|.:..|:
Mouse  2183 L---QLAIQFLFQTYLRTKKKLRVDTEEWIATIEALLSKSLDACQWLVEYFISSEGRELVKVFLL 2244

  Fly  2208 APS-PDVR----TVFVKLVVFFCHFAINDEPLTGYDGANLCEQVLISVLRLLKSEAADYGKHLPH 2267
            ..| .:||    |:..|.:         |..|...|......|:|..:|.||..:..:..|:...
Mouse  2245 ECSVREVRVAVATILEKTL---------DSALFYQDKLKSLHQLLEVLLALLDKDVPENCKNCAQ 2300

  Fly  2268 YFSLFSMYV-GLGTREKQQLLR-----------LNVPLQFIQVALDDGPGPAIKYQYPEFSKLHQ 2320
            |||||:.:| ..|.|....|||           |.|..|..|:......      |..||..||.
Mouse  2301 YFSLFNTFVQKQGIRAGDLLLRHSALRHMISFLLGVSRQNSQIRRWSSA------QAREFGNLHN 2359

  Fly  2321 VVSHLIRCSDVSEKCQSSNQNARPLSNPFKD-PNVA---HEELTPLSTECMDLLFNRTG--YIKK 2379
            .|:.|:..|||     ||.:|..|  ..||. |.::   ...|.||..|...|||...|  |:.:
Mouse  2360 TVALLVLHSDV-----SSQRNVAP--GIFKQRPPISVAPSSPLLPLHEEVEALLFLSEGKPYLLE 2417

  Fly  2380 VI----EDTNVGDEGLKLLQYCSWENPHFSRAVLTELLWQCGFAYCHDMRHHTDLLLNILLIDDS 2440
            |:    |.|......::::.||.:.|.|||..:|..:..|...|..|::::...||..:|:|:|.
Mouse  2418 VMFALRELTGSLLALMEMVVYCCFCNEHFSFTMLHFIKNQLETAPPHELKNTFQLLHEVLVIEDP 2482

  Fly  2441 WQHHRIHNALNGVAEEREGLLETIQRAKTHYQKRAYQIIKCLTQLFHKSPIALQMLHTNSNITRH 2505
            .|..|:    ..|.|...|||..:..:......|.||.:|.|..|..|.|.|.:....||:   |
Mouse  2483 IQVERV----KFVFETENGLLALMHHSNHVDSSRCYQCVKFLVTLAQKCPAAKEYFKENSH---H 2540

  Fly  2506 WSIAVEWLQGELDRQRGIGCQYNSYSWSPPAQ-SNDNTNGYMLERSQSAKNTWSMAFELCPDEVS 2569
            ||.||:|||.::          :.:.|:|.:. ||:.:.|...:|:.||::|.:.|..|    ::
Mouse  2541 WSWAVQWLQKKM----------SEHYWTPQSNVSNETSTGKTFQRTISAQDTLAYATAL----LN 2591

  Fly  2570 EKTDENNEPNLETNMDENKSEPVAQPGGVLEGSTGGTEQLPENK 2613
            ||..                          .||:.|:|..|.|:
Mouse  2592 EKEQ--------------------------SGSSNGSESSPANE 2609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
faf	NP_524612.2	peptidase_C19C	1666..2064	CDD:239124	169/411 (41%)
		UCH	1668..2059	CDD:278850	164/403 (41%)
Usp24	XP_006503239.1	UBA_UBP24	6..42	CDD:270472
		Ubl_UBP24	972..1050	CDD:340585	19/84 (23%)
		peptidase_C19C	1704..2061	CDD:239124	169/410 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D22076at33208
OrthoFinder	1	1.000	-	-		FOG0002455
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102574
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1635
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.720