Protein Alignment faf and usp24

DIOPT Version :9

• Sequence 1: NP_524612.2
• Gene: faf / 43749
• FlyBaseID: FBgn0005632
• Length: 2778
• Species: Drosophila melanogaster
• Sequence 2: XP_005170208.1
• Gene: usp24 / 325631
• ZFINID: ZDB-GENE-030131-4356
• Length: 2621
• Species: Danio rerio
• Alignment Length: 2856
• Identity: 789/2856 - (27%)
• Similarity: 1296/2856 - (45%)
• Gaps: 536/2856 - (18%)

  Fly    30 TTTSPAQSAGSGSGIGTGTGTVANSSLPGGGSG-----SLDGNQDQQPA----TDSQSSDDVAAS 85
            |..||        |:|.|...:.:...||.|.|     ::.|..|..||    .:|:.|:|...:
Zfish    43 TNESP--------GLGYGYEPMESGPSPGSGDGENSGRTVTGGFDPPPAYHDVVESERSNDENGN 99

  Fly    86 LSANSVDSTITIVPPEKLISSFPTTKLRSLTQKISNPRWVVPVLPEQELEVLLNAAIELTQAGVD 150
            .|.||::              ||||.|..|..::....|.:|...|:.|...|.|:..|.:.|:.
Zfish   100 CSGNSME--------------FPTTNLYELESRVFTDHWSIPYKREESLGKCLIASTCLARHGLA 150

  Fly   151 HDCEPCVEFYRNGLSTSFAKILTDEAVNSWKNNIHHCILVSCGKLLHLIAIHMQRDNPY---LLD 212
            ...|.|..|....:..:|.|:||..||:.|...||..|......|:.|:|..:::| |.   |:.
Zfish   151 DADENCKRFIDRCMPEAFKKLLTSSAVHKWGTEIHEGIYNMLMLLVDLVAERVKQD-PIPIGLMG 214

  Fly   213 LLAIVFDPENKFNTFNAGRQPECFAAPDYIWGQLDSNKMYARPPPE--PKNARGWLVDLINRFGQ 275
            :|.:.|:|:|:::..|  |...|......::|:   :.|:|..|..  .|...||||||:||||:
Zfish   215 VLTMAFNPDNEYHFKN--RMKACQRNWAEVFGE---DSMFAVSPSSSYQKEPHGWLVDLVNRFGE 274

  Fly   276 LGGFDNLLERFNIGLELLKRNQNKCTGKNISVEGRVENGAQDNRLTLALIHSLLRPFGQCYELLM 340
            :|||..:         ..|.||.:                    :.:..:.:|::|.|.|.|.|.
Zfish   275 MGGFTAI---------QCKLNQEE--------------------IEIGCVSALVQPLGVCAEYLN 310

  Fly   341 PATIAKYFMPTWNVVLDLLDSFTDEELKREVKPEGRNDYINGIVKSARLLASRLTGQEELIRDLE 405
            .:.:.....|..:.::..:.:..:::||     :.|...|..::.:.:||..|.  |.||:..::
Zfish   311 SSLVQPMLDPVIHKMITYVQNLEEKDLK-----DKRLVSIPELLSAIKLLCMRF--QRELVNVVD 368

  Fly   406 MFRLKMILRLLQVSSFNGKMNALNEINKVLSSVAYFSHRSQPLPHCMPEDEMDWLTADRMAQWIK 470
            ..||.::||:|:...|:.|||:|.|:.|::..    |..|:.:.:.        :..||:..|:.
Zfish   369 DLRLDILLRMLKTPHFSAKMNSLKEVTKLIEE----STVSKTVKNA--------IDTDRLLDWLV 421

  Fly   471 SSDVLGVVLKDSLHQPQYVEKLEKIIRFLIKEQALTLDDLDAVWRAQAGKHEAIVKNVHDLLAKL 535
            .:.||.:.|:.::.|.||.::::.||..|  ...|:||:|..:|:.|||:...:::|:|.::|..
Zfish   422 ENSVLSIALEGNIDQAQYCDRIKGIIELL--GSKLSLDELSKIWKIQAGQSSTVIENIHTIIAAA 484

  Fly   536 AWDFTPEQLDHLFEAFQASMTTANKRQRERLLELIRRLAEDDKNGVMAQKVLKLFWTLAHSQEVP 600
            |..|..:||.|||...|.|....:.|.|::||.||.|:..:.::.....|||::.|.|||...:|
Zfish   485 AVKFNFDQLSHLFVLIQKSWEVESDRVRQKLLSLIGRIGREARSEATTGKVLEVLWELAHLPTLP 549

  Fly   601 PEVLDQALGAHVKILD--YSCSQERDAQKTIWLDKCVDELK-------------------SGDG- 643
            ..::.|||..|:.||.  |:.   ::..|..::.||::::|                   :|..
Zfish   550 TSLVQQALEEHLTILSDAYAV---KETIKRNYIIKCIEDIKKMQIQEDSKSPSETQVSFLTGTWG 611

  Fly   644 -------------------WVLPALRLIRDICCLYDTTTNHAQRTQTSTNRQQVIERLQNDYSLV 689
                               ||:||||.:.:|      |.:..::|....:: .:|:.|:.::.:|
Zfish   612 KKKPSSLAKSSQQTNPQTVWVVPALRQLHEI------TRSFIKQTYQKQDK-SIIQDLKKNFEIV 669

  Fly   690 ILVTNSLTAYMEKVRQMVTDSPGLDATRILIDGRFPHHVQIAERLEFLKFLLKDGQLWLCADQAK 754
            .|:|.||.: ..::...|..|.||..: .|:|||:.:...:...|:||.|.|::..|:|..::||
Zfish   670 KLITGSLVS-CHRLAVSVAGSNGLSGS-TLVDGRYSYQEYLEGHLKFLAFFLQEASLYLVWNRAK 732

  Fly   755 QIWHCLAVNA-VFPADREECFRWFGKLMGEEPDLDPGINKDFFENNILQLDPHLLTESGIKCFER 818
            :||.||.... |...|||.||.||.|  |:. ||:..:.:..|:..||:|:|:.:|.:|...|:.
Zfish   733 EIWECLVSGMDVCELDREMCFEWFTK--GQH-DLESDVQQQLFKEKILKLEPYEITMNGFNLFKT 794

  Fly   819 FFKAVNSKEDKLKAIHRGYMLDNEDLIGKDYLWRV-ITTGGEEIASKAIDLLKEVS-TALGPRLQ 881
            ||:.||..:.:||.......::..||.|.|::||: :.:..|:||::||.|:...| ..|.|:::
Zfish   795 FFENVNLSDHRLKRQGTQLCVERLDLAGMDFIWRIAMESPDEDIANEAIQLIITYSYINLNPKMK 859

  Fly   882 ENIAEFHEMFIGECCSRLR-----------THYGNIVILGKTQLQEELDAPDQSDNTNDESKDSK 935
            ::....|:.||.:|..||.           ||    .:...|::......|..:.:....|:.||
Zfish   860 KDSVSLHKKFIADCYKRLEAASSALGGPTLTH----AVTRATKMLTATAMPTVATSVQSPSRSSK 920

  Fly   936 MRFIEAEKMCRILKVLQEYVKECDRSFSGDRVHLPLSRVTRGKNTILYIRFQNPGRSIDDMEIVT 1000
            :..||     |:|.:.:.||...:..:|..|..||......|....|:|.:::   :.|...:..
Zfish   921 LVIIE-----RLLLLAERYVITIEDLYSVPRTILPHGASFHGHPVTLHITYES---TKDTFTLEA 977

  Fly  1001 HSNETMAAFKRNLLKRIKGTSTANIKVDLFYANDEMIGVSDEINPLYQYTIRDKMNLTAKLTPVG 1065
            |||||:.:.:..:..:: .....|:::   :|||.|:.::.:...|.|....|:.:||.|.:..|
Zfish   978 HSNETIGSIRWKIADQL-SCPVDNVQI---FANDSMLTMNRDQKLLNQLGFSDEQSLTVKSSGTG 1038

  Fly  1066 TGLASSPDSSSDSSTGSPPRPCPDMQRVESESTLPGVIISQNYQYTEFFLKLYQLGSDLEHGRLR 1130
            |...||.|||:.:|:.| .........:|.|.:||||:::   .....|..|||| ::||..|:.
Zfish  1039 TPSGSSADSSASASSSS-SGVFNSAYALEQEKSLPGVVMA---LVCNVFEMLYQL-ANLEEPRIT 1098

  Fly  1131 DSAKVLLHLLPCDRQTIRQLKIMCKVPKAA------VTVAVTGDKIAKDEEEKLYPTEQAGIEDE 1189
            ...:.||.|:|.|.:....|...  |||.:      .|:...|......:...|...:|   ..:
Zfish  1099 LRVRKLLLLIPTDPEVQDALDNF--VPKESSVWSHQKTLFTLGSGSQASKSPSLSSKQQ---HQQ 1158

  Fly  1190 EEHCTPEQMFLHPTPA----QVLYNLSVLHGLLIPALDPLGESALLVQSAWMHSGCAHF------ 1244
            ......|.:|....|.    :|||||.||...|:|..|  .|.|    ...:.|.|.:|
Zfish  1159 SAASILESLFRSSAPGMSTFRVLYNLEVLSSKLMPTSD--DEMA----KTSVKSFCENFLKAGGL 1217

  Fly  1245 --VLELLTKNNFLPSADMHTKRASFQCVLRLAKLFLYIVGSVLSRVGDEPMICDLDNGSR----- 1302
              |:.::.:::.....|..|::..:...|:||:..|  ||..:..:.||.:..|....||
Zfish  1218 SLVVNVMQRDSIPSEVDYETRQGVYSICLQLARFLL--VGQAMPSILDEELSKDDTLSSRPFRNA 1280

  Fly  1303 -----SQVDIL----KQNFSTMPSSSQGTLRAISAKLAVILAREMLSASPEGDRCRTLFSSTLQW 1358
                 .|:.:.    |.::..:..|.:.::|   .:..:..||..:.....||     |:
Zfish  1281 GRQSGRQLSVCGTPEKSSYRQVSVSDRSSIR---VEEIIPAARVAIQTMEVGD-----FT----- 1332

  Fly  1359 SCPDISTIKAVVQLAWASSCGNLQALG--------------------------NSSGDFEDEVIV 1397
                 ||:...::|.||::.|.|..:|                          |.|...|.||..
Zfish  1333 -----STVACFMRLTWAAAAGRLDLVGSSQPIRETTNSLLPLGVRSRVSSTGSNCSSSSEGEVTT 1392

  Fly  1398 PDG-----------QDFSMCKEALEVLT----------ISFILNPSANEALTSDPNWPKFITSIV 1441
            ...           :|..:.:|||.:|.          .||....|.|:          ||..|:
Zfish  1393 LQAGICVKQLFVSIKDTIIAREALSLLVTCLQLRSQQLCSFYSLLSVND----------FIIDIL 1447

  Fly  1442 LKNPLRHVRQVASEQLFLAS---TYCAGD-RRPFVYMVNLLVGA----------LKTLVPQYEST 1492
            |.:|...:|:||.:||:..|   |....| ::|.::::.:::.|          ::.:..:..|.
Zfish  1448 LGSPSGEIRRVACDQLYTLSQSDTSAYPDLQKPNLFLLKVVLTAQLPLWSPTSIMRGVNQRLLSQ 1512

  Fly  1493 CAEFFSVLCRTLSYGCIYNWPLQISE---------GLLGDEIKWLQRIRENVHATGDTQVHEE-- 1546
            |.|:|.:.|:.|.       .|..||         .:|.|||.||    :|...|..|::...
Zfish  1513 CTEYFDLRCQLLD-------DLTTSEMEQLQIGPAAMLEDEISWL----DNFEPTWTTELETSEA 1566

  Fly  1547 ---LLEGHLCLAKELMFFLGADSKAQLNELIHELIDDFLFTASREFLHLRRHGSLRQDTVP-PPV 1607
               ||.|||.|.|.|:...|.:.:.....||.:|:|||||.|||..|:.....|....... .|.
Zfish  1567 DNILLAGHLRLIKTLLSLCGTEKEQFGPSLIQQLLDDFLFRASRIILNSDSSSSTTASIHDFHPK 1631

  Fly  1608 CRSPHTIAAACDLLIALCQLCVPNMKLLTNTLIDFVCTDTDP--LREWDYLPPVGARPTKGFCGL 1670
            |.:..:..||.::|:.|....:.|::|:|..|:. :...:||  .:|:||||||.:|...||.||
Zfish  1632 CSTVSSRLAAYEVLVMLADSSLTNLQLITKELLS-MHHQSDPSLSKEFDYLPPVDSRSISGFVGL 1695

  Fly  1671 KNAGATCYMNSVLQQLYMVPAVRVGILRAHGAATTDGEDFSGDSDLTGGGLGSALFSGPASALVS 1735
            ||.|||||||:|.|||||.|.:..|:|
Zfish  1696 KNGGATCYMNAVFQQLYMQPGLPEGVL-------------------------------------- 1722

  Fly  1736 LPSSSSTIEDGLHDVRKNYHVVILKHVQAIFAHLGHSALQYYVPRGLWTHFKLLGEPVNLREQQD 1800
                  :|||...:..::    :...||::|.||..|.||||||...|..||:..:.:.:|||||
Zfish  1723 ------SIEDDTENPEES----VFCQVQSLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQD 1777

  Fly  1801 AVEFFMSLLESLDEGLKALGQPQLMNATLGGSFSDQKICQECPHRYSKEEPFSVFSVDIRNHSSL 1865
            |.|||.||::.|||.||.:|:.|:...|..|.|||||||::|||||.:||.|...::.:.:..||
Zfish  1778 AYEFFTSLVDQLDEHLKKIGREQIFKNTFQGIFSDQKICKDCPHRYEREETFMALNLGVTSCQSL 1842

  Fly  1866 TESLEQYVKGELLEGADAYHCDKCDKKVVTVKRVCVKKLPPVLAIQLKRFEYDYERVCAIKFNDY 1930
            ..||:|:|:||:|:|::||:|:||.:|..||||.|:|.||.||.|.|.||.:|:|...:||:::.
Zfish  1843 EISLDQFVRGEVLDGSNAYYCEKCKEKRTTVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQ 1907

  Fly  1931 FEFPRILDMEPYTVSGLAKLE--------GEVVEVGDNCQTNVETT---KYELTGIVVHSGQASG 1984
            ..||.:|:||||||||:|:.:        |...|.|.......:.|   .|||.|:|||||||..
Zfish  1908 IRFPWVLNMEPYTVSGMARQDSSADHGENGRGGEAGSGGSPRKKVTISENYELVGVVVHSGQAHA 1972

  Fly  1985 GHYFSYILSKNPANGKCQWYKFDDGEVTECKMHEDEEMKAECFGGEYMGETYDNNLKRMQYRRQK 2049
            |||:|:|..:. .:.:.:||||:|..|.|..|: ||.::.|||||||..:.||.:......||
Zfish  1973 GHYYSFIKDRR-GSARGRWYKFNDNVVEEFDMN-DETLEYECFGGEYRPKVYDQSNPYPDVRR-- 2033

  Fly  2050 RWWNAYMLFYTR-CDQ-TPVQYEPS--------VEQLSLA------------------------- 2079
            |:||||||||.| .|| :||..:.|        .|.|||:
Zfish  2034 RYWNAYMLFYQRISDQNSPVLPKKSRVSIMRQEAEDLSLSAPSSPEISPQSSPRPPRANNDRLTL 2098

  Fly  2080 --------ESRNM-VLPLPKPIERSVRHQNIRFLHSRSIFSVEFFNFIKKLVSCNLLSARSNKIT 2135
                    |.:.: |..:|..|.:.||.:|::|:.:|.:::.::|:|...|.|.|     :.|:.
Zfish  2099 LTRLVKKGEKKGLFVEKMPARIFQMVRDENLKFMKNRDVYNSDYFSFTLSLASVN-----ATKLK 2158

  Fly  2136 PAA-EELSLLGVQLASQFLFHTGFRTKKSLRGPVMEWYDALSHHIRSSALVRKWFANHALLSPPS 2199
            .|: :.::...:|||.|||.||..||||.||....||...:...:..|:...:|...: |::|..
Zfish  2159 HASYQAMAKTSLQLAVQFLLHTYLRTKKKLRVDTEEWIATVEVLLSKSSEACQWMVQY-LVAPEG 2222

  Fly  2200 R--LGEYILMAPSPDVRTVFVKLVVFFCHFAINDEPLTGYDGANLCEQVLISVLRLLKSEAADYG 2262
            |  :...:|.....:||.|...::......|:.      :..|.| :.:|..:|.||..:..|..
Zfish  2223 REIIKICLLECSVREVRVVVATILEKTLESALY------FQDAGL-DCLLDMLLSLLDKDVPDNC 2280

  Fly  2263 KHLPHYFSLFSMYVGLGTREKQQLLRLNVPLQFIQVALDDGPGPA-------IKYQYPEFSKLHQ 2320
            |:...||||||.:...|....|.||:.:...:.:...|  ||...       ...|..||..||.
Zfish  2281 KNCSQYFSLFSNFAQRGCGPCQLLLKHSAYRRMLVFLL--GPNRQNNQHRRWSSAQAREFLHLHN 2343

  Fly  2321 VVSHLIRCSDVSEKCQSSNQNARPLSNPFKDPNVAHEELTPLSTECMDLLFNRTG--YIKKVI-- 2381
            .::.::..:|::.:...:....:..|:....|:   ..|.||..:...|||...|  |:.:|:
Zfish  2344 TLALMVLHTDLTSQRTEAQGVFKQASSGLVAPS---SVLMPLHPDINTLLFKADGQAYLMEVMFA 2405

  Fly  2382 --EDTNVGDEGLKLLQYCSWENPHFSRAVLTELLWQCGFAYCHDMRHHTDLLLNILLIDDSWQHH 2444
              |.:......::::.|.|:.|..||..||..|......|..|::::...:||.||:::|..|..
Zfish  2406 MRELSGPLSFLIEMITYSSFCNEPFSLGVLQLLKNHLETAPPHELKNVFQMLLEILMLEDPLQSQ 2470

  Fly  2445 RIHNALNGVAEEREGLLETIQRAKTHYQKRAYQIIKCLTQLFHKSPIALQMLHTNSNITRHWSIA 2509
            |:..|.    |..:|||..:.::......|.||.:|.|..|..|...|....   ..::.|||.|
Zfish  2471 RLKFAF----ESEKGLLALMHQSNNVDSSRCYQCVKFLVTLAQKCSPAKDYF---KELSGHWSWA 2528

  Fly  2510 VEWLQGELDRQRGIGCQYNSYSWSPPAQ-SNDNTNGYMLERSQSAKNTWSMAFELCPDEVSEKTD 2573
            |:|||.::          :.:.|:|.:. ||:.:.....:|:.||::|.:.|..|    ::||
Zfish  2529 VQWLQKKM----------SEHYWTPQSNVSNETSTAKTFQRTISAQDTLAYATAL----LNEK-- 2577

  Fly  2574 ENNEPNLETNMDENKSEPVAQPGGVLEGSTGGTEQLPENKTPTTSSPSTAAWPAR-GDSNA 2633
                       |::             ||:.|::..|.|:....|....:..|.. |||.:
Zfish  2578 -----------DQS-------------GSSNGSDGSPANENSDRSLRQGSESPMMLGDSRS 2614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
faf	NP_524612.2	peptidase_C19C	1666..2064	CDD:239124	172/409 (42%)
		UCH	1668..2059	CDD:278850	167/401 (42%)
usp24	XP_005170208.1	UBA_UBP24	7..43	CDD:270472	789/2856 (28%)
		peptidase_C19C	1691..2048	CDD:239124	172/408 (42%)
		UCH	1693..2043	CDD:278850	167/401 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D22076at33208
OrthoFinder	1	1.000	-	-		FOG0002455
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102574
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1635
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.720