Protein Alignment faf and Usp24

DIOPT Version :9

• Sequence 1: NP_524612.2
• Gene: faf / 43749
• FlyBaseID: FBgn0005632
• Length: 2778
• Species: Drosophila melanogaster
• Sequence 2: NP_001258135.1
• Gene: Usp24 / 313427
• RGDID: 1306799
• Length: 2617
• Species: Rattus norvegicus
• Alignment Length: 2823
• Identity: 803/2823 - (28%)
• Similarity: 1280/2823 - (45%)
• Gaps: 531/2823 - (18%)

  Fly    34 PAQSAGSGSGIG---TGTGTVANSSLPGGGSGSLDGNQDQQPA----TDSQSSDDVAASLSANSV 91
            |..|.|...|:|   .|.|....|....|||....|..|..||    .|::.:|: ..:.|...|
  Rat    55 PMDSGGPSPGLGGGPRGDGGGEGSGPSRGGSTGGGGGFDPPPAYHEVVDAEKNDE-NGNCSGEGV 118

  Fly    92 DSTITIVPPEKLISSFPTTKLRSLTQKISNPRWVVPVLPEQELEVLLNAAIELTQAGVDHDCEPC 156
            :              ||||.|..|..::....|.:|...|:.|...|.|:..|.:.|:....|.|
  Rat   119 E--------------FPTTNLYELESRVLTDHWSIPYKREESLGKCLLASTYLARLGLSESDENC 169

  Fly   157 VEFYRNGLSTSFAKILTDEAVNSWKNNIHHCILVSCGKLLHLIAIHMQRDNPY---LLDLLAIVF 218
            ..|....:..:|.|:||..||:.|...||..|......|:.|:|..|::| |.   ||.:|.:.|
  Rat   170 KRFMERCMPEAFKKLLTSSAVHKWGTEIHEGIYNMLMLLIELVAERMKQD-PIPIGLLGVLTMAF 233

  Fly   219 DPENKFNTFNAGRQPECFAAPDYIWGQL-DSNKMYARPPPE--PKNARGWLVDLINRFGQLGGFD 280
            :|:|:::..|.      .......|.:: ....|:|..|..  .|...||:|||:|:||:||||.
  Rat   234 NPDNEYHFKNR------MKVSQRNWAEVFGEGNMFAVSPVSTFQKEPHGWVVDLVNKFGELGGFA 292

  Fly   281 NLLERFNIGLELLKRNQNKCTGKNISVEGRVENGAQDNRLTLALIHSLLRPFGQCYELLMPATIA 345
            .:              |.|...::|.               |..:.:|::|.|.|.|.|..:.:.
  Rat   293 AI--------------QAKLHSEDIE---------------LGAVSALVQPLGVCAEYLNSSVVQ 328

  Fly   346 KYFMPTWNVVLDLLDSFTDEELKREVKPEGRNDYINGIVKSARLLASRLTGQEELIRDLEMFRLK 410
            ....|.....:..:.|..:::||     :.|...|..::.:.:||..|.  |.:|:..::..||.
  Rat   329 PMLDPVILTTIQDVRSVEEKDLK-----DKRLVSIPELLSAIKLLCMRF--QPDLVTIVDDLRLD 386

  Fly   411 MILRLLQVSSFNGKMNALNEINKVLSSVAYFSHRSQPLPHCMPEDEMDWLTADRMAQWIKSSDVL 475
            ::||:|:...|:.|||:|.|:.|::..    |..|:.:.:.        :..||:..|:..:.||
  Rat   387 ILLRMLKSPHFSAKMNSLKEVTKLIED----STLSKSVKNA--------IDTDRLLDWLVENSVL 439

  Fly   476 GVVLKDSLHQPQYVEKLEKIIRFLIKEQALTLDDLDAVWRAQAGKHEAIVKNVHDLLAKLAWDFT 540
            .:.|:.::.|.||.::::.||..|  ...|:||:|..:|:.|:|:...:::|:|.::|..|..|.
  Rat   440 SIALEGNIDQAQYCDRIKGIIELL--GSKLSLDELTKIWKIQSGQSSTVIENIHTIIAAAAVKFN 502

  Fly   541 PEQLDHLFEAFQASMTTANKRQRERLLELIRRLAEDDKNGVMAQKVLKLFWTLAHSQEVPPEVLD 605
            .:||:|||...|.|..|...|.|::||.||.|:..:.:....:.|||.:.|.|||...:|..::.
  Rat   503 ADQLNHLFVLIQKSWETETDRVRQKLLSLIGRIGREARFEATSGKVLDVLWELAHLPTLPSSLIQ 567

  Fly   606 QALGAHVKILD--YSCSQERDAQKTIWLDKCVDELK-----SG------DG------------WV 645
            |||..|:.||.  |:.   ::|.|..::.||::::|     ||      ||            ||
  Rat   568 QALEEHLTILSDAYAV---KEAVKRSYIIKCIEDIKRPGEWSGLEKNKKDGFKSSQHNNPQFVWV 629

  Fly   646 LPALRLIRDICCLYDTTTNHAQRTQTSTNRQQVIERLQNDYSLVILVTNSLTAYMEKVRQMVTDS 710
            :||||.:.:|      |.:..::|....:: .:|:.|:.::.:|.|||.||.| ..::...|...
  Rat   630 VPALRQLHEI------TRSFIKQTYQKQDK-SIIQDLKKNFEIVKLVTGSLLA-CHRLAAAVAGP 686

  Fly   711 PGLDATRILIDGRFPHHVQIAERLEFLKFLLKDGQLWLCADQAKQIWHCLAVNA-VFPADREECF 774
            .||... .|:|||:.:...:...|:||.|.|::..|:|..::||:||.||.... |...|||.||
  Rat   687 GGLTGL-TLVDGRYTYREYLEAHLKFLAFFLQEATLYLGWNRAKEIWECLVTGQDVCELDREMCF 750

  Fly   775 RWFGKLMGEEPDLDPGINKDFFENNILQLDPHLLTESGIKCFERFFKAVNSKEDKLKAIHRGYML 839
            .||.|  |:. ||:..:.:..|:..||:|:.:.:|.:|...|:.||:.||..:.:||.......:
  Rat   751 EWFTK--GQH-DLESDVQQQLFKEKILKLESYEITMNGFNLFKTFFENVNLCDHRLKRQGAQLYV 812

  Fly   840 DNEDLIGKDYLWRV-ITTGGEEIASKAIDLLKEVS-TALGPRLQENIAEFHEMFIGECCSRLR-- 900
            :..:|:|.|::|:: :.:..||||::||.|:...| ..|.|||:::....|:.||.:|.:||.
  Rat   813 EKLELVGMDFIWKIAMESPDEEIANEAIQLIINYSYINLNPRLKKDSVSLHKKFIADCYTRLEAA 877

  Fly   901 ---------THYGNIVILGKTQLQEELDAPDQSDNTNDESKDSKMRFIEAEKMCRILKVLQEYVK 956
                     ||    .:...|::......|..:.:.....:.:|:..||     |:|.:.:.||.
  Rat   878 SSALGGPTLTH----AVTRATKMLTATAMPTVATSVQSPYRSTKLVIIE-----RLLLLAERYVI 933

  Fly   957 ECDRSFSGDRVHLPLSRVTRGKNTILYIRFQNPGRSIDDMEIVTHSNETMAAFKRNLLKRIKGTS 1021
            ..:..:|..|..||......|....|.:.:::   :.|...:..|||||:.:.:..:.|:: .:.
  Rat   934 TIEDFYSVPRTILPHGASFHGHLLTLNVTYES---TKDTFTVEAHSNETIGSVRWKIAKQL-CSP 994

  Fly  1022 TANIKVDLFYANDEMIGVSDEINPLYQYTIRDKMNLTAKLTPVGTGLASSPDSSSDSSTGSPPRP 1086
            ..||::   :.||.::.|:.:...|:|....|:..||.|.:..||...||.|||:.||:.| ...
  Rat   995 VDNIQI---FTNDSLLTVNKDQKLLHQLGFSDEQVLTVKTSGSGTPSGSSADSSTSSSSSS-SGV 1055

  Fly  1087 CPDMQRVESESTLPGVIISQNYQYTEFFLKLYQLGSDLEHGRLRDSAKVLLHLLPCDRQTIRQLK 1151
            ......:|.|.:||||:::   .....|..|||| ::||..|:....:.||.|:|.|......|.
  Rat  1056 FSSSYAMEQEKSLPGVVMA---LVCNVFDMLYQL-ANLEEPRITLRVRKLLLLIPTDPAIQEALD 1116

  Fly  1152 IMCKVPKAAVTVAVTGDKIAK----DEEEKLYPTEQAGIEDEEEHCTPEQMFLHPTPA----QVL 1208
            .:..:.:....::.|....:|    ..:::..|:..:.:         |.:|....|.    :||
  Rat  1117 QLDSLGRKKTLLSETSSPSSKSPSLSSKQQQQPSASSIL---------ESLFRSFAPGMSTFRVL 1172

  Fly  1209 YNLSVLHGLLIP-ALDPLGES-ALLVQSAWMHSGCAHFVLELLTKNNFLPSADMHTKRASFQCVL 1271
            |||.||...|:| |.|.:..| |......::.:|....|:.::.:::.....|..|::..:...|
  Rat  1173 YNLEVLSSKLMPTADDDMARSCAKSFCENFLKAGGLSLVVNVMQRDSIPSEVDYETRQGVYSICL 1237

  Fly  1272 RLAKLFLYIVGSVLSRVGDEPMICDLDNGSRSQVDILKQNFSTMPSSSQGTLRAISAKLAVILAR 1336
            :||:..|  ||..:....||              |:.|.....:   |....|.:|.:    .:|
  Rat  1238 QLARFLL--VGQTMPTSLDE--------------DLTKDGIEAL---SSRPFRNVSRQ----TSR 1279

  Fly  1337 EM-LSASPEGDRCRTLFSSTLQWSCPDIS-------------------------TIKAVVQLAWA 1375
            :| |..:||.       ||..|.|..|.|                         |:...::|:||
  Rat  1280 QMSLCGTPEK-------SSYRQLSVSDRSSIRVEEIIPAARVAIQTMEANDFTATVACFMRLSWA 1337

  Fly  1376 SSCGNLQALGNSSGDFEDEVIVPDG------------------------------------QDFS 1404
            ::.|.|..:|:|....|...:.|.|                                    :|..
  Rat  1338 AAAGRLDLVGSSQPIKESNSLFPAGIRNRLSSSGSNCSSSSEGEPAALHAGICVRQQSVSTKDAL 1402

  Fly  1405 MCKEALEVLTISFILNPSANEALTSDPNWPKFITSIVLKNPLRHVRQVASEQLF-LASTYCAGDR 1468
            :..|||.:|.....|......:..|.|....||..|:|.:|...:|:||.:||: |:.|..:.
  Rat  1403 IAGEALSLLVTCLQLRSQQLASFYSLPCVADFIIDILLGSPSAEIRRVACDQLYTLSQTDTSA-- 1465

  Fly  1469 RPFVYMVN-LLVGALKTL-VPQYEST-------------CAEFFSVLCRTLSYGCIYNWPLQISE 1518
            .|.|...| .|:|.:.|. :|.:..|             |.|:|.:.|:.|.       .|..||
  Rat  1466 HPEVQKPNQFLLGVILTAQLPLWSPTSIMRGVNQRLLSQCMEYFDLRCQLLD-------DLTTSE 1523

  Fly  1519 ---------GLLGDEIKWLQRIRENVHATGDT-QVHEELLEGHLCLAKELMFFLGADSKAQLNEL 1573
                     .:|.||:.||.....|..|..:| :....||.|||.|.|.|:...||:.:...:.|
  Rat  1524 MEQLRVSPAAMLEDEVTWLDNFEPNRTAECETSEADNILLAGHLRLIKTLLSLCGAEKEVLGSSL 1588

  Fly  1574 IHELIDDFLFTASREFLHLRRH---GSL---RQDTVPPPVCRSPHTIAAACDLLIALCQLCVPNM 1632
            |..|:|||||.|||  :.|..|   ||.   :||.  .|.|.:.::..||.::|:.|......|:
  Rat  1589 IKPLLDDFLFRASR--IILNSHSPAGSAAISQQDF--HPKCSTVNSRLAAYEVLVMLADSSPSNL 1649

  Fly  1633 KLLTNTLIDFVCTDTDP--LREWDYLPPVGARPTKGFCGLKNAGATCYMNSVLQQLYMVPAVRVG 1695
            :::|..|:. :....||  .:|:||||||.:|...||.||:|.|||||||:|.|||||.|
  Rat  1650 QIITKELLS-MHHQPDPALTKEFDYLPPVDSRSISGFVGLRNGGATCYMNAVFQQLYMQP----- 1708

  Fly  1696 ILRAHGAATTDGEDFSGDSDLTGGGLGSALFSGPASALVSLPSSSSTIEDGLHDVRKNYHVVILK 1760
                                            |...:|:|:...:...:|.           :..
  Rat  1709 --------------------------------GLPESLLSVDDDTDNPDDS-----------VFY 1730

  Fly  1761 HVQAIFAHLGHSALQYYVPRGLWTHFKLLGEPVNLREQQDAVEFFMSLLESLDEGLKALGQPQLM 1825
            .||::|.||..|.||||||...|..||:..:.:.:||||||.|||.||::.:||.||.:|:.|:.
  Rat  1731 QVQSLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYLKKMGREQIF 1795

  Fly  1826 NATLGGSFSDQKICQECPHRYSKEEPFSVFSVDIRNHSSLTESLEQYVKGELLEGADAYHCDKCD 1890
            ..|..|.:||||||::|||||.:||.|...::.:.:..||..||:|:|:||:|||::||:|:||.
  Rat  1796 KNTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEISLDQFVRGEVLEGSNAYYCEKCK 1860

  Fly  1891 KKVVTVKRVCVKKLPPVLAIQLKRFEYDYERVCAIKFNDYFEFPRILDMEPYTVSGLAKLEGEVV 1955
            :|.:||||.|:|.||.||.|.|.||.:|:|...:||:::...||.:|:||||||:|:|:.:.. .
  Rat  1861 EKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWMLNMEPYTVAGMARQDSS-S 1924

  Fly  1956 EVGDNCQTNVE-------------TTKYELTGIVVHSGQASGGHYFSYILSKNPANGKCQWYKFD 2007
            |||:|.: |::             |..|||.|::||||||..|||:|:|..:... ||.:||||:
  Rat  1925 EVGENGR-NMDQGGGGSPRKKVALTENYELVGVIVHSGQAHAGHYYSFIKDRRGC-GKGKWYKFN 1987

  Fly  2008 DGEVTECKMHEDEEMKAECFGGEYMGETYDNNLKRMQYRRQKRWWNAYMLFYTR-CDQ------- 2064
            |..:.|..:: ||.::.|||||||..:.||........||  |:||||||||.| .||
  Rat  1988 DTVIEEFDLN-DETLEYECFGGEYRPKVYDQTNPYPDVRR--RYWNAYMLFYQRVSDQNSPVLPK 2049

  Fly  2065 ----------------------------TPVQYEPSVEQLSL-------AESRNM-VLPLPKPIE 2093
                                        :|..:.|:.::||:       .|.:.: |..:|..|.
  Rat  2050 KSRVSVVRQEAEDLSLSAPSSPEISPQSSPRPHRPNNDRLSILTKLVKKGEKKGLFVEKMPARIY 2114

  Fly  2094 RSVRHQNIRFLHSRSIFSVEFFNFIKKLVSCNLLSARSNKITPAAEELSLLGVQLASQFLFHTGF 2158
            :.||.:|::|:.:|.::|.::|:|:..|.|.|....: :...|...::||   |||.||||.|..
  Rat  2115 QMVRDENLKFMKNRDVYSSDYFSFVLSLASLNATKLK-HPHYPCMAKVSL---QLAVQFLFQTYL 2175

  Fly  2159 RTKKSLRGPVMEWYDALSHHIRSSALVRKWFANHALLSPPSRLGEYILMAPS-PDVR----TVFV 2218
            ||||.||....||...:...:..|....:|...:.:.|....|.:..|:..| .:||    |:..
  Rat  2176 RTKKKLRVDTEEWIATIEALLSKSLDACQWLVEYFISSEGRELVKVFLLECSVREVRVAVATILE 2240

  Fly  2219 KLVVFFCHFAINDEPLTGYDGANLCEQVLISVLRLLKSEAADYGKHLPHYFSLFSMYV-GLGTRE 2282
            |.:         |..|...|......|:|..:|.||..:..:..|:...|||||:.:| ..|.|.
  Rat  2241 KTL---------DSALFYQDKLKSLHQLLEVLLALLDKDVPENCKNCAQYFSLFNTFVQKQGIRA 2296

  Fly  2283 KQQLLR-----------LNVPLQFIQVALDDGPGPAIKYQYPEFSKLHQVVSHLIRCSDVSEKCQ 2336
            ...|||           |.|..|..|:......      |..||..||..|:.|:..:||
  Rat  2297 GDLLLRHSALRHMISFLLGVSQQNSQIRRWSSA------QAREFGNLHNTVALLVLHTDV----- 2350

  Fly  2337 SSNQNARPLSNPFKD-PNVA---HEELTPLSTECMDLLFNRTG--YIKKVI----EDTNVGDEGL 2391
            ||.:|..|  ..||. |.::   ...|.||..|...|||...|  |:.:|:    |.|......:
  Rat  2351 SSQRNVAP--GIFKQRPPISVAPSSPLLPLHEEVEALLFLSEGKPYLLEVMFALRELTGSLLALM 2413

  Fly  2392 KLLQYCSWENPHFSRAVLTELLWQCGFAYCHDMRHHTDLLLNILLIDDSWQHHRIHNALNGVAEE 2456
            :::.||.:.|.|||..:|..:..|...|..|::::...||..||:::|..|..|:    ..|.|.
  Rat  2414 EMVVYCCFCNEHFSFTMLHFIKNQLETAPPHELKNTFQLLHEILVMEDPIQVERV----KFVFET 2474

  Fly  2457 REGLLETIQRAKTHYQKRAYQIIKCLTQLFHKSPIALQMLHTNSNITRHWSIAVEWLQGELDRQR 2521
            ..|||..:..:......|.||.:|.|..|..|.|.|.:....||:   |||.||:|||.::
  Rat  2475 ENGLLALMHHSNHVDSSRCYQCVKFLVTLAQKCPAAKEYFKENSH---HWSWAVQWLQKKM---- 2532

  Fly  2522 GIGCQYNSYSWSPPAQ-SNDNTNGYMLERSQSAKNTWSMAFELCPDEVSEKTDENNEPNLETNMD 2585
                  :.:.|:|.:. ||:.:.|...:|:.||::|.:.|..|    ::||..
  Rat  2533 ------SEHYWTPQSNVSNETSTGKTFQRTISAQDTLAYATAL----LNEKEQ------------ 2575

  Fly  2586 ENKSEPVAQPGGVLEGSTGGTEQLPENK 2613
                          .||:.|:|..|.|:
  Rat  2576 --------------SGSSNGSESSPANE 2589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
faf	NP_524612.2	peptidase_C19C	1666..2064	CDD:239124	169/411 (41%)
		UCH	1668..2059	CDD:278850	164/403 (41%)
Usp24	NP_001258135.1	UBA_UBP24	6..42	CDD:270472
		peptidase_C19C	1684..2041	CDD:239124	169/410 (41%)
		UCH	1686..2036	CDD:278850	164/403 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D22076at33208
OrthoFinder	1	1.000	-	-		FOG0002455
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102574
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1635
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.720