Protein Alignment faf and Usp25

DIOPT Version :9

• Sequence 1: NP_524612.2
• Gene: faf / 43749
• FlyBaseID: FBgn0005632
• Length: 2778
• Species: Drosophila melanogaster
• Sequence 2: XP_006523118.1
• Gene: Usp25 / 30940
• MGIID: 1353655
• Length: 1134
• Species: Mus musculus
• Alignment Length: 1139
• Identity: 201/1139 - (17%)
• Similarity: 343/1139 - (30%)
• Gaps: 468/1139 - (41%)

  Fly  1644 CTDTDPLREW-DYLPPVG-ARPTKGFCGLKNAGATCYMNSVLQQLYMVPAVRVGILRAHGAATTD 1706
            |....|:..| |...|.. .|..|...||||.|.||:.::|:|.|:.:...|..:|.
Mouse   143 CLKRTPIEVWRDSRNPYDRKRQEKAPVGLKNVGNTCWFSAVIQSLFNLLEFRRLVLN-------- 199

  Fly  1707 GEDFSGDSDLTGGGLGSALFSGPASALVSLPSSSSTIEDGLHDVRKNYHVVILKHVQAIFAHLGH 1771
                               :..|::|           :|...:.:::.::..::.::.:||.|..
Mouse   200 -------------------YKPPSNA-----------QDLPRNQKEHRNLPFMRELRYLFALLVG 234

  Fly  1772 SALQYYVPRG----LWTHFKLLGEPVNLREQQDAVEFFMSLLESLDEGLKALGQPQL-------- 1824
            :..:|..|..    |...||     .|..:|||..||...||:.|::..:...:.:.
Mouse   235 TKRKYVDPSRAVEILKDAFK-----SNDSQQQDVSEFTHKLLDWLEDAFQMKAEEETDEEKPKNP 294

  Fly  1825 MNATLGGSFSDQKICQECPHRYSKEEPFSVFSVDIRNHSSLTESLE-QYVKGELLEGADAYHCDK 1888
            |.....|.|....:.:  ..::...|.|..:.:.:.....|.|.|| ..::||:    ::.|.|.
Mouse   295 MVELFYGRFLAMGVLE--GKKFENTEMFGQYPLQVNGFKDLHECLEAAMIEGEI----ESLHSDN 353

  Fly  1889 CDKKVVTVKRVCVKKLPPVLAIQLKRFEYDYERVCAIKFNDYFEFPRILDMEPY----------- 1942
            ..|   :.:.....:|||||..:|.|||::.......|.::..|||::|.::.|
Mouse   354 SGK---SGQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDRYMHRNREITRIK 415

  Fly  1943 -----------TV---------------------------------------------------- 1944
                       ||
Mouse   416 REEIKRLKDYLTVLQQRLERYLSYGSGPKRFPLVDVLQYALEFASSKPVCTSPVDDIDASSSASG 480

  Fly  1945 ----------------------------SGLA---------------------------KLEGEV 1954
                                        ||.|                           .:..|.
Mouse   481 PLPSQSLPSTTEQQGPCASDLPGSSSPASGAALPLRSVIHKPFTQSRIPPDLPMHPAPRHITEEE 545

  Fly  1955 VEVGDNC----QTNVET---------------------------TKYELTGIVVHSGQASGGHYF 1988
            :.|.::|    :|.:|.                           ..|.|..::||.|||:.|||:
Mouse   546 LCVLESCLHRWRTEIENDTRDLQESISRIHRTIELMYSDKSMIQVPYRLHAVLVHEGQANAGHYW 610

  Fly  1989 SYILSKNPANGKCQWYKFDDGEVTECKMHEDEEMKAECFGGEYMGETYDNNLKRMQYRRQKRWWN 2053
            :||..    :.:.:|.|::|..||:...   ||:..:.|||               ||..    :
Mouse   611 AYIFD----HRESRWMKYNDIAVTKSSW---EELVRDSFGG---------------YRNA----S 649

  Fly  2054 AYMLFYTRCDQTPVQYEPSVEQLSLAESRNM--------VLPLPKPIERSVRHQNIRF------- 2103
            ||.|.|.          ....|..:.|..|.        :..||..:...|...|.||
Mouse   650 AYCLMYI----------DDKAQFLIQEEFNKETGQALVGMETLPPDLRDFVEEDNQRFEKELEEW 704

  Fly  2104 ---LHSRSIFSVEFFNFIKKLVSCNLLSARSNKITPAAEELSLLGVQLASQFLFHTGFRTKKSLR 2165
               |..||:..       |.|.:..|..|.::..|..|.....|.....|....|....|.:.:.
Mouse   705 DTQLAQRSLQE-------KLLAAPKLREAEASATTAQAGGADYLEQPSRSDLSKHWKEETLRVIA 762

  Fly  2166 GPVMEWYDALSHHIRS---SALVRKWFANHALLSPPS----------RLGEYILMAPSPDVRTVF 2217
                    ..||.:..   ..:::...|| ....|||          .||::::.|..
Mouse   763 --------KASHDLEDKGPETVLQSKPAN-TTSQPPSSQQGVEVEIPHLGKFVIEAKE------- 811

  Fly  2218 VKLVVFFCHFAINDEPLTGYDGANLC----EQVLIS------VLRLLKSEAADYGKHLPHYFSLF 2272
                             .|||.....    .||:::      ::.:.||.:. |.:..|.
Mouse   812 -----------------GGYDDEQASFQPPWQVMMTPSMQGVIMAIGKSRSV-YDRCGPE----- 853

  Fly  2273 SMYVGLGTREKQQLLRLNVPLQFIQVALDDGPGPAIKYQYPEFSKLHQVVSHLI----------- 2326
               .|.....|.:..||      :::|.:|.| |...|      :||.|:.:.|
Mouse   854 ---AGFFKAIKLEYSRL------VKLAQEDTP-PETDY------RLHHVLVYFIQNQAPKKIIEK 902

  Fly  2327 ---------------RCSDVSEKCQSSNQNARPLSNPFKDPNVAHEELTPLSTECMDLL-----F 2371
                           ||.::.:..|:..:..:|.....::....|.:........|.|:     |
Mouse   903 TLLEQFGDRNLSFDERCHNIMKVAQAKLEMIKPEEVNLEEYEEWHADYKKFRETTMYLITGLENF 967

  Fly  2372 NRTGYIKKVIEDTNVGDEGLKLLQYCSWEN------------------PHFSRAVLTELLWQCG- 2417
            .|..||          |..|.||  |:::|                  .|:.|..|.:|..|..
Mouse   968 QRESYI----------DSLLFLL--CAYQNNKELLSKGPYRGHDGELISHYRRECLLKLNEQAAE 1020

  Fly  2418 -FAYCHDMRHHTDLL---------LNILLIDDSWQHHRIHNALNGVAEEREGL-LETI------- 2464
             |....|...:..|:         |.:||:||              .||::.| :|.:
Mouse  1021 LFESGEDGDVNNGLIIMNEFIVPFLPLLLVDD--------------MEEKDILAVEDMRNRWCSY 1071

  Fly  2465 --QRAKTHYQKRAY----QIIKCLTQL--FHKSP 2490
              |..:.:.|::..    :::.|.|::  ||:.|
Mouse  1072 LGQEMEANLQEKLTDFLPKLLDCSTEIKGFHEPP 1105

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
faf	NP_524612.2	peptidase_C19C	1666..2064	CDD:239124	99/570 (17%)
		UCH	1668..2059	CDD:278850	98/563 (17%)
Usp25	XP_006523118.1	UBA_UBP25	15..60	CDD:270539
		UBP14	<169..637	CDD:227532	89/526 (17%)
		Peptidase_C19I	170..656	CDD:239130	98/563 (17%)
		USP25_C	847..1127	CDD:380451	56/306 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900