DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment faf and Usp25

DIOPT Version :9

Sequence 1:	NP_524612.2	Gene:	faf / 43749	FlyBaseID:	FBgn0005632	Length:	2778	Species:	Drosophila melanogaster
Sequence 2:	XP_038944372.1	Gene:	Usp25 / 304150	RGDID:	1309003	Length:	1125	Species:	Rattus norvegicus

Alignment Length:	1282	Identity:	216/1282 - (16%)
Similarity:	384/1282 - (29%)	Gaps:	523/1282 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly  1527 WLQRIRENVHATGDTQVHEELLE---GHLCLA--------------KELMFF------------- 1561
            :|.::|| :....|.|:.::.|:   |:|.||              :|..::
  Rat    20 FLNQLRE-ITGINDAQILQQALKDSNGNLELAVAFLTAKNAKTPPQEETAYYQTAALPGSDRYIS 83

  Fly  1562 LGADSKAQLNELIHELIDDF-------LFTASREFLHLRRHGSLRQDTVPPPVCRSPHTIAAACD 1619
            :|:.:.|.:.:|..:..||.       |..::|.|   |..|          :......|:...:
  Rat    84 VGSQADANVIDLTGDDKDDLQRAIALSLAESNRTF---RETG----------ITDEEQAISRVLE 135

  Fly  1620 LLIALCQLCVPNMKLLTNTLIDFVCTDTDPLREW-DYLPPVG-ARPTKGFCGLKNAGATCYMNSV 1682
            ..||..:.|:..                .|:..| |...|.. .|..|...||||.|.||:.::|
  Rat   136 ASIAENKACLKR----------------TPIEVWRDSRNPYDRKRQDKAPVGLKNVGNTCWFSAV 184

  Fly  1683 LQQLYMVPAVRVGILRAHGAATTDGEDFSGDSDLTGGGLGSALFSGPASALVSLPSSSSTIEDGL 1747
            :|.|:.:...|..:|.                           :..|::|           :|..
  Rat   185 IQSLFNLLEFRRLVLN---------------------------YKPPSNA-----------QDLP 211

  Fly  1748 HDVRKNYHVVILKHVQAIFAHLGHSALQYYVPRG----LWTHFKLLGEPVNLREQQDAVEFFMSL 1808
            .:.:::.::..::.::.:||.|..:..:|..|..    |...||     .|..:|||..||...|
  Rat   212 RNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVEILKDAFK-----SNDSQQQDVSEFTHKL 271

  Fly  1809 LESLDEGLKALGQPQL--------MNATLGGSFSDQKICQECPHRYSKEEPFSVFSVDIRNHSSL 1865
            |:.|::..:...:.:.        |.....|.|....:.:  ..::...|.|..:.:.:.....|
  Rat   272 LDWLEDAFQMKAEEETDEEKPKNPMVELFYGRFLAMGVLE--GKKFENTEMFGQYPLQVNGFKDL 334

  Fly  1866 TESLE-QYVKGELLEGADAYHCDKCDKKVVTVKRVCVKKLPPVLAIQLKRFEYDYERVCAIKFND 1929
            .|.|| ..::||:    ::.|.|...|   :.:.....:|||||..:|.|||::.......|.::
  Rat   335 HECLEAAMIEGEI----ESLHSDNSGK---SGQEHWFTELPPVLTFELSRFEFNQALGRPEKIHN 392

  Fly  1930 YFEFPRILDMEPY----------------------TV---------------------------- 1944
            ..|||::|.::.|                      ||
  Rat   393 KLEFPQVLYLDRYMHRNREITRIKREEIKRLKDYLTVLQQRLERYLSYGSGPKRFPLVDVLQYAL 457

  Fly  1945 ---------------------------------------------------SGLA---------- 1948
                                                               ||.|
  Rat   458 EFASSKPVCTSPVDDIDATSSTSGSTSSQSLPSTTEQQGTPASDLPSSSPASGAALSLRSVIHKP 522

  Fly  1949 -----------------KLEGEVVEVGDNC----QTNVET------------------------- 1967
                             .:..|.:.|.::|    :|.:|.
  Rat   523 FTQSRIPPDLPMHPAPRHITEEELSVLESCLHRWRTEIENDTRDLQESISRIHRTIELMYSDKSM 587

  Fly  1968 --TKYELTGIVVHSGQASGGHYFSYILSKNPANGKCQWYKFDDGEVTECKMHEDEEMKAECFGGE 2030
              ..|.|..::||.|||:.|||::||..    :.:.:|.|::|..||:...   ||:..:.|||
  Rat   588 IQVPYRLHAVLVHEGQANAGHYWAYIFD----HRESRWMKYNDIAVTKSSW---EELVRDSFGG- 644

  Fly  2031 YMGETYDNNLKRMQYRRQKRWWNAYMLFYTRCDQTPVQYEPSVEQLSLAESRNM--------VLP 2087
                          ||..    :||.|.|.. |:.         |..:.|..|.        :..
  Rat   645 --------------YRNA----SAYCLMYIN-DKA---------QFLIQEEFNKETGQALVGMET 681

  Fly  2088 LPKPIERSVRHQNIRF----------LHSRSIFSVEFFNFIKKLVSCNLLSARSNKITPAAEELS 2142
            ||..:...|...|.||          |..|::..       |.|.:..|..|.|:..|..|....
  Rat   682 LPPDLRDFVEEDNQRFEKELEDWDTQLAQRALQE-------KLLAAQKLREAESSAPTAQAGGPD 739

  Fly  2143 LLGVQLASQFLFHTGFRTKKSLRGPVMEWYDALSHHIRSSALVRKWFANHALLSPPSR------- 2200
            .|.....|....|.   .:::||......:|   |..:....|.:....:....|||:
  Rat   740 YLEQPSRSDLSKHW---KEETLRVIAKASHD---HEDKGPETVLQSKPENTTSQPPSKQQAVEVQ 798

  Fly  2201 ---LGEYILMAPSPDVRTVFVKLVVFFCHFAINDEPLTGYDGANLCEQVLISVLRLLKSEAADYG 2262
               :|::::                        :....|||...:....:..::..:....:.|.
  Rat   799 IPHIGKFMI------------------------ESKEGGYDDEIMMTPSMQGIIMAIGKSRSVYD 839

  Fly  2263 KHLPHYFSLFSMYVGLGTREKQQLLRLNVPLQFIQVALDDGPGPAIKYQYPEFSKLHQVVSHLI- 2326
            :..|.        .|.....|.:..||      :::|.:|.| |...|      :||.|:.:.|
  Rat   840 RCGPE--------AGFFKAIKLEYSRL------VKLAQEDTP-PETDY------RLHHVLVYFIQ 883

  Fly  2327 -------------------------RCSDVSEKCQSSNQNARPLSNPFKDPNVAHEELTPLSTEC 2366
                                     ||.::.:..|:..:..:|.....::....|.:........
  Rat   884 NQAPKKIIEKTLLEQFGDRNLSFDERCHNIMKVAQAKLEMIKPEEVNLEEYEEWHADYKKFRETT 948

  Fly  2367 MDLL-----FNRTGYIKKVIEDTNVGDEGLKLLQYCSWEN------------------PHFSRAV 2408
            |.|:     |.|..||..:            |...|:::|                  .|:.|..
  Rat   949 MYLIIGLENFQRESYIDSL------------LFLICAYQNNKELLSKGPYRGHDGDLISHYRREC 1001

  Fly  2409 LTELLWQCG--FAYCHDMRHHTDLL---------LNILLIDDSWQHHRIHNALNGVAEEREGLL- 2461
            |.:|..|..  |....|......|:         |.:||:|::              |||:.|.
  Rat  1002 LLKLNEQAAELFESGEDREVSNGLIIMNEFIVPFLPLLLVDET--------------EERDILAV 1052

  Fly  2462 ----------------ETIQRAKTHYQKRAYQIIKCLTQL--FHKSP 2490
                            ..:|...|.:..:   ::.|.|::  ||:.|
  Rat  1053 EDMRNRWCSYLGQDMEPNLQEKLTDFLPK---LLDCSTEIKGFHEPP 1096

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
faf	NP_524612.2	peptidase_C19C	1666..2064	CDD:239124	99/569 (17%)
faf	NP_524612.2	UCH	1668..2059	CDD:278850	98/562 (17%)
Usp25	XP_038944372.1	UBA_UBP25	15..60	CDD:270539	10/40 (25%)
		UBP14	<170..637	CDD:227532	89/525 (17%)
		Peptidase_C19I	171..656	CDD:239130	98/562 (17%)
		USP25_C	838..1118	CDD:380451	52/309 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900