DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment faf and USP25

DIOPT Version :9

Sequence 1:	NP_524612.2	Gene:	faf / 43749	FlyBaseID:	FBgn0005632	Length:	2778	Species:	Drosophila melanogaster
Sequence 2:	NP_001269970.1	Gene:	USP25 / 29761	HGNCID:	12624	Length:	1125	Species:	Homo sapiens

Alignment Length:	1264	Identity:	218/1264 - (17%)
Similarity:	394/1264 - (31%)	Gaps:	487/1264 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly  1527 WLQRIRENVHATGDTQVHEELLE---GHLCLA--------------KELMFF------------L 1562
            :|.::|| :....|||:.::.|:   |:|.||              :|..::            :
Human    20 FLNQLRE-ITGINDTQILQQALKDSNGNLELAVAFLTAKNAKTPQQEETTYYQTALPGNDRYISV 83

  Fly  1563 GADSKAQLNELIHELIDDF-------LFTASREFLHLRRHGSLRQDTVPPPVCRSPHTIAAACDL 1620
            |:.:...:.:|..:..||.       |..::|.|   |..|          :......|:...:.
Human    84 GSQADTNVIDLTGDDKDDLQRAIALSLAESNRAF---RETG----------ITDEEQAISRVLEA 135

  Fly  1621 LIALCQLCVPNMKLLTNTLIDFVCTDTDPLREWDYLPPVGARPTKGFCGLKNAGATCYMNSVLQQ 1685
            .||..:.|:..             |.|:..|: ...|....|..|...||||.|.||:.::|:|.
Human   136 SIAENKACLKR-------------TPTEVWRD-SRNPYDRKRQDKAPVGLKNVGNTCWFSAVIQS 186

  Fly  1686 LYMVPAVRVGILRAHGAATTDGEDFSGDSDLTGGGLGSALFSGPASALVSLPSSSSTIEDGLHDV 1750
            |:.:...|..:|.                           :..|::|           :|...:.
Human   187 LFNLLEFRRLVLN---------------------------YKPPSNA-----------QDLPRNQ 213

  Fly  1751 RKNYHVVILKHVQAIFAHLGHSALQYYVPRG----LWTHFKLLGEPVNLREQQDAVEFFMSLLES 1811
            :::.::..::.::.:||.|..:..:|..|..    |...||     .|..:|||..||...||:.
Human   214 KEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVEILKDAFK-----SNDSQQQDVSEFTHKLLDW 273

  Fly  1812 LDEGLKALGQPQL--------MNATLGGSFSDQKICQECPHRYSKEEPFSVFSVDIRNHSSLTES 1868
            |::..:...:.:.        |.....|.|....:.:  ..::...|.|..:.:.:.....|.|.
Human   274 LEDAFQMKAEEETDEEKPKNPMVELFYGRFLAVGVLE--GKKFENTEMFGQYPLQVNGFKDLHEC 336

  Fly  1869 LE-QYVKGELLEGADAYHCDKCDKKVVTVKRVCVKKLPPVLAIQLKRFEYDYERVCAIKFNDYFE 1932
            || ..::||:    ::.|.:...|   :.:.....:|||||..:|.|||::.......|.::..|
Human   337 LEAAMIEGEI----ESLHSENSGK---SGQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLE 394

  Fly  1933 FPRILDMEPY------------------------------------------------------- 1942
            ||::|.::.|
Human   395 FPQVLYLDRYMHRNREITRIKREEIKRLKDYLTVLQQRLERYLSYGSGPKRFPLVDVLQYALEFA 459

  Fly  1943 --------------------------TVSGLAKLEG----------------------------- 1952
                                      |:....:.:|
Human   460 SSKPVCTSPVDDIDASSPPSGSIPSQTLPSTTEQQGALSSELPSTSPSSVAAISSRSVIHKPFTQ 524

  Fly  1953 ------------------EVVEVGDNC----QTNVET---------------------------T 1968
                              |.:.|.::|    :|.:|.                           .
Human   525 SRIPPDLPMHPAPRHITEEELSVLESCLHRWRTEIENDTRDLQESISRIHRTIELMYSDKSMIQV 589

  Fly  1969 KYELTGIVVHSGQASGGHYFSYILSKNPANGKCQWYKFDDGEVTECKMHEDEEMKAECFGGEYMG 2033
            .|.|..::||.|||:.|||::||..    :.:.:|.|::|..||:...   ||:..:.|||
Human   590 PYRLHAVLVHEGQANAGHYWAYIFD----HRESRWMKYNDIAVTKSSW---EELVRDSFGG---- 643

  Fly  2034 ETYDNNLKRMQYRRQKRWWNAYMLFYTRCDQTPVQYEPSVEQLSLAESRNM--------VLPLPK 2090
                       ||..    :||.|.|.. |:.         |..:.|..|.        :..||.
Human   644 -----------YRNA----SAYCLMYIN-DKA---------QFLIQEEFNKETGQPLVGIETLPP 683

  Fly  2091 PIERSVRHQNIRFLHSRSIFSVEFFNFIKKLVSCNLLSARSNKITPAAEELSLLGVQLASQFLFH 2155
            .:...|...|.||......:..:   ..:|.:...||:  |.|:..:  |.|:...|.|..
Human   684 DLRDFVEEDNQRFEKELEEWDAQ---LAQKALQEKLLA--SQKLRES--ETSVTTAQAAGD---- 737

  Fly  2156 TGFRTKKSLRGPVMEWYDALSHHIRSSA--LVRKWFANHALLSPPSRL---GEYILMAPSPDVRT 2215
                 .:.|..|....:   |.|::...  ::.|....|...||.:.|   .|.....|..:.|.
Human   738 -----PEYLEQPSRSDF---SKHLKEETIQIITKASHEHEDKSPETVLQSKPENTTSQPLSNQRV 794

  Fly  2216 VFVKLVVFFCH---FAINDEPLTGYDGANLCEQVLISVLRLLKSEAADYGKHLPHYFSLFSMYVG 2277
            |.|.:.    |   |.|..:. .|||...:....:..::..:....:.|.:..|.        .|
Human   795 VEVAIP----HVGKFMIESKE-GGYDDEIMMTPNMQGIIMAIGKSRSVYDRCGPE--------AG 846

  Fly  2278 LGTREKQQLLRLNVPLQFIQVALDDGPGPAIKYQYPEFSKLHQVVSHLI---------------- 2326
            .....|.:..||      :::|.:|.| |...|      :||.||.:.|
Human   847 FFKAIKLEYARL------VKLAQEDTP-PETDY------RLHHVVVYFIQNQAPKKIIEKTLLEQ 898

  Fly  2327 ----------RCSDVSEKCQSSNQNARPLSNPFKDPNVAHEELTPLSTECMDLL-----FNRTGY 2376
                      ||.::.:..|:..:..:|.....::....|::........|.|:     |.|..|
Human   899 FGDRNLSFDERCHNIMKVAQAKLEMIKPEEVNLEEYEEWHQDYRKFRETTMYLIIGLENFQRESY 963

  Fly  2377 IKKVIEDTNVGDEGLKLLQYCSWEN------------------PHFSRAVLTELLWQCG--FAYC 2421
            |..:            |...|:::|                  .|:.|..|.:|..|..  |...
Human   964 IDSL------------LFLICAYQNNKELLSKGLYRGHDEELISHYRRECLLKLNEQAAELFESG 1016

  Fly  2422 HDMRHHTDLL---------LNILLIDDSWQHHRIHNALNGVAEEREGL-LETI---------QRA 2467
            .|...:..|:         |.:||:|:              .||::.| :|.:         |..
Human  1017 EDREVNNGLIIMNEFIVPFLPLLLVDE--------------MEEKDILAVEDMRNRWCSYLGQEM 1067

  Fly  2468 KTHYQKRAY----QIIKCLTQL--FHKSP 2490
            :.|.|::..    :::.|..::  ||:.|
Human  1068 EPHLQEKLTDFLPKLLDCSMEIKSFHEPP 1096

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
faf	NP_524612.2	peptidase_C19C	1666..2064	CDD:239124	95/569 (17%)
faf	NP_524612.2	UCH	1668..2059	CDD:278850	94/562 (17%)
USP25	NP_001269970.1	UBA_UBP25	15..60	CDD:270539	11/40 (28%)
		SUMO interaction domain (SIM)	77..102		3/24 (13%)
		Required for SUMO paralog-specific binding	89..95		0/5 (0%)
		UCH	168..>405	CDD:278850	59/288 (20%)
		Peptidase_C19I	170..655	CDD:239130	94/562 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..507		2/42 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	727..749		5/30 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900