DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment faf and Usp28

DIOPT Version :9

Sequence 1:	NP_524612.2	Gene:	faf / 43749	FlyBaseID:	FBgn0005632	Length:	2778	Species:	Drosophila melanogaster
Sequence 2:	XP_006510322.1	Gene:	Usp28 / 235323	MGIID:	2442293	Length:	1143	Species:	Mus musculus

Alignment Length:	1241	Identity:	222/1241 - (17%)
Similarity:	383/1241 - (30%)	Gaps:	502/1241 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly  1514 LQISEGLLGDEIKWL--QRIRENVHATGDTQVHEELLEGHLCLAKELMFFLGADSKAQLNELIHE 1576
            |:.|.|.:...:..|  ||::|..|   ||...|.........:|:|:        |::.:|.|:
Mouse    44 LKASNGDITQAVSLLTDQRVKEPSH---DTTAAEPSEVEESATSKDLL--------AKVIDLTHD 97

  Fly  1577 LIDDFLFTASREFLHLRRHGSLRQDTVPPPVCRSPHTIAAACDLLIA--------------LCQL 1627
            ..||.                  |..:...:..||:..|...||..|              .|::
Mouse    98 NKDDL------------------QAAIALSLLESPNIQADNRDLNRAHEANSAETKRSKRKRCEV 144

  Fly  1628 CVPNMKLLTNTLIDFVCTDTDPLREWDYLPPVGARPTKGF-CGLKNAGATCYMNSVLQQLYMVPA 1691
            ...|..                        |...|...|: .||||.|.||:.::|:|.|:.:|.
Mouse   145 WGENHN------------------------PNNWRRVDGWPVGLKNVGNTCWFSAVIQSLFQLPE 185

  Fly  1692 VRVGILRAHGAATTDGEDFSGDSDLTGGGLGSALFSGPASALVSLPSSSSTIEDGLHDVRKNYHV 1756
            .|..:|.                           ::.|.:.|.:..|         |..::|  :
Mouse   186 FRRLVLS---------------------------YNLPQNILENCRS---------HTEKRN--I 212

  Fly  1757 VILKHVQAIFAHLGHSALQYYVPRG----LWTHFKLLGEPVNLREQQDAVEFFMSLLESLDEG-- 1815
            :.::.:|.:||.|..|..::..|..    |...|:...|     :|||..||...||:.|::.
Mouse   213 MFMQELQYLFALLLGSNRKFVDPSAALDLLKGAFRSSEE-----QQQDVSEFTHKLLDWLEDAFQ 272

  Fly  1816 LKALGQPQLMNAT-------LGGSFSDQKICQECPHRYSKEEPFSVFSVDIRNHSSLTESLEQYV 1873
            |.......|.|.:       ..|:|..:.:.:..|  :...|.|..:.:.:..:.:|.|.||
Mouse   273 LAVNVNSHLRNKSENPMVQLFYGTFLTEGVREGKP--FCNNETFGQYPLQVNGYHNLDECLE--- 332

  Fly  1874 KGELLEGADAYHCDKCDKKVVTVKRVCVKKLPPVLAIQLKRFEYDYERVCAIKFNDYFEFPRILD 1938
             |.::||..|..  ..|:.|...:.....||||||..:|.|||::.......|.::..|||:|:.
Mouse   333 -GAMVEGDIALL--PSDRSVKYGQERWFTKLPPVLTFELSRFEFNQSLGQPEKIHNKLEFPQIIY 394

  Fly  1939 MEPYTV----------SGLAKLEGEV----------VEVG------------------------- 1958
            |:.|..          ..:.||:.|:          |:.|
Mouse   395 MDRYMYKSKELIRSKRESVRKLKEEIQVLQQKLERYVKYGSGPSRFPLPDMLKYVIEFASTKPAS 459

  Fly  1959 ---------------------------------DNCQTNVETT---------------------- 1968
                                             ::|..|..:|
Mouse   460 ESCLSGSAEHVTLPLPSVHCPISDLTPKESSSPESCSQNAGSTFSSPEDALPSSEGMNGPFTSPH 524

  Fly  1969 ---------------------------------------------------------------KY 1970
                                                                           .|
Mouse   525 SSLETPAPPAPRTVTDEEMNFVKTCLQRWRSEIEQDIQDLKNCISSSTKAIEQMYCDPLLRQVPY 589

  Fly  1971 ELTGIVVHSGQASGGHYFSYILSKNPANGKCQWYKFDDGEVTECKMHEDEEMKAECFGGEYMGET 2035
            .|..::||.||||.|||::||.::    .:..|.|::|..|||...   ||::.:.:||
Mouse   590 RLHAVLVHEGQASAGHYWAYIYNQ----PRQTWLKYNDISVTESSW---EELERDSYGG------ 641

  Fly  2036 YDNNLKRMQYRRQKRWWNAYMLFYTRCDQTPVQYEPSVEQLSLAESRNMVLPLPKPIERSVRHQN 2100
                |:.:         :||.|.|.. |..| .:..........|:...|..|...:.:.::..|
Mouse   642 ----LRNV---------SAYCLMYIN-DNLP-HFSAEASSNESDETAGEVEALSVELRQYIQEDN 691

  Fly  2101 IRFLHSRSIFSVEFFNFIKKLVSCNLLSAR------------SNKITPAAEELSLLGVQLASQFL 2153
            .||......:..|....|.::.|....|::            |:::...:.|.:::..:..:|.:
Mouse   692 WRFQQEVEEWEEEQSCKIPQMESSPNSSSQDFSTSQESPAVSSHEVRCLSSEHAVIAKEQTAQAI 756

  Fly  2154 FHTGFRTKKS-LRGPVMEWYDA---------LSHHIRSSALVRKWFANHALLSPPSRLGEYILMA 2208
            .:|....:|| :...:.|..:|         |:..:..:|..|.   ..|..:|.|.:.|..:
Mouse   757 ANTAHAYEKSGVEAALSEHNEAEPKKPQETNLAEQLEQAAEARD---TEAAAAPNSEVSEVEI-- 816

  Fly  2209 PSPDVRTVFVKLVVFFCHFAINDEPLTGYDGANLCEQVLIS------VLRLLKSEAADYGKHLPH 2267
              |.|..:.|:            ....|||     |:|::|      :|.:.|:
Mouse   817 --PSVGRILVR------------SDADGYD-----EEVMLSPAMQGVILAIAKA----------- 851

  Fly  2268 YFSLFSMYVGLGTREKQQLLRLNVPLQFIQVALDDGPGPAIKYQYPEFSKLHQV-----VSHLIR 2327
                           :|...|            |......||..:.|:|:|:|:     .||
Mouse   852 ---------------RQTFDR------------DGSEAGLIKAFHEEYSRLYQLAKETPTSH--- 886

  Fly  2328 CSD--VSEKCQSSNQNARP-------LSNPFKDPNVAHEELTPLSTECMDLLFNRTGYIKKVIED 2383
             ||  :........||..|       |...|.|.|::::|              |:..|.||.:.
Mouse   887 -SDPRLQHVLVYFFQNEAPKRVVERTLLEQFADRNLSYDE--------------RSISIMKVAQA 936

  Fly  2384 --TNVGDEGLKLLQYCSWENPH----------------FSRAVLTELLWQCGFAYCHDMRHHTDL 2430
              ..:|.:.:.:.:|..|...:                |.:....|.|....:||    :.:..|
Mouse   937 KLMEIGPDDMNMEEYKRWHEDYSLFRKVSVYLLTGLELFQKGKYQEALSYLVYAY----QSNAGL 997

  Fly  2431 LLNILLIDDSWQHHRIHNALNGVAEEREGLLETIQRAKTHYQKRAYQIIKCLTQLFHKSPIALQM 2495
            |                     |...|.|:.|::...   |::      |||.:|..|   |..:
Mouse   998 L---------------------VKGPRRGVKESVIAL---YRR------KCLLELNAK---AASL 1029

  Fly  2496 LHTNSN 2501
            ..||.:
Mouse  1030 FETNDD 1035

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
faf	NP_524612.2	peptidase_C19C	1666..2064	CDD:239124	107/574 (19%)
faf	NP_524612.2	UCH	1668..2059	CDD:278850	105/566 (19%)
Usp28	XP_006510322.1	UBA_UBP28	23..64	CDD:270540	6/19 (32%)
		UBP14	<162..639	CDD:227532	99/534 (19%)
		Peptidase_C19I	163..653	CDD:239130	105/566 (19%)
		USP28_C	864..1143	CDD:380452	45/227 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900