Protein Alignment faf and USP24

DIOPT Version :9

• Sequence 1: NP_524612.2
• Gene: faf / 43749
• FlyBaseID: FBgn0005632
• Length: 2778
• Species: Drosophila melanogaster
• Sequence 2: XP_016856320.1
• Gene: USP24 / 23358
• HGNCID: 12623
• Length: 2640
• Species: Homo sapiens
• Alignment Length: 2829
• Identity: 799/2829 - (28%)
• Similarity: 1285/2829 - (45%)
• Gaps: 542/2829 - (19%)

  Fly    39 GSGSGIGTGTGTVANSSLPGGGSGSLDGNQDQQPATDSQSSDDVAASLSANSVDSTITIVPPEKL 103
            |.|.|.|.|.|.....|.  ||.|..|.........|::.:|: ..:.|...::
Human    72 GDGGGDGGGGGPSRGGST--GGGGGFDPPPAYHEVVDAEKNDE-NGNCSGEGIE----------- 122

  Fly   104 ISSFPTTKLRSLTQKISNPRWVVPVLPEQELEVLLNAAIELTQAGVDHDCEPCVEFYRNGLSTSF 168
               ||||.|..|..::....|.:|...|:.|...|.|:..|.:.|:....|.|..|....:..:|
Human   123 ---FPTTNLYELESRVLTDHWSIPYKREESLGKCLLASTYLARLGLSESDENCRRFMDRCMPEAF 184

  Fly   169 AKILTDEAVNSWKNNIHHCILVSCGKLLHLIAIHMQRDNPY---LLDLLAIVFDPENKFNTFNAG 230
            .|:||..||:.|...||..|......|:.|:|..:::| |.   ||.:|.:.|:|:|:::..|.
Human   185 KKLLTSSAVHKWGTEIHEGIYNMLMLLIELVAERIKQD-PIPTGLLGVLTMAFNPDNEYHFKNR- 247

  Fly   231 RQPECFAAPDYIWGQL-DSNKMYARPPPE--PKNARGWLVDLINRFGQLGGFDNLLERFNIGLEL 292
                 .......|.:: ....|:|..|..  .|...||:|||:|:||:||||..:
Human   248 -----MKVSQRNWAEVFGEGNMFAVSPVSTFQKEPHGWVVDLVNKFGELGGFAAI---------- 297

  Fly   293 LKRNQNKCTGKNISVEGRVENGAQDNRLTLALIHSLLRPFGQCYELLMPATIAKYFMPTWNVVLD 357
                |.|...::|.               |..:.:|::|.|.|.|.|..:.:.....|.....:.
Human   298 ----QAKLHSEDIE---------------LGAVSALIQPLGVCAEYLNSSVVQPMLDPVILTTIQ 343

  Fly   358 LLDSFTDEELKREVKPEGRNDYINGIVKSARLLASRLTGQEELIRDLEMFRLKMILRLLQVSSFN 422
            .:.|..:::||     :.|...|..::.:.:||..|.  |.:|:..::..||.::||:|:...|:
Human   344 DVRSVEEKDLK-----DKRLVSIPELLSAVKLLCMRF--QPDLVTIVDDLRLDILLRMLKSPHFS 401

  Fly   423 GKMNALNEINKVLSSVAYFSHRSQPLPHCMPEDEMDWLTADRMAQWIKSSDVLGVVLKDSLHQPQ 487
            .|||:|.|:.|::..    |..|:.:.:.        :..||:..|:..:.||.:.|:.::.|.|
Human   402 AKMNSLKEVTKLIED----STLSKSVKNA--------IDTDRLLDWLVENSVLSIALEGNIDQAQ 454

  Fly   488 YVEKLEKIIRFLIKEQALTLDDLDAVWRAQAGKHEAIVKNVHDLLAKLAWDFTPEQLDHLFEAFQ 552
            |.::::.||..|  ...|:||:|..:|:.|:|:...:::|:|.::|..|..|..:||:|||...|
Human   455 YCDRIKGIIELL--GSKLSLDELTKIWKIQSGQSSTVIENIHTIIAAAAVKFNSDQLNHLFVLIQ 517

  Fly   553 ASMTTANKRQRERLLELIRRLAEDDKNGVMAQKVLKLFWTLAHSQEVPPEVLDQALGAHVKILD- 616
            .|..|.:.|.|::||.||.|:..:.:....:.|||.:.|.|||...:|..::.|||..|:.||.
Human   518 KSWETESDRVRQKLLSLIGRIGREARFETTSGKVLDVLWELAHLPTLPSSLIQQALEEHLTILSD 582

  Fly   617 -YSCSQERDAQKTIWLDKCVDELK-----SG------DG-------------------------- 643
             |:.   ::|.|..::.||::::|     ||      ||
Human   583 AYAV---KEAIKRSYIIKCIEDIKRPGEWSGLEKNKKDGFKQGGLTGDYVSLPGYTETKQRSSQL 644

  Fly   644 ------WVLPALRLIRDICCLYDTTTNHAQRTQTSTNRQQVIERLQNDYSLVILVTNSLTAYMEK 702
                  ||:||||.:.:|      |.:..::|....:: .:|:.|:.::.:|.|||.||.| ..:
Human   645 NNPQFVWVVPALRQLHEI------TRSFIKQTYQKQDK-SIIQDLKKNFEIVKLVTGSLIA-CHR 701

  Fly   703 VRQMVTDSPGLDATRILIDGRFPHHVQIAERLEFLKFLLKDGQLWLCADQAKQIWHCLAVNA-VF 766
            :...|....||..: .|:|||:.:...:...|:||.|.|::..|:|..::||:||.||.... |.
Human   702 LAAAVAGPGGLSGS-TLVDGRYTYREYLEAHLKFLAFFLQEATLYLGWNRAKEIWECLVTGQDVC 765

  Fly   767 PADREECFRWFGKLMGEEPDLDPGINKDFFENNILQLDPHLLTESGIKCFERFFKAVNSKEDKLK 831
            ..|||.||.||.|  |:. ||:..:.:..|:..||:|:.:.:|.:|...|:.||:.||..:.:||
Human   766 ELDREMCFEWFTK--GQH-DLESDVQQQLFKEKILKLESYEITMNGFNLFKTFFENVNLCDHRLK 827

  Fly   832 AIHRGYMLDNEDLIGKDYLWRV-ITTGGEEIASKAIDLLKEVS-TALGPRLQENIAEFHEMFIGE 894
            .......::..:|||.|::|:: :.:..||||::||.|:...| ..|.|||:::....|:.||.:
Human   828 RQGAQLYVEKLELIGMDFIWKIAMESPDEEIANEAIQLIINYSYINLNPRLKKDSVSLHKKFIAD 892

  Fly   895 CCSRLR-----------THYGNIVILGKTQLQEELDAPDQSDNTNDESKDSKMRFIEAEKMCRIL 948
            |.:||.           ||    .:...|::......|..:.:.....:.:|:..||     |:|
Human   893 CYTRLEAASSALGGPTLTH----AVTRATKMLTATAMPTVATSVQSPYRSTKLVIIE-----RLL 948

  Fly   949 KVLQEYVKECDRSFSGDRVHLPLSRVTRGKNTILYIRFQNPGRSIDDMEIVTHSNETMAAFKRNL 1013
            .:.:.||...:..:|..|..||......|....|.:.:::   :.|...:..|||||:.:.:..:
Human   949 LLAERYVITIEDFYSVPRTILPHGASFHGHLLTLNVTYES---TKDTFTVEAHSNETIGSVRWKI 1010

  Fly  1014 LKRIKGTSTANIKVDLFYANDEMIGVSDEINPLYQYTIRDKMNLTAKLTPVGTGLASSPDSSSDS 1078
            .|:: .:...||::   :.||.::.|:.:...|:|....|:..||.|.:..||...||.|||:.|
Human  1011 AKQL-CSPVDNIQI---FTNDSLLTVNKDQKLLHQLGFSDEQILTVKTSGSGTPSGSSADSSTSS 1071

  Fly  1079 STGSPPRPCPDMQRVESESTLPGVIISQNYQYTEFFLKLYQLGSDLEHGRLRDSAKVLLHLLPCD 1143
            |:.| .........:|.|.:||||:::   .....|..|||| ::||..|:....:.||.|:|.|
Human  1072 SSSS-SGVFSSSYAMEQEKSLPGVVMA---LVCNVFDMLYQL-ANLEEPRITLRVRKLLLLIPTD 1131

  Fly  1144 ---RQTIRQLKIMCKVPKAAVTVAVTGDKIAKDEEEKLYPTEQAGIEDEEEHCTP------EQMF 1199
               ::.:.||..:             |.|.....|.....::...:..:::| .|      |.:|
Human  1132 PAIQEALDQLDSL-------------GRKKTLLSESSSQSSKSPSLSSKQQH-QPSASSILESLF 1182

  Fly  1200 LHPTPA----QVLYNLSVLHGLLIP-ALDPLGES-ALLVQSAWMHSGCAHFVLELLTKNNFLPSA 1258
            ....|.    :|||||.||...|:| |.|.:..| |......::.:|....|:.::.:::.....
Human  1183 RSFAPGMSTFRVLYNLEVLSSKLMPTADDDMARSCAKSFCENFLKAGGLSLVVNVMQRDSIPSEV 1247

  Fly  1259 DMHTKRASFQCVLRLAKLFLYIVGSVLSRVGDEPMICDLDNGSRSQVDILKQNFSTMPSSSQGTL 1323
            |..|::..:...|:||:..|  ||..:..:.||              |:.|.....:   |....
Human  1248 DYETRQGVYSICLQLARFLL--VGQTMPTLLDE--------------DLTKDGIEAL---SSRPF 1293

  Fly  1324 RAISAKLAVILAREM-LSASPEGDRCRTLFSS-------------------TLQWSCPDI-STIK 1367
            |.:|.:    .:|:| |..:||....|.|..|                   |::.|  |. ||:.
Human  1294 RNVSRQ----TSRQMSLCGTPEKSSYRQLSVSDRSSIRVEEIIPAARVAIQTMEVS--DFTSTVA 1352

  Fly  1368 AVVQLAWASSCGNLQALGNSSGDFEDEVIVPDG-------------------------------- 1400
            ..::|:||::.|.|..:|:|....|...:.|.|
Human  1353 CFMRLSWAAAAGRLDLVGSSQPIKESNSLCPAGIRNRLSSSGSNCSSGSEGEPVALHAGICVRQQ 1417

  Fly  1401 ----QDFSMCKEALEVLTISFILNPSANEALTSDPNWP---KFITSIVLKNPLRHVRQVASEQLF 1458
                :|..:..|||.:|.....|.   ::.|.|..|.|   .||..|:|.:|...:|:||.:||:
Human  1418 SVSTKDSLIAGEALSLLVTCLQLR---SQQLASFYNLPCVADFIIDILLGSPSAEIRRVACDQLY 1479

  Fly  1459 LAS---TYCAGD-RRPFVYMVNLLVGA----------LKTLVPQYESTCAEFFSVLCRTLSYGCI 1509
            ..|   |....| ::|..:::.:::.|          ::.:..:..|.|.|:|.:.|:.|.
Human  1480 TLSQTDTSAHPDVQKPNQFLLGVILTAQLPLWSPTSIMRGVNQRLLSQCMEYFDLRCQLLD---- 1540

  Fly  1510 YNWPLQISE---------GLLGDEIKWLQRIRENVHATGDT-QVHEELLEGHLCLAKELMFFLGA 1564
               .|..||         .:|.|||.||.....|..|..:| :....||.|||.|.|.|:...||
Human  1541 ---DLTTSEMEQLRISPATMLEDEITWLDNFEPNRTAECETSEADNILLAGHLRLIKTLLSLCGA 1602

  Fly  1565 DSKAQLNELIHELIDDFLFTASREFLHLRRH---GSL---RQDTVPPPVCRSPHTIAAACDLLIA 1623
            :.:...:.||..|:|||||.|||  :.|..|   ||.   :||.  .|.|.:.::..||.::|:.
Human  1603 EKEMLGSSLIKPLLDDFLFRASR--IILNSHSPAGSAAISQQDF--HPKCSTANSRLAAYEVLVM 1663

  Fly  1624 LCQLCVPNMKLLTNTLIDFVCTDTDP--LREWDYLPPVGARPTKGFCGLKNAGATCYMNSVLQQL 1686
            |......|::::...|:. :....||  .:|:||||||.:|.:.||.||:|.|||||||:|.|||
Human  1664 LADSSPSNLQIIIKELLS-MHHQPDPALTKEFDYLPPVDSRSSSGFVGLRNGGATCYMNAVFQQL 1727

  Fly  1687 YMVPAVRVGILRAHGAATTDGEDFSGDSDLTGGGLGSALFSGPASALVSLPSSSSTIEDGLHDVR 1751
            ||.|                                     |...:|:|:...:...:|.
Human  1728 YMQP-------------------------------------GLPESLLSVDDDTDNPDDS----- 1750

  Fly  1752 KNYHVVILKHVQAIFAHLGHSALQYYVPRGLWTHFKLLGEPVNLREQQDAVEFFMSLLESLDEGL 1816
                  :...||::|.||..|.||||||...|..||:..:.:.:||||||.|||.||::.:||.|
Human  1751 ------VFYQVQSLFGHLMESKLQYYVPENFWKIFKMWNKELYVREQQDAYEFFTSLIDQMDEYL 1809

  Fly  1817 KALGQPQLMNATLGGSFSDQKICQECPHRYSKEEPFSVFSVDIRNHSSLTESLEQYVKGELLEGA 1881
            |.:|:.|:...|..|.:||||||::|||||.:||.|...::.:.:..||..||:|:|:||:|||:
Human  1810 KKMGRDQIFKNTFQGIYSDQKICKDCPHRYEREEAFMALNLGVTSCQSLEISLDQFVRGEVLEGS 1874

  Fly  1882 DAYHCDKCDKKVVTVKRVCVKKLPPVLAIQLKRFEYDYERVCAIKFNDYFEFPRILDMEPYTVSG 1946
            :||:|:||.:|.:||||.|:|.||.||.|.|.||.:|:|...:||:::...||.:|:||||||||
Human  1875 NAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWMLNMEPYTVSG 1939

  Fly  1947 LAKLEGEVVEVGDNCQTNVE------------TTKYELTGIVVHSGQASGGHYFSYILSKNPANG 1999
            :|:.:.. .|||:|.::..:            |..|||.|::||||||..|||:|:|..:... |
Human  1940 MARQDSS-SEVGENGRSVDQGGGGSPRKKVALTENYELVGVIVHSGQAHAGHYYSFIKDRRGC-G 2002

  Fly  2000 KCQWYKFDDGEVTECKMHEDEEMKAECFGGEYMGETYDNNLKRMQYRRQKRWWNAYMLFYTR-CD 2063
            |.:||||:|..:.|..:: ||.::.|||||||..:.||........||  |:||||||||.| .|
Human  2003 KGKWYKFNDTVIEEFDLN-DETLEYECFGGEYRPKVYDQTNPYTDVRR--RYWNAYMLFYQRVSD 2064

  Fly  2064 Q-----------------------------------TPVQYEPSVEQLSL-------AESRNM-V 2085
            |                                   :|..:.|:.::||:       .|.:.: |
Human  2065 QNSPVLPKKSRVSVVRQEAEDLSLSAPSSPEISPQSSPRPHRPNNDRLSILTKLVKKGEKKGLFV 2129

  Fly  2086 LPLPKPIERSVRHQNIRFLHSRSIFSVEFFNFIKKLVSCNLLSARSNKITPAAEELSLLGVQLAS 2150
            ..:|..|.:.||.:|::|:.:|.::|.::|:|:..|.|.|....: :...|...::||   |||.
Human  2130 EKMPARIYQMVRDENLKFMKNRDVYSSDYFSFVLSLASLNATKLK-HPYYPCMAKVSL---QLAI 2190

  Fly  2151 QFLFHTGFRTKKSLRGPVMEWYDALSHHIRSSALVRKWFANHALLSPPSRLGE-YILMAPSPDVR 2214
            ||||.|..||||.||....||...:...:..|....:|...:.:.|....|.: ::|.....:||
Human  2191 QFLFQTYLRTKKKLRVDTEEWIATIEALLSKSFDACQWLVEYFISSEGRELIKIFLLECNVREVR 2255

  Fly  2215 ----TVFVKLVVFFCHFAINDEPLTGYDGANLCEQVLISVLRLLKSEAADYGKHLPHYFSLFSMY 2275
                |:..|.:         |..|...|......|:|..:|.||..:..:..|:...||.||:.:
Human  2256 VAVATILEKTL---------DSALFYQDKLKSLHQLLEVLLALLDKDVPENCKNCAQYFFLFNTF 2311

  Fly  2276 V-GLGTREKQQLLRLNVPLQFIQVALDDGPGPA---------IKYQYPEFSKLHQVVSHLIRCSD 2330
            | ..|.|....|||.:.....|...|    |.:         ...|..||..||..|:.|:..||
Human  2312 VQKQGIRAGDLLLRHSALRHMISFLL----GASRQNNQIRRWSSAQAREFGNLHNTVALLVLHSD 2372

  Fly  2331 VSEKCQSSNQNARPLSNPFKD-PNVA---HEELTPLSTECMDLLFNRTG--YIKKVI----EDTN 2385
            |     ||.:|..|  ..||. |.::   ...|.||..|...|||...|  |:.:|:    |.|.
Human  2373 V-----SSQRNVAP--GIFKQRPPISIAPSSPLLPLHEEVEALLFMSEGKPYLLEVMFALRELTG 2430

  Fly  2386 VGDEGLKLLQYCSWENPHFSRAVLTELLWQCGFAYCHDMRHHTDLLLNILLIDDSWQHHRIHNAL 2450
            .....::::.||.:.|.|||..:|..:..|...|..|::::...||..||:|:|..|..|:
Human  2431 SLLALIEMVVYCCFCNEHFSFTMLHFIKNQLETAPPHELKNTFQLLHEILVIEDPIQVERV---- 2491

  Fly  2451 NGVAEEREGLLETIQRAKTHYQKRAYQIIKCLTQLFHKSPIALQMLHTNSNITRHWSIAVEWLQG 2515
            ..|.|...|||..:..:......|.||.:|.|..|..|.|.|.:....||:   |||.||:|||.
Human  2492 KFVFETENGLLALMHHSNHVDSSRCYQCVKFLVTLAQKCPAAKEYFKENSH---HWSWAVQWLQK 2553

  Fly  2516 ELDRQRGIGCQYNSYSWSPPAQ-SNDNTNGYMLERSQSAKNTWSMAFELCPDEVSEKTDENNEPN 2579
            ::          :.:.|:|.:. ||:.:.|...:|:.||::|.:.|..|    ::||..
Human  2554 KM----------SEHYWTPQSNVSNETSTGKTFQRTISAQDTLAYATAL----LNEKEQ------ 2598

  Fly  2580 LETNMDENKSEPVAQPGGVLEGSTGGTEQLPENK 2613
                                .||:.|:|..|.|:
Human  2599 --------------------SGSSNGSESSPANE 2612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
faf	NP_524612.2	peptidase_C19C	1666..2064	CDD:239124	169/410 (41%)
		UCH	1668..2059	CDD:278850	164/402 (41%)
USP24	XP_016856320.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D22076at33208
OrthoFinder	1	1.000	-	-		FOG0002455
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102574
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1635
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.720