Protein Alignment faf and Usp40

DIOPT Version :9

• Sequence 1: NP_524612.2
• Gene: faf / 43749
• FlyBaseID: FBgn0005632
• Length: 2778
• Species: Drosophila melanogaster
• Sequence 2: NP_001185502.1
• Gene: Usp40 / 227334
• MGIID: 2443184
• Length: 1235
• Species: Mus musculus
• Alignment Length: 1225
• Identity: 243/1225 - (19%)
• Similarity: 383/1225 - (31%)
• Gaps: 450/1225 - (36%)

  Fly  1656 LPPVGARPTKGFCGLKNAGATCYMNSVLQQLYMVPAVRVGILRAHGAATTDGEDFSGDSDLTGGG 1720
            |.|...|......|::|.|.|||::|:||.|:..|..|
Mouse    29 LEPPAPREFTNLSGIRNQGGTCYLSSLLQTLHFTPEFR--------------------------- 66

  Fly  1721 LGSALFSGPASALVSL-PSSSSTIED-GLHDVRKNYHVVILKHVQAIFAHL------GHSALQYY 1777
                      .||.|| |....::|| ...|.:..   :|...:|.:||.|      ..|.:...
Mouse    67 ----------EALFSLGPEELGSLEDKDKPDAKVR---IIPLQLQRLFAQLLLLDQEAASTIDLT 118

  Fly  1778 VPRGLWTHFKLLGEPVNLREQQDAVEFFMSLLESLDEGLKALGQPQLMNATLGGSFSDQKICQEC 1842
            ...| ||:.:.:       .|.|..|....|..:|:..|.......|::....|:..:|.:|:||
Mouse   119 DSFG-WTNDEEM-------RQHDVQELNRILFSALETSLVGTSGHDLIHRLYHGTIVNQIVCKEC 175

  Fly  1843 PHRYSKEEPFSVFSVDIRNHSSLTESL-EQYVKGELLEGADAYHCDKCDKKVVTVKRVCVKKLPP 1906
            .:...::|.|...:|.::|.|.|.:.| ..||:.|:.:..:.|||..||:.|...|...::||||
Mouse   176 KNISERQEDFLDLTVAVKNVSGLEDELCNMYVEEEIFDYDNLYHCGTCDRLVKAAKSAKLRKLPP 240

  Fly  1907 VLAIQLKRFEYDYERVCAIKFNDYFEFPRILDMEPYTVSGLAKLEGEVVEVGDNCQTNVETTKYE 1971
            .|.|.|.||.:|:.:....|....:.||..::::|:.         |..|:.|      ....|:
Mouse   241 FLTISLLRFNFDFVKCERYKDTSCYTFPLRINLKPFC---------EQSELDD------MEYMYD 290

  Fly  1972 LTGIVVHSGQASGGHYFSYILS-KNPANGKCQWYKFDDGEVTECKMHEDEEMKAECFGGEYMGET 2035
            |..:::|.|...||||..||.. .:..|.:||                 ||:.
Mouse   291 LFSVIIHKGGCYGGHYHVYIKDVDHLGNWQCQ-----------------EEIS------------ 326

  Fly  2036 YDNNLKRMQYRRQKRWWNAYMLFYTRCDQTPVQYEPSVEQLSLAESRNMVLPLPKPIERSVRHQN 2100
             |.|:                               :|:.....|..|..|.:.|.|
Mouse   327 -DTNV-------------------------------NVKAPQSEEEANDPLVVLKTI-------- 351

  Fly  2101 IRFLHSRSIFSVEFFNFIKKLVSCNLLSARSNKITPAAEELSLLGVQLASQFLFHTGFRTKKSLR 2165
                                     ||...:|:| |..        ||..:.|..||....|..|
Mouse   352 -------------------------LLQEEANQI-PVD--------QLGQKLLKKTGISWNKKYR 382

  Fly  2166 ---GPVMEWYDALSHHIRSSALVRKWFANHALL-------SPPSRLGEYILMAPSPDVRTVFVKL 2220
               ||                 :||:...|..:       |..|.|..::..||| |:::
Mouse   383 KQHGP-----------------LRKFLQLHPQIFLLSTDESTVSLLRNHLTQAPS-DLQS----- 424

  Fly  2221 VVFFCHFAINDEPLTGYDGANLCEQVLISVLRLLKSEAADYG--KHLPHYFSLFSMYVGLGTREK 2283
                                  |||    :|..|.||:....  ...||:|.:....|. ..|||
Mouse   425 ----------------------CEQ----ILHTLASESPGLNDDTSCPHWFDINDSKVH-PIREK 462

  Fly  2284 QQLLRLNVPLQFIQVALDDGPGPAIKYQY--------PE--FSKLHQVVSHLIRCSDVSE----- 2333
                  ::..||      .|...|....|        ||  .:..::|..||::..|.:.
Mouse   463 ------DITQQF------QGKESAYMLFYRKATLQRPPEARANPRYRVPCHLLKEMDAANILLQM 515

  Fly  2334 ---KCQSSNQNAR---PLSNPFKDPNVAHEELTPLSTECMDLLFNRTGYIKKVIEDTN------- 2385
               :|.|:|....   .|...::..|.|.......:....||.|::    :|.:.|..
Mouse   516 RRAECDSANSTFELHLHLGPHYRFFNGALHPAVSETESVWDLTFDK----RKTLGDLRQSIFQLL 576

  Fly  2386 ---VGD----------EGLKLLQYCSWENPHFSRAVLTE----LLW----------QCGFAYCHD 2423
               .||          .||.:......::.....|.:.:    .:|          |.||. |.
Mouse   577 ECWEGDMVLSVAKRVPAGLHVYHTLDGDDLTLCEAEVADGEDIFVWNGVEVGGVQIQTGFD-CE- 639

  Fly  2424 MRHHTDLLLNILLIDDSWQHHRIHNALNGVAEEREGLLETIQRAKTHYQKRAYQIIKCLTQLFHK 2488
                 .||||||           |..|:|...:.|.|:|:     .|......::....|.|  .
Mouse   640 -----PLLLNIL-----------HLELSGEGSKCEQLVES-----PHVFPANAEVGAVFTAL--G 681

  Fly  2489 SPI-ALQMLHTNSNITRHWSIAVEWLQGELDRQRGIGCQYNSYSWSPPAQSNDNTNGYMLERSQS 2552
            :|. |:.|....|.....|:...:....:..|::|:  :..|...   .|.:|:.|..:|.:...
Mouse   682 TPAGAILMNSVESADGECWTAVPKEDMKKTFREQGL--RNGSLIL---VQDSDSDNNSLLPKQGR 741

  Fly  2553 AKNT-----WSMAFELCPDEVSEKTDE----------------NNEPNLETNMDENKS-EPVAQP 2595
            ..|:     |......|..|..||..:                ..|..|...:.||.. .|:.:.
Mouse   742 WTNSMNELNWLQVKNFCQSESEEKQVQIAVTMHTVVFDIRIKAIKELKLMKELAENSCLRPIDRN 806

  Fly  2596 GGVLEGSTGGTEQLPENKTPTTSSPSTAAWPARGDSNAIPRLSRQLFGAYTSTGSGSTSG---GS 2657
            |.:|              .|..            ||:.:.....::         ||:.|   |.
Mouse   807 GKLL--------------CPVP------------DSSTLEEAEVKM---------GSSVGLCLGK 836

  Fly  2658 APTS-------ALTTTAGSGANSETESSAQETTGETTINGLTNSLDQMEITAKKKCRRVIIKKLV 2715
            ||||       ||.|....||  |.:...:||                  .:.:.|.:::::|..
Mouse   837 APTSSQLFLFFALGTDIHPGA--EMDIIVEET------------------LSVRDCLKIMLEKSG 881

  Fly  2716 ESKD------------------EEDATTATTAATTEVTTSPATAIATAATLEPAG 2752
            :..:                  |||||....     :..|..|.:.|...|.|.|
Mouse   882 QQGEIWHLRKMDWCYEAGEPLCEEDATLKEL-----MIRSGDTLLLTEGKLPPPG 931

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
faf	NP_524612.2	peptidase_C19C	1666..2064	CDD:239124	92/407 (23%)
		UCH	1668..2059	CDD:278850	92/400 (23%)
Usp40	NP_001185502.1	peptidase_C19C	39..342	CDD:239124	94/426 (22%)
		UCH	42..340	CDD:278850	93/421 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5077
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900