Protein Alignment faf and Usp40

DIOPT Version :10

• Sequence 1: NP_524612.2
• Gene: faf / 43749
• FlyBaseID: FBgn0005632
• Length: 2778
• Species: Drosophila melanogaster
• Sequence 2: NP_001185502.1
• Gene: Usp40 / 227334
• MGIID: 2443184
• Length: 1235
• Species: Mus musculus
• Alignment Length: 1209
• Identity: 240/1209 - (19%)
• Similarity: 380/1209 - (31%)
• Gaps: 418/1209 - (34%)

  Fly  1656 LPPVGARPTKGFCGLKNAGATCYMNSVLQQLYMVPAVRVGILRAHGAATTDGEDFSGDSDLTGGG 1720
            |.|...|......|::|.|.|||::|:||.|:..|..|
Mouse    29 LEPPAPREFTNLSGIRNQGGTCYLSSLLQTLHFTPEFR--------------------------- 66

  Fly  1721 LGSALFSGPASALVSL-PSSSSTIED-GLHDVRKNYHVVILKHVQAIFAHL------GHSALQYY 1777
                      .||.|| |....::|| ...|.:..   :|...:|.:||.|      ..|.:...
Mouse    67 ----------EALFSLGPEELGSLEDKDKPDAKVR---IIPLQLQRLFAQLLLLDQEAASTIDLT 118

  Fly  1778 VPRGLWTHFKLLGEPVNLREQQDAVEFFMSLLESLDEGLKALGQPQLMNATLGGSFSDQKICQEC 1842
            ...| ||:.:.:       .|.|..|....|..:|:..|.......|::....|:..:|.:|:||
Mouse   119 DSFG-WTNDEEM-------RQHDVQELNRILFSALETSLVGTSGHDLIHRLYHGTIVNQIVCKEC 175

  Fly  1843 PHRYSKEEPFSVFSVDIRNHSSLTESL-EQYVKGELLEGADAYHCDKCDKKVVTVKRVCVKKLPP 1906
            .:...::|.|...:|.::|.|.|.:.| ..||:.|:.:..:.|||..||:.|...|...::||||
Mouse   176 KNISERQEDFLDLTVAVKNVSGLEDELCNMYVEEEIFDYDNLYHCGTCDRLVKAAKSAKLRKLPP 240

  Fly  1907 VLAIQLKRFEYDYERVCAIKFNDYFEFPRILDMEPYTVSGLAKLEGEVVEVGDNCQTNVETTKYE 1971
            .|.|.|.||.:|:.:....|....:.||..::::|:.         |..|:.|      ....|:
Mouse   241 FLTISLLRFNFDFVKCERYKDTSCYTFPLRINLKPFC---------EQSELDD------MEYMYD 290

  Fly  1972 LTGIVVHSGQASGGHYFSYILS-KNPANGKCQWYKFDDGEVTECKMHEDE-------------EM 2022
            |..:::|.|...||||..||.. .:..|.:||....|.....:....|:|             :.
Mouse   291 LFSVIIHKGGCYGGHYHVYIKDVDHLGNWQCQEEISDTNVNVKAPQSEEEANDPLVVLKTILLQE 355

  Fly  2023 KAECFGGEYMGETYDNNLKR------MQYRRQKRWWNAYMLFYTRCDQTPVQYEPSVEQLSLAES 2081
            :|.....:.:|:..   ||:      .:||:|......::           |..|.:..||..||
Mouse   356 EANQIPVDQLGQKL---LKKTGISWNKKYRKQHGPLRKFL-----------QLHPQIFLLSTDES 406

  Fly  2082 RNMVLPLPKPIERSVRHQNIRFLHSRSIFSVEFFNFIKKLVSCNLLSARSNKITPAAEELSLLGV 2146
                                                        .:|...|.:|.|..:|
Mouse   407 --------------------------------------------TVSLLRNHLTQAPSDL----- 422

  Fly  2147 QLASQFLFHTGFRTKKSLRGPVM--EWY---DALSHHIRSSALVRK----------WFANHALLS 2196
            |...|.| ||.......|.....  .|:   |:..|.||...:.::          ::....|..
Mouse   423 QSCEQIL-HTLASESPGLNDDTSCPHWFDINDSKVHPIREKDITQQFQGKESAYMLFYRKATLQR 486

  Fly  2197 PPSRLGEYILMAPSPDVRTVFVKLVVFFCHFAINDEPLTGYDGANLCEQVLISVLRLLKSEAADY 2261
            ||..........|               ||.      |...|.||:..|     :|..:.::|:
Mouse   487 PPEARANPRYRVP---------------CHL------LKEMDAANILLQ-----MRRAECDSAN- 524

  Fly  2262 GKHLPHYFSLFSMYVGLGTREKQQLLRLNVPLQFIQVALDDGPGPAIKYQYP----EFSK----- 2317
                    |.|.:::.||..           .:|...||.    ||:.....    .|.|
Mouse   525 --------STFELHLHLGPH-----------YRFFNGALH----PAVSETESVWDLTFDKRKTLG 566

  Fly  2318 -LHQVVSHLIRCSDVSEKCQSSNQNARPLSNPFKDPNVAH-------EELTPLSTECMDLLFNRT 2374
             |.|.:..|:.|.          :....||...:.|...|       ::||....|..|
Mouse   567 DLRQSIFQLLECW----------EGDMVLSVAKRVPAGLHVYHTLDGDDLTLCEAEVAD------ 615

  Fly  2375 GYIKKVIEDTNVGDEGLKLLQYCSWENPHFSRAVLTELLWQCGFAYCHDMRHHTDLLLNILLIDD 2439
            |....|.....||  |:::                     |.||. |.      .||||||
Mouse   616 GEDIFVWNGVEVG--GVQI---------------------QTGFD-CE------PLLLNIL---- 646

  Fly  2440 SWQHHRIHNALNGVAEEREGLLETIQRAKTHYQKRAYQIIKCLTQLFHKSPI-ALQMLHTNSNIT 2503
                   |..|:|...:.|.|:|:     .|......::....|.|  .:|. |:.|....|...
Mouse   647 -------HLELSGEGSKCEQLVES-----PHVFPANAEVGAVFTAL--GTPAGAILMNSVESADG 697

  Fly  2504 RHWSIAVEWLQGELDRQRGIGCQYNSYSWSPPAQSNDNTNGYMLERSQSAKNT-----WSMAFEL 2563
            ..|:...:....:..|::|:  :..|...   .|.:|:.|..:|.:.....|:     |......
Mouse   698 ECWTAVPKEDMKKTFREQGL--RNGSLIL---VQDSDSDNNSLLPKQGRWTNSMNELNWLQVKNF 757

  Fly  2564 CPDEVSEKTDE----------------NNEPNLETNMDENKS-EPVAQPGGVLEGSTGGTEQLPE 2611
            |..|..||..:                ..|..|...:.||.. .|:.:.|.:|
Mouse   758 CQSESEEKQVQIAVTMHTVVFDIRIKAIKELKLMKELAENSCLRPIDRNGKLL------------ 810

  Fly  2612 NKTPTTSSPSTAAWPARGDSNAIPRLSRQLFGAYTSTGSGSTSG---GSAPTS-------ALTTT 2666
              .|..            ||:.:.....::         ||:.|   |.||||       ||.|.
Mouse   811 --CPVP------------DSSTLEEAEVKM---------GSSVGLCLGKAPTSSQLFLFFALGTD 852

  Fly  2667 AGSGANSETESSAQETTGETTINGLTNSLDQMEITAKKKCRRVIIKKLVESKD------------ 2719
            ...||  |.:...:||                  .:.:.|.:::::|..:..:
Mouse   853 IHPGA--EMDIIVEET------------------LSVRDCLKIMLEKSGQQGEIWHLRKMDWCYE 897

  Fly  2720 ------EEDATTATTAATTEVTTSPATAIATAATLEPAG 2752
                  |||||....     :..|..|.:.|...|.|.|
Mouse   898 AGEPLCEEDATLKEL-----MIRSGDTLLLTEGKLPPPG 931

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
faf	NP_524612.2	Ubl1_cv_Nsp3_N-like	<994..1060	CDD:475130
		peptidase_C19C	1666..2064	CDD:239124	98/426 (23%)
		DUF3517	2198..2566	CDD:463438	73/390 (19%)
Usp40	NP_001185502.1	peptidase_C19C	39..342	CDD:239124	91/365 (25%)