Protein Alignment faf and Usp34

DIOPT Version :9

• Sequence 1: NP_524612.2
• Gene: faf / 43749
• FlyBaseID: FBgn0005632
• Length: 2778
• Species: Drosophila melanogaster
• Sequence 2: XP_006514628.1
• Gene: Usp34 / 17847
• MGIID: 109473
• Length: 3583
• Species: Mus musculus
• Alignment Length: 2881
• Identity: 548/2881 - (19%)
• Similarity: 915/2881 - (31%)
• Gaps: 1086/2881 - (37%)

  Fly     7 RHTTGQPGSTAPSSSSSTTSTTTTTTSPAQSAGSGSGIGTGTGTVANSSLPGGGSGS-------- 63
            :|...:...|..|...|:..|..:....:...||.||...|:....|||.....:||
Mouse   548 KHVQQRLSDTEESMQGSSDETANSGEDGSSGPGSSSGHSDGSSNEVNSSHASQSAGSPGSEVQSE 612

  Fly    64 --------------------LDGNQDQQPATDSQSSDDVAASLSANSVDSTITIVPPEKLISSFP 108
                                .:..:|.:...|.:..||.......|...:|.
Mouse   613 DIADIEALKEEEEEEEEEEEEEEEEDDEEEEDEEEDDDDDDDHGHNPAKNTC------------- 664

  Fly   109 TTKLRSLTQKISNPRWVVPVLPEQELEVLLNAAIELTQAGVDHDCEPCVEFYRNGLSTSFAK--I 171
            .|:||:  :|:.||..:  .|.|.:              |...         |||.::...|  :
Mouse   665 GTELRN--RKLENPAGI--CLGESQ--------------GTSE---------RNGTNSGTGKDLV 702

  Fly   172 LTDEAVNSWKNNIHHCILVSCGKLLHLIAIHMQRDNPYLLDLLAIVFDPENKFN------TFNAG 230
            ...|.:.|..|.|.                        :||..|...|||:..:      ....|
Mouse   703 FNTEPLPSVDNRIR------------------------MLDACAHSEDPEHGISGEVSSAHLAQG 743

  Fly   231 RQPECFAAPDYIWGQLDSNKMYARPPPEPKNAR------------------------------GW 265
            .|..|........|:...|:::        |.|                              |.
Mouse   744 SQEACITRSGDFLGETIGNELF--------NCRQFIGPQHHHHHHHHHHHHHHHHHHHHHHHDGH 800

  Fly   266 LVDLINRFGQLGGFDNLLERFNIGLELLKRNQNKCTGKNISVEGRVENGAQDNRLTLALIHSLLR 330
            :||                      ::|..:...|:...:|.:.  |....|
Mouse   801 MVD----------------------DMLSADDVSCSSSQVSAKS--EKNMAD------------- 828

  Fly   331 PFGQCYELLMPATIAKYFMPTWNVVLDLLDSFTDEELKREVKPEGRNDYINGIVKSARLLASRLT 395
                                           |..||                            :
Mouse   829 -------------------------------FDGEE----------------------------S 834

  Fly   396 GQEELIRDLEMFRLKMILRLLQVSSFNGKMNALNEINKVLSSVAYFSHRSQ-PL--PHCMPEDEM 457
            |.||              .|:|::|.....:.|.:....|:|: |..|.|| |.  .|....:.:
Mouse   835 GCEE--------------ELVQINSHAELTSHLQQHLPNLASI-YHEHLSQGPAVHKHQFSSNAV 884

  Fly   458 DWLTADRMAQWIKSSDVLGVVLKDSLHQPQYVEKLEKIIRFLIKEQALTLDDLDAVWRAQAGKHE 522
            ..:..|.:.:  |.:.:|..:::|                    :.|:.|.             |
Mouse   885 TDINLDNVCK--KGNTLLWDIVQD--------------------DDAINLS-------------E 914

  Fly   523 AIVKNVHDLLAKLAWDFTPEQLDHLFEAFQASMTTANKRQRERLLELIRRLAEDDKNGVMAQKVL 587
            .::.....||..|...||..|:                  |.|.:|.......::::.|::.::|
Mouse   915 GLINEAEKLLCSLVCWFTDRQI------------------RMRFIEGCLENLGNNRSVVISLRLL 961

  Fly   588 -KLFWTLAHSQEVPPEVLDQALGAHVKILDYSCSQERDAQKTIWLDKCVDELKSGDGWVLPALRL 651
             |||.|.            |..|:              :..|.|:..          |.
Mouse   962 PKLFGTF------------QQFGS--------------SYDTHWITM----------WA------ 984

  Fly   652 IRDICCLYDTTTNHAQRTQTSTNRQQVIERLQNDYSLVILVTNSLTAYMEKVRQMVTDSPGLDAT 716
                                           :.:.:::.|..::|..|::.:|
Mouse   985 -------------------------------EKELNMMKLFFDNLVYYIQGIR------------ 1006

  Fly   717 RILIDGR-----FPHHVQIAERLEFL----KFLLKDGQLWLCADQAKQIWHCLAVNAVFPADREE 772
                :||     :.|..::..||:||    ..|.......|..:|...:||||       .:..|
Mouse  1007 ----EGRQKHALYSHSAEVQVRLQFLTCVFSTLGSPDHFRLSLEQVDILWHCL-------VEDSE 1060

  Fly   773 CF----RWFGKLMGEEPDLDPGIN--KDFFENNILQLDPHLLTESGIKCFERFFKAVNSKEDKLK 831
            |:    .||...:..:.....|:.  |..|...:.||.|..::.:|:..|:..   .|.......
Mouse  1061 CYDDALHWFLNQVRSKDQHAMGMETYKHLFLEKMPQLKPETISMTGLNLFQHL---CNLARLATS 1122

  Fly   832 AIHRGYMLDNEDLIGKDYLWRVITTGGEEIASKAIDLLKEVSTALGPRLQENIAEFHEMFIGECC 896
            |...|   .|.:|.|.|..|      |..:.:::.|:
Mouse  1123 AYDGG---SNSELCGMDQFW------GIALRAQSGDV---------------------------- 1150

  Fly   897 SRLRTHYGN-IVILGKTQLQEELDAPDQSDNTNDESKDSKMRFIEAEKMCRILKVLQEYVKECDR 960
            ||....|.| ..|.|||.|::|                                  ||::.:|..
Mouse  1151 SRAAIQYINSYYINGKTGLEKE----------------------------------QEFISKCME 1181

  Fly   961 SFS------GDRVHLPLSRVTRGKNTILYIRFQNPGRSIDDMEIVTHSNETMAAFKRNLLK---- 1015
            |..      ....|..|:.:.||   :|.::              ||    :.||:|....
Mouse  1182 SLMIASSSLEQESHSSLTVIERG---LLMLK--------------TH----LEAFRRRFAYHLRQ 1225

  Fly  1016 -RIKGTSTAN-------------------------IKVDLFYANDEMIGVSDEINPLYQYTIRDK 1054
             :|:||..::                         :.::: |.:|::..:..|:...|:...:::
Mouse  1226 WQIEGTGISSHLKALSDKQSLPLRVVCQPAGLPDKMTIEM-YPSDQVADLRAEVTHWYENLQKEQ 1289

  Fly  1055 MNLTAKLTPVGTG----------------LASSPDSSSD------------------SSTGSP-- 1083
            :|..|:|...|..                ::|..:.::|                  .|.|:|
Mouse  1290 INQQAQLQEFGQSSRKGEFPGGLMGPVRMISSGHELTTDYDEKALHELGFKDMQMVFVSLGAPRR 1354

  Fly  1084 ---------PRPC-PDMQRVESESTLPGVIISQNYQYTEFFLKLYQLGS-----------DLEHG 1127
                     |..| |..|:    ..:|.:::.|....|..|..|..|.|           |.|..
Mouse  1355 ERKGEGVQLPASCLPPPQK----DNIPMLLLLQEPHLTTLFDLLEMLASFKPPSGKVAVDDSESL 1415

  Fly  1128 RLRD--------SAKV--LLHLLP-C-----------DRQT--------IRQLKIMCKVPKAAVT 1162
            :..:        |.:|  ||.||| |           |.|:        :.::|...|:..|...
Mouse  1416 KCEELHLHAENLSRRVWELLMLLPTCPNMLTAFQNVSDEQSNDGLNWKELLKIKSAHKLLYALEI 1480

  Fly  1163 VAVTGDKIAKDEEEK------LYPTEQAGIEDEEEH------CTPEQMFLHPTPAQVLYNLSVLH 1215
            :...|....:...|.      |||......||:.|:      |    .|:.....|.|  |.:.:
Mouse  1481 IEALGKPNRRIRRESTGSYSDLYPDSDDSSEDQVENSKNSWTC----KFVAAGGLQQL--LEIFN 1539

  Fly  1216 GLLIPALDPLGESALLVQSAWMHSGCAHFVLELLTKNNFLPS---------------ADMHTKR- 1264
            ..:   |:|..:.:..|   | ...|...:|:|:.:....||               |:.|.||
Mouse  1540 SAI---LEPKEQESWTV---W-QLDCLACLLKLICQFAVDPSDLDLAYHDVFAWSGIAESHRKRT 1597

  Fly  1265 ------------ASFQCVLRLAKLFLYIVGSVLSRVGDEPMICDLDNGSRSQVDILKQNFSTMPS 1317
                        |....:.||.::||.:|
Mouse  1598 WPGKSRKAAGDHAKSLHIPRLTEVFLVLV------------------------------------ 1626

  Fly  1318 SSQGTLRAISAKLAVILAREMLSASPEGDRC--RTLFSSTLQWSCPDISTIKAVVQLAWASSCGN 1380
              |||          .|.:.::|.:...|..  |.|.:.:...|..::|.....:.::||..|
Mouse  1627 --QGT----------SLIQRLMSVAYTYDNLAPRVLKAQSDHRSRHEVSHYSMWLLVSWAHCC-- 1677

  Fly  1381 LQALGNSSGDFEDEVIVPDGQDFSMCKEALEVLTISFILNPSANEALTSD--PNWPKFITSIVLK 1443
                                   |:.|.:|                ..||  .:|.|.:|.::.:
Mouse  1678 -----------------------SLVKSSL----------------ADSDHLQDWLKQLTLLIPE 1703

  Fly  1444 NPLRHVRQVASEQLFLASTYCAGD--RRPFVYMVNLLVGA---LKTL----------VPQYEST- 1492
            ..:||.......:|.| |....||  .|.|     ||:.|   ||.|          :..||..
Mouse  1704 TAVRHESCNGLYKLSL-SGLDGGDSIHRSF-----LLLAASTLLKFLPDAQALKPPRIDDYEEEP 1762

  Fly  1493 -----CAEFFSVLCRTLSYGCIYNWPLQISEGLLGDEIKWLQRIRENVH---ATGDTQVHEELLE 1549
                 |.|:|.:||:.:                            :|:|   |:..|.:..:.|.
Mouse  1763 LLKPGCKEYFWLLCKLV----------------------------DNIHIKDASQTTLLDLDALA 1799

  Fly  1550 GHL--CL-AKELMFFLGA----DSKAQLNELIHELI---DDFLFT-ASREFLH--------LRRH 1595
            .||  |: ::|::..|..    |..:.|..|...:|   ..|.|: ..:|||.        |...
Mouse  1800 RHLADCIRSREILDHLDGSIEDDGLSGLLRLATSVIKHKPPFKFSREGQEFLRDIFNLLFLLPSL 1864

  Fly  1596 GSLRQDTVPPPVCRSPHTIAAACDLLIALCQLCVPNMKLLTNTLIDFVCTDTDPLREWDYLPPVG 1660
            ...||     |.|:|....|||.|||:.:.:..|.|.:|:.|.::...........:|||.|...
Mouse  1865 KDRRQ-----PKCKSHSCRAAAYDLLVEMVKGSVENYRLIHNWVMAQHMQSAHAPYKWDYWPHED 1924

  Fly  1661 ARPTKGFCGLKNAGATCYMNSVLQQLYMVPAVRVGILRAHGAATTDGEDFSGDSDLTGGGLGSAL 1725
            .|....|.||.|.|||||:.|.:|||||:|..|                             .|:
Mouse  1925 VRAECRFVGLTNLGATCYLASTIQQLYMIPEAR-----------------------------QAV 1960

  Fly  1726 FSGPASALVSLPSSSSTIEDGLHDVRKNYHVVILKHVQAIFAHLGHSALQYYVPRGLWTHFKLLG 1790
            |:...|                .|::   |...|..:|.:|.:|..|..:.|.||.....:.:..
Mouse  1961 FTAKYS----------------EDMK---HKTTLLELQKMFTYLMESECKAYNPRPFCKTYTMDK 2006

  Fly  1791 EPVNLREQQDAVEFFMSLLESLDEGLKALGQPQLMN---ATLGGSFSDQKICQECPHRYSKEEPF 1852
            :|:|..||:|..|||..|:..::|     ..|:|.|   :..||..::..:..:|.|.....|.|
Mouse  2007 QPLNTGEQKDMTEFFTDLITKVEE-----MSPELKNTVKSLFGGVITNNVVSLDCEHVSQTAEEF 2066

  Fly  1853 SVFSVDIRNHSSLTESLEQYVKGELLEGADAYHCDKCDKKVVTVKRVCVKKLPPVLAIQLKRFEY 1917
            ......:.:..::.|||::....:.|||.:.|.|..|.|||...||.|.||||.:|:....|:.:
Mouse  2067 YTVRCQVADMKNIYESLDEVTIKDTLEGDNMYTCSHCGKKVRAEKRACFKKLPRILSFNTMRYTF 2131

  Fly  1918 DYERVCAIKFNDYFEFPRILDMEPYT---VSGLAKLEGEVVEVGDNCQTNVETTKYELTGIVVHS 1979
            :...:...|.|.:|.||..|||.|||   :.|.:..:....:|||..: :.|:.:|:|.|:.||:
Mouse  2132 NMVTMMKEKVNTHFSFPLRLDMTPYTEDFLMGKSDRKEGFKDVGDRSK-DTESYEYDLIGVTVHT 2195

  Fly  1980 GQASGGHYFSYILS-KNP---ANGKCQWYKFDDGEVTECKMHEDEEMKAECFGGEYMGETYDNNL 2040
            |.|.||||:|:|.. .||   .|.|  ||.|:|.||   |..:..::.:||||||...:|||:..
Mouse  2196 GTADGGHYYSFIRDIVNPHAYKNNK--WYLFNDAEV---KPFDSAQLASECFGGEMTTKTYDSVT 2255

  Fly  2041 KRMQYRRQKRWWNAYMLFYTRCDQTPVQYEPSVEQLSLAESRNMVLPLPKPIERSVRHQNIRFLH 2105
            .:......::..:||||||.|       .||..|     ..|.....:...:...:.|.|::||.
Mouse  2256 DKFMDFSFEKTHSAYMLFYKR-------MEPEEE-----NGREYKFDVSSELLEWIWHDNMQFLQ 2308

  Fly  2106 SRSIFSVEFFNFIKKLVSCNLLSARSNKITPAAEELSLLGVQLASQFLFHTGFRTKKSLRGPVME 2170
            .::||...:|.|:.:|.||      .....|..:.:||:..:|::.|:..|...:|:  :..:::
Mouse  2309 DKNIFEHTYFGFMWQLCSC------IPSTLPDPKAVSLMTAKLSTSFVLETFIHSKE--KPTMLQ 2365

  Fly  2171 WYDALSHHIRSSALVRKWFANHALLSPPSRLG-------EYILMAPSPDVRTVFVKLVV------ 2222
            |.:.|:....:|....:||.:        |:.       :.::..|:..||.:|.:|.:
Mouse  2366 WIELLTKQFNNSQAACEWFLD--------RMADDDWWPMQILIKCPNQIVRQMFQRLCIHVIQRL 2422

  Fly  2223 --FFCHFAINDEPLTGYD---------GANLCEQVLISVLRLLKSEAA-DYGKHLPHYFSLFSMY 2275
              ...|..:......|.|         |...|....:..|.|:..... .:.|||..||:....:
Mouse  2423 RPVHAHLYLQPGMEDGSDDMDASVEDIGGRSCVTRFVRTLLLIMEHGVKPHSKHLTEYFAFLYEF 2487

  Fly  2276 VGLGTREKQQLLRLNVPLQFIQVALDDGPGPAIKYQYPEFSKLHQVVSHLIRCSDVSEKCQSSNQ 2340
            ..:|..|.|.||.|......:...:.. .||    :.|:...|.:            |:.:...:
Mouse  2488 AKMGEEESQFLLSLQAISTMVHFYMGT-KGP----ENPQVEVLSE------------EEGEEEEE 2535

  Fly  2341 NARPLSNPFKDPNVAHEELTPLSTECMDLLFNRTGYIKKVIEDTNVGDEGLKLLQYCSWENPHFS 2405
            ....||       :|.|:..|.:.|.|..|      :..::|.:. .:..|.|.|
Mouse  2536 EEDILS-------LAEEKYRPAALEKMIAL------VALLVEQSR-SERHLTLSQ---------- 2576

  Fly  2406 RAVLTELLWQCG-----FAYCH-----DMRHHTDLLLNILLIDDSWQHHRIHNALNGVAEEREGL 2460
                |::....|     |.:.|     ::|...:|:.::.         |.:|.|   ||....:
Mouse  2577 ----TDMAALTGGKGFPFLFQHIRDGINIRQTCNLIFSLC---------RYNNRL---AEHIVSM 2625

  Fly  2461 LETIQRAKTHYQKRAYQIIKCLTQLFH-------KSPIALQMLHTNSNITRHWSI-------AVE 2511
            |.|.....|  .:.|....|.||.|..       ..|.|..:|.      |.|.:       .::
Mouse  2626 LFTSIAKLT--PEAANPFFKLLTMLMEFAGGPPGMPPFASYILQ------RIWEVIEYNPSQCLD 2682

  Fly  2512 WLQGELDRQRGIGCQYNSYSW 2532
            ||..:..|.:      .::||
Mouse  2683 WLAVQTPRNK------LAHSW 2697

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
faf	NP_524612.2	peptidase_C19C	1666..2064	CDD:239124	126/407 (31%)
		UCH	1668..2059	CDD:278850	122/400 (31%)
Usp34	XP_006514628.1	peptidase_C19C	1930..2279	CDD:239124	126/414 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D625455at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920