DRSC/TRiP Functional Genomics Resources

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Protein Alignment faf and T24B8.7

DIOPT Version :10

Sequence 1:NP_524612.2 Gene:faf / 43749 FlyBaseID:FBgn0005632 Length:2778 Species:Drosophila melanogaster
Sequence 2:NP_495931.4 Gene:T24B8.7 / 174440 WormBaseID:WBGene00011980 Length:2938 Species:Caenorhabditis elegans


Alignment Length:3359 Identity:642/3359 - (19%)
Similarity:1148/3359 - (34%) Gaps:1094/3359 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 TGQPGSTAPSSSSSTTSTTTTTTSPAQSAGSGSGIGTGTGTVANSSLPGGGSGSLDGNQDQQPAT 74
            :|..|....|:|.:|.:.::...:||:...: .||.....:.:.::.....|.....|||.....
 Worm    80 SGDEGPRKRSASPATANQSSWGDNPAKKICT-EGIDLWVQSTSEATAVPDVSQQYQDNQDMLITM 143

  Fly    75 DSQSSD-DVAASLSANSVDSTITIVPPEKLISSFPTTKLRSLTQKISNPRWVVPVLPEQELEVLL 138
            ..:|.: |.|..||.|.|:..|                 :.||::||.                |
 Worm   144 GFKSEEIDTALRLSNNDVEKAI-----------------QYLTREISG----------------L 175

  Fly   139 NAAIELTQAGVDHDCEPCVEFYRNGLSTSFAKILTDEAVNSWKN-----------NIHHCILVSC 192
            ::|.....:.|:....|..:..||....|..:.:.:|....|.:           |.|..::...
 Worm   176 DSAPITASSSVEKSKYPLNDLVRNQFVESDEEDVAEEMRTVWDDASMARIKTILENNHKYVIFHQ 240

  Fly   193 GKLLH---LIAIHMQRDNPYLLDLLAIVFDPENKFNTFNAGRQPECF--------------AAPD 240
            ...||   ::|.::.|...:  :.::.|.:..::|.:|..||...|.              ..|.
 Worm   241 NGTLHRRLIVATNILRSGKH--ERMSEVLNFVDEFMSFIIGRHVNCSDVRPGFELLRQLLELQPP 303

  Fly   241 YIWGQLDSN-----------KMYARPPPEPKNARGWLV-----DLINRFGQLG-GFDNLLER--- 285
            || |:.:::           .:.||....|.:.:..|.     :..|:|...| .:.:|.||   
 Worm   304 YI-GEPEAHAIEQFYIAITPMLCARLTITPSSVKTVLAIDEMFNFRNKFFIQGVQYIDLPEREFP 367

  Fly   286 --FNIGLELLKRNQNKCTGKNIS----------VEGRVEN-GAQD-NRLTLALIHSLLRPFGQCY 336
              ..|.||.|:|.:.|.....::          ::.:|:. |.:| :.:||..:..|||..    
 Worm   368 PLKYIDLERLERLEYKRIYAYLADVFVDALIPMIDEKVDAIGDEDTSEVTLLDLQCLLRAL---- 428

  Fly   337 ELLMPATIAKYFM-----------PTWNVVLDLLDSF---TDEELKREVKPEGRNDYINGIVKSA 387
                  .|...||           .||  :...||.|   .|:|::..:......|.:..||   
 Worm   429 ------NIFSNFMHRGNDLFLCKLETW--ISKSLDRFRIVNDKEVRDALIRRQGLDLLQEIV--- 482

  Fly   388 RLLASRLTGQEELIRDLEMFRLKMILRLLQVSSFNGKMNALNEINKVLSSVAYFSHRSQPLPHCM 452
             :|..|.  ..|:....:..||..:.:.::.......::||.|    |.::|...||:..:....
 Worm   483 -ILCDRF--GLEVATTTQSARLNYLRKWIKCPQMESILHALEE----LGTIADRFHRTGGMTITR 540

  Fly   453 PEDEMDWLTADRMAQWIKSSDVLGVVLKDSLHQPQYVEKLEKIIRFLIKEQALTLDDLDAVWRAQ 517
            |:..::   .:...:|::.:.||.:||..::....|||:::.|::::..|  ||.|||..||..:
 Worm   541 PKSHVN---EEFFKKWLEENKVLQIVLTGNMDHVVYVERIQPILQYMTPE--LTFDDLKFVWSLR 600

  Fly   518 AGKHEAIVKNVHDLLAKLAWDFTPEQLDHLFEAFQASMTTANKRQRERLLELIRRLA-EDDKNGV 581
            .|:....|.|.:.::..::.....||::.|.|.|:.|..:...|..|.:......:| :.|::..
 Worm   601 KGRMGVSVDNFNKIMEFISKSVNNEQIEWLIELFKKSFRSRETRLYEPIFNFSYTIAIQKDRDDE 665

  Fly   582 MAQKVLKLFWTLAHSQEVPP-----EVLDQALGAHVKILDYSCSQ-ERDAQKTIWLDKCVDELKS 640
            ...|:..:.|.|.|....||     :.::..:..|..:|.....: |||:    :|...:|.|..
 Worm   666 CKLKICNVIWELIHIARGPPRCGSFKAIEHGMKKHCDLLGMMFDKSERDS----FLTNMMDGLNV 726

  Fly   641 GDGWVLPALRLIRDICCLY--------------------DTTTNHAQRTQTSTNRQQ----VIER 681
            .:|:        .:|..:|                    |.|.:.....:.|...::    :::|
 Worm   727 DEGF--------NEITVVYLFIMLDKLKRTFTPKRSTHGDETLSRVNELKASLRERKLADPLLDR 783

  Fly   682 LQNDYSLVILVTN-----SLTAYMEKVRQMVTDSPGLDATRILIDGRFPHHVQ------------ 729
            |:|    :..|.:     ||.|..:.....|.:|..        |....|||.            
 Worm   784 LEN----IRHVAHERFEASLNANQDSQSNAVFESTN--------DVFGSHHVDNILTTSVYGCTD 836

  Fly   730 ----IAERLEFLKFLLKDGQLWLCADQAKQIWHCLAVNAVFPADREECFRWFGKLMGEEPDLDPG 790
                :...|..||        ||         |.:..:.|   |.|...|.| |:..|:.|..|.
 Worm   837 YGFVLQNTLRLLK--------WL---------HDVDASIV---DVEYVQRLF-KIFIEQSDSKPQ 880

  Fly   791 INKD----FFENNILQLDP--------HL-------LTESGIKCFERFFKAV----NSKEDKLKA 832
            ...:    .||..::.:.|        ||       |..:|::||.::::.:    |.:...:::
 Worm   881 EKTEIFGFLFEVRMVLMRPETSRAIITHLCGMDIFTLQITGLRCFCKYWEELPILSNEESRPVES 945

  Fly   833 IHRGYMLDNEDLIGKDYLWRVITTGG-EEIASKAIDLLKEVSTALGPRLQENIAEFHEMFIGECC 896
            .......|||   .|.::|::|.... :::..|.::...|                .::.:.|..
 Worm   946 FIVKLQKDNE---CKLFVWKLILFNQFDDVVEKCMETFCE----------------RDLVLVESP 991

  Fly   897 SRLRTH-YGNIVILG------KTQLQEELDAP------DQSDNTNDESKDSKMRFIEAEKMC--R 946
            ..:|.| |..:.:..      |::|.:....|      |.::.|.:|. :.|...:..:.|.  .
 Worm   992 YSVRHHTYSFLSVFSFYVEKLKSELYKRSGKPLTEISYDTTELTMNED-EIKQHDVPLDGMLTET 1055

  Fly   947 ILKVLQEYVKECDR--SFSGDRVHLPLSRVTRGKN-----TILYIRFQNPGRSIDD-----MEIV 999
            |::.|...|:...|  ....::.|:.....:.|.:     ....|..:|....||.     ..::
 Worm  1056 IVRALNRLVRFMTRFVELGNEKNHMIRENPSHGSSISGHAVTFNIELKNDDDDIDCGLNAWKTLI 1120

  Fly  1000 THSNETMAAFKRNLLKRI---KGTS--------------TANIKVDLFYANDEMIGVSDEINPLY 1047
            ..|:.|:..||..:.||:   :|.:              .||::.|  :...:.:.::.|.:.::
 Worm  1121 CDSSTTVGEFKVRIAKRLHFHEGMTEFTVHKREDDLTMGEANLRYD--FLTLQSVKLASETDSVF 1183

  Fly  1048 QYTIRDKMNLTAKLTPVGTGLASSPDSSSDSSTGSPPRPCPDMQ-------RVESESTLPGVIIS 1105
               :.:|:.:..|           |..||:..:        |:|       :...|..||..|||
 Worm  1184 ---LSEKLRILVK-----------PKKSSNRRS--------DLQNHQYSQKKALREDFLPMSIIS 1226

  Fly  1106 QNYQYTEFFLKLYQLGSDLEHGRLRDSAKVLLHLLPCDRQTIRQLKIMCKVPKAAVTVAVTGDKI 1170
            :    ..|:..|::|.|:.:. .:|.|.:.||.|||.....::|:..              || :
 Worm  1227 K----CNFYDLLHELASNGDK-YIRASVRRLLLLLPTQPSILKQITF--------------GD-M 1271

  Fly  1171 AKDEEEKLYPTEQAGIEDE-EEHCTPEQMFLHPTPAQVLYNLSVLHGLLIPALDPLGESALLVQS 1234
            ..||:|.|    ...|.:. .|:.||.:      |.::||.|..:..::.|       :.|..|:
 Worm  1272 DDDEDEPL----TIKINNMCAEYMTPME------PGRMLYALEAISSVVAP-------TRLTAQA 1319

  Fly  1235 AWMHSGCAHFVLEL----------LTKNNFLP-----SADMHTKRASFQCVLRLAKLFLYIVGSV 1284
            ....:...:.:||:          |||.|.:|     ..|.|:          :.:..:.|:.||
 Worm  1320 TEDATELTNALLEIDVIKNLTDGVLTKPNVIPLNKCSPGDRHS----------IFERIIQIIRSV 1374

  Fly  1285 LSRVGDEPMICDLDNGSRSQVDILKQNFSTMPSSSQGTLRAISAKLAVILAREMLSASPEGD--- 1346
            .:  |....|..:.|..|.:.: :::....|..|.| |.|:|...:...|.::.:...|..|   
 Worm  1375 YT--GRNTFIKMIRNEFRIREE-MRKTCERMLQSRQ-TPRSIDQPMDYALTKQQIMPPPCVDNQN 1435

  Fly  1347 -----------RCRTLFSSTL--------QWSCPDI----------------------------- 1363
                       :.::||||.:        :|..||:                             
 Worm  1436 NPAYSSSGSVVQFKSLFSSYIKIITSFMQRWDLPDLIAFLESIRNFQWIHVATESLLTSEIEPFA 1500

  Fly  1364 ---------------STIKAVVQ------------------------LAWASSCGNLQA------ 1383
                           ..|:|||:                        ..|..|.|::.|      
 Worm  1501 ETNQNKGKKTRETASDLIRAVVKGERWGDECRLIIVKKAFSLIRHMVREWVGSHGDIAAPLLETL 1565

  Fly  1384 -LGNSSGDFEDEVIVPDGQD----------FSMCKEALEVLTIS------FILNPSANEALTSDP 1431
             |.||...|..:|:|...|:          ..:.|::.|:..:|      ..::...::..||| 
 Worm  1566 FLNNSWVQFYQDVLVNSQQEAYRKYVQENIVKIGKDSFEITCVSLKMLLEMFMSLPLHDGFTSD- 1629

  Fly  1432 NWPKFITSIVLKNPLRHVRQVASEQLFLASTYCAGDRRPFVYMVNLLVGALKTLVP--QYES--T 1492
                      |....|..||           :|.              |.::|:|.  .:||  .
 Worm  1630 ----------LNELQRRQRQ-----------HCD--------------GIVQTVVEIFYFESPRR 1659

  Fly  1493 CAEFFSVLCRTLSYGCIYNWPLQISEGLLGDEIKWL-------------QRIRENVHATGDTQVH 1544
            |.|.    .:.:.:..:.:.|::|    :.|:||.|             ..:.||::|....::.
 Worm  1660 CRED----QKDIDWSQLGHKPIEI----IRDQIKSLLGFKPRFCTTNNDLALTENIYAAAKMRMI 1716

  Fly  1545 EELLEGHLCLAKELMFFLGADSKAQLNELIHELIDDFLF-------TASREFLHLRRHGSLRQDT 1602
            .       ||   |.:...:|.:......|..:|:||||       .:..|...:|.....|:  
 Worm  1717 S-------CL---LPYCSQSDIEDCSKAFIDAIINDFLFPELPDIEDSMFEEESIRWEYQARE-- 1769

  Fly  1603 VPPPVCRSPHTIAAACDLLIALCQLCVPNMKLLTNTLIDFVCTDT--DPLREWDYLPPVGARPTK 1665
                         ||...|.|.|:....|...|.|....|:....  ||    .|.|.:..|...
 Worm  1770 -------------AAIQTLNAFCERSYKNSHQLLNMWSKFMIAQKTYDP----SYRPIIRGRQFD 1817

  Fly  1666 GFCGLKNAGATCYMNSVLQQLYMVPAVRVGILRAHGAATTDGEDFSGDSDLTGGGLGSALFSGPA 1730
            . .|:||.|.|||||:::|||..||                                     |.:
 Worm  1818 K-VGMKNDGGTCYMNAMIQQLVHVP-------------------------------------GLS 1844

  Fly  1731 SALVSLPSSSSTIEDGLHDVRKNYHVVILKHVQAIFAHLGHSALQYYVPRGLWTHFKLLGE-PVN 1794
            ..|::|.:....:..|      :....:|..:|.:||.|..:..|..||.|||..|:...: |:|
 Worm  1845 RELIALQNIDPQLRWG------DNTAALLCELQRVFAQLNFAQCQAIVPEGLWKEFRFEPDMPLN 1903

  Fly  1795 LREQQDAVEFFMSLLESLDEGLKALGQPQLMNATLGGSFSDQKICQECPHRY-SKEEPFSVFSVD 1858
            .::..||::|:..||:..|..||.|..|.|......|.:|.:|||..|.||| |.:|.|:..|:.
 Worm  1904 TKQHHDAIDFYSILLDKCDNVLKKLELPPLFQNRFFGKYSYEKICYGCWHRYKSPDEEFNCISLA 1968

  Fly  1859 IRNHSSLTESLEQYVKGELLEGADAYHCDKCDKKVVTVKRVCVKKLPPVLAIQLKRFEYDYERVC 1923
            : :..:|.|:||.::...::||.:||||:|||:|..|:.|....:||..:.||||||.||.....
 Worm  1969 L-SGDNLEEALENFLAAHVMEGENAYHCEKCDEKKTTLNRTSFLELPSTMTIQLKRFTYDLVNNM 2032

  Fly  1924 AIKFNDYFEFPRILDMEPYTVSG--------------LAKLEGEVVEV----------------- 1957
            ..|.|..|.||..:||.||..:.              :....||..|.                 
 Worm  2033 IRKDNQLFRFPFEIDMTPYMTTSRHVPDEHVQDLFDEMLYGNGEADEAPSPPHKNGVAEKPNLGS 2097

  Fly  1958 GDNCQTNVETTK----------------------------------YELTGIVVHSGQASGGHYF 1988
            |.....::|:.:                                  |||.|::.|||.|:.|||:
 Worm  2098 GSASTPSLESAQKKMFRRHRSSTMRLSQSFANTSGFDTPSQQKPLIYELVGVLAHSGIATAGHYY 2162

  Fly  1989 SYILSK------NPANGKCQWYKFDDGEVTECKMHEDEEMKAECFGGEYMGETYDNNLKRMQYRR 2047
            |:|..:      :|...|  |:..:|..|:....:..|::   .:||.:..|.....|.     .
 Worm  2163 SFIKERREEFRDSPHYNK--WHHINDMIVSPMSFNNIEDL---WYGGTFTQEGVFIGLD-----E 2217

  Fly  2048 QKRWWNAYMLFYTRCDQTP------------------VQYEPSVEQLSLAESRNMVL--PLPKPI 2092
            :.|.||||:|||.:....|                  |.::.|.|.:...|.:...:  .|.|.:
 Worm  2218 RVRHWNAYVLFYEKKRDEPTALIPRHIIDRLNDVKPKVTFDVSDEIMDDGEDKMKAVQDALKKDM 2282

  Fly  2093 ERSVRHQNIRFLHSRSIFSVEFFN-----FI--KKLVSCNLLSARSNKITPAAE-----ELSLLG 2145
            ..: |...||..:|..:...:|.|     |:  :...|.:|.....|.:.|..:     |.::..
 Worm  2283 SEA-RKLRIRMFNSMDLKMKKFLNDDYCKFLDDRDFFSFDLYQIYINSLLPLLKREETVEYTVTD 2346

  Fly  2146 VQLASQFLFHTGFRTKKSLRGPVMEWYDALSHHIRSSALVR-KW--FANHALLSPPSRLGEYI-- 2205
            :..|..|                     .|:....:|.::| .|  |..|...:.|....:.|  
 Worm  2347 LDKADFF---------------------KLAFEYIASYIIRVAWMMFDEHRPKNFPRAATDLIRL 2390

  Fly  2206 LMAPSPDVRTVFVKLVVFFCHFAINDEPLTGYDGANLCEQVLISVLRLLKSEAADYGKHLPHYF- 2269
            |:...||.:..|.|.:.     |.|.|.||                |:|::...|......|.. 
 Worm  2391 LLLRHPDNKMFFFKSLE-----ANNSEMLT----------------RMLETTEHDIRASFWHCMR 2434

  Fly  2270 SLFSMYVGLGTREKQQLLRLNVPLQFIQVALDDG------------------------------P 2304
            |...::| |....|.:.:....|   ....|||.                              |
 Worm  2435 SALRLWV-LENGNKDENMMEPSP---DSTDLDDDDEEDDEDDEDDDLEDEDSETEEMFRQDMMRP 2495

  Fly  2305 GPAIKYQYPEFSKLHQVVSHLIRCSDVSEKCQSSNQNARPLSNPF--KDPNVAHEELTPLSTECM 2367
            .|.            .:||.|:           .||:..|...|.  .|.:.|..:...:....:
 Worm  2496 SPM------------ALVSQLV-----------MNQSRPPQLKPMLPVDLSKARSQRLNIVRRIV 2537

  Fly  2368 DLL------FNRTG--YIKKVIE----DTNVGDEGLKLLQYCSWENPHFSRAVLTELLWQ----- 2415
            .:|      ...:|  |.:.::|    .:.:.:.|..:|..|:      :..::.|.||:     
 Worm  2538 QVLPFRIHRMEGSGRHYSRSLVEMLYMISRLNEFGKSVLHVCN------ALQLVGEFLWEDYSTV 2596

  Fly  2416 -CGFAYCHDMRH-----------HTDLLL-----NILLIDDSWQHHR----------IHNALNGV 2453
             |...:..|...           :.:|||     ::|.|.|...|:|          ::.:|...
 Worm  2597 FCRLRFSEDRIKGLGLWPYLPGLYFELLLDTMNRSLLHIIDPHLHYRHLLMTTQGKFMNESLALY 2661

  Fly  2454 AEEREGLLETIQRAKTHYQKRAY-QIIKCLT---QLFHKSPIA---------------------L 2493
            ...||. .||.:....:.:|..: :|:.|..   ||..:|.:.                     :
 Worm  2662 CASREE-HETTEGKSVNDEKSLHSRIVLCYVRQIQLIVRSEVPDAAQEYIFNACQILLKAFLKDV 2725

  Fly  2494 QMLHTNSNITRHWSIAVEWLQGELD-RQRGI--------GCQYNSYSWSPPAQSNDNTN----GY 2545
            |.:.|:   ..|||..:::.   :| .||.:        .|...:..|...|:.:|...    ..
 Worm  2726 QYMFTS---IEHWSHVIDFF---IDLAQRLVRVDLSSLGACLLKNLMWVGIAEDDDTVEPGVLPV 2784

  Fly  2546 MLERSQSAKNTWSMAFELCPDEVSEKTD-----ENNEPNLETNMDENKSEPVAQPGGVLEGSTGG 2605
            |||        |            ::||     :.||......:.::                  
 Worm  2785 MLE--------W------------KETDYTKYRKMNEALFNIRIIKH------------------ 2811

  Fly  2606 TEQLPENKTPTTSSPSTAAWPARGDSNAIPRLSRQLFGAYTSTGSGSTSGGSAPTSALTTTAGSG 2670
                ||.:.                  .:.|.|::....:..:.:.:......|           
 Worm  2812 ----PELRA------------------VLLRCSKRFRSIFKMSYAENDIDSDEP----------- 2843

  Fly  2671 ANSETESSAQETTGETTINGLTNSLDQMEITAKKKCRRVIIKKLVESKD---EEDATTATTAATT 2732
                .:.|.:...|...:...|||.|.........|...   :::|:|:   |||.....:||:.
 Worm  2844 ----MDESDEVMIGPQLLKRATNSTDLTRSAVPSACATA---RVIETKEINLEEDLKANLSAASL 2901

  Fly  2733 EVTTSPATAIATAATLEPAGMSELTTMVEKNLIISQENPQAKSS 2776
            |:|..|        :||.. :|..::..:.::|...|||.|:.:
 Worm  2902 EMTEQP--------SLEEV-LSVDSSEEDISMIALSENPGAEDN 2936

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fafNP_524612.2 Ubl1_cv_Nsp3_N-like <994..1060 CDD:475130 13/87 (15%)
peptidase_C19C 1666..2064 CDD:239124 127/470 (27%)
DUF3517 2198..2566 CDD:463438 82/484 (17%)
T24B8.7NP_495931.4 UBA 133..168 CDD:197551 11/51 (22%)
peptidase_C19C 1819..2234 CDD:239124 127/468 (27%)

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