Protein Alignment faf and T05H10.1

DIOPT Version :10

• Sequence 1: NP_524612.2
• Gene: faf / 43749
• FlyBaseID: FBgn0005632
• Length: 2778
• Species: Drosophila melanogaster
• Sequence 2: NP_495686.2
• Gene: T05H10.1 / 174290
• WormBaseID: WBGene00011507
• Length: 1326
• Species: Caenorhabditis elegans
• Alignment Length: 1133
• Identity: 243/1133 - (21%)
• Similarity: 387/1133 - (34%)
• Gaps: 372/1133 - (32%)

  Fly  1655 YLPPV---GARPTKGFCGLKNAGATCYMNSVLQQLYMVPAVRVGILRAHGAATTDGEDFSGDSDL 1716
            |..||   |.|    :.||.|...|||:||::|.|||.|..|        .|..|.|
 Worm    76 YAIPVDENGHR----YVGLVNQAMTCYLNSLVQSLYMTPEFR--------NAMYDWE-------- 120

  Fly  1717 TGGGLGSALFSGPASALVSLPSSSSTIEDGLHDVRKNYHVVILKHVQAIFAHLGHSALQYYVPRG 1781
                            .|..|:.       :.:.||.....|...:|.:|..|..|.......:.
 Worm   121 ----------------YVQQPAH-------IKEQRKKAEQSIPCQLQKLFLLLQTSENDSLETKD 162

  Fly  1782 L-----WTHFKLLGEPVNLREQQDAVEFFMSLLESLDEGLKALGQPQLMNATLGGSFSDQKICQE 1841
            |     ||..:..       :|.|..|....:.::|:...|.....:|:.....|:..|...|.:
 Worm   163 LTQSFGWTSNEAY-------DQHDVQELCRLMFDALEHKWKGTEHEKLIQDLYRGTMEDFVACLK 220

  Fly  1842 CPHRYSKEE----------PFSVFSVDIRNHSSLTESLEQYVKGELLEGADAYHCDKCDKKVVTV 1896
            |.....|.:          ||..    |..:.|:.|:|..:|:.|||:|::.|.|:.|..|....
 Worm   221 CGRESVKTDYFLDLPLAVKPFGA----IHAYKSVEEALTAFVQPELLDGSNQYMCENCKSKQDAH 281

  Fly  1897 KRVCVKKLPPVLAIQLKRFEYDYERVCAIKFNDYFEFPRILDMEPY-------TVS------GLA 1948
            |.:.:.:.|.:|.||||||::||..:..||.||...||.:||:..|       |.|      |..
 Worm   282 KGLRITQFPYLLTIQLKRFDFDYNTMHRIKLNDKMTFPDVLDLNDYVNKEKRSTTSSAWQQIGKN 346

  Fly  1949 KLEGEV--VEVGD----NCQTNVETTK------------------------------YELTGIVV 1977
            |.|.|.  :|:|.    .|...|::..                              |||..::|
 Worm   347 KSENEEDDMELGSPNPKRCTPGVQSPNRYQGSENVCVGQPIDHAAVDDIVKTSGDNVYELFSVMV 411

  Fly  1978 HSGQASGGHYFSYILSKNPANGKCQWYKFDDGEVTECKMHEDEEMKAECFGGEYMGETYDNNLKR 2042
            |||.|:|||||:||  ||....:  ||.|:|..|......|.|    :.|||...|....|.
 Worm   412 HSGNAAGGHYFAYI--KNLDQDR--WYVFNDTRVDFATPLEIE----KSFGGHPSGWNQSNT--- 465

  Fly  2043 MQYRRQKRWWNAYMLFYTRCD-----------QTPVQYEPSVEQLSLAESRNMVLPLPKPIERSV 2096
                      |||||.|.|.|           |.|...:.|.|:.             |.:||..
 Worm   466 ----------NAYMLMYRRIDPKRNARFILSNQLPQHIKDSQEKW-------------KRLEREA 507

  Fly  2097 RHQNIRFLHSRSIFSVEFFNFIKKLVSCN--------LLSARSNKITPAAEELSLLGVQLASQFL 2153
            ..:.:|.|           :.|:..|:.|        |...:...:||..       .|:|..|
 Worm   508 EDERLRKL-----------SLIQVYVTINYPFPSVVTLPDKKQLDLTPQK-------YQIAEDF- 553

  Fly  2154 FHTGFRTKKSLRGPVMEWYDALSHHIRSSALVRKWFANHALLSPPSRLGEYILMAPSPDVRTVFV 2218
              ..::|:.|...|:...:                  |||......|...|.|.......|.::|
 Worm   554 --GEYKTEISREMPIKNVF------------------NHAFEFFNERARAYNLPFTKNSARLIYV 598

  Fly  2219 K---LVVFFCHFAINDEPLTGYDGANLCEQVLISVLRLLKSEAAD-YGKHLPHYFSLFSMYVGLG 2279
            :   |::.|...|..|:.|.             ||..:...|... ||.|.
 Worm   599 EHGSLMMDFKSKADMDKKLR-------------SVFNVNHGEPGSMYGVHF-------------- 636

  Fly  2280 TREKQQLLRLNVPLQFIQVALDDGPGPAIKYQYPEFSKLHQVVSHLIRCSDVSEKCQSSNQNARP 2344
                  :|.:.:...|..|.:.:  ...||.|..:..| ....:.||...|.:||......   .
 Worm   637 ------ILDVRIASSFFPVDIKN--KITIKVQRVDIGK-KTTANELIVVVDANEKMIKVKS---W 689

  Fly  2345 LSNPFKDP-----NVAHEELTPLSTEC----MDLLFNRTGYIKKVIEDTNVGDEGLKLLQYCSWE 2400
            :...|:|.     | |...|...|:.|    :|:..|.|.:             |..:.||....
 Worm   690 IGGQFRDDIHGVLN-ARVVLEVASSRCEFMMIDVSHNATEF-------------GSLIQQYVGHT 740

  Fly  2401 NP--HFSRAVLTELLWQCGFAYCHDMRHHTDLLLNILLIDDSWQHHRI-HNALNGVAEEREGLLE 2462
            .|  ::...:.|.:..:...|...|.:         |..|.|..:|.: ....:.:.:.|....|
 Worm   741 TPTLYYDGGLNTMVTKESQEATLADRK---------LPFDKSVMYHILDRKCFSTMVKVRLPSQE 796

  Fly  2463 TIQRAKTHYQKRAYQ---------IIKCLTQLFHKSPIALQMLHT--NSNITRH----------- 2505
            .|::|.:  .|.|||         |:|...:|:::...|::::.|  .::.|.|
 Worm   797 EIEKAAS--TKNAYQGPTWAETIAIMKEEDRLWNEPRAAVEVMSTVSRTDTTDHALVADTDDEPI 859

  Fly  2506 ----------WSIAVEWLQGELDRQRGIG---CQYNSYSWSPPAQSNDNTNGYMLE-RSQSAKNT 2556
                      .|::::    ::|...||.   |. |:...||.....|:.:...|: :||
 Worm   860 PSGRGSTASMRSVSMD----DIDADIGISGSLCN-NTPQMSPCVSEGDDADESQLDGKSQ----- 914

  Fly  2557 WSMAFELCPDEVSEKTDE---NNEPNLETNMDENKSEPVAQPGGVLEGSTGGTEQLPENKTPTTS 2618
                  |..|.:.:.:.:   |.:|  :.::::|           |:.:.|       ::||:.|
 Worm   915 ------LMSDYMQKTSPDFYYNRDP--QNHLNKN-----------LKIALG-------DETPSES 953

  Fly  2619 SPSTAAWPARGDSNAIPRLSRQLFGAYT 2646
            ..:.::    |.|..:|..|.|...:.|
 Worm   954 LSAVSS----GQSTLVPSTSNQALSSMT 977

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
faf	NP_524612.2	Ubl1_cv_Nsp3_N-like	<994..1060	CDD:475130
		peptidase_C19C	1666..2064	CDD:239124	122/472 (26%)
		DUF3517	2198..2566	CDD:463438	77/419 (18%)
T05H10.1	NP_495686.2	peptidase_C19C	86..477	CDD:239124	122/465 (26%)
		USP47_C	<1159..1318	CDD:466158