Protein Alignment faf and Usp48

DIOPT Version :10

• Sequence 1: NP_524612.2
• Gene: faf / 43749
• FlyBaseID: FBgn0005632
• Length: 2778
• Species: Drosophila melanogaster
• Sequence 2: NP_001392866.1
• Gene: Usp48 / 170707
• MGIID: 2158502
• Length: 1054
• Species: Mus musculus
• Alignment Length: 1043
• Identity: 225/1043 - (21%)
• Similarity: 365/1043 - (34%)
• Gaps: 343/1043 - (32%)

  Fly  1657 PPVGARPTKGFCGLKNAGATCYMNSVLQQLYMVPAVRVGILRAHGAATTDGEDFSGDSDLTGGGL 1721
            |....|....|.||.|.|||||:|:.||..::...:|
Mouse    78 PNCERRKKNSFVGLTNLGATCYVNTFLQVWFLNLELR---------------------------- 114

  Fly  1722 GSALFSGPASALVSLPSSSSTIEDGLHDVRKNYHVVILKHVQAIFAHLGHSALQYYVPRGLWTHF 1786
             .||:..|::.      |..|..||:|..:......|.:|:|.:||.|.:|..:|..|.|.   .
Mouse   115 -QALYLCPSTC------SDYTKGDGIHGGKDYEPQTICEHLQYLFALLQNSNRRYIDPSGF---V 169

  Fly  1787 KLLGEPVNLREQQDAVEF---FMSLLESLDEGLKALGQPQLMNAT---LGGSFSDQKICQECPHR 1845
            |.||  ::..:||||.||   ||||||   :.|.....|.:.|..   ..|.::...:|.:|...
Mouse   170 KALG--LDTGQQQDAQEFSKLFMSLLE---DTLSKQKNPDVRNVVQQQFCGEYAYVTVCNQCGRE 229

  Fly  1846 YSKEEPFSVFSVDIRNHSSLTESLEQYVKGELLEGADAYHCDKCDKKVVTVKRVCVKKLPPVLAI 1910
            ......|....::|:.|..||:.:.:::|.|.|||.:.|.|:.|..|....:::.:..||..|.:
Mouse   230 SKLVSKFYELELNIQGHKQLTDCISEFLKEERLEGDNRYFCENCQSKQNATRKIRLLSLPCTLNL 294

  Fly  1911 QLKRFEYDYERVCAIKFNDYFEFPRILDMEPYTVSGLAKLEGEVVEVGDNCQTNVETTKYELTGI 1975
            ||.||.:|.:.....|.|.|..|...||||||    :....|..|              |||:.:
Mouse   295 QLMRFVFDRQTGHKKKLNAYIGFSESLDMEPY----VEHKGGSFV--------------YELSAV 341

  Fly  1976 VVHSG-QASGGHYFSYILSKNPANGKCQWYKFDD-------GEVTECKMHED-------EEMKAE 2025
            ::|.| .|..|||.:::  |:|.:|  :||||:|       |:..:..:.||       :..|.:
Mouse   342 LIHRGVSAYSGHYIAHV--KDPQSG--EWYKFNDEDIEKMEGKKLQLGIEEDLAEPSKSQTRKPK 402

  Fly  2026 CFGGEYMGETYDNNLKRMQYRRQKRWWNAYMLFY----TRCDQTPVQYEPSVEQL---------- 2076
            |..|.:...                  |||||.|    ...:.|.||....:::|
Mouse   403 CGKGTHCSR------------------NAYMLVYRLQAQEKNHTMVQVPAFLQELVDRDNSKFEE 449

  Fly  2077 ---SLAESRNMVLPLPKPIERSVRHQNIRFLHSRSIFSVEFFNFIK--------------KLVSC 2124
               .:||.|...:...|     .:|:.::.|:.|.....|.:.|:.              |.:..
Mouse   450 WCVEMAEMRKQSVDKGK-----AKHEEVKELYQRLPAGAEPYEFVSLEWLQKWLDESTPTKPIDN 509

  Fly  2125 NLLSARSNKITPAAEELSLLGVQLASQF---LFHTGF-----RTKKS--------------LRGP 2167
            |......:|:.|  :::|::  :..|::   :|::.:     .|.|:              |:..
Mouse   510 NACLCSHDKLHP--DKISIM--KRISEYAANIFYSRYGGGPRLTVKALCKDCVVERCRVLRLKNQ 570

  Fly  2168 VMEWYDALSHHIRSS-----------ALVRKWFANHALLSPPSRLGEYILMAPSPDVRTVFVKLV 2221
            :.|.|.|:::.::|:           :.:|.| ...||.....:.||    |...:.:
Mouse   571 LNEDYKAVNNLLKSTMKGSDGFWVGKSSLRSW-RQLALEQLDEQDGE----AEQSNGK------- 623

  Fly  2222 VFFCHFAIN---------------DEPLTGYDGANLCEQVLISV----LRLLKSEAADYGKHLPH 2267
                   ||               :|....::...||....:|:    .||:..||  :.| |..
Mouse   624 -------INGSTFNKDESKEEKKEEEEELNFNEDILCPHGELSISENERRLVSQEA--WSK-LQQ 678

  Fly  2268 YF---------------------------SLFSMYVGLGTREKQQLLRLNVPLQFIQVALDDGPG 2305
            ||                           :|..|   :...:|..|..|          ..|...
Mouse   679 YFPKAPEFPSYRECCSQCKILEREGEENEALHKM---IANEQKTSLPNL----------FQDKNR 730

  Fly  2306 PAIKYQYPEFSKLHQVVSHLI------------RCSDVSE------KC---------QSSNQNAR 2343
            |.:. .:||.:....:|||..            |.:.||.      .|         .|..:...
Mouse   731 PCLS-NWPEDTDALYIVSHFFLDEWRKFVRKPARSAPVSSIGNAALLCPHGGLMFTFPSLTKEDS 794

  Fly  2344 PLSNPFKD-----PNVAHEELT---PLSTECMDLLFNRTGYIKKVIEDT--NVGDEGLKLLQYCS 2398
            .|..|.:.     |..||..:.   |...:.:..||    .:.|||:.|  .|||......||.|
Mouse   795 KLCQPLERREGGWPTAAHNNIALIWPSEWQMIQKLF----VVDKVIKITRIEVGDVNPSQTQYIS 855

  Fly  2399 WENPHFSRAVLTELLWQCGFAYCHDMRHHTDLLL-------NILLIDDSWQHHRI---------- 2446
              .|.........||.|    ...|:|.:|...:       |..::.||.....:
Mouse   856 --EPSLCPDCREGLLCQ----QQRDLREYTQATIYVHKVVDNKKVMKDSAPELNVSSSETEEDKE 914

  Fly  2447 -----------HNALNGVAEEREGLLETIQRAKTHYQKRAYQIIKCLTQLFHKSPIALQMLHTNS 2500
                       .|..||..:.:    :|.|:....|||   |:|:..|:  |:.....:.|..::
Mouse   915 EAKPDGEKDPDFNQSNGSTKRQ----KTSQQGYVAYQK---QVIRRSTR--HRKVRGEKALLVSA 970

  Fly  2501 NIT 2503
            |.|
Mouse   971 NQT 973

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
faf	NP_524612.2	Ubl1_cv_Nsp3_N-like	<994..1060	CDD:475130
		peptidase_C19C	1666..2064	CDD:239124	115/422 (27%)
		DUF3517	2198..2566	CDD:463438	77/417 (18%)
Usp48	NP_001392866.1	Peptidase_C19L	90..419	CDD:239133	113/411 (27%)
		DUSP	484..554	CDD:399383	11/73 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	611..641		5/47 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	898..942		6/47 (13%)
		Ubl_USP48	958..1053	CDD:340493	3/16 (19%)