DRSC/TRiP Functional Genomics Resources

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Protein Alignment faf and puf

DIOPT Version :10

Sequence 1:NP_524612.2 Gene:faf / 43749 FlyBaseID:FBgn0005632 Length:2778 Species:Drosophila melanogaster
Sequence 2:XP_313408.6 Gene:puf / 1274308 VectorBaseID:AGAMI1_013112 Length:4617 Species:Anopheles gambiae


Alignment Length:2678 Identity:503/2678 - (18%)
Similarity:834/2678 - (31%) Gaps:1048/2678 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 DTRRHTTGQPGSTAPSSSSSTTSTTT-----------TTTSPAQSAGSG-SGIGTGTGTVANSSL 56
            |.:.||         ..|...||..|           |....::|||:. :.|.||.|..  :.|
Mosquito   500 DPKEHT---------EQSIYITSALTKLIWMRDCSRQTLIDMSKSAGNTINDIATGRGDY--NEL 553

  Fly    57 PGG--GSGSLDG--NQDQQPATDSQSSDDVAASLSANSVDSTITIV------PPEKLISSFPTTK 111
            |..  .|.|:||  ::|:.|..|| |..||.:|:        :.:|      ||..::.      
Mosquito   554 PSSSENSVSVDGTNSEDEHPEDDS-SDPDVPSSV--------VPVVVAGGHKPPGPILG------ 603

  Fly   112 LRSLTQKISNPRWVVPVLPEQELEVLLNAAIELTQAGVDHDCEPCVEFYRNGLSTSFAKILTDEA 176
                            ::|::|.|             .|:...||.:        :..||..||.
Mosquito   604 ----------------MVPDREGE-------------SDNGAPPCKQ--------ARHKICCDET 631

  Fly   177 VNSWKNNIHHCILVSCGKLLHLIAIHMQRDNPYLLDLLAIVFDPENKFNTFNAGRQPECFAAPDY 241
            .:.                                   :|..:|:    .:|..|          
Mosquito   632 TDD-----------------------------------SIKVEPD----IYNVQR---------- 647

  Fly   242 IWGQLDSNKMYARPPPEPKNARGWLVDLINRFGQLG-----GFDNLLERFNIGLELLKRNQ--NK 299
                   ||...|.|...::        ||.|.:.|     |.| :.|.|.:..:|.|:.:  :.
Mosquito   648 -------NKEKIRIPLMTRS--------INTFNEEGTSSDDGID-MDEAFLMRKKLRKKRRKISG 696

  Fly   300 CTGKNISVEGRVENGAQDNRLTLALIHSLLRPFGQCYELLMPATIAKYFMPTWNVVLDLLDSFTD 364
            .|.|.:.......:..:|:.|..|::     |...|.:..:..::.::...            ..
Mosquito   697 LTRKELQELHESVSDVEDSDLLAAML-----PDSDCSDNNLQTSVLRHIQQ------------QQ 744

  Fly   365 EELKREVKPEGRNDY-------------INGIVKSARLLASR-------LTGQEELIRDLEMFRL 409
            ::.:::.:...::.:             |.|:.:..:.|.:|       ..|...|..|      
Mosquito   745 QQQQQQAQQAQQHHHHHHHHHGGPLGPGIVGMSEREQQLVARAGNSLMGAAGVASLGDD------ 803

  Fly   410 KMILRLLQVSSFNGKM------NALNEI--------------NKVLSSVAYFSHRSQPLPHCMPE 454
                    ||||.|.|      |.||..              ||...::|.|.....|   |  |
Mosquito   804 --------VSSFMGAMGEGRLINFLNAADAADHDGSCSSPMSNKSEKNMADFDDEDSP---C--E 855

  Fly   455 DEMDWLTADRMAQWIKSSDVLGVVLKDSLHQPQYVEKLEKI------------------IRFLIK 501
            :|:..|.|                ..:||||...:.:...|                  ::.|..
Mosquito   856 EELAQLAA----------------RAESLHQGFPISRPRSIGTVAGPSPLRAGAAGMGMMKHLPH 904

  Fly   502 EQALTLDDLDAVWRAQAGKHEAIVKNVHDLLAKLAWDFTPEQLDHLFEAFQASMTTANK------ 560
            :.:             .|.|.....|....:.|.....|.:    :.:|..|:..:|..      
Mosquito   905 QHS-------------PGMHRMGANNGAIKMGKGGSTKTKD----ILQATAAAAASAGPVGTMMI 952

  Fly   561 ----RQRERLL---ELIRRLAEDDKNGVMAQKVLKLFWTLAHSQEVPPEVLDQALGAHVKILDYS 618
                |..:..|   .|:..|.:|||.|.:.:.:                    ||.|...:....
Mosquito   953 GTPYRFPDVCLPGNTLLWDLLQDDKIGQLGESI--------------------ALEAEKVLGTLL 997

  Fly   619 CSQERDAQKTIWLDKCVDELKSGDGWVLPALRLIRDICCLY----DTTTNHAQRTQTSTNRQQVI 679
            |.......:|.:::.|:..|..... |:.:|:|:..:...:    |.||:            ||:
Mosquito   998 CFHTDKHIRTRFIEGCLQNLAENRS-VVTSLKLLPKLFASFQQFRDVTTH------------QVV 1049

  Fly   680 ERLQNDYSLVILVTNSLTAYMEKVRQMVTDSPGLDATRILI---DGR------FPHHVQIAERLE 735
            ...:..:.::....|:|..|....|    :|.|  |..:::   ||.      :.|..||..||:
Mosquito  1050 LWSERQHRMMFHFFNNLKHYTSTFR----NSAG--AASVVLPPSDGTGQCGPLYSHVTQIQVRLQ 1108

  Fly   736 FLKFLLKD----GQLWLCADQAKQIWHCLAVNAVFPADREEC----FRWFGKLM--GEEPDLDPG 790
            ||..:..|    ....|..:|...:|.||       |:..||    |.|....:  |:...|  |
Mosquito  1109 FLTSVFSDVGSPRSFRLTLNQVDSLWACL-------ANDPECSDCLFSWLQAQVKGGDTHAL--G 1164

  Fly   791 IN--KDFFENNILQLDPHLLTESGIKCFERFFKAVNSKEDKLKAIHRGYMLDNE-DLIGKDYLWR 852
            :|  :..:...:.:|.|..::...:..|::.|..  .:|:.......|...|.| |.:|.::||:
Mosquito  1165 LNAIQHLYLKRLSELKPEGISMVALGLFQQLFTL--GREEIFGQPVDGGERDRETDTVGMEHLWK 1227

  Fly   853 V-ITTGGEEIASKAIDLLKEVSTALGPRLQENIAEFHEMFIGECCSRLRTHYGNIVILGKTQLQE 916
            : :.....:::..||..:...       ..|...::...|:.:|.:.|            :|..|
Mosquito  1228 IALRATNTDVSLSAIQYINTY-------YMEKQLKYEHQFVAQCMNHL------------SQAVE 1273

  Fly   917 ELDAPDQSDNTNDESKDSKMRFIEAEKMC--RILKVLQEYVKECDRSFSGDRVHLPLSRVTRGKN 979
            ||:  ..|||....:        |...||  |.|.:|..::....|.::.......|.....|.:
Mosquito  1274 ELN--QHSDNNGPAT--------EYALMCVQRALMLLNTHLDTFRRRYAYHLRRWALEGKDIGAH 1328

  Fly   980 TILYIRFQNPGRSI----------DDMEIVTHSNETMAAFKRNLLK---------RIKGTSTANI 1025
            :.|  |.:.||..|          |...:..|:::.:|..|..:.|         :.| |:.|| 
Mosquito  1329 SAL--RTEGPGPPIRIVLQPAGVPDKSFLNMHASDLVADLKAEIAKWWEKYQAAPQAK-TAPAN- 1389

  Fly  1026 KVDLFYANDEMIGVSDEIN--------PLYQYTIRDKMNLTAKLTPVGTGLASSPDSSSDSSTGS 1082
                   |....|...|.|        |:....:.|.   ..::...|..:.|..|..|.:..|.
Mosquito  1390 -------NTSTPGSGGEQNSAGGGSPAPVLGLLLNDG---PLRIITQGQEITSEYDERSLADVGF 1444

  Fly  1083 PPRPC------------------PDMQRVESESTLPGVIISQNYQYTEFFLKLYQLGSDLEHG-- 1127
            .....                  |.||....:..||.:::.:...:.:.|..:..|| |::..  
Mosquito  1445 KDNQMVYVSLGGRSGRRREQSENPSMQPPPPKDCLPTLLLLKPPYFEQLFRLMQTLG-DMKISTT 1508

  Fly  1128 --RLRDSAKV---------LLHLLP-CDR--QTIRQLKIMCKV-PKAAVTVAVTGDKIAKDE--E 1175
              |.:.:.|.         :|.:|| |..  .|::.|...|.. ||.        |:..::|  |
Mosquito  1509 GERCQPNTKAQLLSRRVWDILAMLPTCPSFFSTLKNLSFKCAARPKT--------DEQCEEELGE 1565

  Fly  1176 EKLYPTEQAGIEDEEEH----------CTPEQMFLHPTPAQVLYNLS----VLHGLLIPALDPLG 1226
            .||  .:|.|.|..|..          |...:..|.|      |||.    .||           
Mosquito  1566 AKL--PQQRGDESAEGSVKETDPLLGGCYTLEEILDP------YNLQKFMYALH----------- 1611

  Fly  1227 ESALLVQSAWMHSGCAHFVLELLTKNNFL-------PSADMHTKRASF----------------- 1267
                              ::|.|.|:.|:       ....||.|:..|                 
Mosquito  1612 ------------------IVESLCKSKFVGNCCGSGAGGVMHLKQVPFTEGGNNRGTVGVAGTSS 1658

  Fly  1268 QCVLRLAKLFLYI--------------------VGSVLS---------RVGDEPM---------- 1293
            :.:|...:|.|.|                    |.:..|         ||...|.          
Mosquito  1659 KTLLVKNQLKLKISSSKSLKMQQQSGTPRQETSVAAATSNRSPSKGGKRVDFAPTSPGPGVVKPT 1723

  Fly  1294 -ICDLDNGS----RSQVDILKQNFSTMPSSSQGTLRAISAKLAVILAREMLSASPEG-------- 1345
             :|..|..|    :.:.|...:|....|:....|.:....:...  .::.:...|||        
Mosquito  1724 PLCSEDERSAVLAKDRADESAENKENTPNCDGATSKPEEQRTGE--TQQAIECEPEGANTGNAHQ 1786

  Fly  1346 -------------------DRCRTLFSST--LQWS-----CPDIS-----TIKAVVQLA------ 1373
                               ||..:..||:  ::||     |..::     .:..|:|.:      
Mosquito  1787 DPVQVDEPKKSERNRDAEADRNESCASSSRVVEWSDEFMRCGGLAHLYRIFLSGVLQKSTDGSDE 1851

  Fly  1374 -----WASSC-GNL---------------QALGNSSGDFEDEVIVPDGQDFSMCKEALEVL---- 1413
                 |...| .:|               :|.||:       :::|     .:.:|.|.:.    
Mosquito  1852 SELNEWRHDCLASLLRIMCLLGMDELKATEAEGNA-------ILIP-----PLNRETLALFEPRP 1904

  Fly  1414 ---TISFILNPSANEALTSDPNWPK---------------------------------------F 1436
               .|:.|||   .|:|..:||..|                                       :
Mosquito  1905 TLERIASILN---EESLPVNPNLFKTGLFGRPQVIHYAMNLLVCYAHSCKEVRRLLWTIEANSLW 1966

  Fly  1437 ITSIVLKNPLRHVRQVASEQLFLASTYCAGDRRPFVYMVNLLVGALKTLVP-------------- 1487
            :..::|.:|...||:.|...|:   ..|.|:.:.:..::..|:..|..|:|              
Mosquito  1967 LQRLILDDPEPAVRREACAALY---RLCLGNAQTYYELMAPLLSKLVALLPLAENMKPQSLTGGP 2028

  Fly  1488 -----------------QYESTCAEFFSVLCRTLSYGCIYNWPLQISEGLLGDEIKWLQRIRENV 1535
                             .|...|.::|.:|||.:.              .|..|:     :|.|.
Mosquito  2029 GGGIYGALLSAGDETKEPYGPACRDYFWLLCRLVD--------------ALSPEL-----LRGNA 2074

  Fly  1536 -HATGDTQVHEELLEGHLCLAKELMFFLGADSKAQLNELIHELIDDFLFTASREFLHLRRHGS-- 1597
             |:.||.....:.              :|.|...|  ::...:::       |::|. .||||  
Mosquito  2075 GHSAGDELQPRDA--------------IGLDDMCQ--QVARSILE-------RDYLE-SRHGSPD 2115

  Fly  1598 -------------LRQDTV---------------------------PPPVCRSPHTIAAACDLLI 1622
                         |:.|..                           ..|.|:|....|||.|||:
Mosquito  2116 DGLFGLLNLMANLLKFDPAFKYSLVGQEFMISVFCCLFELPSPEDREKPKCKSHAARAAAYDLLV 2180

  Fly  1623 ALCQLCVPNMKLLTNTLIDFVCTDTDPLREWDYLPPVGARPTKGFCGLKNAGATCYMNSVLQQLY 1687
            .:|:....|..||...|:............|||.|....|...|:.||.|.||||||.|.:|.|:
Mosquito  2181 EMCRNAPKNYLLLHGKLMQQHRAGPHSPYPWDYWPQDEGRSECGYVGLTNLGATCYMASCIQHLF 2245

  Fly  1688 MVPAVRVGILRAHGAATTDGEDFSGDSDLTGGGLGSALFSGPASALVSLPSSSSTIEDGLHDVRK 1752
            |.|..|..||    :.:||.                             |..             
Mosquito  2246 MTPQTRDAIL----SISTDA-----------------------------PQK------------- 2264

  Fly  1753 NYHVVILKHVQAIFAHLGHSALQYYVPRGLWTHFKLLGEPVNLREQQDAVEFFMSLLESLDEGLK 1817
              |...|..:|.:||:|..|..:.|.||.....:::..:|:|..||:|..|||:.|:..|:|...
Mosquito  2265 --HKATLCELQRMFAYLMESERKAYCPRSFCRVYQMDHQPLNTGEQKDMAEFFIDLVSKLEEMTP 2327

  Fly  1818 ALGQPQLMNATLGGSFSDQKICQECPHRYSKEEPFSVFSVDIRNHSSLTESLEQYVKGELLEGAD 1882
            .|  ..|:.....|..|:..:..:|.|.....|.|......:.:..:|.|||::....:.|||.:
Mosquito  2328 DL--KNLVKRIFCGVISNNVVSLDCGHVSRTLEEFYTVRCQVADMRNLHESLDEVTVKDTLEGDN 2390

  Fly  1883 AYHCDKCDKKVVTVKRVCVKKLPPVLAIQLKRFEYDYERVCAIKFNDYFEFPRILDMEPY----- 1942
            .|.|.:|.|||...||.|.||||.:|.....|:.::...:...|.|.:|.||..|||..|     
Mosquito  2391 MYTCSQCGKKVRAEKRACFKKLPQILCFNTMRYTFNMVTMLKEKVNTHFSFPMRLDMSGYVEKTL 2455

  Fly  1943 --------------------------------------------------TVSGL---------- 1947
                                                              |.:||          
Mosquito  2456 MPHHYQEEKRKSQMRRSHSRNVSESSATGEVNPAGTSGLDDNSSSSASSSTSTGLMSTGSECGNG 2520

  Fly  1948 ------------AKLEGEVVEV---------------GDNCQTNV-------------------- 1965
                        .:.|.|.||:               .|:...|:                    
Mosquito  2521 GNKTNGPAPAVEKQQESEDVEMKNASSDEKDGADDRKNDSSNGNLSDSSNGDLQRQQQTMDEEES 2585

  Fly  1966 ----ETTKYELTGIVVHSGQASGGHYFSYILSKN---PANGKCQWYKFDDGEVTECKMHEDEEMK 2023
                |..:|:|.|:.||:|.|.||||:|:|..:|   ..|.:.:|:.|:|.||   |:.:..::.
Mosquito  2586 EDFNEHYEYDLVGVTVHTGNADGGHYYSFIKERNEDGDPNHQERWFLFNDAEV---KLFDPSQIA 2647

  Fly  2024 AECFGGEYMGETYDNNLKRMQYRRQKRWWNAYMLFY---------TRCDQTPVQY-------EPS 2072
            |||||||...:|||:..::......::..:||||||         .:.||...|.       .||
Mosquito  2648 AECFGGEMTSKTYDSVAEKYLDFSFEKTNSAYMLFYEWRSNKGKNVQRDQAEEQQATNSATTAPS 2712

  Fly  2073 VEQLSLAESRNMV 2085
            .|:.|...|.:.|
Mosquito  2713 AEKRSSTASNSSV 2725

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fafNP_524612.2 Ubl1_cv_Nsp3_N-like <994..1060 CDD:475130 15/82 (18%)
peptidase_C19C 1666..2064 CDD:239124 128/525 (24%)
DUF3517 2198..2566 CDD:463438
pufXP_313408.6 None
Blue background indicates that the domain is not in the aligned region.

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