DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment faf and usp48

DIOPT Version :9

Sequence 1:	NP_524612.2	Gene:	faf / 43749	FlyBaseID:	FBgn0005632	Length:	2778	Species:	Drosophila melanogaster
Sequence 2:	NP_001120167.1	Gene:	usp48 / 100145207	XenbaseID:	XB-GENE-5938602	Length:	1039	Species:	Xenopus tropicalis

Alignment Length:	720	Identity:	166/720 - (23%)
Similarity:	263/720 - (36%)	Gaps:	219/720 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1601 DTVPPPVCRSPHTIAAACDLLIALC--QLCVPNMKLLTNTLI--------------DFVCTDTDP 1649
            |||.|......| |.||..:.:..|  .:|..|.|...|.|:              .|...| ||
Frog    16 DTVRPEEVGQEH-IEAAYRVRLEPCVRGICRRNCKGNPNCLVGVGEHIWLGEIDENTFHNID-DP 78

  Fly  1650 LREWDYLPPVGARPTKGFCGLKNAGATCYMNSVLQQLYMVPAVRVGILRAHGAATTDGEDFSGDS 1714
            ..|        .|....|.||.|.|||||:|:.:|..::...:|
Frog    79 NSE--------RRKKNTFVGLTNLGATCYVNTFVQVWFLNMELR--------------------- 114

  Fly  1715 DLTGGGLGSALFSGPASALVSLPSSSSTIEDGLHDVRKNYHVVILKHVQAIFAHLGHSALQYYVP 1779
                    .||:      |.....|:...|..:.:.::.....|.:|:|.:||.|.:|..:|..|
Frog   115 --------RALY------LYENSWSAEKAEQCIQEDKEYEPQTICEHLQYLFALLQNSNRRYIDP 165

  Fly  1780 RGLWTHFKLLGEPVNLREQQDAVEF---FMSLLESLDEGLKALGQP---QLMNATLGGSFSDQKI 1838
            .   :..|.||  ::..:||||.||   ||||||   :.|....:|   .::.....|.::...|
Frog   166 S---SFIKALG--LDTGQQQDAQEFSKLFMSLLE---DTLSKQKEPIVKNIIQEQFCGQYAYVTI 222

  Fly  1839 CQECPHRYSKEEPFSVFSVDIRNHSSLTESLEQYVKGELLEGADAYHCDKCDKKVVTVKRVCVKK 1903
            |.:|.........|....::|:.|..|||.:.:::|.|.|||.:.|.|:.|..|....:::.:..
Frog   223 CSQCSRESRLVSKFYELELNIQGHKQLTECIAEFLKEEKLEGDNRYFCENCQSKQNATRKIRLLD 287

  Fly  1904 LPPVLAIQLKRFEYDYERVCAIKFNDYFEFPRILDMEPYTVSGLAKLEGEVVEVGDNCQTNVETT 1968
            |||.|.:||.||.:|.:.....|.|.|..|...|||:||    |.:.:|              |.
Frog   288 LPPTLNLQLMRFVFDRQTGHKKKLNTYIGFSETLDMDPY----LDQTDG--------------TY 334

  Fly  1969 KYELTGIVVHSG-QASGGHYFSYILSKNPANGKCQWYKFDD-------GEVTECKMHEDEEM--- 2022
            .|||:.:::|.| .|..|||.:::  |:|..|  :||||:|       |:..:..:.||.|.
Frog   335 SYELSAVLIHRGVSAYSGHYIAHV--KDPQTG--EWYKFNDEDIEKMEGKKLQLGIEEDLEQSKT 395

  Fly  2023 ---KAECFGGEYMGETYDNNLKRMQYRRQKRWWNAYMLFYTRCDQTPVQYEPSVEQLSLAESRNM 2084
               |.:|..|.:...                  |||||.|               :|...|.:::
Frog   396 APRKPKCGKGIHCSR------------------NAYMLVY---------------RLKTVEKQDV 427

  Fly  2085 VLPLPKPIERSVRHQNIRFLHSRSIFSVEFFNFIKKLVSCNLLSARSNKITPAAEELSLLGVQLA 2149
            ...:|..:::.|...|.:|    ..:.||..:..::.|...  .|:..::....:.|. .|...|
Frog   428 TFEVPAFLQKLVELDNCKF----EEWCVEMVDMRRESVDKG--KAKHEEVKELYQRLP-AGADSA 485

  Fly  2150 SQFLFHTGFRTKKSLRGPVMEWYDALSHHIRSSALVRKWFANHALLSP--------------PSR 2200
            .:|:              .:||             ::||........|              |.:
Frog   486 YEFV--------------PLEW-------------LQKWLDESTPTKPIDNSKCLCSHGKLHPDK 523

  Fly  2201 LGEYILMAPSPDVRTVFVKLVVFFCHFAINDEPLTGYDGA------NLCEQVLIS---VLRLLKS 2256
            :.  ::...|.....:|.|                .|.|:      .||:..::.   ||||...
Frog   524 IS--LMKRISQHAADIFYK----------------RYGGSPRLTDDALCKDCVVERCRVLRLKNQ 570

  Fly  2257 EAADY 2261
            ...||
Frog   571 LNEDY 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
faf	NP_524612.2	peptidase_C19C	1666..2064	CDD:239124	113/417 (27%)
faf	NP_524612.2	UCH	1668..2059	CDD:278850	111/410 (27%)
usp48	NP_001120167.1	UCH	89..417	CDD:278850	111/410 (27%)
		Peptidase_C19L	90..418	CDD:239133	112/425 (26%)
		DUSP	483..554	CDD:283896	13/115 (11%)
		UBQ	933..1039	CDD:294102
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910