Protein Alignment sip3 and HRD1

DIOPT Version :10

• Sequence 1: NP_651894.3
• Gene: sip3 / 43747
• FlyBaseID: FBgn0039875
• Length: 626
• Species: Drosophila melanogaster
• Sequence 2: NP_014630.1
• Gene: HRD1 / 854149
• SGDID: S000005373
• Length: 551
• Species: Saccharomyces cerevisiae
• Alignment Length: 434
• Identity: 95/434 - (21%)
• Similarity: 182/434 - (41%)
• Gaps: 126/434 - (29%)

  Fly     7 SVCMALTSAVIGFAYYQKQQFYPAVVYIT-KSNASMGVIYIQFFVIV--FMFGKLLSKIFLGTLR 68
            ::.:.:|..:..:..|...:...:.:.:| |.|....::.:..|:::  .:..:||:|:..|.||
Yeast    11 AIFVVVTYLLTFYCVYSATKTSVSFLQVTLKLNEGFNLMVLSIFILLNSTLLWQLLTKLLFGELR 75

  Fly    69 AAEFEHLLERFWYALTETCLAFTVFRDDFNPRFVALFTV------LLFLKSFHWLAEERVDFM-- 125
            ..|.||:.||..:.:..|....::|.:.:      .|||      ||:||.|||:.::|::.:
Yeast    76 LIEHEHIFERLPFTIINTLFMSSLFHERY------FFTVAFFGLLLLYLKVFHWILKDRLEALLQ 134

  Fly   126 --ERSPVLGWLFHIRVGSLLTVLGILDYVLL------IHAYNSTLVRGPTVQLVFGFEYAI---- 178
              ..|..:..|...|....|.:|.::||.::      |:....:.:...::.|:...|:.:
Yeast   135 SINDSTTMKTLIFSRFSFNLVLLAVVDYQIITRCISSIYTNQKSDIESTSLYLIQVMEFTMLLID 199

  Fly   179 LLTVIASTAIKY----------------VLHA------------------------AEMRTDTPW 203
            ||.:...|.:.:                ::|.                        .:.|..|..
Yeast   200 LLNLFLQTCLNFWEFYRSQQSLSNENNHIVHGDPTDENTVESDQSQPVLNDDDDDDDDDRQFTGL 264

  Fly   204 ENKAVFLLYTELVIGLIKVVLYILFVVIMAKIYALPMFVFRPMFFTI--------------RNFR 254
            |.|.::....::....:|..|::..::    .:.:||.:.:.:.:.|              || .
Yeast   265 EGKFMYEKAIDVFTRFLKTALHLSMLI----PFRMPMMLLKDVVWDILALYQSGTSLWKIWRN-N 324

  Fly   255 KALNDVIMSRRAIRNMNTLYPDATPEELRQS---DNICIICREDMVNHS-------------KKL 303
            |.|:|.:::             .|.|:|:.|   |||||||.:::: ||             |:|
Yeast   325 KQLDDTLVT-------------VTVEQLQNSANDDNICIICMDELI-HSPNQQTWKNKNKKPKRL 375

  Fly   304 PCGHIFHTTCLRSWFQRQQTCPTCRL-------NILRTP-TVNS 339
            |||||.|.:||::|.:|.||||.|||       |:::|. |.||
Yeast   376 PCGHILHLSCLKNWMERSQTCPICRLPVFDEKGNVVQTTFTSNS 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sip3	NP_651894.3	HRD1	20..>365	CDD:227568	94/421 (22%)
HRD1	NP_014630.1	HRD1	5..551	CDD:227568	95/434 (22%)