DRSC/TRiP Functional Genomics Resources

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Protein Alignment sip3 and SYVN1

DIOPT Version :9

Sequence 1:NP_001263152.1 Gene:sip3 / 43747 FlyBaseID:FBgn0039875 Length:626 Species:Drosophila melanogaster
Sequence 2:NP_757385.1 Gene:SYVN1 / 84447 HGNCID:20738 Length:617 Species:Homo sapiens


Alignment Length:646 Identity:305/646 - (47%)
Similarity:401/646 - (62%) Gaps:77/646 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 LLSSVCMALTSAVIGFAYYQKQQFYPAVVYITKSNASMGVIYIQFFVIVFMFGKLLSKIFLGTLR 68
            ::.:..:|||.||:..|||.|.||||.|||:|||:.||.|:|||.||:||:.||::.|:|.|.||
Human     6 VMMAASLALTGAVVAHAYYLKHQFYPTVVYLTKSSPSMAVLYIQAFVLVFLLGKVMGKVFFGQLR 70

  Fly    69 AAEFEHLLERFWYALTETCLAFTVFRDDFNPRFVALFTVLLFLKSFHWLAEERVDFMERSPVLGW 133
            |||.||||||.|||:||||||||||||||:||||||||:|||||.||||||:|||||||||.:.|
Human    71 AAEMEHLLERSWYAVTETCLAFTVFRDDFSPRFVALFTLLLFLKCFHWLAEDRVDFMERSPNISW 135

  Fly   134 LFHIRVGSLLTVLGILDYVLLIHAYNSTLVRGPTVQLVFGFEYAILLTVIASTAIKYVLHAAEMR 198
            |||.|:.||:.:|||||::.:.|||:|.|.||.:||||||||||||:|::.:..||||||:.:::
Human   136 LFHCRIVSLMFLLGILDFLFVSHAYHSILTRGASVQLVFGFEYAILMTMVLTIFIKYVLHSVDLQ 200

  Fly   199 TDTPWENKAVFLLYTELVIGLIKVVLYILFVVIMAKIYALPMFVFRPMFFTIRNFRKALNDVIMS 263
            ::.||:||||::|||||..|.|||:||:.|:.||.|::..|:|..|||:..:|.|:||:.|.|||
Human   201 SENPWDNKAVYMLYTELFTGFIKVLLYMAFMTIMIKVHTFPLFAIRPMYLAMRQFKKAVTDAIMS 265

  Fly   264 RRAIRNMNTLYPDATPEELRQSDNICIICREDMVNHSKKLPCGHIFHTTCLRSWFQRQQTCPTCR 328
            |||||||||||||||||||:..||:||||||:||..:|:|||.|||||:||||||||||||||||
Human   266 RRAIRNMNTLYPDATPEELQAMDNVCIICREEMVTGAKRLPCNHIFHTSCLRSWFQRQQTCPTCR 330

  Fly   329 LNILRTP-TVNSTAMPRQGDEAVAAAAGNP--------------IPAAAGV-------------- 364
            :::||.. ...|...|...|:....|...|              .|...|:              
Human   331 MDVLRASLPAQSPPPPEPADQGPPPAPHPPPLLPQPPNFPQGLLPPFPPGMFPLWPPMGPFPPVP 395

  Fly   365 -QPAGG--VPPPAPTAVVDGNQARADVNVAGGQALPPNFADLFGDASG-LPNGLPNLAGLQIPPP 425
             .|:.|  |.||:.:|......:.|....|.|.:.....|...|..|| .|...| ..|...|||
Human   396 PPPSSGEAVAPPSTSAAALSRPSGAATTTAAGTSATAASATASGPGSGSAPEAGP-APGFPFPPP 459

  Fly   426 PV-MPMISPFMIPPHFGYLTPLPPPPIPQDLTNFTDEELRAMEGLQRDHIVQRLKLLQNINLMLD 489
            .: ||:..||..|       |:|.|  |......|.|||||:||.:|.|:..||:.|:||:.:||
Human   460 WMGMPLPPPFAFP-------PMPVP--PAGFAGLTPEELRALEGHERQHLEARLQSLRNIHTLLD 515

  Fly   490 SAGIMMSQYQSLSARLQLTAVTPATAVNGSADSSVYDMPSTSATAMAQLETHQVTPTAAASSASP 554
            :|.:.::||  |:....|....|||:||.:.:::...:.:.|:|::...|.  .|||..||..:|
Human   516 AAMLQINQY--LTVLASLGPPRPATSVNSTEETATTVVAAASSTSIPSSEA--TTPTPGASPPAP 576

  Fly   555 TM---PA-EKVTIEDLGADADEDDIPSTATEAVSIPNSDADFEENSSELGELRKRRLKFLE 611
            .|   || |.|..|::..|.:.|                         ..|||:|||:.||
Human   577 EMERPPAPESVGTEEMPEDGEPD-------------------------AAELRRRRLQKLE 612

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sip3NP_001263152.1 HRD1 20..>365 CDD:227568 220/374 (59%)
zf-RING_2 287..328 CDD:290367 32/40 (80%)
SYVN1NP_757385.1 Involved in FAM8A1 interaction. /evidence=ECO:0000269|PubMed:28827405 1..251 154/244 (63%)
Necessary and sufficient for SEL1L interaction. /evidence=ECO:0000269|PubMed:28827405 1..84 46/77 (60%)
HRD1 10..>333 CDD:227568 216/322 (67%)
Interaction with p53/TP53. /evidence=ECO:0000269|PubMed:17170702 236..270 17/33 (52%)
zf-RING_2 289..330 CDD:290367 32/40 (80%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 337..375 5/37 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 393..453 15/60 (25%)
HAF-H domain, necessary to form higher-order Hrd1 complexes. /evidence=ECO:0000303|PubMed:28827405 480..535 22/56 (39%)
Nha1_C <528..611 CDD:285783 29/109 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 535..617 30/105 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165155265
Domainoid 1 1.000 396 1.000 Domainoid score I757
eggNOG 1 0.900 - - E1_COG5243
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 551 1.000 Inparanoid score I1138
Isobase 1 0.950 - 0 Normalized mean entropy S1478
OMA 1 1.010 - - QHG56438
OrthoDB 1 1.010 - - D271732at33208
OrthoFinder 1 1.000 - - FOG0004154
OrthoInspector 1 1.000 - - oto89721
orthoMCL 1 0.900 - - OOG6_102274
Panther 1 1.100 - - LDO PTHR22765
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2905
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.720

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