DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sip3 and Hrd1B

DIOPT Version :9

Sequence 1:	NP_001263152.1	Gene:	sip3 / 43747	FlyBaseID:	FBgn0039875	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	NP_849843.3	Gene:	Hrd1B / 842812	AraportID:	AT1G65040	Length:	460	Species:	Arabidopsis thaliana

Alignment Length:	418	Identity:	152/418 - (36%)
Similarity:	227/418 - (54%)	Gaps:	29/418 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 TSAVIGFAYYQKQQFYPAVVYITKSNASMGVIYIQFFVIVFMFGKLLSKIFLGTLRAAEFEHLLE 77
            |..||..|:..:.|||||.||::.|..::.|:.....|::.....|:..:|||:||.||.|.|.|
plant    15 TLVVIYHAFSSRGQFYPATVYLSTSKINLVVLLNMGLVLMLSLWNLVKIVFLGSLREAEVERLNE 79

  Fly    78 RFWYALTETCLAFTVFRDDFNPRFVALFTVLLFLKSFHWLAEERVDFMERSPVLGWLFHIRVGSL 142
            :.|..|.|...|.|:||.||:..|::|...||.:|..||:|::||:::|.:|.:..|.|:|:.|.
plant    80 QAWRELMEILFAITIFRQDFSVGFISLVVTLLLIKGLHWMAQKRVEYIETTPSVTLLSHVRIVSF 144

  Fly   143 LTVLGILDYVLLIHAYNSTLV--RGPTVQLVFGFEYAILLTVIASTAIKYVLHAAEMRTDTPWEN 205
            :..|.||| .||.::....|:  |..::.:.|.|||.||.|...|..:||..:..:|..:..||.
plant   145 MVFLLILD-CLLTYSSIQQLIQSRKASMSVFFTFEYMILATTTVSIIVKYAFYVTDMLKEGQWEG 208

  Fly   206 KAVFLLYTELVIGLIKVVLYILFVVIMAKIYALPMFVFRPMFFTIRNFRKALNDVIMSRRAIRNM 270
            |.|:..|.|||..|:.:.:|:.|.:::...|.||:.:.|.::.|.|||:..:.|.:..|:...||
plant   209 KPVYTFYLELVRDLLHLSMYLCFFLMIFMNYGLPLHLIRELYETFRNFKIRVTDYLRYRKITSNM 273

  Fly   271 NTLYPDATPEELRQSDNICIICREDMVNHSKKLPCGHIFHTTCLRSWFQRQQTCPTCRLNILRTP 335
            |..:||||||||..:|..||||||:|.: :|||.|||:||..|||||.:||.||||||  .|..|
plant   274 NDRFPDATPEELSSNDATCIICREEMTS-AKKLVCGHLFHVHCLRSWLERQNTCPTCR--ALVVP 335

  Fly   336 TVNSTAMPRQGDEAVAAAAGNPIPAAAGVQPAGGVPPPAPTAVVDGN----QARADVNVAGGQA- 395
            ..|:|          :.|:||..|....:|...|      |:..||.    .|.|..|::..:|
plant   336 AENAT----------STASGNRGPHQESLQQGTG------TSSSDGQGSSVSAAASENMSRHEAR 384

  Fly   396 --LPPNFADLFGDASGLPNGLPNLAGLQ 421
              ...:.|.::|.:...|:....|...|
plant   385 FQAAASAASIYGRSIVYPSSANTLVWSQ 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sip3	NP_001263152.1	HRD1	20..>365	CDD:227568	135/346 (39%)
sip3	NP_001263152.1	zf-RING_2	287..328	CDD:290367	26/40 (65%)
Hrd1B	NP_849843.3	HRD1	9..386	CDD:227568	147/390 (38%)
Hrd1B	NP_849843.3	zf-RING_2	291..330	CDD:290367	26/39 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	196	1.000	Domainoid score	I901
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	268	1.000	Inparanoid score	I931
OMA	1	1.010	-	-		QHG56438
OrthoDB	1	1.010	-	-		D897451at2759
OrthoFinder	1	1.000	-	-		FOG0004154
OrthoInspector	1	1.000	-	-		otm3333
orthoMCL	1	0.900	-	-		OOG6_102274
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2905
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.740