DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sip3 and Rnf145

DIOPT Version :9

Sequence 1:	NP_001263152.1	Gene:	sip3 / 43747	FlyBaseID:	FBgn0039875	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	NP_001350095.1	Gene:	Rnf145 / 74315	MGIID:	1921565	Length:	663	Species:	Mus musculus

Alignment Length:	453	Identity:	106/453 - (23%)
Similarity:	176/453 - (38%)	Gaps:	108/453 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 VIYIQFFVIVFMFGKLLSKIFLGTLRAAEFEHLLERFWYALTETC--------LAFTVFRDDFNP 99
            |:::.|:::  :|...:...|....:.|..|.||..|..::.|.|        |.|||
Mouse   229 VLFMVFWLV--LFALQIYSYFSTRDQPASRERLLFLFLTSIAECCSTPYSLLGLVFTV------- 284

  Fly   100 RFVALFTVLL---FLKSFHWLAEE-----------------------RVDFMERSPVLGWLFHIR 138
            .||||..:.|   :|:.:.....:                       .:..:.|:.:|..:..|.
Mouse   285 SFVALGVLTLCKFYLQGYRAFMNDPAMNRGMTEGVTLLILAVQTGLIELQVVHRAFLLSIILFIV 349

  Fly   139 VGSLL-TVLGILD-------------------------YVLLIHAYNSTLVRGPTVQLVFGFEYA 177
            |.|:| ::|.|.|                         ::|:..||.:.::    .|. |..::.
Mouse   350 VASILQSMLEIADPIVLALGASRDKSLWKHFRAVSLCLFLLVFPAYMAYMI----CQF-FHMDFW 409

  Fly   178 ILLTVIAS---------TAIKYVLHAAEMRTDTPWENKAVFLLYT-------ELVIGLIKVVLYI 226
            :|:.:.:|         |...|||...|.....|.||....:.|.       |.|:.|. ||.|.
Mouse   410 LLIIISSSILTSLQVLGTLFIYVLFMVEEFRKEPVENMDDVIYYVNGTYRLLEFVVALC-VVAYG 473

  Fly   227 LFVVIMAKIYAL-PMFVFRPMFFTIRNFRKAL--NDVIMSRRAIRNMNTLYPDATPEELRQSDNI 288
            :...|..:...: .|.:|...::.:. .|..|  ...::.|.|:..:.:| |.||.|:|.:.::|
Mouse   474 VSETIFGEWTVMGSMIIFIHSYYNVW-LRAQLGWKSFLLRRDAVNKIKSL-PVATQEQLEKHNDI 536

  Fly   289 CIICREDMVNHSKKLPCGHIFHTTCLRSWFQRQQTCPTCRLNILRTPTVNSTAMPRQGDEAV--- 350
            |.||.:|| ..:...||.|.||..||:.|...|.|||.|..::     .||:.:|..|.||.
Mouse   537 CAICYQDM-KSAVITPCSHFFHAGCLKKWLYVQDTCPLCHCHL-----KNSSQLPGLGTEAAPQP 595

  Fly   351 AAAAGNPIPAAAGVQPAGGVPPPAPTAVVDGNQARADVNVAGGQALPPNFADLFGDASGLPNG 413
            .|.|...|....|.:|.....||. |...:|:...:: ::..|.|.....||. |:...:|.|
Mouse   596 PAGAEQNIVLQEGPEPPDHESPPG-TGTQEGSGDSSE-HINRGSASQEGAADA-GEGPQIPEG 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sip3	NP_001263152.1	HRD1	20..>365	CDD:227568	94/403 (23%)
sip3	NP_001263152.1	zf-RING_2	287..328	CDD:290367	18/40 (45%)
Rnf145	NP_001350095.1	TRC8_N	8..506	CDD:372682	57/292 (20%)
		YLYF motif. /evidence=ECO:0000269\|PubMed:29374057	81..84
		HRD1	<520..627	CDD:227568	40/114 (35%)
		RING-H2_RNF145	533..575	CDD:319598	18/42 (43%)
		RING-H2 finger (C3H2C3-type)	537..574	CDD:319598	17/37 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	587..663		19/72 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845735
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D897451at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750