Protein Alignment sip3 and amfra

DIOPT Version :9

• Sequence 1: NP_001263152.1
• Gene: sip3 / 43747
• FlyBaseID: FBgn0039875
• Length: 626
• Species: Drosophila melanogaster
• Sequence 2: NP_998328.2
• Gene: amfra / 406442
• ZFINID: ZDB-GENE-040426-2190
• Length: 620
• Species: Danio rerio
• Alignment Length: 621
• Identity: 148/621 - (23%)
• Similarity: 248/621 - (39%)
• Gaps: 155/621 - (24%)

  Fly    51 IVFMFGKLLSKIFLGTLRAAEFEHLLERFW----YALTETCLAFTVFRDDFNPRFVALFTVLLFL 111
            |:.:.||::..|..|.||.:|.:||.::||    |..........|.|.:....:...|::|:||
Zfish    87 ILMLIGKVIQCIVFGPLRVSEKQHLKDKFWNFIFYKFIFIFGVLNVQRVEEVVLWCLWFSMLIFL 151

  Fly   112 KSFHWLAEERVDFMERSPVLGWLFHIRVGSLL-TVLGILDYVLLIHAYNSTLVRGPTVQLVFGFE 175
            .....|.::|.:::..||......|:||.:|| :||.....:.::.|....:....||  .|...
Zfish   152 HLMVQLCKDRFEYLSFSPTTPMSSHVRVLALLVSVLSCCGGLAVLCALAGHIHGMHTV--AFMAA 214

  Fly   176 YAILLTV-IASTAIKYVLHAAEMRTDTPWENKAVFLLYTELV-------IGLIKVVLYILFVVIM 232
            ..:|:|| .....|:|.:|..::..:..||||:.::.||:.:       :.|:..:..:||..|.
Zfish   215 ECLLVTVRTGHVIIRYSIHLWDLNHEGTWENKSSYIYYTDFIMELAILSLDLMHHIHMLLFGNIW 279

  Fly   233 AKIYALPMFV-FRPMFFTI-RNFRKALNDVIMSRRAIRNMNTLYPDATPEELRQSDNICIICRED 295
            ..:.:|.:|: .|.:|..: |..|:..|.:    |.|.||.:.:..||||||..:::.|.||.:.
Zfish   280 LSMASLVIFMQLRHLFHEVQRRIRRHKNYL----RVIDNMESRFAVATPEELAANNDDCAICWDS 340

  Fly   296 MVNHSKKLPCGHIFHTTCLRSWFQRQQTCPTCRLNILRTPTVNSTAMPRQGDEAVAAAAGNPIPA 360
            |.. ::||||||:||.:|||||.::..:|||||:::      |.....|:.:|      |...|.
Zfish   341 MTT-ARKLPCGHLFHNSCLRSWLEQDTSCPTCRMSL------NIHEGRREREE------GQREPL 392

  Fly   361 AAGVQPAGGVPPPAPTAVVDGNQARADVNVAG------GQALP---PNFA-------DLFGDASG 409
            ...:..||..            .|||.:|...      |..:.   |:|:       ::.|.|..
Zfish   393 EDNMAAAGAA------------DARAHINQHNHFFHFDGSRIASWLPSFSVEVMHTTNILGIAQA 445

  Fly   410 LPNGLPNLAGLQIPPPPVMPMISPFMIPPHFGYLTPLPPPPIPQDLTNFTDEELRAMEGLQRDHI 474
            ..:.|..:|               ..|...|        |.:|..|                  |
Zfish   446 NNSQLNGMA---------------HQIQEMF--------PQVPYHL------------------I 469

  Fly   475 VQRLKLLQNINLMLDSAGIMMSQYQSLSARLQLTAVTPAT-----AVNGSADSSVYDMPSTSATA 534
            :|.|:|.:::.:..|:.         |..|:|:...|.:|     .:|.:::... ...|.|..|
Zfish   470 LQDLQLTRSVEVTTDNI---------LEGRIQVPFPTQSTDRTPIQMNAASEDGA-GASSGSEVA 524

  Fly   535 MAQLETHQVTPTAAASSASPTM----------------------PAEKVTIEDLGADADEDDIPS 577
            ..:.|..:|..:..:.||....                      |.:......||||.| |.:||
Zfish   525 APEAEDFEVRGSRFSKSADERQRMLMQRKEELLLRARRRYLHKKPEDGDAYSVLGADND-DSVPS 588

  Fly   578 TATEAVSIPNSDADFEENSSELGELRKRRLKFLEER 613
                          .|:..|:...||:|||....||
Zfish   589 --------------IEDEDSDSVTLRRRRLAAAAER 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sip3	NP_001263152.1	HRD1	20..>365	CDD:227568	94/328 (29%)
		zf-RING_2	287..328	CDD:290367	20/40 (50%)
amfra	NP_998328.2	zf-rbx1	79..>375	CDD:331150	89/294 (30%)
		RING-H2_AMFR	332..375	CDD:319369	22/43 (51%)
		RING-H2 finger (C3H2C3-type)	334..371	CDD:319369	19/37 (51%)
		CUE_AMFR	451..491	CDD:270604	12/89 (13%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D271732at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820