DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sip3 and Syvn1

DIOPT Version :9

Sequence 1:	NP_001263152.1	Gene:	sip3 / 43747	FlyBaseID:	FBgn0039875	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	XP_006230914.1	Gene:	Syvn1 / 361712	RGDID:	1310488	Length:	612	Species:	Rattus norvegicus

Alignment Length:	645	Identity:	299/645 - (46%)
Similarity:	405/645 - (62%)	Gaps:	80/645 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LLSSVCMALTSAVIGFAYYQKQQFYPAVVYITKSNASMGVIYIQFFVIVFMFGKLLSKIFLGTLR 68
            ::.:..:|||.||:..|||.|.||||.|||:|||:.||.|:|||.||:||:.||::.|:|.|.||
  Rat     6 VMMAASLALTGAVVAHAYYLKHQFYPTVVYLTKSSPSMAVLYIQAFVLVFLLGKVMGKVFFGQLR 70

  Fly    69 AAEFEHLLERFWYALTETCLAFTVFRDDFNPRFVALFTVLLFLKSFHWLAEERVDFMERSPVLGW 133
            |||.||||||.|||:||||||||||||||:||||||||:|||||.||||||:|||||||||.:.|
  Rat    71 AAEMEHLLERSWYAVTETCLAFTVFRDDFSPRFVALFTLLLFLKCFHWLAEDRVDFMERSPNISW 135

  Fly   134 LFHIRVGSLLTVLGILDYVLLIHAYNSTLVRGPTVQLVFGFEYAILLTVIASTAIKYVLHAAEMR 198
            |||.|:.||:.:|||||::.:.|||:|.|.||.:||||||||||||:|::.:..||||||:.:::
  Rat   136 LFHCRIVSLMFLLGILDFLFVSHAYHSILTRGASVQLVFGFEYAILMTMVLTIFIKYVLHSVDLQ 200

  Fly   199 TDTPWENKAVFLLYTELVIGLIKVVLYILFVVIMAKIYALPMFVFRPMFFTIRNFRKALNDVIMS 263
            ::.||:||||::|||||..|.|||:||:.|:.||.|::..|:|..|||:..:|.|:||:.|.|||
  Rat   201 SENPWDNKAVYMLYTELFTGFIKVLLYMAFMTIMIKVHTFPLFAIRPMYLAMRQFKKAVTDAIMS 265

  Fly   264 RRAIRNMNTLYPDATPEELRQSDNICIICREDMVNHSKKLPCGHIFHTTCLRSWFQRQQTCPTCR 328
            |||||||||||||||||||:..||:||||||:||..:|:|||.|||||:||||||||||||||||
  Rat   266 RRAIRNMNTLYPDATPEELQAMDNVCIICREEMVTGAKRLPCNHIFHTSCLRSWFQRQQTCPTCR 330

  Fly   329 LNILRTPTVNSTAMPRQGDEAVAAAAGNPIPAAAGVQPAGGVPP--PAPTAVVDG---------- 381
            :::||      .::|.|....       |.||..|..||...||  |.|.....|
  Rat   331 MDVLR------ASLPAQSPPP-------PEPADQGAPPAPHPPPLLPQPPNFPQGLLPPFPPGMF 382

  Fly   382 ------------------NQARADVNVAGGQALPPNFADLFGDASGLPNGLP---NLAGLQIPPP 425
                              .:|.|..:.:...:.|...|..  .|:|.....|   ::.|.:..|.
  Rat   383 PLWPPMGPFPPVPPPPSSGEAAAPPSTSAATSRPSGAATT--TAAGTSTSAPASGSVPGPEAGPA 445

  Fly   426 PVMPMISPFM---IPPHFGYLTPLPPPPI-PQDLTNFTDEELRAMEGLQRDHIVQRLKLLQNINL 486
            |..|...|:|   :||.|.:    ||.|: |......|.|||||:||.:|.|:..||:.|:||:.
  Rat   446 PGFPFPPPWMGMPLPPPFAF----PPMPVPPAGFAGLTPEELRALEGHERQHLEARLQSLRNIHT 506

  Fly   487 MLDSAGIMMSQYQSLSARLQLTAVTPATAVNGSADSSVYDMPSTSATAMAQLETHQVTPTAAASS 551
            :||:|.:.::||  |:....|....|||:||.:.:::...:.:|.:|::...|.     .|.:..
  Rat   507 LLDAAMLQINQY--LTVLASLGPPRPATSVNPTEETASTVVSATPSTSVPSSEA-----PAPSLG 564

  Fly   552 ASPTMPAEKVTIEDLGADADEDDIPSTATEAVSIPNSDADFEENSSELGELRKRRLKFLE 611
            |||.:|           :|::...|.:.:.|..:|      |:...:..|||:|||:.||
  Rat   565 ASPPIP-----------EAEKPPAPESVSTAEELP------EDGEPDAAELRRRRLQKLE 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sip3	NP_001263152.1	HRD1	20..>365	CDD:227568	219/344 (64%)
sip3	NP_001263152.1	zf-RING_2	287..328	CDD:290367	32/40 (80%)
Syvn1	XP_006230914.1	HRD1	10..>333	CDD:227568	216/322 (67%)
Syvn1	XP_006230914.1	fibronec_FbpA	<524..>597	CDD:411474	19/94 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349150
Domainoid	1	1.000	396	1.000	Domainoid score	I729
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	554	1.000	Inparanoid score	I1080
OMA	1	1.010	-	-		QHG56438
OrthoDB	1	1.010	-	-		D271732at33208
OrthoFinder	1	1.000	-	-		FOG0004154
OrthoInspector	1	1.000	-	-		oto96831
orthoMCL	1	0.900	-	-		OOG6_102274
Panther	1	1.100	-	-	LDO	PTHR22765
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2905
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770