Protein Alignment sip3 and Rnf145

DIOPT Version :10

• Sequence 1: NP_651894.3
• Gene: sip3 / 43747
• FlyBaseID: FBgn0039875
• Length: 626
• Species: Drosophila melanogaster
• Sequence 2: NP_001099248.1
• Gene: Rnf145 / 287212
• RGDID: 1309561
• Length: 664
• Species: Rattus norvegicus
• Alignment Length: 457
• Identity: 103/457 - (22%)
• Similarity: 173/457 - (37%)
• Gaps: 127/457 - (27%)

  Fly    43 VIYIQFFVIVFMFGKLLSKIFLGTLRAAEFEHLLERFWYALTETC--------LAFTVFRDDFNP 99
            |:::.|:::  :|...:...|....:.|..|.||..|..::.|.|        |.|||
  Rat   229 VLFMVFWLV--LFALQIYSYFSTRDQPASRERLLFLFLTSIAECCSTPYSLLGLVFTV------- 284

  Fly   100 RFVALFTVLL---FLKSFHWLAEE-----------------------RVDFMERSPVLGWLFHIR 138
            .||||..:.|   :|:.:.....:                       .:..:.|:.:|..:..|.
  Rat   285 SFVALGVLTLCKFYLQGYRAFMNDPAMNRGMTEGVTLLILAVQTGLIELQVVHRAFLLSIILFIV 349

  Fly   139 VGSLL-TVLGILD-------------------------YVLLIHAYNSTLVRGPTVQLVFGFEYA 177
            |.|:| ::|.|.|                         ::|:..||.:.::    .|. |..::.
  Rat   350 VASILQSMLEIADPIVLALGASRDKSLWKHFRAVSLCLFLLVFPAYMAYMI----CQF-FHMDFW 409

  Fly   178 ILLTVIAS---------TAIKYVLHAAEMRTDTPWENKAVFLLYTELVIGLIKVVLYILFVVIMA 233
            :|:.:.:|         |...|||...|.....|.||....:.|   |.|..:::.:::.:.::|
  Rat   410 LLIIISSSILTSLQVLGTLFIYVLFMVEEFRKEPVENMDDVIYY---VNGTYRLLEFLVALCVVA 471

  Fly   234 KIYALPMF----VFRPMFFTIRNF-----RKAL--NDVIMSRRAIRNMNTLYPDATPEELRQSDN 287
            ...:..:|    |...|...|.::     |..|  ...::.|.|:..:.:| |.||.|:|.:.::
  Rat   472 YGVSETIFGEWTVMGSMIIFIHSYYNVWLRAQLGWKSFLLRRDAVNKIKSL-PIATKEQLERHND 535

  Fly   288 ICIICREDMVNHSKKLPCGHIFHTTCLRSWFQRQQTCPTCRLNILRTPTVNSTAMPRQGDE---- 348
            ||.||.:|| ..:...||.|.||..||:.|...|.|||.|..::     .||:.:|..|.|
  Rat   536 ICAICYQDM-KSAVITPCSHFFHAGCLKKWLYVQDTCPLCHCHL-----KNSSQLPGLGTEPAPQ 594

  Fly   349 -AVAAAAGNPIPAAAGVQPAGGVPPPAPTAVVDGNQARADVN-----------------VAGGQA 395
             .||.|..| |....|.:|.....||.|.|..........:|                 :|.|:|
  Rat   595 PPVAGAEQN-IVLQEGPEPPDHETPPGPGAQEGSGDNSEYINRSSASREGDADPGDGPQIAEGEA 658

  Fly   396 LP 397
            .|
  Rat   659 CP 660

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sip3	NP_651894.3	HRD1	20..>365	CDD:227568	93/406 (23%)
Rnf145	NP_001099248.1	TRC8_N	8..506	CDD:463960	55/293 (19%)
		HRD1	<520..643	CDD:227568	42/130 (32%)
		RING-H2_RNF145	533..575	CDD:319598	18/42 (43%)