Protein Alignment sip3 and hrd1

DIOPT Version :9

• Sequence 1: NP_001263152.1
• Gene: sip3 / 43747
• FlyBaseID: FBgn0039875
• Length: 626
• Species: Drosophila melanogaster
• Sequence 2: NP_596376.1
• Gene: hrd1 / 2539900
• PomBaseID: SPBC17D11.02c
• Length: 677
• Species: Schizosaccharomyces pombe
• Alignment Length: 675
• Identity: 175/675 - (25%)
• Similarity: 280/675 - (41%)
• Gaps: 112/675 - (16%)

  Fly     1 MQLLLSSVCMALTSAVIGFAYYQKQQFYPAVVYITKS----NASMGVIYIQFFVIVFMFGKLLSK 61
            :.:|.|.|...|:   :..:.|.....|.|.|.|::|    ...:.|....||.|    ...|..
pombe     5 LYVLASLVLFGLS---VLLSLYSSANVYSATVMISQSPVHITIGLNVCLCLFFAI----ANALKT 62

  Fly    62 IFLGTLRAAEFEHLLERFWYALTETCLAFTVFRDDFNPRFVALFTVLLFLKSFHWLAEERVDFME 126
            :..|:|:..|.|.|.|:||..|||..||.||||:..:..|..|.:.|:|.:.||.:...|.:.::
pombe    63 LLFGSLQTFELELLYEQFWITLTEIMLAITVFREAISISFFMLLSTLMFARVFHSICSFRTERLQ 127

  Fly   127 RSPVLGWLFHI--RVGSLLTVLGILDYVLLIHAYNSTLVRGPTVQLVFGFEYAILLTVIASTAIK 189
             ..:....|||  |:.....||.|||..|:...:.|..:...:.:::|..|:::||..:...|.|
pombe   128 -IQLTDQRFHIFSRLTCAYFVLSILDASLIYLCFTSEHLGDKSTRMLFVCEFSVLLLNLTIEASK 191

  Fly   190 YVLHAAEMR-TDTPWENKAVFLLYTELVIGLIKVVLYILFVVIMAKIYALPMFVFRPMFFTIRNF 253
            ..::..|.| .|..|:.|:.:|...|:....::::.|.|..:......::|::..|.|:....:.
pombe   192 LCIYLYEARHLDQVWDEKSTYLFRLEVCRDGLRLLAYSLLFMYQFPYVSVPIYSIRQMYTCFYSL 256

  Fly   254 RKALNDVIMSRRAIRNMNTLYPDATPEELRQSDNICIICREDMVNHS------------------ 300
            .:.:.:....|:|.|:||.:||.||.|:|..||..|.||||:|.:..
pombe   257 FRRIREHARFRQATRDMNAMYPTATEEQLTNSDRTCTICREEMFHPDHPPENTDEMEPLPRGLDM 321

  Fly   301 --KKLPCGHIFHTTCLRSWFQRQQTCPTCRLNILRTPTVNSTAMPRQGDEAVAAAAGNPIPAAAG 363
              |:||||||.|..|||:|.:||||||.||.:::...: :.|.:|..             |....
pombe   322 TPKRLPCGHILHFHCLRNWLERQQTCPICRRSVIGNQS-SPTGIPAS-------------PNVRA 372

  Fly   364 VQPAGGVPPP--APTAVVDGNQARADVNVAGGQALPPNFADLFGDASGLPNGLPNLAGLQIPPPP 426
            .|.|..||.|  .||..     |...:..:..|..|.  |..|   :|:||.  |.:|.......
pombe   373 TQIATQVPNPQNTPTTT-----AVPGITNSSNQGDPQ--ASTF---NGVPNA--NSSGFAAHTQD 425

  Fly   427 VMPMISPFMIPPHFGYLTPLPPP-----PIPQDLTNFTDEELRAMEGLQRDHIVQRLKLL----Q 482
            :..:| |..|....|: |.||.|     |.....|:.|:.......|...:......:..    .
pombe   426 LSSVI-PRRIALRDGW-TMLPIPGTRRIPTYSQSTSTTNPSATPTTGDPSNSTYGGPQTFPNSGN 488

  Fly   483 NINLMLDSAGI-------MMSQYQSLSARLQLTAV-TPATAVNGSADSSVYDMPSTSATAMAQLE 539
            |.|.....|||       :.|..||||....:|:: ..|::.:.:..||:.::...|.......|
pombe   489 NPNFNRGIAGIVPPGWRLVSSNTQSLSTNSAMTSLYQNASSADNNLGSSLPNVVPLSRGLTQSNE 553

  Fly   540 THQVTPTAAASSASPTMPAEKVTIEDLGADADEDDIPSTATEAVSIPNSDADFEENSSELGELRK 604
            |....|.|:::.:|        .:.:|....||      ..|.||  |..||:....:.|.:|
pombe   554 TSNTFPAASSNISS--------QLRELHTKIDE------LRETVS--NFRADYNSIRTSLNQL-- 600

  Fly   605 RRLKFLEERNKSAATNER---TTAE 626
                     ..::..|||   |:|:
pombe   601 ---------EAASGINERIQTTSAD 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sip3	NP_001263152.1	HRD1	20..>365	CDD:227568	106/371 (29%)
		zf-RING_2	287..328	CDD:290367	24/60 (40%)
hrd1	NP_596376.1	HRD1	1..514	CDD:227568	146/544 (27%)
		zf-RING_2	291..351	CDD:290367	24/59 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	113	1.000	Domainoid score	I1560
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	168	1.000	Inparanoid score	I1202
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004154
OrthoInspector	1	1.000	-	-		oto101134
orthoMCL	1	0.900	-	-		OOG6_102274
Panther	1	1.100	-	-	LDO	PTHR22765
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6571
SonicParanoid	1	1.000	-	-		X2905
TreeFam	1	0.960	-	-
	12	11.850