DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sip3 and hrdl-1

DIOPT Version :9

Sequence 1:	NP_001263152.1	Gene:	sip3 / 43747	FlyBaseID:	FBgn0039875	Length:	626	Species:	Drosophila melanogaster
Sequence 2:	NP_492602.2	Gene:	hrdl-1 / 172833	WormBaseID:	WBGene00009164	Length:	579	Species:	Caenorhabditis elegans

Alignment Length:	405	Identity:	82/405 - (20%)
Similarity:	142/405 - (35%)	Gaps:	86/405 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LLSSVCMALTSAVIGFAYYQKQ-------------------------------QFYPAVVYITKS 37
            |..||.:|:.::|..|..::.|                               .|:....||...
Worm    34 LALSVLVAIVASVTVFTTFRSQPELQKLIEEELRNNTRLSSAYGLNIEALSGHTFFQIAHYILSD 98

  Fly    38 NASMGVIYIQFFVIVFMFGKLLSKIFLGTLRAAEFEHLLER--FWYALTETCLAFTVFRDDFNPR 100
            ...:.|....:|.|:.:..:|:.|:....| |.:.|::..:  |.|.|........|.......|
Worm    99 TTLIWVAINSYFAILAVCTRLIIKLTFKEL-ARQEENVARQAFFCYVLLTIVYLSVVIGPQKGHR 162

  Fly   101 FVALFT---VLLFLKSFHWLAEERVDFMERSPVLG---------WLFHIRVGSLLTVLGILDYVL 153
            .:....   :..||....::..:|:..:..|...|         :||.:.:.          ...
Worm   163 VMPWMIWGGICAFLSHLQFITCQRLKHISPSCDRGSQKISFLSLFLFFVSIA----------MTF 217

  Fly   154 LIHAYNSTLVRGPTVQLVFGFEYAILLTVIASTAIKY-VLHAAEMRTDTP--------WENKAVF 209
            ||..:...|...|.|.|.|.    .||.|..||.|.: .:.::.:.:..|        |     .
Worm   218 LISRFQHHLTWQPAVLLYFD----CLLAVFRSTYILFRCISSSRVFSFNPDSVRHFNYW-----L 273

  Fly   210 LLYTELVIGLIKVVLYILFVVIMAKIYALPMFVFRPMFFTIRNFRKALNDVIMSRRAIRNMNTLY 274
            .|.|..|..||:::.:...:.....:....:|....|..|.....:.|:.....::...::...|
Worm   274 ELITNFVCELIQMLSFAQLLAFSPGLNLTSIFFLYHMKLTYNCMTEQLSRHRNHKKIFEHIERSY 338

  Fly   275 PDATPEELRQSDNICIICREDMVNHSKKLPCGHIFHTTCLRSWFQRQQTCPTCRLNI------LR 333
            |..   :....|:.|::|.| ::..|::|||.|.||..||..|..:..:|||||..|      :|
Worm   339 PSV---KCANGDDRCVVCWE-LLGTSRRLPCSHQFHDWCLMWWLAQDSSCPTCRCTIPSPQDQIR 399

  Fly   334 TP--TVNSTAMPRQG 346
            .|  ..|||.:...|
Worm   400 QPPEVGNSTRLRFNG 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sip3	NP_001263152.1	HRD1	20..>365	CDD:227568	76/389 (20%)
sip3	NP_001263152.1	zf-RING_2	287..328	CDD:290367	16/40 (40%)
hrdl-1	NP_492602.2	HRD1	<200..>407	CDD:227568	50/229 (22%)
		zf-RING_2	348..388	CDD:290367	16/40 (40%)
		CUE_AMFR	449..489	CDD:270604
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D271732at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820