Protein Alignment sip3 and RNF145

DIOPT Version :9

• Sequence 1: NP_001263152.1
• Gene: sip3 / 43747
• FlyBaseID: FBgn0039875
• Length: 626
• Species: Drosophila melanogaster
• Sequence 2: NP_001186309.1
• Gene: RNF145 / 153830
• HGNCID: 20853
• Length: 693
• Species: Homo sapiens
• Alignment Length: 439
• Identity: 100/439 - (22%)
• Similarity: 173/439 - (39%)
• Gaps: 114/439 - (25%)

  Fly    43 VIYIQFFVIVFMFGKLLSKIFLGTLRAAEFEHLLERFWYALTETC--------LAFTVFRDDFNP 99
            |:::.|:::  :|...:...|....:.|..|.||..|..::.|.|        |.|||
Human   259 VLFMVFWLV--LFALQIYSYFSTRDQPASRERLLFLFLTSIAECCSTPYSLLGLVFTV------- 314

  Fly   100 RFVALFTVLL---FLKSFHWLAEE-----------------------RVDFMERSPVLGWLFHIR 138
            .||||..:.|   :|:.:.....:                       .:..:.|:.:|..:..|.
Human   315 SFVALGVLTLCKFYLQGYRAFMNDPAMNRGMTEGVTLLILAVQTGLIELQVVHRAFLLSIILFIV 379

  Fly   139 VGSLL-TVLGILD-------------------------YVLLIHAYNSTLVRGPTVQLVFGFEYA 177
            |.|:| ::|.|.|                         ::|:..||.:.::    .|. |..::.
Human   380 VASILQSMLEIADPIVLALGASRDKSLWKHFRAVSLCLFLLVFPAYMAYMI----CQF-FHMDFW 439

  Fly   178 ILLTVIAS---------TAIKYVLHAAEMRTDTPWENKAVFLLYTELVIGLIKVVLYILFVVIMA 233
            :|:.:.:|         |...|||...|.....|.||....:.|   |.|..:::.:::.:.::|
Human   440 LLIIISSSILTSLQVLGTLFIYVLFMVEEFRKEPVENMDDVIYY---VNGTYRLLEFLVALCVVA 501

  Fly   234 KIYALPMF----VFRPMFFTIRNF-----RKAL--NDVIMSRRAIRNMNTLYPDATPEELRQSDN 287
            ...:..:|    |...|...|.::     |..|  ...::.|.|:..:.:| |.||.|:|.:.::
Human   502 YGVSETIFGEWTVMGSMIIFIHSYYNVWLRAQLGWKSFLLRRDAVNKIKSL-PIATKEQLEKHND 565

  Fly   288 ICIICREDMVNHSKKLPCGHIFHTTCLRSWFQRQQTCPTCRLNILRTPTVNSTAMPRQGDEAVA- 351
            ||.||.:|| ..:...||.|.||..||:.|...|:|||.|..::     .||:.:|..|.|.|.
Human   566 ICAICYQDM-KSAVITPCSHFFHAGCLKKWLYVQETCPLCHCHL-----KNSSQLPGLGTEPVLQ 624

  Fly   352 --AAAGNPIPAAAGVQPAGGVPPPAPTAVVDGNQ------ARADVNVAG 392
              |.|...:....|.:|.|....|. |.:.:|::      ||...|..|
Human   625 PHAGAEQNVMFQEGTEPPGQEHTPG-TRIQEGSRDNNEYIARRPDNQEG 672

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sip3	NP_001263152.1	HRD1	20..>365	CDD:227568	91/404 (23%)
		zf-RING_2	287..328	CDD:290367	18/40 (45%)
RNF145	NP_001186309.1	TRC8_N	38..536	CDD:290425	55/293 (19%)
		zf-rbx1	<564..605	CDD:289448	18/41 (44%)
		zf-RING_2	565..605	CDD:290367	18/40 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155263
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D897451at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840