Protein Alignment sip3 and RNF139

DIOPT Version :9

• Sequence 1: NP_001263152.1
• Gene: sip3 / 43747
• FlyBaseID: FBgn0039875
• Length: 626
• Species: Drosophila melanogaster
• Sequence 2: NP_009149.2
• Gene: RNF139 / 11236
• HGNCID: 17023
• Length: 664
• Species: Homo sapiens
• Alignment Length: 385
• Identity: 97/385 - (25%)
• Similarity: 148/385 - (38%)
• Gaps: 87/385 - (22%)

  Fly     1 MQLLLSSVCMALTSAVIGFAYYQKQQFYPAVVYITKSNASMG-VIYIQFFVIVFMFGKLLSKIFL 64
            |..::|||...|...::.|           :....:.:..:| |..:.||::....|       |
Human   294 MSAVISSVAHYLGLGILAF-----------IGSTEEDDRRLGFVAPVLFFILALQTG-------L 340

  Fly    65 GTLRAAEFEHLLERFWYALTETCLAFTVFRDDFNPRFVALFT--VLLFLKSFHWLAEERVDFMER 127
            ..||..|....|.|      ..||..|...     .|:...|  ||:.|.:.|..:     |...
Human   341 SGLRPEERLIRLSR------NMCLLLTAVL-----HFIHGMTDPVLMSLSASHVSS-----FRRH 389

  Fly   128 SPVLGWLFHIRVGSLLTVLGI-LDYVLLIH-AYNSTLVRGPTVQLVFGFEYAILLTVIASTAIKY 190
            .|||      .|.:.|.:|.: |.|||..| |.|:.|.      .|..|...:.|.||.|..: |
Human   390 FPVL------FVSACLFILPVLLSYVLWHHYALNTWLF------AVTAFCVELCLKVIVSLTV-Y 441

  Fly   191 VLHAAEMRTDTPWENKAVFLLYTELVIGLIKVVLYILFVVIM-------------AKIYALPMFV 242
            .|...:...:..||....::.|......:|:    .:|.|:|             :||.|..|.:
Human   442 TLFMIDGYYNVLWEKLDDYVYYVRSTGSIIE----FIFGVVMFGNGAYTMMFESGSKIRAFMMCL 502

  Fly   243 FRPMFFTIRNFRKALN--DVIMSRR-AIRNMNTLYPDATPEELRQSDNICIICREDMVNHSKKLP 304
            .  .:|.|  :.:|.|  ...|:|| |::.:|:| |:.....|::.:::|.||..:....::..|
Human   503 H--AYFNI--YLQAKNGWKTFMNRRTAVKKINSL-PEIKGSRLQEINDVCAICYHEFTTSARITP 562

  Fly   305 CGHIFHTTCLRSWFQRQQTCPTCRLNILRTPTV--NSTAMPRQG--------DEAVAAAA 354
            |.|.||..|||.|...|.|||.|...:.....:  ||......|        :|||..||
Human   563 CNHYFHALCLRKWLYIQDTCPMCHQKVYIEDDIKDNSNVSNNNGFIPPNETPEEAVREAA 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sip3	NP_001263152.1	HRD1	20..>365	CDD:227568	91/366 (25%)
		zf-RING_2	287..328	CDD:290367	16/40 (40%)
RNF139	NP_009149.2	TRC8_N	19..516	CDD:316245	64/276 (23%)
		RING-H2_RNF139	545..586	CDD:319597	16/40 (40%)
		RING-H2 finger (C3H2C3-type)	547..585	CDD:319597	16/37 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	601..664		6/22 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5243
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D897451at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6571
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940