Protein Alignment betaGlu and GUSB

DIOPT Version :10

• Sequence 1: NP_651893.1
• Gene: betaGlu / 43746
• FlyBaseID: FBgn0270927
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: NP_000172.2
• Gene: GUSB / 2990
• HGNCID: 4696
• Length: 651
• Species: Homo sapiens
• Alignment Length: 626
• Identity: 269/626 - (42%)
• Similarity: 387/626 - (61%)
• Gaps: 35/626 - (5%)

  Fly    55 GLLYPRDSETREVRSLDGMWQLVRSDPYD-PLQGIREKWFMDALRKTGREIISMPVPASYNDITT 118
            |:|||::|.:||.:.|||:|.. |:|..| ..:|..|:|:...|.::| ..:.||||:|:|||:.
Human    26 GMLYPQESPSRECKELDGLWSF-RADFSDNRRRGFEEQWYRRPLWESG-PTVDMPVPSSFNDISQ 88

  Fly   119 D-NLRDHVGTVWYERTFFVPRSWKTMQRT--WLRFSSVHYSAVVWINGRNATSHSIGHLPFESEI 180
            | .||..||.|||||...:|..|....||  .||..|.|..|:||:||.:...|..|:||||::|
Human    89 DWRLRHFVGWVWYEREVILPERWTQDLRTRVVLRIGSAHSYAIVWVNGVDTLEHEGGYLPFEADI 153

  Fly   181 SGLLSFG---GDNRITVMCDNRLSNRTIPQGSVYKVATDDGTVP----IQSYTFDFFNYAGIHRS 238
            |.|:..|   ...|||:..:|.|:..|:|.|:: :..||....|    :|:..||||||||:.||
Human   154 SNLVQVGPLPSRLRITIAINNTLTPTTLPPGTI-QYLTDTSKYPKGYFVQNTYFDFFNYAGLQRS 217

  Fly   239 VHLYTTPLLHISDLEVTTQLTKEGLGRIDYRVWLDASKEGLQIQPIQLRVQLRDKDGHVAAQQIN 303
            |.|||||..:|.|:.|||.:.::. |.::|::    |.:|..:  .:|.|:|.|.:..|.|   |
Human   218 VLLYTTPTTYIDDITVTTSVEQDS-GLVNYQI----SVKGSNL--FKLEVRLLDAENKVVA---N 272

  Fly   304 KAVYHGTLLVPNATPWWPYLMHSDPGYLYNLQFELFVASNEKELESLQDTYRLPVGIRSLSWDND 368
            .....|.|.||..:.|||||||..|.|||:|:.:|   :.:..|..:.|.|.||||||:::....
Human   273 GTGTQGQLKVPGVSLWWPYLMHERPAYLYSLEVQL---TAQTSLGPVSDFYTLPVGIRTVAVTKS 334

  Fly   369 SLLLNGKPLYLRGFGRHEDSDIRGKGLDNALLARDFNLLKWTGANAYRTSHYPYSEESMQFADQH 433
            ..|:||||.|..|..:|||:||||||.|..||.:|||||:|.||||:|||||||:||.||..|::
Human   335 QFLINGKPFYFHGVNKHEDADIRGKGFDWPLLVKDFNLLRWLGANAFRTSHYPYAEEVMQMCDRY 399

  Fly   434 GIMIIDECPAVNIDIFEPQLLEN-----HMSSLEQLIHRDRNHPSVVAWSVANEPRSNKQGALKY 493
            ||::|||||.|.:.:  ||...|     ||..:|:::.||:|||:||.|||||||.|:.:.|..|
Human   400 GIVVIDECPGVGLAL--PQFFNNVSLHHHMQVMEEVVRRDKNHPAVVMWSVANEPASHLESAGYY 462

  Fly   494 FEFLVNYVREIAHGRPLTAAINANSSSCHLAQFLDIVGFNRYNSWYQNSGRTDMILNLLTIEAQS 558
            .:.::.:.:.:...||:|...|:|.::...|.::|::..|.|.|||.:.|..::|...|..:.::
Human   463 LKMVIAHTKSLDPSRPVTFVSNSNYAADKGAPYVDVICLNSYYSWYHDYGHLELIQLQLATQFEN 527

  Fly   559 WRDRFGKPVIQFEYGGDTMEGMHSLPAFIWSEEYQVELFSRHFKAFDELRGRGWFIGEFVWNFAD 623
            |..::.||:||.|||.:|:.|.|..|..:::||||..|..::....|:.| |.:.:||.:|||||
Human   528 WYKKYQKPIIQSEYGAETIAGFHQDPPLMFTEEYQKSLLEQYHLGLDQKR-RKYVVGELIWNFAD 591

  Fly   624 FRTAQTITRVGGNKKGVFTRNRQPKEVAHILRRRYFALAKE 664
            |.|.|:.|||.|||||:|||.||||..|.:||.||:.:|.|
Human   592 FMTEQSPTRVLGNKKGIFTRQRQPKSAAFLLRERYWKIANE 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
betaGlu	NP_651893.1	Bgal_small_N	56..662	CDD:481240	266/621 (43%)
GUSB	NP_000172.2	Bgal_small_N	27..631	CDD:481240	266/622 (43%)