DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smvt and Slc5a7

DIOPT Version :9

Sequence 1:	NP_651891.2	Gene:	Smvt / 43744	FlyBaseID:	FBgn0039873	Length:	591	Species:	Drosophila melanogaster
Sequence 2:	NP_445973.2	Gene:	Slc5a7 / 85426	RGDID:	69270	Length:	580	Species:	Rattus norvegicus

Alignment Length:	490	Identity:	89/490 - (18%)
Similarity:	177/490 - (36%)	Gaps:	106/490 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 GVFALVL--SISAAIGVYFGFFAK----GEDTTEEYLMGGKRMKTIPIAISLVASQLSAISIMTI 88
            |:.|::|  .:...:|::..:..|    .|:.:|..::||:.:..:....::.|:.:....|...
  Rat     7 GLVAIILFYLLIFLVGIWAAWKTKNSGNAEERSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGT 71

  Fly    89 PAEMYAYGINWVFNVVCMVLVVPLLNYLVIPVFYNNNIT--NCYEYLEMRFCRKVRVLQTF---- 147
            ...:|..|..              |.:...|:.|:.::.  ..:....||....|.:|..|
  Rat    72 AEAVYGPGCG--------------LAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIY 122

  Fly   148 -------IFILT----MFFMLPIFIFLPSLAFAQVTGFNVHLINTVVCSICVFYTMFGGIKAVVW 201
                   :||..    ||:...||..| ....:.:...:|::...|...|.:.||:.||:.:|.:
  Rat   123 GKRMGGLLFIPALMGEMFWAAAIFSAL-GATISVIIDVDVNISVIVSALIAILYTLVGGLYSVAY 186

  Fly   202 TDVIQA-AIMVASVVLVGVLGAH----RVGGFFEVLRIAGEGGRLDINYNFDLTTRSTIWNIFTS 261
            |||:|. .|.:...:.|....:|    .:|  |..:....:...|....:.::.|....:.:...
  Rat   187 TDVVQLFCIFIGLWISVPFALSHPAVTDIG--FTAVHAKYQSPWLGTIESIEVYTWLDNFLLLML 249

  Fly   262 ATMMWTGYVGLNQSCVQRIVSLPSLGHARRSLVLFGFG-FILIMFFNCFTGIVIYSRFHDC---- 321
            ..:.|..|       .||::|..|..:|:....|..|| .::.:...|...|...:.::..
  Rat   250 GGIPWQAY-------FQRVLSSSSATYAQVLSFLAAFGCLVMALPAICIGAIGASTDWNQTAYGF 307

  Fly   322 -DPIQSGHVSKVDKMVPYFVQDTVGNLWGMPGVFISCVFSAALSTLSASINSLGGVVYFDYIKPH 385
             ||........:..:|..::.....:.:|:..|..:.:.||..|.||||          .....:
  Rat   308 PDPKTKEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSAS----------SMFARN 362

  Fly   386 IRHTEHRANV-------IMKLFVFFTG-----------------------IYCILGGMVIENFNS 420
            |.....|.|.       :|::.||..|                       :|.|:       |..
  Rat   363 IYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWYLSSDLVYIII-------FPQ 420

  Fly   421 ILQVIYSIGGMSFGSTCGVFMLGMLVPKSHGRAAL 455
            :|.|::..|..::|:..| ::.|:.:..:.|...|
  Rat   421 LLCVLFIKGTNTYGAVAG-YIFGLFLRITGGEPYL 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smvt	NP_651891.2	SLC5sbd_NIS-SMVT	27..548	CDD:271383	89/490 (18%)
Slc5a7	NP_445973.2	SLC5sbd_CHT	8..495	CDD:271368	88/489 (18%)
Slc5a7	NP_445973.2	Mediates interaction with SEC14L1. /evidence=ECO:0000269\|PubMed:17092608	502..580
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340173
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740