DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smvt and slc5a6b

DIOPT Version :9

Sequence 1:	NP_651891.2	Gene:	Smvt / 43744	FlyBaseID:	FBgn0039873	Length:	591	Species:	Drosophila melanogaster
Sequence 2:	XP_005158632.1	Gene:	slc5a6b / 796312	ZFINID:	ZDB-GENE-050913-86	Length:	603	Species:	Danio rerio

Alignment Length:	576	Identity:	191/576 - (33%)
Similarity:	299/576 - (51%)	Gaps:	36/576 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 PDSQFVFNATDYGVFALVLSISAAIGVYFGFFAKGEDTTEEYLMGGKRMKTIPIAISLVASQLSA 82
            |.....|...||.:|.|:|..|.:||:|:.|....:.||:|:|:..:.||.:|:::||:|:..||
Zfish     3 PAGHKYFTVIDYVIFGLLLVASMSIGLYYAFTGGRQSTTQEFLIADRSMKCLPLSLSLMATFQSA 67

  Fly    83 ISIMTIPAEMYAYGINWVFNVVCMVLVVPLLNYLVIPVFYNNNITNCYEYLEMRFCRKVRVLQTF 147
            ::|:..|||:||:|..:.|.....||.:.:..::.||:||..::|:.|:|||:|||:.||:..|.
Zfish    68 VAIIGTPAEVYAHGTQYWFIGCSYVLGLLIPAHIFIPLFYRLHLTSVYQYLELRFCKAVRICGTV 132

  Fly   148 IFILTMFFMLPIFIFLPSLAFAQVTGFNVHLINTVVCS--ICVFYTMFGGIKAVVWTDVIQAAIM 210
            .||..|...:.:.|:.|:||...||||  ||...|:.:  :|..||..||:||||||||.|..:|
Zfish   133 TFIFQMVIYMGVGIYTPALALNAVTGF--HLWGAVLATGLVCTLYTALGGLKAVVWTDVFQTVVM 195

  Fly   211 VASVVLVGVLGAHRVGGFFEVLRIAGEGGRLD-INYNFDLTTRSTIWNIFTSATMMWTGYVGLNQ 274
            ....:.|.::|.|:.||..|......:|||:. |:.|.|.|.|.|.|.:......:.....|:||
Zfish   196 FTGQLAVIIVGVHQAGGLSEAWGKVRDGGRISGIDLNPDPTVRHTFWTLAVGGVFLMLSLYGVNQ 260

  Fly   275 SCVQRIVSLPSLGHARRSLVLFGFGFILIMFFNCFTGIVIYSRFHDCDPIQSGHVSKVDKMVPYF 339
            :.|||.:|..:...|..|..:......|.:..:|..|:|:::.:....|::..:::..|:||.||
Zfish   261 AQVQRYLSSRTEREAVMSCYMVFPCLQLALLLSCLMGLVMFACYGQNSPVEQQYITSKDQMVLYF 325

  Fly   340 VQDTVGNLWGMPGVFISCVFSAALSTLSASINSLGGVVYFDYIKPHIRHTEHRANVIMKLFVFFT 404
            |.|.:.|..|:||:|::|:|||:|||:|::.|||..|...|.||||...||.||.::.||.....
Zfish   326 VMDMLQNFPGLPGLFVACLFSASLSTISSAFNSLATVTMVDLIKPHYSMTEARATLLSKLLALSY 390

  Fly   405 GIYCILGGMVIENFN-SILQVIYSIGGMSFGSTCGVFMLGMLVPKSHGRAALVGVLASIACMATI 468
            ||.|:....::...| |:||...||.||..|...|:|.||:..|.::...|:.|:.|.      :
Zfish   391 GIICLAMAYLVHLMNSSVLQAALSIFGMIGGPLLGLFCLGIFFPCANSIGAVTGLSAG------L 449

  Fly   469 VILSW-GRNHYDTLPTSTSACPASLNGTIKDISTASPLFLGSTTEAPVGEKEFSI---LDLSFNW 529
            ::..| |...:  |....|.....||.|| .:...|.....:|.|.....:...:   ..||:.|
Zfish   450 LMAFWVGIGGF--LTRMPSPVIPLLNSTI-TVPDVSENITAATAELEADSRSAGLHGFYSLSYMW 511

  Fly   530 YTVTGFVITWLIGIPLSYI--------LKSGPDYKPNPKLLSPVVQPFVHYKLTPS 577
            |:........::|:.:|.|        :.||..|        |||:....| |.||
Zfish   512 YSALSSCTVLIVGLIISCITGPTKGDDVASGTVY--------PVVKTAQSY-LKPS 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smvt	NP_651891.2	SLC5sbd_NIS-SMVT	27..548	CDD:271383	178/528 (34%)
slc5a6b	XP_005158632.1	SLC5-6-like_sbd	9..532	CDD:294310	180/533 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D489472at33208
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820