Protein Alignment Smvt and SLC5A2

DIOPT Version :10

• Sequence 1: NP_651891.2
• Gene: Smvt / 43744
• FlyBaseID: FBgn0039873
• Length: 591
• Species: Drosophila melanogaster
• Sequence 2: XP_006721135.3
• Gene: SLC5A2 / 6524
• HGNCID: 11037
• Length: 698
• Species: Homo sapiens
• Alignment Length: 640
• Identity: 129/640 - (20%)
• Similarity: 247/640 - (38%)
• Gaps: 97/640 - (15%)

  Fly     8 TVLATAATVVPDSQFVFNATDYGVFALVLSISAAIGVYFGFFAKGEDTTEEYLMGGKRMKTIPIA 72
            |...:|..:......:.|..|..|.|....:...:|:: ........|...|.:.|:.|...|:.
Human     5 TEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLW-SMCRTNRGTVGGYFLAGRSMVWWPVG 68

  Fly    73 ISLVASQLSAISIMTIPAEMYAYGI---NWVFNVVCMVLVVPLLNYLVIPVFYNNNITNCYEYLE 134
            .||.||.:.:...:.:.....|.|:   .:.:|.:.:||   ||.:|..||:....:....:||.
Human    69 ASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVL---LLGWLFAPVYLTAGVITMPQYLR 130

  Fly   135 MRF-CRKVR----VLQTFIFILTMFFMLPIFIFLPSLAFAQVTGFNVHLINTVVCSICVFYTMFG 194
            .|| .|::|    ||..|::|.|   .:.:.:|..::...|..|:|::.....:..|.:.||:.|
Human   131 KRFGGRRIRLYLSVLSLFLYIFT---KISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTG 192

  Fly   195 GIKAVVWTDVIQAAIMVASVVLVGVLGAHRVGGFFEVL-RIAGEGGRLDIN--------YNFDLT 250
            |:.|:::||.:|..:::....::.....|.|||:..:. :..|....|.::        .:|...
Human   193 GLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSLTVSEDPAVGNISSFCYR 257

  Fly   251 TRSTIWNIF---TSATMMWTG-YVGL----------NQSCVQRIVSLPSLGHARRSLVLFGFGFI 301
            .|...:::.   .:..:.|.. .:||          :|..|||.::..||.|.:...:|.|:..:
Human   258 PRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCLAGKSLTHIKAGCILCGYLKL 322

  Fly   302 LIMFFNCFTGIVIYSRFHD---------CDPIQSGHVSKVDKMVPYFVQDTVGNLWGMPGVFISC 357
            ..||.....|::....:.|         |..:....|...:...|..|...:.|  |:.|:.::.
Human   323 TPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVGCSNIAYPRLVVKLMPN--GLRGLMLAV 385

  Fly   358 VFSAALSTLSASINSLGGVVYFD-YIKPHIRHTEHRANVIMKLFVFFTGIYCILGGMVIE--NFN 419
            :.:|.:|:|::..||...:...| |.:...|..:....::.:|:|.|..:..:....|::  ...
Human   386 MLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDRELLLVGRLWVVFIVVVSVAWLPVVQAAQGG 450

  Fly   420 SILQVIYSIGGMSFGSTCGVFMLGMLVPKSHGRAALVGVLASIACMATIVI--LSWGRNHYDTLP 482
            .:...|.::..........||:|.:.||:.:.:.|..|::..:......:|  .|:|....
Human   451 QLFDYIQAVSSYLAPPVSAVFVLALFVPRVNEQGAFWGLIGGLLMGLARLIPEFSFGSGSC---- 511

  Fly   483 TSTSACPASLNGTIKDISTASPLFL--------GSTTEAPVGEKEFSILDLSF------------ 527
            ...|||||.|.| :..:..|..||.        .|...||:..|....|..|.
Human   512 VQPSACPAFLCG-VHYLYFAIVLFFCSGLLTLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDA 575

  Fly   528 ----------------NWYTVTGFVITWLIGIP--LSYILKSGPDYKPNPKLLSP 564
                            :...:.|....|.:|:.  .|..|.:||.:...|:..:|
Human   576 DEQQGSSLPVQNGCPESAMEMNGRAPCWEVGLEELSSRKLTAGPQFPSEPQAPAP 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smvt	NP_651891.2	SLC5sbd_NIS-SMVT	27..548	CDD:271383	121/603 (20%)
SLC5A2	XP_006721135.3	SLC5sbd_SGLT2	24..698	CDD:212056	126/621 (20%)