DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smvt and slc5a5

DIOPT Version :9

Sequence 1:	NP_651891.2	Gene:	Smvt / 43744	FlyBaseID:	FBgn0039873	Length:	591	Species:	Drosophila melanogaster
Sequence 2:	NP_001082860.1	Gene:	slc5a5 / 561445	ZFINID:	ZDB-GENE-060503-585	Length:	601	Species:	Danio rerio

Alignment Length:	567	Identity:	179/567 - (31%)
Similarity:	284/567 - (50%)	Gaps:	55/567 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 FNATDYGVFALVLSISAAIGVYFGF-FAKGEDTTEEYLMGGKRMKTIPIAISLVASQLSAISIMT 87
            |...||.|||.:|.:|..||::... ...|....:.:..||:....:|:.:||.||.:||:.::.
Zfish    11 FCLVDYAVFAAMLGVSVGIGLFQSLRKTPGRSKVDSFFTGGRGFSAVPVGLSLCASFMSAVQVLG 75

  Fly    88 IPAEMYAYGINWVFNVVCMVLVVPLLNYLVIPVFYNNNITNCYEYLEMRFCRKVRVLQTFIFILT 152
            :|:|.|.||..:::..:...|...:...|.:||||...||:..:||.|||.|.:::|.:..||:.
Zfish    76 VPSETYLYGFKFLYMCLGQGLNSLMTAVLFVPVFYRLKITSSSQYLGMRFGRGMQLLGSLQFIVA 140

  Fly   153 MFFMLPIFIFLPSLAFAQVTGFNV--HLINTVVCSICVFYTMFGGIKAVVWTDVIQAAIMVASVV 215
            ......|.||.|::...|.||.|:  .|.:|.:  ||.|||..||:|||:||||.|..:|::..:
Zfish   141 TLLYTGIVIFAPAVILNQATGLNMWASLFSTGL--ICTFYTTVGGMKAVIWTDVFQIVVMLSGFI 203

  Fly   216 LVGVLGAHRVGGFFEVLRIAGEGGRLDIN-YNFDLTTRSTIWNIFTSATMMWTGYVGLNQSCVQR 279
            .|.:.|....||...||.||..|.|::.| :..|...|.:.|:.....||:|....|.||:.|||
Zfish   204 AVFIQGTILAGGPARVLEIANNGSRINFNDFAIDPQRRYSFWSFTVGGTMVWLSMYGANQAQVQR 268

  Fly   280 IVSLPSLGHARRSLVLFGFGFILIMFFNCFTGIVIYSRFHDCDPIQSGHVSKVDKMVPYFVQDTV 344
            .:|..:...|:.:|::...|..||:......|||:::.:.:|||::.|.:|..|:.:||.|.|..
Zfish   269 YISCRTEKQAQLALLVNQVGLCLIVSSAATCGIVMFALYSNCDPLKIGRISAPDQYMPYLVLDIF 333

  Fly   345 GNLWGMPGVFISCVFSAALSTLSASINSLGGVVYFDYIKPHIRHTEHRANVIM-KLFVFFTGIYC 408
            .|..|.||:|::|.:|..|||:|.|||::..|...|.:||.:.....|..::: :....|.|:.|
Zfish   334 RNHPGFPGLFLACAYSGTLSTVSTSINAMAAVTMEDVMKPWLITISQRKQLMLSRALSLFYGLGC 398

  Fly   409 ILGGMVIENFN-SILQVIYSIGGMSFGSTCGVFMLGMLVPKSHGRAALVGVLASIACMATIVILS 472
            |....:....: .:||..:::.|:..|...|.|.|||.||.::......||.... |::  :.|:
Zfish   399 ITMAALSSLLDWGVLQGSFTVMGVVNGPLLGAFALGMFVPATNKPGVFSGVAVGF-CLS--LWLA 460

  Fly   473 WGRNHY-------DTLPTSTSAC---PASLNGTIKDISTASPLFLGSTTEAPVGEKEFSILDLSF 527
            .|...|       ..||||...|   .|:||.|...::::.|                  ||.||
Zfish   461 VGSTIYPPSPQIMGVLPTSAGQCLTTNATLNTTASVLASSVP------------------LDYSF 507

  Fly   528 -NWYTV---------TGFVITWLIGIPLSYILKSGPDYKP--NPKLL 562
             |.|::         |..|:  |:|:.:|||  :||..|.  :|.||
Zfish   508 QNIYSISYLYFGALSTSAVV--LVGVVVSYI--TGPTKKDSISPGLL 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smvt	NP_651891.2	SLC5sbd_NIS-SMVT	27..548	CDD:271383	170/546 (31%)
slc5a5	NP_001082860.1	SLC5-6-like_sbd	14..549	CDD:320982	176/561 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580007
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1180002at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.950