DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smvt and slc5a8l

DIOPT Version :9

Sequence 1:	NP_651891.2	Gene:	Smvt / 43744	FlyBaseID:	FBgn0039873	Length:	591	Species:	Drosophila melanogaster
Sequence 2:	NP_001030141.1	Gene:	slc5a8l / 556156	ZFINID:	ZDB-GENE-061110-98	Length:	610	Species:	Danio rerio

Alignment Length:	551	Identity:	183/551 - (33%)
Similarity:	297/551 - (53%)	Gaps:	21/551 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 FNATDYGVFALVLSISAAIGVYFGFFAKGEDTTEEYLMGGKRMKTIPIAISLVASQLSAISIMTI 88
            |:..||.|||.::.::|.||::..|..:.|.:::|:|:||::|..:|:|:||.||.:|.|:::..
Zfish    11 FSVWDYVVFAGLILVAAGIGLFQSFRGRKEASSDEFLLGGRQMTAVPVALSLTASFMSGITVIGT 75

  Fly    89 PAEMYAYGIN-WVFNVVCMVLVVPLLNYLVIPVFYNNNITNCYEYLEMRFCRKVRVLQTFIFILT 152
            |||.|.||.. |:| .:...::..:...:.:|:||..|||:.|||||||:.:.:||:.|.::|:.
Zfish    76 PAEAYLYGTPFWLF-FISYAIMSTISAEIFVPLFYRLNITSTYEYLEMRYNKLIRVIGTSMYIIQ 139

  Fly   153 MFFMLPIFIFLPSLAFAQVTGFNVHLINTVVCSICVFYTMFGGIKAVVWTDVIQAAIMVASVVLV 217
            ......:.||.|:||..|:||.::..:.....::|:.|...||:|||:||||.|..||:...|.|
Zfish   140 TALYTGMVIFAPALALNQITGLDLWGVLVATGAVCIIYCTLGGLKAVIWTDVFQMIIMLGGFVAV 204

  Fly   218 GVLGAHRVGGFFEVLRIAGEGGRLD-INYNFDLTTRSTIWNIFTSATMMWTGYVGLNQSCVQRIV 281
            ...||...||...|...:..||||: .:::.|...|.:.|.|....::||.....:|||.|||.:
Zfish   205 IARGAVLQGGLGRVWNDSFYGGRLETFSFDPDPLRRHSFWTIVVGGSLMWASMYSINQSQVQRYI 269

  Fly   282 SLPSLGHARRSLVLFGFGFILIMFFNCFTGIVIYSRFHDCDPIQSGHVSKVDKMVPYFVQDTVGN 346
            |..::.||:.||.:...|..:.:.....:|:.:||.:.||||..:..|...|:::||.|.|.:.:
Zfish   270 SCRTMTHAKLSLYVNMVGLWVTVSLAMMSGLTMYSIYKDCDPFTNKDVGATDQLLPYLVMDILAD 334

  Fly   347 LWGMPGVFISCVFSAALSTLSASINSLGGVVYFDYIKPHIRH-TEHRANVI-MKLFVFFTGIYCI 409
            ..|:||:|::..:|..|||:|:|||:|..|...|::||.... ||.:.:.| |.:.||: |..||
Zfish   335 FPGLPGLFVAAAYSGTLSTVSSSINALVAVTVEDFMKPAWPSLTERQLSWINMGMSVFY-GAVCI 398

  Fly   410 LGGMVIENFNSILQVIYSIGGMSFGSTCGVFMLGMLVPKSHGRAALVGVLASIACMATIVILSW- 473
            ....|.....:|||...||.||..|...|::||||....::....|.|:.:.:|      |..|
Zfish   399 GMAGVASMMGNILQAALSIFGMISGPLLGLYMLGMFFRCANSTGGLAGLASGLA------ITLWV 457

  Fly   474 --GRNHYDTLPTSTSACPASLNGTI----KDISTASPL--FLGSTTEAPVGEKEFSILDLSFNWY 530
              |...|..||..|...|.|:.|.:    .:.:|.:|.  .|.:||..|......:...||:.::
Zfish   458 GIGAQLYPPLPEKTLRLPLSVEGCVALNTSETTTMTPFSTVLQTTTPQPRPALADNWYSLSYLYF 522

  Fly   531 TVTGFVITWLIGIPLSYILKSGPDYKPNPKL 561
            :..|.|:|.:|.:.:|.|.......|..|:|
Zfish   523 SPVGIVVTMIIALIVSAISGGCKQKKVRPEL 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smvt	NP_651891.2	SLC5sbd_NIS-SMVT	27..548	CDD:271383	178/533 (33%)
slc5a8l	NP_001030141.1	SLC5sbd_SMCT1	8..547	CDD:271402	180/543 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580016
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1180002at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.940