Protein Alignment Smvt and Slc5a8

DIOPT Version :10

• Sequence 1: NP_651891.2
• Gene: Smvt / 43744
• FlyBaseID: FBgn0039873
• Length: 591
• Species: Drosophila melanogaster
• Sequence 2: NP_001178916.1
• Gene: Slc5a8 / 500820
• RGDID: 1564146
• Length: 611
• Species: Rattus norvegicus
• Alignment Length: 611
• Identity: 228/611 - (37%)
• Similarity: 324/611 - (53%)
• Gaps: 64/611 - (10%)

  Fly    24 FNATDYGVFALVLSISAAIGVYFGFFAKGEDTTEEYLMGGKRMKTIPIAISLVASQLSAISIMTI 88
            |...||.|||.:|.||||||:|:.|...|:.|::::||||:.|..:|:|:||.||.:||::::..
  Rat    10 FVVWDYVVFAGMLLISAAIGIYYAFAGGGQQTSKDFLMGGRSMSAVPVALSLTASFMSAVTVLGT 74

  Fly    89 PAEMYAYGINWVFNV--VCMVLVVPLLNYLVIPVFYNNNITNCYEYLEMRFCRKVRVLQTFIFIL 151
            |||:|.:|.  :|::  |....||.:...:.:||||...||:.|||||:||.|.:|:..|.:||:
  Rat    75 PAEVYRFGA--IFSIFGVTYFFVVVISAEVFLPVFYRLGITSTYEYLELRFNRFIRLCGTVLFIV 137

  Fly   152 TMFFMLPIFIFLPSLAFAQVTGFNVHLINTVVCS--ICVFYTMFGGIKAVVWTDVIQAAIMVASV 214
            .......|.|:.|:||..|||||:  |...||.:  :|.||...||:||||||||.|..||||..
  Rat   138 QTILYTGIVIYAPALALNQVTGFD--LWGAVVATGVVCTFYCTLGGLKAVVWTDVFQVGIMVAGF 200

  Fly   215 VLVGVLGAHRVGGFFEVLRIAGEGGRLDI-NYNFDLTTRSTIWNIFTSATMMWTGYVGLNQSCVQ 278
            ..|.:..:...||...:|..|..||||:. |:|.:...|.|.|.|....|..||...|:|||.||
  Rat   201 ASVIIQASITQGGINTILSDASNGGRLNFWNFNPNPLQRHTFWTIIVGGTFTWTTIYGVNQSQVQ 265

  Fly   279 RIVSLPSLGHARRSLVLFGFGFILIMFFNCFTGIVIYSRFHDCDPIQSGHVSKVDKMVPYFVQDT 343
            |.:|..|..||:.||.:...|..:|:..:.|.|:.:|||:|||||..|..||:||:::||.|.|.
  Rat   266 RYISCKSRLHAKLSLYVNLVGLWVILICSVFCGLALYSRYHDCDPWTSKKVSEVDQLMPYLVLDI 330

  Fly   344 VGNLWGMPGVFISCVFSAALSTLSASINSLGGVVYFDYIKPHIRH-TEHRANVIMKLFVFFTGIY 407
            :.|..|:||:|::|.:|..|||:|:|||:|..|...|.|||..:. :|...:.|.:......|..
  Rat   331 LKNYPGVPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPRFKSLSEKSLSWISQGMSVLYGAL 395

  Fly   408 CILGGMVIENFNSILQVIYSIGGMSFGSTCGVFMLGMLVPKSHGRAALVGVLASIACMATIVILS 472
            ||....|.....::||...||.||..|...|:|.||:|||.::...|..|:||..|....:.|
  Rat   396 CIGMAAVASLMGALLQAALSIFGMVGGPLLGLFSLGILVPFANSVGAFAGLLAGFAVSLWVGI-- 458

  Fly   473 WGRNHYD-----TLPTS--TSACPASLNGTIKDISTASPLFLGSTTEAPVGEKEFSILD-----L 525
             |...|.     |||.|  |..|.::.|||  |..        ||||.|.....|.|.|     |
  Rat   459 -GAQLYPPLPERTLPLSLETHGCNSTHNGT--DWM--------STTEMPFSTSAFQIHDVERSAL 512

  Fly   526 SFNWYTVT-------GFVITWLIGIPLSYILKSGPDYKPNPKLLSPVVQPF-------------V 570
            ..|||:::       |.:.|.|:||.:| :...|.....:|:.|. ..|.|             :
  Rat   513 MDNWYSLSYLYFSTIGTLTTLLVGILIS-LATGGRKQNLDPRFLL-TKQDFLSNFDVFKKKTHVL 575

  Fly   571 HYKLTP-----SDEP--HQLNLEKPE 589
            :||:.|     :|.|  :.:.|..|:
  Rat   576 NYKMHPVEDGGTDNPAFNHVELNFPD 601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smvt	NP_651891.2	SLC5sbd_NIS-SMVT	27..548	CDD:271383	215/545 (39%)
Slc5a8	NP_001178916.1	SLC5sbd_SMCT1	7..549	CDD:271402	217/556 (39%)