DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smvt and Slc5a8

DIOPT Version :9

Sequence 1:	NP_651891.2	Gene:	Smvt / 43744	FlyBaseID:	FBgn0039873	Length:	591	Species:	Drosophila melanogaster
Sequence 2:	NP_001178916.1	Gene:	Slc5a8 / 500820	RGDID:	1564146	Length:	611	Species:	Rattus norvegicus

Alignment Length:	611	Identity:	228/611 - (37%)
Similarity:	324/611 - (53%)	Gaps:	64/611 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 FNATDYGVFALVLSISAAIGVYFGFFAKGEDTTEEYLMGGKRMKTIPIAISLVASQLSAISIMTI 88
            |...||.|||.:|.||||||:|:.|...|:.|::::||||:.|..:|:|:||.||.:||::::..
  Rat    10 FVVWDYVVFAGMLLISAAIGIYYAFAGGGQQTSKDFLMGGRSMSAVPVALSLTASFMSAVTVLGT 74

  Fly    89 PAEMYAYGINWVFNV--VCMVLVVPLLNYLVIPVFYNNNITNCYEYLEMRFCRKVRVLQTFIFIL 151
            |||:|.:|.  :|::  |....||.:...:.:||||...||:.|||||:||.|.:|:..|.:||:
  Rat    75 PAEVYRFGA--IFSIFGVTYFFVVVISAEVFLPVFYRLGITSTYEYLELRFNRFIRLCGTVLFIV 137

  Fly   152 TMFFMLPIFIFLPSLAFAQVTGFNVHLINTVVCS--ICVFYTMFGGIKAVVWTDVIQAAIMVASV 214
            .......|.|:.|:||..|||||:  |...||.:  :|.||...||:||||||||.|..||||..
  Rat   138 QTILYTGIVIYAPALALNQVTGFD--LWGAVVATGVVCTFYCTLGGLKAVVWTDVFQVGIMVAGF 200

  Fly   215 VLVGVLGAHRVGGFFEVLRIAGEGGRLDI-NYNFDLTTRSTIWNIFTSATMMWTGYVGLNQSCVQ 278
            ..|.:..:...||...:|..|..||||:. |:|.:...|.|.|.|....|..||...|:|||.||
  Rat   201 ASVIIQASITQGGINTILSDASNGGRLNFWNFNPNPLQRHTFWTIIVGGTFTWTTIYGVNQSQVQ 265

  Fly   279 RIVSLPSLGHARRSLVLFGFGFILIMFFNCFTGIVIYSRFHDCDPIQSGHVSKVDKMVPYFVQDT 343
            |.:|..|..||:.||.:...|..:|:..:.|.|:.:|||:|||||..|..||:||:::||.|.|.
  Rat   266 RYISCKSRLHAKLSLYVNLVGLWVILICSVFCGLALYSRYHDCDPWTSKKVSEVDQLMPYLVLDI 330

  Fly   344 VGNLWGMPGVFISCVFSAALSTLSASINSLGGVVYFDYIKPHIRH-TEHRANVIMKLFVFFTGIY 407
            :.|..|:||:|::|.:|..|||:|:|||:|..|...|.|||..:. :|...:.|.:......|..
  Rat   331 LKNYPGVPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPRFKSLSEKSLSWISQGMSVLYGAL 395

  Fly   408 CILGGMVIENFNSILQVIYSIGGMSFGSTCGVFMLGMLVPKSHGRAALVGVLASIACMATIVILS 472
            ||....|.....::||...||.||..|...|:|.||:|||.::...|..|:||..|....:.|
  Rat   396 CIGMAAVASLMGALLQAALSIFGMVGGPLLGLFSLGILVPFANSVGAFAGLLAGFAVSLWVGI-- 458

  Fly   473 WGRNHYD-----TLPTS--TSACPASLNGTIKDISTASPLFLGSTTEAPVGEKEFSILD-----L 525
             |...|.     |||.|  |..|.::.|||  |..        ||||.|.....|.|.|     |
  Rat   459 -GAQLYPPLPERTLPLSLETHGCNSTHNGT--DWM--------STTEMPFSTSAFQIHDVERSAL 512

  Fly   526 SFNWYTVT-------GFVITWLIGIPLSYILKSGPDYKPNPKLLSPVVQPF-------------V 570
            ..|||:::       |.:.|.|:||.:| :...|.....:|:.|. ..|.|             :
  Rat   513 MDNWYSLSYLYFSTIGTLTTLLVGILIS-LATGGRKQNLDPRFLL-TKQDFLSNFDVFKKKTHVL 575

  Fly   571 HYKLTP-----SDEP--HQLNLEKPE 589
            :||:.|     :|.|  :.:.|..|:
  Rat   576 NYKMHPVEDGGTDNPAFNHVELNFPD 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smvt	NP_651891.2	SLC5sbd_NIS-SMVT	27..548	CDD:271383	215/545 (39%)
Slc5a8	NP_001178916.1	SLC5sbd_SMCT1	7..549	CDD:271402	217/556 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340161
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1180002at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.850