DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smvt and slc5a12

DIOPT Version :9

Sequence 1:	NP_651891.2	Gene:	Smvt / 43744	FlyBaseID:	FBgn0039873	Length:	591	Species:	Drosophila melanogaster
Sequence 2:	NP_956662.1	Gene:	slc5a12 / 393339	ZFINID:	ZDB-GENE-040426-1343	Length:	623	Species:	Danio rerio

Alignment Length:	574	Identity:	195/574 - (33%)
Similarity:	311/574 - (54%)	Gaps:	36/574 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 FNATDYGVFALVLSISAAIGVYFGFFAKGEDTTEEYLMGGKRMKTIPIAISLVASQLSAISIMTI 88
            |.|.||.|||.:..:|:.|||:|....:.:..::|:|:||::|...|:|:||.||.:||::::..
Zfish     7 FQAGDYVVFACLFVVSSGIGVFFAIKERNKAPSKEFLVGGRQMSCGPVALSLTASFMSAVTVIGA 71

  Fly    89 PAEMYAYGINWVFNVVCMVLVVPLLNYLVIPVFYNNNITNCYEYLEMRFCRKVRVLQTFIFILTM 153
            ||::|.:|.::|...|....||.....|.:||||.:.||:.|||||:|||:.|||..|.|:|:..
Zfish    72 PADVYRFGASYVIFGVAYTFVVFFTAELFLPVFYRSGITSTYEYLELRFCKLVRVAATLIYIIQT 136

  Fly   154 FFMLPIFIFLPSLAFAQVTGFNVHLINTVVCS--ICVFYTMFGGIKAVVWTDVIQAAIMVASVVL 216
            .....:.::.|:||..|||||:  |..::..:  :|.||...||:|||||||..|..:||...:.
Zfish   137 ILYTGVVVYAPALALNQVTGFD--LWGSIFATGIVCTFYCTLGGLKAVVWTDAFQMVVMVVGFLT 199

  Fly   217 VGVLGAHRVGGFFEVLRIAGEGGRLDINYNFDLT--TRSTIWNIFTSATMMWTGYVGLNQSCVQR 279
            |.:.|:.|.||...|...:..||||.: ::||::  .|.|.|.:....|..|.|..|:|||.:||
Zfish   200 VLIQGSSRAGGIENVWSTSRTGGRLQV-FDFDVSPLRRHTFWTLSVGGTFTWLGIYGVNQSTIQR 263

  Fly   280 IVSLPSLGHARRSLVLFGFGFILIMFFNCFTGIVIYSRFHDCDPIQSGHVSKVDKMVPYFVQDTV 344
            .:|..:.||||.:|.|...|..:|:|....:|:::||.:..|||..||.:|..|:::||||.:.:
Zfish   264 CISCKTEGHARWALYLNLLGLWIILFCAVVSGLIMYSYYSHCDPWSSGLISAPDQLMPYFVMEIL 328

  Fly   345 GNLWGMPGVFISCVFSAALSTLSASINSLGGVVYFDYIKPHIRHTEHR-ANVIMKLFVFFTGIYC 408
            |...|:||:|::|.||..|||::||||:|..|:|.|::........:| |:.|.|......|:.|
Zfish   329 GAFPGLPGLFVACAFSGTLSTVAASINALATVMYEDFVSQCFPDLSNRAASWISKALCVAFGVAC 393

  Fly   409 ILGGMVIENFNSILQVIYSIGGMSFGSTCGVFMLGMLVPKSHGRAALVGVLASIACMATI----V 469
            ....:.......|:|...||.||..|...|:|.||:|.|.::.:.|:.|::..|:....:    .
Zfish   394 TTMAVAASYMGGIVQAALSIHGMCGGPVLGLFSLGILFPFTNLKGAVGGLIVGISLSFWVGVGAF 458

  Fly   470 ILSWGRNHYDTLPTSTSACPASLNGTIKDISTASPLFLGSTTEAPVGEKEF---SILDLSFNWYT 531
            |.....|:...|..:|:.|         :|:.|:.....:|......::.:   |...:|:.:|:
Zfish   459 IYPAPSNNTHALELNTAGC---------NITAAAFEPTSATVTQLTSDRNWLADSWYSMSYLYYS 514

  Fly   532 VTGFVITWLIGIPLSYILKSGPDYKPNPKLLSP-------VVQPFVHYKLTPSD 578
            ..||:.|...|:.::  |.:||   .:||||.|       .|..|...|.|.:|
Zfish   515 AVGFIGTVAAGLLIT--LLTGP---MDPKLLKPGMTRSVKEVMCFCTEKFTEAD 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smvt	NP_651891.2	SLC5sbd_NIS-SMVT	27..548	CDD:271383	180/532 (34%)
slc5a12	NP_956662.1	SLC5sbd_SMCT2	4..533	CDD:212089	183/539 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580037
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1180002at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.950