Protein Alignment Smvt and Slc5a8

DIOPT Version :10

• Sequence 1: NP_651891.2
• Gene: Smvt / 43744
• FlyBaseID: FBgn0039873
• Length: 591
• Species: Drosophila melanogaster
• Sequence 2: NP_663398.2
• Gene: Slc5a8 / 216225
• MGIID: 2384916
• Length: 611
• Species: Mus musculus
• Alignment Length: 595
• Identity: 219/595 - (36%)
• Similarity: 315/595 - (52%)
• Gaps: 52/595 - (8%)

  Fly    24 FNATDYGVFALVLSISAAIGVYFGFFAKGEDTTEEYLMGGKRMKTIPIAISLVASQLSAISIMTI 88
            |...||.|||.:|.||||||:|:.|...|:.|::::||||:.|..:|:|:||.||.:||::::..
Mouse    10 FVVWDYVVFAGMLLISAAIGIYYAFAGGGQQTSKDFLMGGRSMSAVPVALSLTASFMSAVTVLGT 74

  Fly    89 PAEMYAYGINWVFNVVCMVLVVPLLNYLVIPVFYNNNITNCYEYLEMRFCRKVRVLQTFIFILTM 153
            |||:|.:|..:...|:....||.:...:.:||||...||:.|||||:||.|.:|:..|.:||:..
Mouse    75 PAEVYRFGAIFSIFVITYFFVVVISAEVFLPVFYRLGITSTYEYLELRFNRCIRLCGTILFIVQT 139

  Fly   154 FFMLPIFIFLPSLAFAQVTGFNVHLINTVVCS--ICVFYTMFGGIKAVVWTDVIQAAIMV---AS 213
            .....|.|:.|:||..|||||:  |...||.:  :|.||...||:||||||||.|..|||   ||
Mouse   140 ILYTGIVIYAPALALNQVTGFD--LWGAVVATGVVCTFYCTLGGLKAVVWTDVFQVGIMVAGFAS 202

  Fly   214 VVLVGVLGAHRVGGFFEVLRIAGEGGRLDINYNFDLT--TRSTIWNIFTSATMMWTGYVGLNQSC 276
            |::...:..|   |..::|..|..||||:. :|||..  .|.|.|.|....|..||...|:|||.
Mouse   203 VIIQASITQH---GINKILSDAFNGGRLNF-WNFDPNPLQRHTFWTIVIGGTFTWTTIYGVNQSQ 263

  Fly   277 VQRIVSLPSLGHARRSLVLFGFGFILIMFFNCFTGIVIYSRFHDCDPIQSGHVSKVDKMVPYFVQ 341
            |||.:|..|..||:.||.:...|..:|:..:.|.|:.:|||:.:|||..|..||.:|:::||.|.
Mouse   264 VQRYISCKSRLHAKLSLYVNLVGLWVILTCSIFCGLALYSRYRECDPWTSKKVSAIDQLMPYLVL 328

  Fly   342 DTVGNLWGMPGVFISCVFSAALSTLSASINSLGGVVYFDYIKPHIRH-TEHRANVIMKLFVFFTG 405
            |.:.|..|:||:|::|.:|..|||:|:|||:|..|...|.|||..:. :|...:.|.:......|
Mouse   329 DILKNYPGVPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPRFKSLSEKSLSWISQGMSVLYG 393

  Fly   406 IYCILGGMVIENFNSILQVIYSIGGMSFGSTCGVFMLGMLVPKSHGRAALVGVLASIACMATIVI 470
            ..||....:.....::||...||.||..|...|:|.||:|||.::...||.|:||..|....:.|
Mouse   394 ALCIGMAALASLMGALLQAALSIFGMVGGPLLGLFSLGILVPFANSIGALTGLLAGFAISLWVGI 458

  Fly   471 LSWGRNHYDTLPTSTSACPASLNGTIKDISTASPLFLGSTTEAPVGEKEFSI-----LDLSFNWY 530
               |...|..||..|...|....|.  :|:.....:: ||||.|.....|.|     ..|..|||
Mouse   459 ---GAQLYPPLPERTLPLPLETYGC--NITHNGSDWM-STTEMPFSTSAFQIHNAERTPLMDNWY 517

  Fly   531 TVT-------GFVITWLIGIPLSYILKSGPDYKPNPKLLSPVVQPF-------------VHYKLT 575
            :::       |.:.|..:||.:| :...|.....:|:.|. ..|.|             ::|||.
Mouse   518 SLSYLYFSTIGTLTTLFVGILIS-LSTGGRKQNLDPRFLL-TKQDFLSNFDVFKKRNHVLNYKLH 580

  Fly   576 P-----SDEP 580
            |     :|.|
Mouse   581 PVEVGGTDNP 590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smvt	NP_651891.2	SLC5sbd_NIS-SMVT	27..548	CDD:271383	207/540 (38%)
Slc5a8	NP_663398.2	SLC5sbd_SMCT1	7..549	CDD:271402	209/551 (38%)
		PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q8N695	609..611