Protein Alignment Smvt and SLC5A11

DIOPT Version :9

• Sequence 1: NP_651891.2
• Gene: Smvt / 43744
• FlyBaseID: FBgn0039873
• Length: 591
• Species: Drosophila melanogaster
• Sequence 2: NP_001339171.1
• Gene: SLC5A11 / 115584
• HGNCID: 23091
• Length: 675
• Species: Homo sapiens
• Alignment Length: 639
• Identity: 139/639 - (21%)
• Similarity: 249/639 - (38%)
• Gaps: 162/639 - (25%)

  Fly    28 DYGVFALVLSISAAIGVYFGFFAKGEDTTEEYLMGGKRMKTIPIAISLVASQLSAISIMTIPA-- 90
            |..|..|......|:|::.....| .||.:.|.:.|..|...|:..||.||.:.:...:.:..
Human    28 DIAVLVLYFLFVLAVGLWSTVKTK-RDTVKGYFLAGGDMVWWPVGASLFASNVGSGHFIGLAGSG 91

  Fly    91 -----EMYAYGINWVFNVVCMVLVVPLLNYLVIPVFYNNNITNCYEYLEMRFCRKVR------VL 144
                 .:.||.:|.:|:|:       :|.::.:|::....:|...|||..|| ..:|      ||
Human    92 AATGISVSAYELNGLFSVL-------MLAWIFLPIYIAGQVTTMPEYLRKRF-GGIRIPIILAVL 148

  Fly   145 QTFIFILTMFFMLPIFIFLPSLAFAQVTGFNVHLINTVVCSICVFYTMFGGIKAVVWTDVIQAAI 209
            ..||:|.|   .:.:.::..::...|....:::|....:.:|...||:.||:.||::||.:|..|
Human   149 YLFIYIFT---KISVDMYAGAIFIQQSLHLDLYLAIVGLLAITAVYTVAGGLAAVIYTDALQTLI 210

  Fly   210 M-VASVVLVGVLGAHRVGGFFEVLRIAGEGGRLDINYNFDLTT-----------RSTIWNIF--- 259
            | :.::.|:|...| .|||.        ||  |...|...|.:           |...::||
Human   211 MLIGALTLMGYSFA-AVGGM--------EG--LKEKYFLALASNRSENSSCGLPREDAFHIFRDP 264

  Fly   260 TSATMMWTG-----------YVGLNQSCVQRIVSLPSLGHARRSLVLFGFGFILIMFFNCFTGIV 313
            .::.:.|.|           |...:|..|||.::..:|.||:...::..:..:|.:|...|.|:|
Human   265 LTSDLPWPGVLFGMSIPSLWYWCTDQVIVQRTLAAKNLSHAKGGALMAAYLKVLPLFIMVFPGMV 329

  Fly   314 IYSRFHD---------CDPIQSGHVSKVDKMVPYFVQDTVGNLWGMPGVFISCVFSAALSTLSAS 369
            ....|.|         |..|.|......|...|..|.:.:..  |:.|:.::.:.:|.:|:|::.
Human   330 SRILFPDQVACADPEICQKICSNPSGCSDIAYPKLVLELLPT--GLRGLMMAVMVAALMSSLTSI 392

  Fly   370 INSLGGVVYFD---YIKPHIRHTEHRANVIMKLFVFFTGIYCIL---------GGMV---IENFN 419
            .||...:...|   :::|  |.:|....::.::||....:..||         ||.:   |::.:
Human   393 FNSASTIFTMDLWNHLRP--RASEKELMIVGRVFVLLLVLVSILWIPVVQASQGGQLFIYIQSIS 455

  Fly   420 SILQ----VIYSIG---------GMSFGSTCGVFMLGML------------VPKSHGRAALV--- 456
            |.||    |::.:|         |..:|...|: :||::            ..:...|..||
Human   456 SYLQPPVAVVFIMGCFWKRTNEKGAFWGLISGL-LLGLVRLVLDFIYVQPRCDQPDERPVLVKSI 519

  Fly   457 -----GVLASIACMATIVILSWGR--------------NHYDTLPTSTSACPA-------SLNGT 495
                 .::.|...:.|:..:||..              ..:|.:.....|.||       |.||.
Human   520 HYLYFSMILSTVTLITVSTVSWFTEPPSKEMVSHLTWFTRHDPVVQKEQAPPAAPLSLTLSQNGM 584

  Fly   496 IKDISTASPLF------LGSTTEAPVGEKEFSILDLSFNWYTVTGFVITWLIGI 543
            .:..|::|..|      ...|....:..|:..::.           .|.||.||
Human   585 PEASSSSSVQFEMVQENTSKTHSCDMTPKQSKVVK-----------AILWLCGI 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smvt	NP_651891.2	SLC5sbd_NIS-SMVT	27..548	CDD:271383	139/639 (22%)
SLC5A11	NP_001339171.1	SLC5sbd_SGLT6	28..675	CDD:271381	139/639 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146425
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840