DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smvt and Slc5a5

DIOPT Version :9

Sequence 1:	NP_651891.2	Gene:	Smvt / 43744	FlyBaseID:	FBgn0039873	Length:	591	Species:	Drosophila melanogaster
Sequence 2:	NP_443215.2	Gene:	Slc5a5 / 114613	RGDID:	69267	Length:	618	Species:	Rattus norvegicus

Alignment Length:	618	Identity:	190/618 - (30%)
Similarity:	300/618 - (48%)	Gaps:	75/618 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 FNATDYGVFALVLSISAAIGVYFGFFAKGEDTTEEYLMGGKRMKTIPIAISLVASQLSAISIMTI 88
            |.|.||||||.:|.:|..||::.|....|:.:.:::..||:::..:|:.:||.||.:||:.::.:
  Rat    12 FGAWDYGVFATMLLVSTGIGLWVGLARGGQRSADDFFTGGRQLAAVPVGLSLAASFMSAVQVLGV 76

  Fly    89 PAEMYAYGINWVFNVVCMVLVVPLLNYLVIPVFYNNNITNCYEYLEMRFCRKVRVLQTFIFILTM 153
            |||...||:.:::.....:|...|..:|.:|:||...:|:.|:|||:||.|.||:..|..:::..
  Rat    77 PAEAARYGLKFLWMCAGQLLNSLLTAFLFLPIFYRLGLTSTYQYLELRFSRAVRLCGTLQYLVAT 141

  Fly   154 FFMLPIFIFLPSLAFAQVTGFNV--HLINTVVCSICVFYTMFGGIKAVVWTDVIQAAIMVASVVL 216
            .....|.|:.|:|...||||.::  .|::|.:  ||..||..||:||||||||.|..:|:....:
  Rat   142 MLYTGIVIYAPALILNQVTGLDIWASLLSTGI--ICTLYTTVGGMKAVVWTDVFQVVVMLVGFWV 204

  Fly   217 VGVLGAHRVGGFFEVLRIAGEGGRLDI-NYNFDLTTRSTIWNIFTSATMMWTGYVGLNQSCVQRI 280
            :...|...:||...:|.:|....|::: :::.|..:|.|.|......|::|....|:||:.|||.
  Rat   205 ILARGVILLGGPRNMLSLAQNHSRINLMDFDPDPRSRYTFWTFIVGGTLVWLSMYGVNQAQVQRY 269

  Fly   281 VSLPSLGHARRSLVLFGFGFILIMFFNCFTGIVIYSRFHDCDPIQSGHVSKVDKMVPYFVQDTVG 345
            |:..:.|.|:.:|::...|..||:......|||::..:.||||:.:|.:|..|:.:|..|.|...
  Rat   270 VACHTEGKAKLALLVNQLGLFLIVASAACCGIVMFVYYKDCDPLLTGRISAPDQYMPLLVLDIFE 334

  Fly   346 NLWGMPGVFISCVFSAALSTLSASINSLGGVVYFDYIKPHIRHTEHRANV-IMKLFVFFTGIYC- 408
            :|.|:||:|::|.:|..|||.|.|||::..|...|.|||.:.....|..| |.|...|..|..|
  Rat   335 DLPGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKPRMPGLAPRKLVFISKGLSFIYGSACL 399

  Fly   409 -------ILGGMVIENFNSILQVIYSIGGMSFGSTCGVFMLGMLVPKSHGRAALVGVLASIACMA 466
                   :|||       .:||..:::.|:..|...|.|.||||:|..:....|.|:.|.:|...
  Rat   400 TVAALSSLLGG-------GVLQGSFTVMGVISGPLLGAFTLGMLLPACNTPGVLSGLAAGLAVSL 457

  Fly   467 TIVILSW----GRNHYDTLPTSTSAC---------PASLNGTIKDISTASPLFLGSTTEAPVGEK 518
            .:.:.:.    |......||||.:.|         |.:.|.     |...| ..|..|..|....
  Rat   458 WVAVGATLYPPGEQTMGVLPTSAAGCTNDSVLLGPPGATNA-----SNGIP-SSGMDTGRPALAD 516

  Fly   519 EFSILDLSFNWYTVTGFVITWLIGIPLSYILKSGPDYKPN--PKLL------------------- 562
            .|  ..:|:.:|...|.:.|.|.|..:||:  :||..:.:  |.||
  Rat   517 TF--YAISYLYYGALGTLTTMLCGALISYL--TGPTKRSSLGPGLLWWDLARQTASVAPKEDTAT 577

  Fly   563 -------SPVVQPFVHYK---LTPSDEPHQLNL 585
                   .|...|.|..|   |.|..|.|.|.|
  Rat   578 LEESLVKGPEDIPAVTKKPPGLKPGAETHPLYL 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smvt	NP_651891.2	SLC5sbd_NIS-SMVT	27..548	CDD:271383	172/545 (32%)
Slc5a5	NP_443215.2	SLC5sbd_NIS	15..549	CDD:271393	175/552 (32%)
Slc5a5	NP_443215.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	587..618		9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340155
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1180002at2759
OrthoFinder	1	1.000	-	-		FOG0000151
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR42985
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X112
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.850