DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smvt and Slc5a10

DIOPT Version :9

Sequence 1:	NP_651891.2	Gene:	Smvt / 43744	FlyBaseID:	FBgn0039873	Length:	591	Species:	Drosophila melanogaster
Sequence 2:	XP_006532041.1	Gene:	Slc5a10 / 109342	MGIID:	1926089	Length:	611	Species:	Mus musculus

Alignment Length:	605	Identity:	134/605 - (22%)
Similarity:	238/605 - (39%)	Gaps:	114/605 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ATAATVVPDSQFVFNATDYGVFALVLSISAAIGVYFGFFAKGEDTTEEYLMGGKRMKTIPIAISL 75
            :|....||.||  .:.||..|.::..:::.|:|::....| .::|...|.:.|:.|...||..||
Mouse    40 STGDAHVPGSQ--LSVTDIIVISVYFALNVAVGIWSACRA-NKNTVSGYFLAGRDMAWWPIGASL 101

  Fly    76 VASQLSAISIMTIPAE-----MYAYGINWVFNVVCMVLVVPLLNYLVIPVFYNNNITNCYEYLEM 135
            .||...:...:.:...     :...|..|                         ||....||::.
Mouse   102 FASSEGSGLFVGLAGSGAAGGLAVAGFEW-------------------------NIVTLPEYIQK 141

  Fly   136 RF-CRKVRV-LQTFIFILTMFFMLPIFIFLPSLAFAQVTGFNVHLINTVVCSICVFYTMFGGIKA 198
            || .:::|. |.....:|::|..:.|.::..:|......|:|.:|...:..:|...||:.||:..
Mouse   142 RFGGQRIRTYLSVLSLMLSVFTKISIDLYAGALFVHICLGWNFYLSTILTLAITALYTIAGGLAT 206

  Fly   199 VVWTDVIQAAIMVASVVLVGVLGAHRVGGFFEVLRIAGEGG--------------RLDINYNF-D 248
            |::||.:|..|||...|::.|...:::|| :|.|..|....              |.|..:.| |
Mouse   207 VIYTDALQTIIMVVGAVILAVKAFNQIGG-YEQLEAAYAQAIPSRTIPNTTCHLPRADAMHMFRD 270

  Fly   249 LTTRSTIWNIFT-SATMMWTGYVGLNQSCVQRIVSLPSLGHARRSLVLFGF------------GF 300
            .:|....|...| ..|:|.|.|...:|..|||.:|..:|.||:...:|..:            |.
Mouse   271 PSTGDLPWTGMTFGLTIMATWYWCTDQVIVQRSLSARNLNHAKAGSILASYLKMLPMGLMIMPGM 335

  Fly   301 ILIMFFNCFTGIVIYSRFHDCDPIQSGHVSKVDKMVPYFVQDTVGNLWGMPGVFISCVFSAALST 365
            |..:.|....|.|:.|   :|.......:...:...|..|.:.:.  .|:.|:.|:.:.:|.||:
Mouse   336 ISRVLFPDDVGCVVPS---ECLRACGAEIGCSNIAYPKLVMELMP--IGLRGLMIAVMMAALLSS 395

  Fly   366 LSASINSLGGVVYFD---YIKPHIRHTEHRANVIMKLFVFFTGIYCILGGM------VIENFNSI 421
            |::..||...:...|   .::|.....|        |.:....:..:|.|:      |::..||.
Mouse   396 LTSIFNSSSTLFTMDIWRQLRPSAGERE--------LLLVGRLVIVVLIGVSVAWIPVLQGSNSG 452

  Fly   422 LQVIY--SIGGMSFGSTCGVFMLGMLVPKSHGRAALVGVLASIACMATIVILSWGRNHYDTLPT- 483
            ...||  |:..........:|:||:...:::.:.|..|::|.:...|..::|.:   .|...|.
Mouse   453 QLFIYMQSVTSSLAPPVTAIFILGIFWRRANEQGAFWGLMAGLVVGALRLVLEF---LYPEPPCG 514

  Fly   484 STSACPASLNGTIKDISTASPLFL--------GSTTEAPVGEKEFSILDLSFNWYTVTGFVITWL 540
            .....||.|. ::..:..|..|||        ||....|..:::..    :..|:|:..   .|.
Mouse   515 QIDTRPAPLR-SLHYLHFAIALFLLTCAVMAAGSLLSPPPQQRQIE----NLTWWTLAP---NWS 571

  Fly   541 IGIPLSYILKSGPDYKPNPK 560
            :|      .|:|....|..:
Mouse   572 LG------TKTGDGQTPQKR 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smvt	NP_651891.2	SLC5sbd_NIS-SMVT	27..548	CDD:271383	126/575 (22%)
Slc5a10	XP_006532041.1	SLC5-6-like_sbd	52..611	CDD:382020	129/591 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836496
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740