DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2187 and SLC5A3

DIOPT Version :9

Sequence 1:	NP_001189331.1	Gene:	CG2187 / 43743	FlyBaseID:	FBgn0017448	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_008864.4	Gene:	SLC5A3 / 6526	HGNCID:	11038	Length:	718	Species:	Homo sapiens

Alignment Length:	584	Identity:	122/584 - (20%)
Similarity:	228/584 - (39%)	Gaps:	128/584 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 YFVFVIMLGASAGIGVYFGFFSKSKNTTEEYLRGGKKMQTLPIAISLVASQLSGIAIMSIPAESY 93
            ||:.|:.:|       :|..:..:::|...|...|:.|..:.|..||..|.:.....:.:.....
Human    16 YFILVMCIG-------FFAMWKSNRSTVSGYFLAGRSMTWVAIGASLFVSNIGSEHFIGLAGSGA 73

  Fly    94 TYGFNYIFVVLAMLVVIPILIYIIVPVFYENNVSNCYEYLEMRFNKRTRQLVTFFFVTNS----- 153
            ..||.........|:::.:|.::.:|::..:.|....|||..||.....|:   :|...|
Human    74 ASGFAVGAWEFNALLLLQLLGWVFIPIYIRSGVYTMPEYLSKRFGGHRIQV---YFAALSLILYI 135

  Fly   154 FLMLPVYMFIPSLAFAQVTGMNIHLINVMVSSICIFYTMLGGIKAVVWTDVVQGAIMLLSVVAVG 218
            |..|.|.::..:|...:..|.|:::..:::..:....|:.||:.||::||.:|..:|::..:.:.
Human   136 FTKLSVDLYSGALFIQESLGWNLYVSVILLIGMTALLTVTGGLVAVIYTDTLQALLMIIGALTLM 200

  Fly   219 VLGTIRSGGMFTVMER----ASDGGRFNFDFGL-------------------DPRIRMTFW---- 256
            ::..:..||...|..|    :.|.......:.|                   :|......|
Human   201 IISIMEIGGFEEVKRRYMLASPDVTSILLTYNLSNTNSCNVSPKKEALKMLRNPTDEDVPWPGFI 265

  Fly   257 -GATMGGIFMWTGHIGLNQSCVQRIVSLPSYSHAKKSLIVSGLGFLIISFFNTISGI---IMFAR 317
             |.|...::.|..    :|..|||:::..:.:|||.|.:::|...|:..|...:.|:   |:|..
Human   266 LGQTPASVWYWCA----DQVIVQRVLAAKNIAHAKGSTLMAGFLKLLPMFIIVVPGMISRILFTD 326

  Fly   318 YYGC-DP---ML-----AGL--VSKPD---KMMPFFVQDIMGHLAGMPGVFISCVFSAALSSLSA 368
            ...| :|   ||     ||.  ::.|.   |::|          .|:.|:.::.:.:|.:|.|.:
Human   327 DIACINPEHCMLVCGSRAGCSNIAYPRLVMKLVP----------VGLRGLMMAVMIAALMSDLDS 381

  Fly   369 TLNSLAGVVYFDYIKPRIRHTEAR-----------------ANWAMKLIVVVMGGYCILGGFMVQ 416
            ..||.:.:...|..|...:...:|                 ..| :.:||.:.||...|   .:|
Human   382 IFNSASTIFTLDVYKLIRKSASSRELMIVGRIFVAFMVVISIAW-VPIIVEMQGGQMYL---YIQ 442

  Fly   417 NFNSILQTVVTITGINTGAVVGVFLLGMFVPRCNAKTA----VTSIIVSVVAMVWIIAN-----G 472
            .....|          |..|..:|||.:|..|||.:.|    :...::..|.::...|.     .
Human   443 EVADYL----------TPPVAALFLLAIFWKRCNEQGAFYGGMAGFVLGAVRLILAFAYRAPECD 497

  Fly   473 QMNFKSGLIK---YEVLPNSLDQCEARGLYMIAEAINKTDFTPVTMKPPSGAPV-TTAFHSDRD 532
            |.:.:.|.||   |..:        |.||:.:...|  |....:...||:...: ||.|.|.::
Human   498 QPDNRPGFIKDIHYMYV--------ATGLFWVTGLI--TVIVSLLTPPPTKEQIRTTTFWSKKN 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2187	NP_001189331.1	SLC5sbd_NIS-SMVT	27..561	CDD:271383	122/584 (21%)
SLC5A3	NP_008864.4	SLC5sbd_SMIT	9..718	CDD:271382	122/584 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146408
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740