Protein Alignment CG2187 and SLC5A2

DIOPT Version :10

• Sequence 1: NP_651890.1
• Gene: CG2187 / 43743
• FlyBaseID: FBgn0017448
• Length: 623
• Species: Drosophila melanogaster
• Sequence 2: XP_006721135.3
• Gene: SLC5A2 / 6524
• HGNCID: 11037
• Length: 698
• Species: Homo sapiens
• Alignment Length: 699
• Identity: 161/699 - (23%)
• Similarity: 256/699 - (36%)
• Gaps: 220/699 - (31%)

  Fly    29 YFVFVIMLGASAGIGVYFGFFSKSKNTTEEYLRGGKKMQTLPIAISLVASQL------------- 80
            ||:.||      |:|:: .....::.|...|...|:.|...|:..||.||.:
Human    32 YFLLVI------GVGLW-SMCRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGA 89

  Fly    81 -SGIAIMSIPAESYTYGFNYIFVVLAMLVVIPILIYIIVPVFYENNVSNCYEYLEMRFNKRTRQL 144
             ||:|:..       :.:|.:||||       :|.::..||:....|....:||..||..|..:|
Human    90 ASGLAVAG-------FEWNALFVVL-------LLGWLFAPVYLTAGVITMPQYLRKRFGGRRIRL 140

  Fly   145 V-----TFFFVTNSFLMLPVYMFIPSLAFAQVTGMNIHLINVMVSSICIFYTMLGGIKAVVWTDV 204
            .     .|.::   |..:.|.||..::...|..|.||:...:.:..|.:.||:.||:.|:::||.
Human   141 YLSVLSLFLYI---FTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDT 202

  Fly   205 VQ------GAIMLLSVVAVGVLGTIRSGGMF----------TVMERASDGGRFNFDFGLDP---- 249
            ||      ||.:|:......|.|   ..|:|          ||.|..:.|...:|.:...|
Human   203 VQTFVILGGACILMGYAFHEVGG---YSGLFDKYLGAATSLTVSEDPAVGNISSFCYRPRPDSYH 264

  Fly   250 --RIRMTF---WGATMGGIFMWTG-HIGLNQSCVQRIVSLPSYSHAKKSLIVSGLGFLIISFFNT 308
              |..:|.   |.|.:.|:.:.:| :...:|..|||.::..|.:|.|...|:.|...|...|...
Human   265 LLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCLAGKSLTHIKAGCILCGYLKLTPMFLMV 329

  Fly   309 ISGIIMFARY-------------------YGCD----PMLAGLVSKPDKMMPFFVQDIMGHLAGM 350
            :.|:|....|                   .||.    |.|.      .|:||          .|:
Human   330 MPGMISRILYPDEVACVVPEVCRRVCGTEVGCSNIAYPRLV------VKLMP----------NGL 378

  Fly   351 PGVFISCVFSAALSSLSATLNSLAGVVYFDY---IKPRIRHTE---ARANWAMKLIVVVMGGYCI 409
            .|:.::.:.:|.:|||::..||.:.:...|.   ::||....|   ....|.:.::||.:....:
Human   379 RGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDRELLLVGRLWVVFIVVVSVAWLPV 443

  Fly   410 L----GGFM---VQNFNSILQTVVTITGINTGAVVGVFLLGMFVPRCNAKTAVTSIIVSVVAMVW 467
            :    ||.:   :|..:|.|...|:          .||:|.:||||.|.:.|           .|
Human   444 VQAAQGGQLFDYIQAVSSYLAPPVS----------AVFVLALFVPRVNEQGA-----------FW 487

  Fly   468 IIANGQMNFKSGLIKYEVLPNSLDQCEARGLYM-IAEAINKTDFTPVTMKPPSGAPVTTAFHSDR 531
                       |||              .||.| :|..|.:..|...:...||..|   ||....
Human   488 -----------GLI--------------GGLLMGLARLIPEFSFGSGSCVQPSACP---AFLCGV 524

  Fly   532 DFSLYDISFYWYKVLGSALVFLCA--IPLSYIWR--------------PDENEKQNPKLYSPFVR 580
            .:..:.|..::...|.:..|.||.  ||..::.|              .|.:|:|..
Human   525 HYLYFAIVLFFCSGLLTLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADEQQGS-------- 581

  Fly   581 KFLSLPVT-----------------DQDLEEVPLRGSKVAATPDLRIEP 612
               ||||.                 :..|||:..|  |:.|.|....||
Human   582 ---SLPVQNGCPESAMEMNGRAPCWEVGLEELSSR--KLTAGPQFPSEP 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG2187	NP_651890.1	SLC5sbd_NIS-SMVT	27..561	CDD:271383	144/615 (23%)
SLC5A2	XP_006721135.3	SLC5sbd_SGLT2	24..698	CDD:212056	161/699 (23%)