DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2187 and SLC5A1

DIOPT Version :9

Sequence 1:	NP_001189331.1	Gene:	CG2187 / 43743	FlyBaseID:	FBgn0017448	Length:	623	Species:	Drosophila melanogaster
Sequence 2:	NP_000334.1	Gene:	SLC5A1 / 6523	HGNCID:	11036	Length:	664	Species:	Homo sapiens

Alignment Length:	688	Identity:	152/688 - (22%)
Similarity:	265/688 - (38%)	Gaps:	164/688 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 STTTTTTTTMASAVSSASQDLRFGLTDYFVFVIMLGASAGIGVYFGFFSKSKNTTEEYLRGGKKM 66
            ||.:..||.:...|.  :.:|.....|..:.||.......:|:: ..||.::.|...:...|:.|
Human     4 STWSPKTTAVTRPVE--THELIRNAADISIIVIYFVVVMAVGLW-AMFSTNRGTVGGFFLAGRSM 65

  Fly    67 QTLPIAISLVASQL--------------SGIAIMSIPAESYTYGFNYIFVVLAMLVVIPILIYII 117
            ...||..||.||.:              |||||         .||.:     ..||::.:|.::.
Human    66 VWWPIGASLFASNIGSGHFVGLAGTGAASGIAI---------GGFEW-----NALVLVVVLGWLF 116

  Fly   118 VPVFYENNVSNCYEYLEMRFNKRTRQLVTFFFVTNSFLMLPVYMFIPSLA-------FAQVT-GM 174
            ||::.:..|....|||..||..:..|      |..|.|.|.:|:|....|       |..:. |:
Human   117 VPIYIKAGVVTMPEYLRKRFGGQRIQ------VYLSLLSLLLYIFTKISADIFSGAIFINLALGL 175

  Fly   175 NIHLINVMVSSICIFYTMLGGIKAVVWTDVVQGAIMLL-SVVAVG------------------VL 220
            |::|...::.:|...||:.||:.||::||.:|..|||: |::..|                  .:
Human   176 NLYLAIFLLLAITALYTITGGLAAVIYTDTLQTVIMLVGSLILTGFAFHEVGGYDAFMEKYMKAI 240

  Fly   221 GTIRSGGMFTVMERASDGGRFNFDFGLDPRIRMTFWGATMGGIFMWTGHI-GL----------NQ 274
            .||.|.|..|..|:.......:|....||          :.|...|.|.| |:          :|
Human   241 PTIVSDGNTTFQEKCYTPRADSFHIFRDP----------LTGDLPWPGFIFGMSILTLWYWCTDQ 295

  Fly   275 SCVQRIVSLPSYSHAKKSLIVSGLGFLIISFFNTISGIIMFARY---------YGCDPMLAGLVS 330
            ..|||.:|..:.||.|...|:.|...|:..|...:.|:|....|         ..|:......|.
Human   296 VIVQRCLSAKNMSHVKGGCILCGYLKLMPMFIMVMPGMISRILYTEKIACVVPSECEKYCGTKVG 360

  Fly   331 KPDKMMPFFVQDIMGHLAGMPGVFISCVFSAALSSLSATLNSLAGVVYFD-YIKPRIRHTEARAN 394
            ..:...|..|.::|.:  |:.|:.:|.:.::.:|||::..||.:.:...| |.|.|.|.:|....
Human   361 CTNIAYPTLVVELMPN--GLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYAKVRKRASEKELM 423

  Fly   395 WAMKLIVVVMGGYCILGGFMVQNFNS--ILQTVVTITGINTGAVVGVFLLGMFVPRCNAKTAVTS 457
            .|.:|.::|:.|..|....:||:..|  :...:.:||......:..||||.:|..|.|...|...
Human   424 IAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFWKRVNEPGAFWG 488

  Fly   458 IIVSVVAMVWIIANGQMNFKSGLIKYEVLPNSLDQCEARGLYMIAEAINKTDFTPVTMKPPSGAP 522
            :|:.:                                   |..|:..|.:..:...:...||..|
Human   489 LILGL-----------------------------------LIGISRMITEFAYGTGSCMEPSNCP 518

  Fly   523 VTTAFHSDRDFSLYDISFYWYKVLGSALVFLCAIPLSYIWRPDEN--------EKQNPKLYSPFV 579
            ..          :..:.:.::.::..|:.|:..:.:|.:.:|..:        ..:|.|
Human   519 TI----------ICGVHYLYFAIILFAISFITIVVISLLTKPIPDVHLYRLCWSLRNSK------ 567

  Fly   580 RKFLSLPVTDQDLEEVPLRGSKVAATPDLRIEPTEKEK 617
            .:.:.|...:::::|.|      ..|.::..:..||:|
Human   568 EERIDLDAEEENIQEGP------KETIEIETQVPEKKK 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2187	NP_001189331.1	SLC5sbd_NIS-SMVT	27..561	CDD:271383	136/597 (23%)
SLC5A1	NP_000334.1	SLC5sbd_SGLT1	27..664	CDD:271379	146/663 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146414
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740